Malangizo ntchito, ndi analogi "Cefotaxime" ndi ndemanga

"Cefotaxime" (zikuonetsa ntchito, malamulo kwa kuwerengetsa mlingo mulingo woyenera, komanso analogues wotchuka adzapatsidwa pansipa) ndi masiku theka-kupanga mankhwala. Ndi kugonjetsedwa beta-lactamases ndipo akugwira ntchito ndi galamu HIV ndi galamu alibe tizilombo onse. Limagwirira amuzolengedwa anachita chifukwa yimitsira wa luso la zigawo za kusintha kwa zinthu zachilengedwe kunachitika selo nembanemba tizilombo toyambitsa matenda.

The mankhwala ndi kulowa m'thupi, mwadala wawononga chamtanda lumikiza peptidoglycan, kotero koyenera kuti mabakiteriya kuonetsetsa zopezera makoma achilengedwe. Monga amadziwika, chitetezo ndi zoletsa zosakaniza zotanuka akagwiriridwa selo - n'zosavuta kwambiri chandamale.

Fomu kumasulidwa

The medicament "Cefotaxime" (jakisoni Buku ndi infusions akupereka ngati dera Zimatheka yobereka wa chinthu yogwira) umaperekedwa kwa msika mankhwala mu woyera kapena wachikasu ufa, amene akutumikira monga maziko yokonza njira. Izi otchedwa jekeseni ampoules.

The original 10 ml buku Mbale la galasi mandala. Leni misa reagent alipo yemweyo mankhwala wagawo zimadalira kudzazidwa ndi masanjidwewo (0.5, 1.0 kapena magalamu 2.0).

pharmacokinetic sewero

Iwo ayenera yomweyo kudziŵika kuti si analogi "Cefotaxime" ali yemweyo katundu pharmacokinetic monga pachiyambi. Makamaka ngati tikukamba za mlingo wa mayamwidwe zigawo ku malo jekeseni, mayamwidwe wa wothandizila awa, kuweruza ndi ndemanga madokotala ambiri, ndi zambiri mofulumira kuposa mayamwidwe yoyamba ya zomwezi "Duataksa" kapena "Tsetaksa". "Chodabwitsa" chifukwa lagona pa gulu koyamba chitsanzo molekyulu. Akatswiri mayankho awo anatsindika mfundo yakuti Indian generic pamwamba akupanga "wodetsedwa mankhwala" mu mawonekedwe a opangidwa kuchokera zovuta cephalosporin zomwe kwambiri kubweza kagayidwe wa zosakaniza zina.

Iwo anapeza kuti "Cefotaxime" (kuwerenga enshrined mu kalozera wa nduna kuti mankhwala kuperekedwa, kuthetsa Mwina kopita mu kukhalapo kwa magazi) akusonyeza msinkhu ndi mkulu wa kumanga zonsezo plasma, pamene nthawi ya zotsatira microbicidal zimasiyanasiyana pasanathe maola 11-12. Kukhala kuyambira kusintha wothandiza wogawana anagawira mu thupi, kuphatikizapo fupa (ndende pazipita ndi anatinso mu myocardium ndi chikhodzodzo ndulu).

Chofunika waukulu umene uli chililaka chotchinga placental ndipo amakhala mbali yofunika ya pericardium ndi madzimadzi cerebrospinal. Wapakati theka moyo wa mtsempha kukapanda kuleka kulowetsedwa Kodi musalumphe ola limodzi ndi jekeseni mu mnofu - Mphindi zana limodzi-makumi asanu ndi atatu. Aliyense wa kuchepetsa kudzikundikira chuma ndi unalibe - gawo la zigawo zikuluzikulu pamodzi ndi excreted mu ya ndulu ndi zina (90%) - mkodzo. Zikatero, chiwerengero cha metabolites yogwira okha 20-30% ya mlingo kutumikiridwa, i.e. 70% ya njira zosiyira thupi lopanda likufa zosintha structural.

zikuonetsa kuti

Makampaniwa ndi kukhazikika bwino ngati blocker njira opatsirana ndi yotupa akuthamanga tizilombo, makamaka tcheru cefotaxime. Ndipo umboni wa zimenezi si maphunziro matenda - mfundo yofanana angathe kukhala mutawerenga ambiri ndemanga zabwino kuikidwa pa webusaiti mutu umene ndi mankhwala zothandiza kwambiri kuteteza tizilombo toyambitsa matenda. Front pharmacological ntchito mankhwala mu mokwanira lonse, koma nthawi zambiri "Mmaso" kugwa aakulu kapena matenda pachimake aimpso zikuchitika ndi kapepala mkodzo, komanso chapamwamba matenda kupuma.

Ine ndiyenera kunena kuti, ngakhale ngati chizindikiro Mtheradi wa zikuchokera ndi analogi "Cefotaxime" kaya "Tsefasin" kapena "Tsetaks" simungathe kupatsidwa ntchito kutengera ndi momwe pamwamba. mfundo ndi yakuti anthu ambiri amakonda generics yekha "wachibale buku 'amuzolengedwa chitsanzo cha dongosolo lapachiyambi la makhalidwe, choncho yeniyeni khadi mankhwala kuti amaganizira ndandanda ndi mlingo" awiri "ayenera kuwerengetsa katswiri wodziwa.

The mankhwala choyambirira akulimbikitsidwa kugwiritsa ntchito ngati:

• wodwala matenda ndi kudwala a dongosolo kupuma mu mawonekedwe a chibayo, abscess kapena matenda, ndi maantibayotiki ena musati kubweretsa zotsatira anakhumba;
• wodwalayo ali wolemedwa ndi bakiteriya matenda oumitsa khosi mwapang'onopang'ono;
• mayesero anatsimikizira pamaso pa endocarditis;
• mu nthawi postoperative sanathe kupewa mavuto mu mawonekedwe a chiwonongeko focal wa khungu ndi / kapena Kakhungu a ziwalo zofunika kwambiri;
• wothandizila opatsirana anakhala ku fupa, ndi mu mnofu jekeseni ndi mankhwala-ofanana matanthauzo mulibe kuchita zosayenera pa iwo;
• Galamu alibe kapena galamu HIV atagonjetsa lamoto mabala ndi matenda chikwiyire lonse (mpaka sepsis);
• pali kufunika zodzitetezera.

Akatswiri Independent amakonda kukhulupirira kuti pali pang'ono analogue aliyense "Cefotaxime" wokhoza akusonyeza anasonyeza mphamvu zabwino ndi matenda Lyme. M'pofunikanso kukumbukira mmene choyambirira phunziro kwa ntchito zonse, ndi ntchito kuthana bwino (ndemanga anadzipereka kwa mokoma njira achire, odwala anayikidwa pa maonekedwe).

Ntchito ndi mlingo

"Cefotaxime" malangizo (jakisoni, malinga ndi madokotala ena komanso anthu odwala si mogwira mtima chikhale dropper) ali pabwino ngati kanthu wokonda nkhondowo matenda mankhwala kusankha aakulu bakiteriya. Monga tanenera poyamba, pali atatu yobereka madera reagent: ndi kukapanda kuleka kulowetsedwa kapena ndege, komanso kudzera mu mnofu jekeseni. malamulo Wonse ntchito yokonza madzimadzi ntchito kulibe, kotero ndikofunika kudziwa pasadakhale akafuna utsogoleli wa mankhwala.

Mlengi, makamaka, akuonetsa zotsatirazi aligorivimu izi:

• kwa jekeseni / TH: 1 galamu ya ufa zidzasungunuka mu 4 ml ya madzi, lidocaine wa kapena novocaine;
• jekeseni mtsempha: 1 g wa mankhwala n'kofunika kupasuka mu madzi wosabala (4 ml);
• chifukwa / mu kulowetsedwa: botolo ndi magalamu awiri cefotaxime ayenera kuwonjezera 100 ml ya NaCl (0,9%) kapena yemweyo peresenti asanu shuga.

Kutumiza nthawi reagent:

• pa / mamita jekeseni: 5-10;
• pa / mu ndege oyamba: 5.3 Mph;
• pamene wakhala dropper: 50-60 min.

Mawerengedwe a mlingo moyenera ndi amakonza yomanga phwando mulingo woyenera ikuchitika payekha. Iwo amaganizira zaka wodwalayo ndi thupi lake, komanso mtundu wa matenda ndi siteji ya chitukuko. Komanso, kusinthidwa anapanga mbiri achire.

Komabe, malangizo koma likunena zambiri pa mitengo pafupifupi ntchito "cefotaxime" mankhwala. Majekeseni (ufa kuchepetsedwa, anafotokoza pamwamba, koma, chochititsa chidwi, pafupifupi onse ndemanga chimakhala chogwidwa ndi lingaliro limene jekeseni - zimatenga chopweteka kwambiri ndi zosasangalatsa, ngakhale ndi malangizo onse a Mlengi), makamaka Kwalamulidwa zinthu wopepuka, ziboola maola 4-12 ndi mlingo umodzi wa magalamu 1-2. Pakuti yovuta ndi subcritical zofunika mu zochitika / oyamba (pa mlingo wa 2 ga maola 4 aliwonse, koma osapitirira 12 g / tsiku).

Madokotala kusankha chakudya motsogozedwa ndi mnyamata wodwala thupi ndi thupi okwana anachita ( "muyeso" - awiri sikisi jakisoni ndege; 50-180 mg / kg).

zotsatira zoyipazi

Pamene kugawa ndi medicament "Cefotaxime" (jakisoni mavoti si okweza ngati kukapanda kuleka kulowetsedwa, kuyambira / mamita oyamba nthawi zambiri limodzi ndi ululu; chifukwa chimenechi, monga "zosungunulira" nthawi ndi procaine kapena lidocaine wa) sangathe lilibe zigawo atypical kanthu a dongosolo ndi ziwalo wodwalayo.

chovomerezeka:

• matupi awo sagwirizana "mayankho" mu mawonekedwe a zikuluzikulu urticaria, angioedema kapena candidiasis;
• mavuto pa mlingo wa mundawo m'mimba (kusanza, kawirikawiri - cholestatic matenda a chikasu ndiyo);
• matenda mu magazi (a akuponya achiyesa kupatsidwa zinthu za m'mwazi, hemolytic magazi m'thupi ndi m. p.).

zotsatira za mankhwala osokoneza bongo

Kugwiritsa kuwonjezeka mu lamulo tsiku ndi zinadzala ndi dysbiosis ndi encephalopathy; mwina otembenuza irritations khungu.

Ntchito yaikulu ndiyo kuonetsetsa kuti amasiya reagent yoperekera mu thupi. miyeso zina zofunika ziziyenda boma kumanga ntchito mankhwala zakupha chikumbumtima pharmacological (ndi polojekiti ndi dokotala).

Malinga ndi contraindications Mlengi

Malinga ndi zimene anapatsidwa mu mawu boma, "cefotaxime" (jakisoni kwa ana, zambiri zotchulidwa akafika miyezi 30 zakubadwa, pamaso kutsatira Ine / kulowetsedwa) sayenera kugwiritsidwa ntchito:

• pa mimba;
• hypersensitivity kuti zosakaniza;
• kutsegula ndi kutseka magazi;
• Ngati nkhani ya enterocolitis kale akuimira mu mbiri.

Mwanjira mankhwala

Mu phunziro choyambirira tikunena chakuti njira zina zivute zitani sayenera kuperekedwa pamodzi (kuchokera chipangizo wina wa zachipatala) ndi njira maantibayotiki "cefotaxime".

Majekeseni (pogwiritsa ntchito kukapanda kuleka mu mawu a mogwirizana pharmacological ndi zigawo zikuluzikulu za mankhwala ena, si wosiyana kuchokera / mamita jekeseni), makamaka, kungakhale kuwonongeka kwa impso, ngati "wogwirizana" anatchulidwa kukonzekera kuchita aminoglycoside iliyonse kapena kuzungulira diuretic. Nayenso interlocks katulutsidwe tubular kwambiri ziletsa achire ndondomeko anapatsidwa reactant ndipo kumapangitsa kuwonjezeka ndende zake.

Kulumikizana ndi antiplatelet komanso osafunika chifukwa cha kufala kwa magazi.

Special malangizo malo

"Cefotaxime" (tableted analogs, malinga ndi ndemanga ndemanga sakhala ogwira) nthawi zina amakwiya onyenga Kumbusa chitsanzo ndi "spoofs" mkodzo kuwunika kwa shuga woona.

Pamene yaitali mankhwala metering chigawo zikuchokera magazi ayenera ikuchitika osachepera 1 nthawi mu masiku 10.

Mu masiku oyambirira a mankhwala si kukusalani mawonekedwe choopsa cha m'mimba. Ndipo, characteristically, monga analogi "Cefotaxime" (ana osakwanitsa zaka 12 analemba kuti: "understudy" ali osavomerezeka), monga "Fagotsef" ofanana chithunzi matenda ndi zochepa wamba.

Kumwa mowa pa mankhwala pamaziko a reagent ndi koletsedwa.

Zomwe ziri chimodzimodzi analogous kuti "Cefotaxime" kulengeza ntchito Akatswiri paokha?

Comments pa "Sefotake" ndi "Tsefantrale" ponena za anafotokoza pharmacological mankhwala osokonezeka. Tikayang'ana ndemanga, cholinga chawo ndi ogwira ntchito zambiri kuposa kulemba malangizo akuchipatala kugula chimodzimodzi chomwecho "Tsefabola" kapena "msonkho pa wodzachititsa." Komabe, odwala ena amakonda kukhulupirira kuti zotsatira achire zitsanzo za anatchula bwino kumatanthauza ndi Mwina wa chitukuko cha zochita atypical yakusatetezeka mkulu.

Pamene maonekedwe funso anakulira ku pokha "cefotaxime" kuti sanamve kuwawa, madokotala ambiri amalangiza:

• mayeso, ndipo si kuyankha ngati kusapeza pophika yeniyeni (ngati matendawa ndi kulimbikira ndi procaine kuchepetsedwa ufa, ndiye pali chifukwa chokhulupirira kuti azunzike - zotsatirapo za ziwengo osati zotsatira mwachindunji zinthu);
• kufunafuna njira yabwino.

Analysis wa malingaliro zikusonyeza kuti ambiri "ulemu" mwa ofanana matanthauzo amaitcha "The Lorax." Koma izi zisanachitike m'malo a reactant wina ndi mzake ayenera kukaonana ndi katswiri.