Amlodipine kalozera

Medicine "Amlodipine" Mwina mukudziwa kuti ambiri m'nthawi ya dzanja. Kwenikweni, mankhwala Kwalamulidwa kwa odwala angina. Tiyeni tione mankhwala "Amlodipine" amene malangizo muli mfundo zotsatirazi.

Zikuchokera. piritsi limodzi (5 mg) munali yogwira mankhwala amlodipine besylate. Monga excipients ntchito lactose, wowuma mbatata, collidone, microcrystalline mapadi, mankhwala enaake a stearate.

mafotokozedwe General. "Amlodipine" Mapale woyera kapena pafupifupi woyera ndi olowa awiri amaganiza. Nthawi zina kuwala akhoza kupezeka marbling.

Pharmacodynamics. Dihydropyridine otumphukira - midadada kashiamu "wosakwiya" wachiwiri m'badwo ngalande ali gipotezivnoe ndi zotsatira antianginal. Kugwirizana ndi dihydropyridine cholandilira ndi kumenya anatseka misewu ya njira calcium, potero kuchepetsa transmembrane Ndime ya ayoni kashiamu mu maselo (mokulirapo mu minofu yosalala makoma chotengera kuposa myocytes mtima). zotsatira Antianginal chifukwa cha kukula kwa mitsempha ndipo arterioles inali ku periphery kuti: angina umenshaetsnizhaet azikhala ischemia m'mnyewa wamtima, mtsempha wamagazi zotumphukira zambiri, potero kuchepetsa okwana mtima kukana zotumphukira, kuwonjezera amathandiza kuchepetsa preload mtima, amachepetsa kufunika mtima wa oxygen. Odwala ndi angina, tsiku limodzi mlingo kumawonjezera mothamanga nthawi fiznagruzki, kubweza chitukuko cha ischemia ndi angina, kuphatikiza zonse amachepetsa multiplicity kuukira angina komanso kufunika kwa nitroglycerin. Choncho, odwala angina kufuna "Amlodipine" mtsogoleri chitsimikizo.

Pharmacokinetics. Pambuyo makonzedwe m'kamwa wa mankhwala pang'onopang'ono odzipereka kwa mundawo m'mimba. Mtheradi pafupifupi bioavailability ndi 64%, ndi kuikapo maganizo kwambiri mu seramu magazi pambuyo maola 6-9. Khola othandiza magazi zimawonedwa tsiku 7. Chakudya sikumangotikhudza mayamwidwe wa amlodipine. Odwala achikulire (zaka zoposa 65) ndi excretion wa mankhwala ndi wosakwiya poyerekeza ndi achinyamata, koma kusiyana kumeneku si kukomoka kwambiri.

"Amlodipine" malangizo muli zonse zofunika ali ndi zizindikiro zotsatirazi ntchito: a wolumikizira oopsa (osakaniza kapena ofanana njira monotherapy), exertional angina, vasospastic angina (Prinzmetal a angina).

Contraindications.

- mkulu kudziwa pophika yogwira ndi ena ofanana ena dihydropyridine;

- hypotension mu mawonekedwe chaukali;

- cardiogenic mantha, kugwa;

- wosakhazikika angina (kupatulapo - Prinzmetal angina);

- mkaka wa m'mawere ndi mimba;

- kwa anthu osakwana zaka 18 a chitetezo ndi zotsatira sizinachitike anakhazikitsa.

Mlingo ndi njira ya ntchito. Tengani "Amlodipine" malangizo lili motere: mkati, mlingo osachepera 5 mg, pazipita - 10 mg 1 nthawi patsiku. Pamene matenda oopsa mlingo yokonza akhoza kukhala 5 mg pa tsiku. Pamene zikwapu anatengedwa kamodzi 5-10 mg wa pa tsiku. odwala woonda, komanso odwala otsika ndi odwala ndi mkhutu chiwindi uziyenda kutumikiridwa 2.5 mg.

malangizo apadera. Pa nthawi ya mankhwala ndi "Amlodipine" ayenera kutsatira kulemera ndi kumwa zinthu monga sodium, nthawi zina amafuna zakudya zapadera. Nkofunika kutsatira kutsuka mano ndi mano, pitani mano zonse (kupewa kupweteka ndi magazi m'kamwa). Ndi akawawonjezere mlingo wa mankhwalawa okalamba amafuna polojekiti mosamala. Zotsatira za mankhwala pa kukhoza kuyendetsa galimoto palibe deta. Komabe, tiyenera adzanyamula kukumbukira kuti anthu ena zingayambitse chizungulire pang'ono ndipo kusinza.