Cholinesterase zoletsa: ntchito pharmacological

Amadziwika kuti mantha dongosolo ali synapses ambiri. N'zofunika kwa kufala kwa zikhumbo. pochita zimenezi mitundu yambiri ya owayimira. Pakati pawo, - .., Acetylcholine, norepinephrine, GABA, serotonin, etc. owayimira (transmitters) ndi zofunika kulanda chizindikiro pakati manyuroni. Komanso, chifukwa iwo ikuchitika malemeredwe kapena chopinga musculature. Mu pathologies osiyanasiyana mantha ntchito dongosolo timene akhoza linaphwanya. Izi zimachitika chifukwa njira atrophic ndi osachiritsika a mu ubongo. Mu milandu, ntchito mankhwala zofunika amplifying kapena attenuating kufala chizindikiro. Ndi ofanana ndi gulu pharmacological ndi zoletsa cholinesterase. Iwo ntchito myasthenia, neuritis, amyotrophic lateral sclerosis, matenda a Alzheimer, pathologies bongo.

Mmene zoletsa cholinesterase

Cholinesterase zoletsa - ndi mankhwala kuti chimagwiritsidwa ntchito ubongo maganizo. Iwo agawidwa m'magulu angapo, omwe amagwira ntchito pa nkhani zosiyanasiyana. The kanthu mankhwala zinthu ndi kutsekereza cholinesterase. enzyme limeneli likupezeka anthu onse athanzi ndipo amene akudwala matenda osiyanasiyana. M'pofunika zongothyola mtundu - acetylcholine. Monga zotsatira zake chopatsilira ake adzitsitsa kuti choline acid acetic. Mu pathologies zosiyanasiyana za ubongo kotekisi manja kumachitika pang'onopang'ono. Chifukwa cha zimenezi, ena nyumba akhoza kugwa kwathunthu, kuphatikizapo dongosolo cholinergic. Kuwonjezera ubongo manja, zimenezi zimapangitsa kuti njira osachiritsika a autoimmune, matenda chikhalidwe, tizilombo. Chifukwa chiwonongeko cha forebrain mtima pali kutchulidwa kusowa kwa mtundu - acetylcholine. Ngati n'zotheka anali Sitiperewedwa chinthu, m'pofunika kanthu pa enzyme adzautaya. Chifukwa chaichi, ndi zoletsa cholinesterase ntchito. Chifukwa cha iwo, mtundu ntchito kungapitirire kwa zaka zingapo.

Cholinesterase zoletsa: mankhwala gulu

Pali mitundu ingapo ya mankhwala anticholinesterase. Iwo ali m'magulu malinga ndi zotsatira pharmacological pa enzyme ndi. Ena kutsekereza cholinesterase sizingasinthe, ena - mongoyembekezera. Kuonetsetsa 3 magulu medicaments. Pakati pawo:

1. Kusintha blockers. Izi zoletsa cholinesterase kanthu pa ma siginalo postsynaptic. Chifukwa cha iwo, enzyme yochepa linasokonekera. gulu Izi zikuphatikizapo acridines ndi piperidine.
2. Psevdoneobratimye blockers cholinesterase. limagwirira zochita ndi molumikizana ndi gawo onionovoy wa molekyulu enzyme. Komanso akhoza kumumanga kwa maselo a acetylcholine. katundu izi ndi gulu la carbamates.
3. zoletsa sizingasinthe wa cholinesterase. Gulu la mankhwala odziwika monga organo-phosphates njira. Nthumwi za medicament "Mankhwalawa a metrifonate".

Gulu la acridines monga "ndege chonyamulira" mankhwala ndi "Velnakrin". Oimira carbamates - mankhwala "rivastigmine", "Epistatigmin".

Zikuonetsa ntchito zoletsa cholinesterase

zoletsa Cholinesterase ntchito pofuna kuchiza matenda minofu ya chiyambi chapakati, manja ndi matenda osachiritsika ubongo. Komanso, mankhwala akupezeka mu mawonekedwe a madontho. Iwo ntchito pa intraocular kuthamanga okwera - khungu. Mankhwala ziletsa cholinesterase kusintha anasonyeza zochizira matenda a maganizo, matenda kukatenga ndi Alzheimer. Zokonda ndi kupereka piperidine gulu, popeza kusankha ndi zotsatira ochepa mbali. M'zaka zaposachedwapa, ndi zizindikiro ntchito mankhwala kuchuluka. Ichi ndi chifukwa kuphunzira zambiri za katundu wawo. Matenda amene zotchulidwa anticholinesterase mankhwala monga myasthenia gravis, matumbo atony, akulu dystrophy, amyotrophic lateral sclerosis ziwalo za miyendo chiyambi osachiritsika. zoletsa sizingasinthe ntchito ngati poizoni.

Contraindications ntchito mankhwala cholinesterase

Mankhwala mu gulu ili si ntchito matenda convulsive, hyperkinesis wa etiology iliyonse. Iwo contraindicated odwala ndi matenda a mtima kwambiri, mphumu, thyrotoxicosis. Ndi osafunika kutenga anticholinesterases ndi concomitant chapamimba chilonda, enteritis. Mankhwala simungathe kuziona kwa akazi apakati ndi lactating.

Cholinesterase zoletsa: kusankha mankhwala matenda a Alzheimer

matenda a Alzheimer - ndi atrophic CNS, mmene muli amnesia, umunthu chisokonezo ndi maganizo. Asayansi padziko lonse akuyesetsa kupeza mankhwala a matenda. Pa wofatsa ndi zolimbitsa kukula kwa matenda ndi mankhwala wosankha "donepezil". Zikutanthauza kusintha cholinesterase woletsa, kumakhudza kusankha. mankhwala A ntchito za cholinga cha mankhwala pathogenetic. Sangathe kuchiza wodwala kwathunthu, koma kubweza chitukuko cha zizindikiro matenda a Alzheimer.