Malangizo a "Simvastatin" omwe amagwiritsidwa ntchito ngati mankhwala osokoneza bongo, omwe ali mbali ya gulu la statin ndipo ndilo loletsa mtundu wa reductase mtundu wa HMG-CoA. Mankhwalawa ndi mankhwala osokoneza bongo, chifukwa mumapangidwe ake muli zotsekedwa, zotchedwa lactone mphete, zomwe zitalowa mkati mwa thupi la munthu zimadetsedwa ndi hydrolyzed. Kugwiritsiridwa ntchito kwa mankhwala "Simvastatin" (malangizo othandizira pa izi amatsindika kwambiri) amathandiza kuchepetsa magulu a magazi a triglycerides ndi lipoproteins, komanso kolesteroloni yonse. Pa nthawi yomweyi, zotsatira zothandizira zimayamba kuonekera, pafupi masiku 12 mpaka 14 mutangoyamba kumene ntchito, ndipo zotsatira zowonjezera zimakwaniritsidwa pa sabata lachinayi kapena lachisanu ndi chimodzi.
Mankhwalawa amapangidwa makamaka ngati mapiritsi ozungulira a biconvex. Zomwe zimagwiritsidwa ntchito pazigawo zonse zimagwiritsa ntchito milligrams ya simvastatin. Zowonjezera zigawozi ndi shuga wa mkaka, polyvinylpyrrolidone, calcium stearate, citric acid, hypromellose, microcrystalline cellulose, butyl hydroxy anisole, ascorbic acid, starch yambewu, titani dioxide, talc ndi macrogol 4000.
Kuika mankhwala osokoneza bongo "Simvastatin" malangizo omwe amagwiritsa ntchito amagwiritsa ntchito uphungu, mwachitsanzo, pa chithandizo cha anthu odwala hypercholesterolemia. Komabe, gwiritsani ntchito chida ichi pazifukwazi ngati kungakhale kopanda thanzi la mankhwala. Pofuna kuthandizidwa pamodzi ndi hypercholesterolemia, kukonza "Simvastatin" ndibwino kwambiri. Zizindikiro zogwiritsira ntchito zikuphatikizapo matenda monga hypertriglyceridemia.
Pewani mapiritsi awa kuti anthu omwe akuvutika ndi zovuta za chiwindi, kuphatikizapo kupweteka kwa impso. Ngati simukugwirizana ndi simvastatin kapena zigawo zina zothandizira, akatswiri amalangiza kuti asatenge mankhwala osokoneza bongo "Simvastatin". Malangizo ogwiritsira ntchito salola kuti mankhwalawa aperekedwe kwa odwala omwe ali ndi zaka khumi ndi zisanu ndi zitatu, amayi apakati, ndi amayi omwe akuyamwitsa. Mosamala muyenera kugwiritsa ntchito mapiritsiwa odwala matenda a chiwindi, arterial hypotension kapena khunyu. Pokhala ndi chizolowezi choledzeretsa ndi matenda aakulu a impso, mankhwala "Simvastatin" ayenera kutengedwa pokhapokha kuyang'aniridwa ndi dokotala. Kuphatikiza apo, mndandanda wa zosiyana zotsutsana zikuphatikizapo kuwonjezeka ndi kuchepa kwa mitsempha ya mafupa.
Zokhudzana ndi mankhwalawa, "Simvastatin", choyamba, apa tiyenera kufotokozera chiopsezo cha matenda opatsirana, mitsempha ya m'mimba, arterial hypotension, myopathy, lupus-like syndrome, rhabdomyolysis ndi thrombocytopenia. Kuwonjezera pamenepo, kukhumudwa, chizungulire, kukhumudwa, kusala kudya, angioedema, kutupa kwa khungu, hyperemia, urticaria, eosinophilia, photosensitivity, vasculitis, malungo, minofu paresthesia, kuchepa kwa magazi ndi alopecia.