Loperamide hydrochloride. Loperamide hydrochloride - malangizo Buku

ndi mankhwala "Loperamide hydrochloride 'N'chiyani? A yankho mabuku funso limeneli lili mu zipangizo operekedwa ndi nkhaniyi. Komanso angakuuzeni mwatsatanetsatane za mmene kumwa mankhwala, pamene ndi mlingo zomwe.

zambiri

The medicament "Loperamide hydrochloride" ndi mankhwala symptomatic amene amagwiritsidwa ntchito pofuna kuchiza pachimake ndi aakulu m'mimba. Izi mankhwala anagulitsa popanda mankhwala ndipo amagulitsidwa pafupifupi mankhwala pa mtengo angagulidwe.

zotsatira pharmacological

Kukonzekera "Loperamide hydrochloride" malangizo amene zinapeza malo okhala katoni, amachepetsa motility ndi mmene minofu yosalala intestine ndi kumabwezera mmbuyo peristalsis za thupi, kuwonjezeka kwambiri polumikizira nthawi ya nkhani zake. Choncho, medicament anapereka ochitachita zotsatira antidiarrhoeal. Tikumbukenso kuti mankhwala "Loperamide hydrochloride" amayamba mwamsanga kwambiri. Pa phwando la mankhwala mkati zotsatira achire kumatenga za 4-6 maola.

Pharmacokinetics

Chotero medicament ndi odzipereka mu intestine ndi osauka kwambiri (40%). Chifukwa kufanana mkulu maselo makoma m'mimba, komanso digiri yapamwamba ya biotransformation pa ndimeyi choyamba kudzera mwa milingo chiwindi plasma wa chigawo unmodified atalandira njira 2 mg (1 kapisozi) ndi zosakwana 2 ng / ml. Ndende pazipita thunthu yogwira pambuyo ntchito njira kukufika pambuyo pa 2.5 maola, ndipo pambuyo makapisozi a - pambuyo maola 5. KUMANGA zonsezo plasma akupezeka 97%. Izi mankhwala zimapukusidwa mu chiwindi ndi lachokera ku gawo ku mkodzo, monga conjugates ndi ya ndulu, komanso ndi chimbudzi.

mawonekedwe amasulidwe mankhwala ndi kapangidwe kake

Kukonzekera "Loperamide hydrochloride," ntchito amene akambidwa hereinafter, ndi akugulitsa mawonekedwe:

• Mankhwala ufa njira.
• 2 mg, anayikidwa mu katoni 50, 30, 20 kapena 10 zidutswa.
• 2 mg wa makapisozi anaika mu phukusi 30, 20 kapena 10 zidutswa.
• Gelatin makapisozi molimba chikasu, amene ali ndi ufa woyera ndi mbali yogwira - loperamide hydrochloride. Aliyense kapisozi lili 2 mg wa mankhwala yogwira. Kuwonjezera ankaimira medicament lili mu kapangidwe kake ndi zosakaniza wothandiza: talc, chimanga wowuma, lactose, magnesium stearate ndi silika colloidal. Gelatin makapisozi ndi malonda likupezeka katoni 20 kapena 10 zidutswa.

Kodi aliyense ali ndi yogwira pophika loperamide hydrochloride? Kugwiritsa ntchito mankhwala mu mankhwala ndipo walola mankhwala monga "Imodium" ndi "Diara". Komabe, anthu ake mu formulations izi n'chochepa kwambiri kusiyana mu medicament zatchulidwazi.

Mankhwala "Loperamide hydrochloride": tanthauzo?

Malinga ndi malangizo, mankhwala chofunika kutenga milandu zotsatirazi:

• Kuti matenda mpando pa ileostomy.
• Pamene matenda kagayidwe kachakudya ndi matumbo mayamwidwe, amene amayamba ndi kusintha mwadzidzidzi kwambiri zakudya kapena zikuchokera mwachizolowezi zakudya (mwachitsanzo, panthawi ya chakudya, pa ulendo).
• Ngati mankhwala othandiza mu m'mimba matenda.
• Monga mankhwala symptomatic kwa pachimake kapena aakulu m'mimba (matupi awo sagwirizana, poizoni mankhwala kapena chiyambi m'maganizo).

Contraindications ntchito mankhwala

Nthawi zina, mungathe kugwiritsa ntchito mankhwala "loperamide" (mapiritsi)? Malangizo mankhwala limati kuti ali osavomerezeka chifukwa:

• matumbo kutsekeka;
• m'mimba, zomwe zayamba chifukwa kamwazi, pachimake pseudomembranous enterocolitis kapena matenda ena pa mundawo m'mimba;
• diverticulosis;
• pachimake anam'peza matenda a m'matumbo;
• hypersensitivity.

Iwo ayenera kukumbukira kuti mankhwala m'mimba kwa ana ayenera mankhwala okha 4 chaka. Komanso, mogwirizana ndi malangizo a limatanthauza "loperamide" ali contraindicated mu trimester mimba ndi pa mkaka wa m'mawere. Mosamala mankhwala Kwalamulidwa kulephera chiwindi.

The medicament "Loperamide hydrochloride": malangizo ntchito

Mapiritsi ndi makapisozi a mankhwala kumwedwa pakamwa popanda kutafuna. Mlingo wa mankhwala zimadalira m'badwo wa mtima ndi matenda mwamphamvu.

Pa matenda otsekula m'mimba pachimake akuluakulu monga mlingo woyamba kutumikiridwa 4 mg wa mankhwala kenako - by 2 mg wa nthawi iliyonse defecation (ngati mpando akadali madzi).

Mu aakulu m'mimba mlingo woyamba ndi 2 mg. mankhwala wothandiza achikulire ayenera anamanga kuti wodwalayo chopondapo pafupipafupi anali 1 kapena 2 nthawi patsiku. The pazipita tsiku mlingo - 16 mg.

Zotsatira akangofika kutenga mankhwala amenewa akufotokozera pasanathe maola 48. Ngati Komabe, masiku 2-4, ntchito mpaka 16 mg wa mankhwala tsiku lililonse, simungathe inu kuchita zotsatira anakhumba, nthawi zonse muyenera kukaonana ndi dokotala, amene anawapulumutsa kusintha matenda. Ntchito ya mankhwala Mungathe kubwereza, koma chithandizo ngati zenizeni kapena kudya pang'ono alibe matenda mpando.

Monga ana, monga mankhwala ayenera kugwiritsidwa ntchito zaka 4 zokha. Mlingo ndi amadalira m'badwo wa mtima kwakukulu ndi matenda.

Ana kwa zaka 4 mpaka 7, mankhwala ayenera kupatsidwa nthawi 3-4 tsiku 1 mg. Nthawi mankhwala ndi masiku 3. Ana kwa zaka 7 mpaka 12 kutumikiridwa kanayi pa tsiku piritsi 1 masiku 5. Pa matenda otsekula m'mimba ana pachimake koyamba mlingo akhale 1 kapisozi. The pazipita tsiku mlingo ana - 8 mg.

Ngati mwana ali m'mimba anati pambuyo pa zinthu defecation nthawi yaitali, nthawi iliyonse ayenera kuperekedwa 1 kapisozi, koma osapitirira 6 mg wa pa makilogalamu 20 thupi patsiku. Ngati mwana sapita chimbudzi maola oposa 12, ndipo pambuyo normalization wa chopondapo phwando kuperekedwa ndi mankhwala akulangizidwa kuti asiye.

mankhwala ambiri osokoneza bongo

Pankhaniyi cha mankhwala osokoneza bongo ndi mankhwala wodwalayo zotsatirazi zolakwika zingaoneke:

• chisokonezo mu mgwirizano kayendedwe;
• constriction kuwatenga ophunzira;
• stupor;
• kusinza;
• kuchuluka chigoba minofu kamvekedwe;
• matumbo kutsekeka;
• kupuma maganizo.

Kuchitira ngati pathological States Madokotala amakonda mankhwala "Naloxone" ntchito ndi munthawi yomweyo mankhwala symptomatic.

zotsatira zoyipazi

Tikumbukenso kuti pambuyo ntchito yokonza "Loperamide hydrochloride" odwala akhoza kuona zotsatira zosiyana mbali. Nthawi zambiri zidzachitika ndi ntchito yaitali mankhwala. Choncho ankaimira medicament angayambitse zotsatira zotsatirazi mbali:

• flatulence;
• kuvutika electrolyte;
• kusanza;
• matumbo omangana;
• chizungulire;
• gastralgia;
• nseru;
• hypovolemia;
• kusinza;
• youma pakamwa.

Ana, mankhwala zimayambitsa kusapeza m'mimba komanso totupa pakhungu. kawirikawiri medicament "Loperamide hydrochloride" zingachititse posungira mkodzo kapena kutsekeka m'matumbo.

Ngati masiku 2 zinthuzo chiyani kutha, ndipo wodwala safuna kumva bwino, nthawi zonse muyenera kukaonana ndi dokotala, amene adzakhala anaika ena (ofanana) mankhwala. Ngati mankhwala si kuthandiza, ndi bwino kuti tione matenda amene amayambitsa kutsekula m'mimba.

Mwanjira mankhwala

Malinga ndi malangizo, pamene ntchito yokonzekera "Loperamide hydrochloride" ndi "Cholestyramine" Mwachangu woyamba ndichepe. Ngati mukufuna kugwiritsa ntchito mankhwala ndi njira "Co-trimoxazole" kapena "Ritonavir", ndiye muyenera kudziwa kuti bioavailability yake kwambiri kuchuluka.

Kusamala

Mankhwala "Loperamide hydrochloride" ayenera kumwedwa mosamala kwambiri mu kuwonongeka kwa chiwindi. Amagwiritsidwanso osavomerezeka ntchito zinthu izi kuchipatala komwe chopinga wa peristalsis matumbo. Popeza mphamvu zokwanira achire pambuyo 2 masiku pambuyo ka mankhwala ndi zofunika kuti sule matenda a dokotala ndi kuthetsa matenda Genesis m'mimba.