Mankhwala "Ingaron": ndemanga madokotala, malangizo ntchito, analogs

Chifooke chitetezo chokwanira zingachititse matenda ambiri. Pambuyo chamoyo mosadziteteza - kuwala "m'zigawo" kwa tizilombo toyambitsa matenda. Chifukwa - chitukuko cha matenda, zimakhala zovuta kuchiza, amene angathe kuwononga mpaka kalekale thanzi, ndipo ngakhale imfa. Zobwezeretsa chitetezo cha m'thupi ndi kulamulira zinthu, ntchito wothandizila immunomodulatory, monga "Ingaron". Madokotala za kukonzekera izi zimatsutsana, choncho kuyesera kupanga lingaliro, popeza anaphunzira zambiri mudziwe mwatsatanetsatane mankhwala.

Pharmacological kanthu wothandizila

Maziko a immunomodulatory mankhwala ndi Popanga madzi a gamma-interferon ongokhala 144 kwa amino zidulo, yeniyeni, mitembo yawo. Woyamba atatu (Cys-Bakuman-Cys) m'malo mwa anakumana. Chimodzimodzi Popanga madzi a gamma-interferon ndi imodzi mwa mankhwala zofunika nawo zochita m'thupi la chamoyo. Zolandilira chifukwa ndi maselo zachilengedwe wakupha, macrophages, T lymphocytes ndi neutrophils. Yakudza kwa amino asidi pawiri (Popanga madzi a gamma-interferon) facilitates ndondomeko ya kutsegula ntchito effector maselo pamwamba monga bactericidal, cytotoxicity, ndi kaphatikizidwe superksidnyh nitroxide ankafuna kusintha zinthu mopitirira ndi cytokines okhala odana ndi yotupa ndi bactericidal kanthu. Unazunguliridwa mu phukusi mankhwala "Ingaron" Buku limanena kuti yaikulu lachindunji mavairasi oyambitsa zotsatira za pophika yogwira. Izi zimatheka ndi chakuti kwa amino asidi pawiri midadada ya kugawanika kwa RNA ndi DNA mavairasi ndi tinthu awo okhwima. Komanso, interferon Popanga madzi a gamma ali ndi kutchulidwa cytotoxic zotsatira pa maselo amene ndi kachilombo. Iwo ananenanso kuti mankhwala kumabwezera mmbuyo mapuloteni kaphatikizidwe ndondomeko kutupa ndi kuwonjezera mawu a majini C2 ndi C4.

mawonekedwe Ndinamasulidwa zikuchokera mankhwala

Mukhozanso mankhwala m'njira ziwiri zokha. Choyamba - lyophilisate, amene ntchito pokonza njira kwa makonzedwe subcutaneous ndi mu mnofu. Interferon Popanga madzi a gamma Komanso, mankhwala m'gulu excipient mannitol. Mukhozanso mankhwala ofunikira mbale amene ankanyamula mu makatoni mabokosi 1, 5, 10 ndi mayunitsi 20. Idatha kusintha mankhwala popanda kuuzidwa.

Kunena za mtundu wachiwiri wa mankhwala, kapangidwe kake ndi ofanana ndi woyamba. Koma apa ntchito lyophilizate ichi, chimene komanso mmatumba mu mbale kukonzekera madontho kwa makonzedwe intranasal. Aliyense paketi makatoni molumikizana ndi kukonzekera zofunika limapangidwa madzi a jekeseni mu ampoule kapena nsupa ya 5 ml. Izi chigawo zina ndi zosungunulira yokonza njira.

Pakali pano, mitundu ina ya kumasulidwa kwa mankhwala si, kotero musati muziyang'anira zina "Ingaron" mankhwala pharmacies. mapiritsi si chopangidwa ndi makampani opanga mankhwala.

Kuti mankhwala mankhwala ngati njira yothetsera jakisoni subcutaneous ndi mu mnofu?

Musanawerenge ndi zizindikiro kwa phwando mawonekedwe mankhwala, ayenera kuti m'pofunika ntchito Kwalamulidwa yekha ndi dokotala. Ndipotu njira ya utsogoleli ndi mlingo ntchito zimadalira chikhalidwe cha matenda ndi njira zake.

Immunomodulating mankhwala "Ingaron" ndi chigawo chimodzi cha mankhwala zovuta mitundu aakulu a tizilombo matenda a chiwindi B ndi C, TB m'mapapo mwanga, matenda oncological, HIV / AIDS. Nthawi zambiri njira Kwalamulidwa kwa odwala matenda urogenalnogo chlamydia, aakulu prostatitis, matenda maliseche gerpevirusnoy ndi matailosi. Ndinapeza mankhwala "Ingaron" ntchito mankhwala ndi kupewa anthu papilloma HIV ndi mavuto opatsirana odwala ndi matenda aakulu granulomatous.

Ntchito njira yothetsera makonzedwe intranasal

mawonekedwe mankhwala kawirikawiri amagwiritsidwa ntchito zosiyanasiyana za mankhwala. Komabe, nthawi zambiri izo tikulimbikitsidwa monga prophylaxis ndi chithandizo cha mitundu yosiyanasiyana ya fuluwenza, kuphatikizapo H5N1 ndi H1N1, amene amadziwika ngati "mbalame" chimfine. Mu nthawi ya miliri mankhwala kumathandiza chitetezo cha m'thupi kulimbana ndi matenda tizilombo toyambitsa matenda.

Pamene ntchito limodzi ndi zikutanthauza zofunika mankhwala kuchira amapezeka mofulumira kwambiri. Komanso, odwala kulandira amatanthauza "Ingaron" matenda chimfine amakonzedwa pokha pokha lakutali.

Kukonzekera njira jekeseni ndi dongosolo n'zimene

Monga tanena mlingo mankhwala azigawira dokotala nawo, matenda motsogozedwa ndi matenda mwamphamvu. Komanso, katswiri umalimbikitsa tcheru wodwalayo pa njira ya akuluakulu a wothandizila ndi nthawi ya mankhwala.

Ndipo kuyambira medicament ndi chopangidwa mu mawonekedwe a lyophilisate chabe pamaso ntchito zake kukhala bwino kukonzekera njira jekeseni. Chifukwa chaichi, nkhani za mbale wina sitimadzipereka mu 2 ml ya madzi a jekeseni.

Mu ophatikizana mankhwala likamanena aakulu a tizilombo matenda a chiwindi B kapena C, komanso matenda HIV / AIDS ndi TB m'mapapo mwanga tsiku mlingo odwala wamkulu chimachititsa 450-500 zikwi. IU. Majekeseni anapangidwa 1 nthawi tsiku, tsiku lililonse kapena maziko tsiku. Malinga ndi kuopsa kwa Inde matenda a chithandizo zingakhale za masiku 30 mpaka 90, ndipo ngati n'koyenera zingakhale, zotchulidwa dokotala, kubwereza miyezi ingapo. Pofuna kupewa chitukuko cha mavuto odwala ndi aakulu granulosa matenda, iwo anaika tsiku kapena tsiku lililonse 500 zikwi. IU "Ingaron" mankhwala. Reviews madokotala akusonyeza kuti azimuth zabwino zimawonedwa ntchito mankhwala kwa masiku 2-3. Koma apa pali njira ya mankhwala matendawa ayenera kukhala osachepera 5 jekeseni. Ponena za odwala matenda a khansa, ndiye, malingana ndi kuopsa kwa matenda, ambiri tsiku mlingo zingasiyane 400 600 zikwi. IU. Koma nthawi ya mankhwala anatsimikiza payekha ndi kusintha kale mu ndondomeko ya mankhwala malinga ndi zotsatira za mayesero matenda.

Anthu amene anapezeka ndi matenda monga matenda gerpevirusnaya, urogenital chlamydia kapena nsungu zoster, Kwalamulidwa 5 jakisoni subcutaneous tsiku lililonse. The tsiku mlingo pafupifupi ya mankhwala mu matenda pamwamba wamkulu akhale 500 zikwi. IU.

Kuthandiza chitetezo cha m'thupi ndi kuthandiza kuti kulimbana ndi odwala aakulu prostatitis tikulimbikitsidwa aliyense masiku awiri jekeseni ya mankhwala "Ingaron". Njira ya mankhwala - 10 jekeseni wa 100 zikwi IU ..

Pamene anogenital njerewere mankhwala jekeseni subcutaneously tsiku lililonse 100 zikwi. IU. Kutalika kwa mankhwala zimadalira zovuta matendawa, koma osachepera 5 jekeseni.

njira dongosolo yopereka kwa intranasal ntchito

Patsogolo ntchito fomu iyi zikutanthauza lyophilisate akhoza zidzasungunuka mu 5 ml ya madzi, amene kale ophatikizidwa mu phukusi mankhwala. Yankho chifukwa anali anga kudzera pipette m'mphunomo.

Pamene inu muona zizindikiro woyambirira wa fuluwenza kapena SARS mankhwala "Ingaron" Buku akuonetsa ntchito nthawi 5-8 tsiku 2 madontho uliwonse ndimeyi m'mphuno. Kutalika kwa mankhwala zambiri masiku 5-7.

Adzakhululukidwa anakumbukira kuti kupewa matenda bakiteriya ndi tizilombo ya kupuma thirakiti njira amagwiritsidwa ntchito. Mwachitsanzo, kukhudzana ndi munthu wodwala kapena supercooling mankhwala kwa masiku 10 m'manda mu mphuno 1 nthawi patsiku 2-3 madontho. Kuchita njirayi ayenera kukhala pambuyo kukonza njira za m'mphuno mphindi zosachepera 30 pamaso chakudya. Ngati kukhudzana ndi munthu wodwala anali wosakwatiwa, monga mankhwala ndi njira yokwanira adzagwa "Ingaron" mphuno kamodzi kokha.

Kuti mankhwala ndi wogawana anagawira, izo m'pofunika minofu mphuno mapiko kwa mphindi zingapo pambuyo instillation.

Dongosolo mu mnofu wa mankhwala kwa ana

Popanga madzi a gamma interferon zambiri m'gulu la mankhwala ovuta matenda ambiri ana. Choncho, anaikidwa akudwala pang'ono pambuyo kuchotsa papillomas ndi papillomatosis kupuma.

Mu mnofu medicament akulimbikitsidwa odwala ndi pachimake kutupa B. mlingo The tsiku la mankhwala masamu pa nkhani iliyonse zochokera chakuti aliyense kilogalamu ya kulemera kwa wodwalayo ayenera kukhala laling'ono 10 chikwi. IU. Majekeseni anapangidwa 1 nthawi patsiku kwa masiku 7-10, mlingo anachepetsedwa ndi theka patapita nthawi mwasankha. The njira ya mankhwala ikupitirira kwa masabata 3, ndi jakisoni ndi kamodzi mu masiku awiri.

Ikani "Ingaron" ana ndi yogwira chiwindi B. protracted matenda pachimake ndi aakulu izi odwala yaing'ono kutumikiridwa jakisoni intramuscularly 10 chikwi. 1 IU pa makilogalamu thupi kawiri pa mlungu. zimenezi ndi kwa miyezi 1 2, koma m'njira zapamwamba kwambiri kapena matendawa akhoza akupempha miyezi 6.

Ngati mwana anapezeka ndi aakulu yogwira chiwindi D (HDV), ndi momwe pali zizindikiro za matenda enaake chiwindi, mankhwala Kwalamulidwa kwa 5 zikwi. 1 IU pa makilogalamu thupi. Chikuyendetsedwera kawiri pa mlungu. The njira ya mankhwala - 8 jakisoni, ndipo zikhoza kukhala miyezi 1-6.

Koma ngati zizindikiro za matenda enaake akadali pano mu chiwindi aakulu yogwira, ndiye kawiri pa sabata, jekeseni ya mankhwala pa mlingo wa 5 zikwi. IU pa kilogalamu ya kulemera kwa mwana. Majekeseni anapanga pasanathe masiku 30, ndipo ngati pali zizindikiro za decompensation kenako, kubwereza mpikisanowo mu miyezi 2.

Baby akudwala matenda amenewa aakulu bakiteriya monga matenda, enteritis, laryngitis kapena pharyngitis akapitawo 10 000 IU pa kilogalamu ya kulemera kwa thupi. Ndipo mwezi umodzi mwanayo ayenera kulandira jekeseni 2-3 mlungu uliwonse. Mobwerezabwereza mankhwala zotchulidwa dokotala maphunziro angathe kuchitidwa osati kale kuposa miyezi 3.

Perifocal kayendetsedwe mankhwala ana

Ngati achinyamata amene akudwala matenda keratoacanthoma, squamous kapena kwatuluka chiphuphu chakhansa, gawo la mankhwala ovuta tingafunike monga Popanga madzi a gamma interferon. tsiku ake kutumikiridwa mwachindunji pansi pakati pa ndondomeko yotupa pa 100-250 zikwi. IU kwa masiku 10. Pamene m'dera zochita yotupa ndi aakulu jekeseni ikuchitika masiku 1-2. Atamaliza njira ya mankhwala ndi "Ingaron" ayankhe madokotala amalangiza onyamula cryodestruction kulimbitsa zotsatira achire.

Nthawi zina, ana Kwalamulidwa makonzedwe subconjunctival mankhwala ndi?

Nthawi zambiri mankhwala ntchito pochiza matenda a maso zochizira odwala ndi zaka 7. Choncho, pamene keratoiridocyklites ndi stromal keratitis dokotala wanu angakulangizeni jakisoni subconjunctival wa interferon Popanga madzi a gamma. Mlingo ndi pafupipafupi mankhwala zikudalira pa choopsa chitukuko matenda. Chiyambi lokonzekera ikuchitika pansi mankhwala oletsa ululu pamalopo ndi ntchito mankhwala ochititsa munthu, kawirikawiri 0.5% tetracaine njira. kuchuluka kungakhale kwa jekeseni 10 20.

Apakhungu ntchito mankhwala

Komanso amatanthauza "Ingaron" (ndemanga madokotala amatsimikizira nkhani iyi) Iyamba ayambe odwala keratitis kungotengeka ndi conjunctivitis. Ntchito yothetsera matenda amenewa alili.

Kuti akonze njira nkhani za ampoule wina sitimadzipereka mu 5 ml ya sodium kolorayidi ndi pa lotsatira maola 12 pali m'firiji. Ikani yophika "Ingaron" (madontho) nthawi 6-8 tsiku. Ndi kutha kwa zizindikiro za kutupa mlingo mafunsidwe ndi kuchepa kwa nthawi 3-4. Kutalika kwa mankhwala sayenera upambana masiku 14.

Pofuna kuthetsa contraindicated?

Kaya mawonekedwe, mankhwala ali osavomerezeka ntchito kwa anthu tsankho munthuyo interferon Popanga madzi a gamma, kapena aliyense wa ancillary zigawo mankhwala. Musawachite njira ndi amayi apakati.
Izo kutiletsa ntchito "Ingaron" shuga ndi matenda autoimmune njira yothetsera subcutaneous ndi mu mnofu jekeseni. madontho mphuno si kutumikiridwa odwala zaka 7.

Zotsatira zoyipa za mankhwala ndi overdosing

Monga mankhwala aliwonse, wothandizila "Ingaron" (madontho jakisoni) angapo mavuto. Choncho, m'dera lawo siligwirizana anachita angayambe yoyang'anira subcutaneous kapena mu mnofu wa mankhwala. Nthawi zambiri kumaonekera mwa mawonekedwe a redness a khungu, limodzi ndi ululu wofatsa. Odwala ena chithandizocho angayambitse kupweteka kwa minofu hyperthermia.

Pa nthawi imene mankhwala ntchito pa mlingo woposa 000 IU cha 1000, kumaonjezera ngozi ya zizindikiro za chimfine monga mutu, kutopa, arthralgia ndi pyrexia. Ndipo ngati mlingo wa chikwaniritso cha mbali anafotokoza muli ang'onoang'ono, palibe kufunika kwa mankhwala symptomatic. Pa nthawi imene zizindikiro ndi mpofunikila wambiri amatanthauza "Paracetamol".

Kodi akuganiza za "Ingaron" kukonzekera madokotala?

Back mu 1957, chifukwa cha khama la asayansi anatulukira ndi kuphunzira mwatsatanetsatane interferon. Kuyambira nthawi imeneyo zinalembedwa kale zambiri zokhudza sayansi za kufunika kwa izi mankhwala multicomponent kwachilengedwenso m'madera osiyanasiyana mankhwala. Ndipo ngati ntchito interferon ku matenda monga a chiwindi kapena khansa zotupa, kwathunthu anatsimikizira kwambiri za maphunziro matenda, kuthekera wa phwando ake mu ozizira ndi nthawi yathu ndi nkhani mkangano. Tiyeni tiyese kumvetsetsa chifukwa zounikira za mankhwala padziko zokambirana ndi za chimodzimodzi kwa zaka zambiri. Ambiri madokotala ku positi-mokakamizidwa analimbikitsa zizindikiro loyamba SARS anaika mankhwala "Ingaron" mphuno. Reviews madokotala pamene tikukamba za isanayambike mofulumira zotsatira achire ndi kuonjezera chitetezo cha mthupi.

Western mankhwala zounikira maganizo zosiyana kwathunthu pa nkhani imeneyi. Iwo sindikukana athandize interferon ndi SARS, koma kutsindika pa zochita zoipa, zomwe zingachititse "Ingaron" - utsi kapena madontho. Pambuyo yaitali ntchito kupewa nthawi zambiri chifukwa cha mkwiyo ndi kukokoloka kwa amphuno mucosa, maonekedwe a magazi ndi sneezing, komanso chifukwa kuchepa lakuthwa chiwerengero cha maselo oyera ndi magazi (leukopenia).

Ndiponso, "Ingaron" (dontho) - kalozera komanso imatiuza za izo - zingachititse anachita, osati distinguishable ndi zizindikiro za chimfine. Ndi pa mfundo imeneyi ndipo amanena kuti madokotala Western sindigwiritsa ntchito Popanga madzi a gamma interferon mankhwalawa odwala ndi chimfine ndi SARS.

Tisadalire ndemanga ngati wosanganiza madokotala, zovuta kulankhula za kuthekera kwa "Ingaron" njira.

analogues mankhwala

Pakali pano, mankhwala zochokera interferon zokwanira. Kufotokozera zobwezedwa amenewa kungakhale chakuti kuyambira kutsegula kwa mankhwala kwa amino asidi wakhala kuposa zaka pafupifupi. Ndipo ngakhale kuti mankhwala kuti ntchito pa chilengedwe cha mankhwala atsopano ndi bwino.

Monga mankhwala "Ingaron" analogues muli gawo la interferon lapansi. Odziwika kwambiri awa ndi zipangizo monga "Laferobion", "Ingaron A", "Human Interferon", "Avonex", "Alfaferon" neri Al. mankhwala tatchula muli gawo la pawiri kwa amino asidi - interferon. Iwo ankagwiritsa ntchito zosiyanasiyana za mankhwala mu dziko lathu zochizira matenda zovuta za etiology tizilombo toyambitsa matenda. Koma Dziwani kuti ngakhale anachokera ku zinthu mankhwala, kuwagwiritsa ntchito nokha sikuthandiza. Ndipotu, aliyense wa iwo ali contraindications ake ndi zingasokoneze wa munthu wodwalayo. Phindu la mankhwala anapatsidwa zochokera interferon ayenera kukhala wotsimikiza basi katswiri. The ntchito sing'anga ali m'gulu mawerengedwe a zipangizo mlingo ndi kusankha njira ya utsogoleli. Mu njira ya mankhwala, kaya mankhwala anaikidwa "Ingaron" analogues zochokera Popanga madzi a gamma-interferon kapena mankhwala okhala alpha-interferon, katswiri liyang'anire otaya mphamvu ya matenda ndiponso munthu payekha kusintha nthawi ya mankhwala.