Acid phosphatase mu mwazi: khama decoding ndi mlingo

Acid phosphatase - puloteni kuti Iyamba kuwonongeka kwa mamolekyulu mu thupi. Khama la mlingo wake mu magazi n'kofunika Kupeza Vuto chikhalidwe thanzi. Pali mitundu ingapo ya phosphatases asidi, amene kugawana zimagwirira ntchito zofanana, koma wosiyanasiyana Chrixitu poyerekezera zimakhala thupi, magwero chromosomal, zikuchokera.

kukufikira

Zoyendetsedwa enzyme mu mapangidwe acidic, choncho dzina. Acid phosphatase opezeka mu zimakhala zosiyanasiyana ndipo maselo akhoza ili mu lysosomes ndi kupitirira. Chiwerengero chachikulu kwambiri anatsimikiza mu prostate, komanso maselo ziwalo zotsatirazi:

• chiwindi;
• ndulu;
• mafupa;
• maselo magazi (erythrocytes, maselo othandiza magazi kuundana, macrophages).

Mu wathanzi chamoyo ntchito ya phosphatase asidi ndi m'malo otsika. Oimira wa mwamuna theka mlingo wake imakhala ya Prostatic phosphatase, ndi zomwe anawononga mu chiwindi ndi magazi maselo. The michere ya thupi wamkazi analenga kotheratu ndi chiwindi ndi erythrocytes, maselo othandiza magazi kuundana.

Lysosomal asidi phosphatase

Iwo ankakhala mu maselo ambiri. kulakwa kwake ndi autosomal recessive matenda, zomwe akuti ndi chifukwa cha njira kagayidwe kachakudya pathological. Symptomatology cha matenda kumaonekera motere:

• likukulira kunyansidwa ndi kusanza;
• kufooka, kusakhala ndi dzuwa;
• kutsitsa magazi;
• paubwana - opisthotonus (khunyu wochitika arching wa Arc kumbuyo, odwala kudalira pamwamba pa bedi yekha pakhosi ndi mapazi);
• magazi.

Ngati mlingo enzyme ndi osakwanira okha maselo oyera, odwala zambiri zowawa exacerbations matenda aakulu.

Prostatic asidi phosphatase

Amaona pentopeni njira khansa prostate. Mtundu wa enzyme anatsimikiza ndi ngati mbeu chikhomo madzimadzi m'mayesero (kugwiririra). Acid phosphatase liukitsidwa, ndi masiku angapo pambuyo opaleshoni ya prostate kapena biopsy maziko.

Akadakwanitsira pH chizindikiro kwa uziyenda bwino za enzyme ndi - 4.6. Ntchito limapezeka yekha munthuyo kufika msinkhu.

Panopa kudziwa mlingo wa phosphatase Prostatic ngati chikhomo khansa recedes ku maziko a chidwi kuchuluka prostate pokha Antigen, okhoza kutsimikiza pamaso pa matenda pamisinkhu kale chitukuko. Komabe, zizindikiro za Prostatic asidi phosphatase chofunika kwambiri akuneneratu zisadzachitikenso la ndondomeko khansa pambuyo opaleshoni chifukwa kwakukulu Prostate kuchotsa.

kusanthula kudziwa mphamvu ya mankhwala otchedwa benign prostatic hyperplasia ndi pathologies ena Prostatic.

eritrotsitarnaja phosphatase

Izi ndi polymorphic enzyme kuti si maselo ofiira a magazi komanso maselo ena a m'thupi. The pH akadakwanitsira ntchito zake zimasiyanasiyana 5.2 kuti 6.2.

Acidic magazi phosphatase zingadziŵike kulongosolerana bambo. mitundu ina enzyme zokhudza zinthu zotsatirazi:

• kutengera za kumtundu kwa magazi m'thupi hemolytic;
• kudwala, amene amakhala ndi chitukuko cha hemolytic magazi m'thupi chapansipansi kudya nyemba;
• magazi m'thupi kugwiritsa ntchito mankhwala ena kapena kukhala ndi matenda a chiyambi tizilombo toyambitsa matenda.

Pali mitundu ya erythrocyte asidi phosphatase mwachindunji zokhudzana kuyan'anila kuti zimachitika ndili mwana.

Macrophage mtundu wa phosphatase asidi

The enzyme ndi zofunika matenda a matenda Gaucher. Ichi ndi matenda tinatengera amene amadera kudzikundikira mu chiwindi, ndulu, impso, ubongo, m'mapapo glucocerebroside (zinthu organic ku gulu la mafuta). Matendawa limodzi ndi kuwonjezeka kwambiri mu kukula kwa matupi tatchulawa, kuchepa lakuthwa chiwerengero cha maselo onse magazi, khunyu, khunyu chonsechi, retardation maganizo.

Macrophage asidi phosphatase amadziwikanso ankaona pentopeni enieni khansa acheya selo. matenda limodzi ndi kupanga ndalama chapadera cha enzyme, amene anatsimikiza magazi.

phosphatase osteoclasts

Otchedwa maselo osteoclasts fupa udindo uwonongedwe. Sitepe ndi yofunika kukula fupa ndi kukonzanso unit. Liwilo fupa imfa umabweretsa matenda otsatirawa:

• Paget ndi matenda (pathological kaphatikizidwe yachibadwa fupa mapangidwe ndi zinthu zake);
• hypercalcemia a chotupa chija;
• ofuntha ya chithokomiro ndi parathyroid zopangitsa ;
• postmenopause osakaniza ndi kufooka kwa mafupa.

Zotsatira - fractures pafupipafupi ndi kupata kupatulira wa nyumba fupa. Khama la osteoclasts phosphatase asidi limasonyeza milingo apamwamba michere mu maziko a pathologies pamwambapa.

Kukonzekera ndi kuchititsa diagnostics

Kachulukidwe zizindikiro atsimikiziridwa zinthu zasayansi. kusanthula ayenera ikuchitika pambuyo 2 masiku ku nthawi za kayendetsedwe zina matenda. Ngati mukufuna kuwunika mlingo wa Prostatic asidi phosphatase, zimenezi ziyenera kuchitidwa osati kale kuposa maola 48 pambuyo biopsy ndi, palpation ya prostate, chikhodzodzo catheterization. Pankhani anyamata, zotsatira kungakhale positives onyenga.

Mpanda mfundo kafukufuku ikuchitika pa chopanda kanthu m'mimba. Mukhoza kumwa madzi okha, kumwa tiyi, khofi, timadziti ndi zakumwa zina ndikoletsedwa. Masana, muyenera kusiya mowa, mafuta, mbale kusuta ola 1 isanafike kusanthula - kusuta. Otsiriza theka la ora pamaso zakudya chuma ayenera amachitika bata ndi mtima.

Kwa matenda a magazi venous ntchito, ndicho seramu ake kupewa hemolysis. Zotsatira kafukufuku amadziwika tsiku lotsatira pambuyo pa phunziroli.

The njira ntchito

Kulongosolerana mlingo wa okwana asidi phosphatase ntchito njira immunochemical ndi kudziwika chemiluminescent. Gwiritsani ntchito magawo wapadera kuti mucheze ndi michere ena. machitidwe panopa ntchito luminol opangidwa kuchokera peroxidase osakaniza hydrogen peroxide njira. Amenewa ndi anawonjezera E (mwachitsanzo, N-yodofenol) angathe kuwonjezera luminescence njira kwa nthawi zikwi zingapo.

Pali kachitidwe zina kuti ntchito zamchere phosphatase ndi AMPPD gawo lapansi, kupanga njira yodziwira kwambiri tcheru. Ubwino wa njira ndi kuphunzira mtendere wa reagents ntchito, palibe chiopsezo radiological. Zofooka zochokera zovuta za ndondomeko matenda.

wakudziko

Total asidi phosphatase kafukufuku anasonyeza U / L. magawo ake kololeka ikhoza kusintha kutengera ndi msinkhu komanso jenda.

Normal Prostatic zizindikiro asidi phosphatase - zosakwana 2.1 ng / ml. Chiwerengerochi onse pamwamba kusonyeza zabwino matenda.

Pamene mlingo wa enzyme chinawonjezeka?

The matenda oopsa kwambiri omwe miyeso kachulukidwe pamwamba yachibadwa:

• thrombocytopenia - maola angapo maselo magazi udindo clotting ake;
• thromboembolism - blockage wa lumen wa chachikulu mtsempha wamagazi thrombus, alibe kwa mpanda chotengera, kapena embolus amene ali m'magazi;
• matenda Hemolytic - matenda limodzi ndi chiwonongeko chachikulu maselo a magazi kumasula ndalama yaikulu ya bilirubin mu m'magazi;
• mwapang'onopang'ono Paget ndi matenda - fupa kudwala zida limene ndi vutoli pakati pa mafupa mapangidwe ndi chiwonongeko cha zigawo mokomera otsiriza;
• myeloma - zilonda chotupa ndondomeko chikhalidwe, amene anapezeka ndi B-lymphocytes, udindo kaphatikizidwe maselo zodzitetezera;
• Niemann kuwasankha matenda - cholowa kudwala yodziwika ndi kagayidwe mkhutu mafuta ndi kudzikundikira lipids ku ziwalo zina (chiwindi, ndulu, mapapo, mtima, impso);
• masiku angapo pambuyo opaleshoni ya prostate ndi minofu yake biopsy.

Acidic, zamchere phosphatase - gulu la michere udindo njira zofunika m'thupi. Ndi mothandizidwa awo ochokera zochita yofunika zotsatizana. Kuona mlingo wa michere zimathandiza kufufuza kupezeka kwa kudwala ndipo ndiliyesa kuthandiza kuwukonza zina mkulu khalidwe la moyo.