"Budesonide": malangizo ntchito ndi analogues. "Budesonide" inhalation: ndemanga, mtengo

Mphumu tithe yoyamba padziko lonse mwa matenda kugwirizana ndi ofuntha wa chitetezo cha m'thupi. Kuchitira izo amalenga yaikulu ya mankhwala. Wina chida amenewa ndi "budesonide". Analogs za mankhwala ndi amagwiritsidwanso zochizira matenda broncho-obstructive. Nanga mankhwalawa?

"Budesonide" ndi chiyani?

mankhwala ili gulu la glucocorticoids Mpweya. Chida ichi ndi analogi kupanga apanga mu thupi lathu (mu adrenal kotekisi) mahomoni. Wotani kwenikweni ali "Budesonide"?

Malangizo ntchito mankhwala akusonyeza kuti wothandizila ndi kumawonjezera kuchuluka kwa maselo yogwira beta-adrenergic mu Airways.

Komanso, midadada mankhwala kanthu za prostaglandins yotupa ndi leukotrienes, pofuna chitukuko cha kutupa mu mucosa bronchial.

Kumakhudza zotsatira zake pambuyo makonzedwe tsiku pa masiku angapo (zambiri za 5-7 masiku).

Ndi mmodzi wa mankhwala zazikulu kuchitira aakulu bronchial mphumu aakulu obstructive matenda m'mapapo mwanga. Mu masiteji koyamba chitukuko cha matenda amenewa alibe ntchito.

Nanga "Budesonide" ali zimakhudzanso maselo chandamale?

pharmacodynamics

Mankhwala kudzera inhalation ntchito, komanso odzipereka padziko phapo (kuchokera pamwamba pa amphuno mucosa pafupifupi umalandira makope zokhudza zonse).

Zolemba malire plasma ndende ya mankhwala zimawonedwa mkati mphindi 45 pambuyo inhalation. 85 peresenti ya mankhwala onse ukubwera chimamanga kuti albumin magazi otsalawo gawo excreted sichinasinthe.

Iwo kukonzedwa ndi chiwindi. Excreted m'thupi kudzera thirakiti m'mimba (mu ya ndulu) ndi mkodzo.

Odwala ndi matupi awa kudwala anaona yaitali sachedwa mankhwala mu magazi, chimene chinayambitsa chitukuko ambiri a mavuto ndi ambiri osokoneza mahomoni glucocorticoid.

N'zotheka ntchito mankhwala mawonekedwe piritsi zochizira zokhudza zonse connective minofu (koma 10 peresenti yokha ya kuchuluka okwana mankhwala amene walowa thirakiti m'mimba angakhale ndi zotsatira achire).

Angagwiritsidwenso ntchito pochiza matenda sanali yotupa wa amphuno mucosa chifukwa kanthu yaitali m'deralo.

zikuonetsa

Nthawi zina Komabe, mukhoza perekani "Budesonide"? Malangizo ndandanda ntchito matenda yayikulu kwambiri mu mankhwala angagwiritsidwe ntchito:

• Bronchial mphumu. Mankhwala anakhala zikomo otchuka kuti zotsatira zake odana ndi yotupa ndi luso ziletsa ntchito ya owayimira yotupa.
• matenda amene amatupitsa. Zochepetsera matenda ntchito mawonekedwe tableted mankhwala. mankhwala umaperekedwa kupangira chikhululukiro m'njira wofatsa ndi zolimbitsa matendawa.
• Chithandizo cha rhinitis. Izo zimasonyeza utumiki wa intranasal mawonekedwe budesonide mpumulo zizindikiro za malungo nsipu ndi matupi awo sagwirizana rhinitis. An wothandizila kwambiri zochepetsera matenda ndi "Budesonide Formoterol".
• Kupewa zisadzachitikenso wa polyposis, amphuno mucosa. mankhwala ntchito kumayambiriro postoperative nthawi. Pafupifupi 95 peresenti ya milandu kumathandiza kukonzanso chitukuko cha polyposis.

matenda tatchulazi ndi njira yaikulu, imene anasankha "budesonide".

Nthawi zina, mankhwala angathe kuperekedwa kupewa chitukuko cha matenda obstructive m'mapapo. Zikatero monga odwala matenda a kuntchito kapena ntchito zinthu woopsawo ntchito. Koma tiyenera kukumbukira kuti ngakhale ntchito mankhwala kupewa, sitiyenera kuiwala mosamala dosing wa mankhwala, kuyambira mwinamwake chiopsezo kuti mavuto ndi zopangitsa kwa adrenal, ndi achire matenda glucocorticoids.

Nthawi zina Komabe, ntchito yake contraindicated?

contraindications

Kodi njira ndi matenda, musagwiritsire ntchito "Budesonide"? Malangizo ntchito mankhwala akusonyeza matenda otsatirawa:

• Kuchuluka kudziwa mankhwala kapena zigawo zake. Kubereka osauka angioedema.
• The yogwira mawonekedwe a chifuwa chachikulu.
• Matenda a m'mapapo chiyambi mafangasi.
• Pachimake njira opatsirana kapepala kakuti m'mimba.
• Aakulu kwa chiwindi insufficiency.
• zaka ana.

Mu matenda onsewa, ntchito corticosteroids ndikoletsedwa. Ichi ndi chifukwa chakuti mankhwala kapena amalimbikitsa ndondomeko imathandiza kapena kuvutika yake. ana sangathe ntchito mankhwala chifukwa kuti akhoza kusokoneza kupanga thupi mahomoni glucocorticoid chifukwa cha insolvency wa kotekisi adrenal.

Pali zofooka, imene kusamala kwambiri ayenera kugwiritsidwa ntchito "budesonide". Malangizo pa ntchito linachenjeza kuti mosamala kwambiri ayenera kugwiritsa ntchito mankhwala kwa anthu ndi oopsa, shuga, pheochromocytoma, osamvera chapamimba chilonda ndi mmatumbo chilonda.

mbali zotsatira

Pakali pano palibe mankhwala, ntchito n'cholinga apanga makamaka mbali zotsatira. Mwatsoka, "Budesonide 'ndi mankhwala ndi sipekitiramu mwachilungamo lalikulu la zochitika chowawa zochita zake.

Ngati inu ntchito "budesonide" inhalation, zotsatira waukulu mbali ya ntchito chake chidzakhala lokhudza kulankhula (dysphonia), hoarseness, pakamwa youma, chifuwa, paradoxical bronchospasm chitukuko.

Pamene anatengedwa pakamwa, angathe kukhumudwa, chizungulire, ndi irritability.

Dongosolo mtima angamvere kuti kumayambiriro "Budesonide" chitukuko cha vasculitis, kuchuluka kuthamanga zokhudza zonse magazi, tachycardia.

Mankhwala zikhoza ndi aggravation matenda m'mimba - zilonda, kapamba. Komanso kumapangitsa chitukuko cha matenda dyspeptic.

Ndi zoipa zokhudza dongosolo minofu ndi mafupa. Mwina chitukuko cha kufooka kwa mafupa, myasthenia gravis, molumikizana mafupa.

Ovuta kwambiri mbali kwenikweni ndi matenda Cushing a. Zimachitika chifukwa chakuti m'nthawi ya kulandira glucocorticoids amachepetsa kaphatikizidwe mahomoni yake. Ngati corticosteroids ntchito kwa nthawi yaitali, zopangitsa adrenal amangokhala Kusiya lithe thupi mankhwala kuti kwenikweni zimakhudza umoyo wa wodwalayo. N'chifukwa chake m'pofunika mosamala kuwunika mahomoni mlingo analandira, komanso ufulu kusiya kumwa iwo.

kusintha mlingo

Kodi Mlingo ayenera kuperekedwa "Budesonide? Malangizo wakuuzani amapereka zotsatirazi dosing chakudya.

Kugwiritsa ntchito njira inhalation "budesonide" pogwiritsa ntchito mwamphamvu la matenda. Mlingo akadakwanitsira munthu wamkulu ndi 200-800 micrograms patsiku. The pazipita tsiku mlingo sayenera upambana 1.5 mg. Ana, mankhwala ali contraindicated ntchito, ndipo analogs ake amapatsidwa malinga ndi kukula kwa choncho.

Mawonekedwe m'kamwa mankhwala ntchito kwa mphindi 30-60 musanadye. Ntchito mpaka 3 mg ndi 3 nthawi patsiku. The njira ya mankhwala ndi mankhwala akumwa pafupifupi 2 miyezi. Chakuti mankhwala ikuchitika pang'onopang'ono kupewa mavuto obwera.

Intranasal zambiri anatumizidwa "Budesonide Iziheyler". mlingo amusankha payekha munthu aliyense, malinga ndi kukula kwa ndondomekoyi. Pafupifupi ntchito 2-3 madontho a mankhwala aliyense mphuno kawiri pa tsiku. Ana, mawonekedwe mankhwala ali contraindicated. The njira ya mankhwala kwa masabata 2.

Mogwirizana ndi mankhwala ena

Ena mwa mankhwala pamene ntchito limodzi ndi "Budesonide" akhoza kusokoneza mayamwidwe ake. Mankhwalawa monga zoletsa wa cytochrome P450. Mwachitsanzo, ngati inu kugwiritsa ntchito "budesonide" ( "Pulmicort" - monga analogi ndi) ndi mankhwala monga "Ketoconazole" "mankhwalawa" Mwina m'mbuyo excretion ndi mwazi wa glucocorticoid amene ali zinadzala ndi chitukuko cha kuledzera m'thupi ndi maonekedwe a mavuto mankhwala.

Pamodzi amalandira "Budesonide" ndi zina okodzetsa ( "Indap") limathandiza kuti chitukuko cha hypokalemia mu mtima, zomwe mosakayikira bwanji ntchito za mtima.

mankhwala angapo (mwachitsanzo, Mankhwalawa ayenera kumwedwa - "Almagel") pamene ntchito "budesonide" khama pa chilichonse tingati ena odana nafe, i.e. musalole wina khama zotsatira zake achire. Chifukwa cha ichi, tikulimbikitsidwa kugwiritsa ntchito mankhwala pa imeneyi ya maola osachepera awiri (amangonena za mawonekedwe m'kamwa mankhwala).

Kugwiritsa ntchito mankhwala kwa inhalation

Popeza mankhwala wakhala linalengedwa zochizira matenda pa mundawo kupuma, m'pofunika kumvetsa mu njira zimene ayenera kuperekedwa iwo.

Mpweya mtundu wa mankhwala analenga ndithu kwambiri, koma ntchito zawo zambiri lokhazikika m'njira zambiri.

Choyamba, mankhwala zambiri kutumikiridwa ntchito nebulizer. makina limakupatsani kulowa mu Airways mosamalitsa chikufanana mlingo wa mankhwala. Kawirikawiri akusowa gawo limodzi la ufa inhalation, kuti akawamange zizindikiro za mphumu kapena COPD.

Chifukwa chaichi, anthu okaona "Budesonide-mbadwa." Izi mankhwala okhala ndi olimba Russian. Mu kapangidwe kake mankhwala amanyamula kuyimitsidwa wa (kapena ufa) "Budesonide". The nebulizer anatenga makaseti ndi mankhwala, ndiye inspiratory wothandizila akulowa bronchi ndi mapapo.

mankhwala angapo zilipo mu mawonekedwe a aerosol, chimene mulinso "budesonide". dzina Trade iwo angakhale osiyana ndi mzake, koma pophika yogwira kudakali glucocorticoid chomwecho. Ngati mukumwa mankhwala amenewa, tiyenera kukumbukira kuti mlingo wina wa aerosol lili 0,05 ml ya budesonide ndi (ndikofunika kudziwa kuti si kuti kuchititsa ambiri osokoneza wa glucocorticoids).

Mtengo wa mankhwala

Popeza kukula kwa apano mankhwala msika sikovuta kukatenga okha, "Budesonide" kwa inhalation. mtengo wake ndi analogues ake zingasiyane, koma tiyenera kukumbukira kuti onse chomwecho mu dongosolo lawo la waukulu yogwira pophika ndi budesonide. Mtengo wa mankhwala kudzadalira amene amapanga mankhwala, ndipo ngati kuli mankhwala patenti kapena mankhwala angaperekedwe.

Mankhwala amagulitsidwa yekha mu pharmacies. Kodi Zikhala ndalama zingati "Budesonide"? mtengo wake ndi analogues ake ndi avareji ya ku 300 2000 rubles. Izi zidalira pa amene ali Mlengi ndi amene mawonekedwe za kumasulidwa mankhwala. Mwachitsanzo, mankhwala monga "benacort" amapangidwa mu mawonekedwe a makapisozi ndi ufa inhalation. Nthawi zambiri, ndalama 400 rubles. mankhwala British ndi zambiri zodula. Mwachitsanzo, "Budesonide Formoterol" kupanga British ili mkati rubles 2,000, amene si aliyense angakwanitse. Mwachidule kugula Chisiloveniya, amene si amasiyana ntchito, ndipo mtengo kwambiri.

Mu maphunziro izo zatsimikiziridwa kuti mankhwala okwera mtengo kwambiri ndi pafupifupi zosatheka wolephera Anzawo ndalama. Choncho chimene mankhwala kugula - kusankha munthu aliyense malingana ndi zosowa zake ndi chitetezo.

Reviews yokonzekera

mankhwala Glucocorticoid wachita kale ntchito ndi odwala ambiri ndi matenda a obstructive aakulu kapena mphumu. Pafupifupi odwala onse ndi mawonekedwe choopsa cha amodzi mwa matenda amenewa amagwira ntchito "budesonide". analogues ake zimakhala selo mwachilungamo lonse mu kaundula wa mankhwala ndi matenda amenewa, kawirikawiri amamva kulikonse. mankhwala monga, mwachitsanzo, "Apulein" "Benakap" "Buderin", kale pamwambapa "Pulmicort" ndi "benacort" etc.

Malinga ndi odwala ambiri, mankhwala izi ndi zopambana mu zochizira matenda pa mundawo kupuma. Ndithu anthu ochepa amene sanalambire wathandiza inhalation mawonekedwe a glucocorticoid kapena osakaniza ake ndi beta-agonists.

Ndi yoyenera mankhwala dosing anali angakhale ndi kusintha kwambiri odwalawo. Panopa ambiri sitingapeze kuganiza za moyo ndi moyo wabwino popanda kugwiritsa ntchito mankhwala.

Komabe, ngakhale ndemanga zambiri zabwino, pali mbali yoipa ya mankhwala monga "Budesonide" - mtengo.

Kwa nthawi yaitali panali chizolowezi ufulu kusankhidwa mphumu mankhwala odwala wosowa. odwala onse akanakhoza kubwera kwa mankhwala, ndi pa ulaliki kwa bukuli zogwirizana kumasuka mankhwala zofuna zawo.

Pakali pano, nawonso ankachita, koma chimadalira, amene ali oyenera kumasula mankhwala kwambiri mwapang'ono. Tsopano mankhwala awa ndi kwaulere ndi anthu olumala 1 ndi magulu 2, komanso ana; anthu ena ndi kugula mankhwala kwa ndalama zawo. Popeza kuti lokonzekera chimaonetsa kwambiri, osati munthu aliyense angakwanitse chithandizo chotere.