"Enalapril": malangizo ntchito ndi mayankho. Analogs "Enalapril"

Ngati muli ndi mavuto ndi magazi, ambiri amalandira kuchokera ayamikira madokotala kutenga mankhwala "enalapril" (mapiritsi). Kuyambira chimene chimathandiza kuchotsa mankhwalawa? Chifukwa cha matenda (ie, mwachindunji kwa BP), kapena amachita zinthu pa amadzibisa angapo, kubwezeretsa ntchito bwinobwino a dongosolo mtima, kuchititsa magazi amabwerera wabwinobwino? Kumvetsa mmene miyala ndi "Enalapril" kuthamanga kofunika kuti ayanjane ndi chiongoko boma ntchito mankhwala. Komanso, tikambirana angapo analogs za mankhwala ndi yogwira pophika ndi ali gwero.

Kufotokozera lokonzekera, mawonekedwe kumasulidwa, makamaka yosungirako ndi zinthu yopereka wa pharmacies

Mankhwala "Enalapril" kuthamanga opangidwa ndi makampani mankhwala padziko lonse. Waukulu yogwira pophika mankhwala ndi enalapril maleate imene gulu amayanjana ake amatanthauza Ace-blockers. Panopa, pali miyala ndi yogwira pophika zili 5, 10 ndi 20 mg. Chifukwa chakuti yokonza "Enalapril" kuthamanga likukhudza ntchito kwa CCC ndi chiwerengero cha machitidwe ena mu thupi, amasulidwe pharmacies chochitidwa ndi mankhwala.

Nthawi kukhazikitsa ndi ntchito za mankhwala okha zaka 3 kuchokera tsiku zokolola zake. Choncho mapiritsi Musataye katundu wawo achire pamene kusungidwa malamulo. Opanga Mpofunika kusunga medicament youma, kutetezedwa ku dzuwa, pa kutentha osachepera 15 ndipo si madigiri oposa 25.

Analogs "Enalapril" ndi katundu chomwecho, kotero ayamikira ntchito mankhwala, ndipo angaone pa yosungirako awo.

Pharmacodynamics medicament

Enalapril maleate (yogwira pophika mapiritsi) palokha si bwanji wotuluka mu njira thupi. chakuti pawiri izi ankaona kuti ngati "prodrug" kuti ndi chifukwa cha ochepa zochita hydrolysis kupanga chinthu chatsopano kwathunthu - enalaprilat.

Ndi kumafooketsa pa Ace ntchito kuposa imfayo kuchepa kwambiri kuchuluka kwa aldosterone mu thupi la munthu. Mwachidule, zotsatira za "Enalapril" tichipeza mu kutsitsa magazi (onse diastolic ndi systolic) ndi kucheperachepera katundu minofu mtima (myocardium).

Chifukwa, kuzipenya yaitali ife tinapeza kuti, ngakhale kuchepetsa magazi pambuyo kutenga mankhwala "enalapril" odwala akhala sichidamsowa mlingo wa magazi mu ubongo. Komanso, mapiritsi phwando kumatheka ndi aimpso ndi inatsekeratu magazi.

Yaitali ntchito mankhwala anasonyeza mkulu efficacy mu minofu hypertrophic, isanafalikire mu ventricle kumanzere kwa minofu mtima, kuposa thandizo kuteteza patsogolo kulephera mtima. Komanso, mankhwala "enalapril" kwa miyezi 6 kusintha chikhalidwe cha odwala yamitsempha yamagazi dilatation kumanzere ndi magazi aziyenda bwino mu myocardium, chifukwa kuchokera ischemia.

The yogwira mankhwala mankhwala opezeka mu madzi a m'magazi pambuyo ola 1 pambuyo phwando miyala ndipo kenako pazipita pambuyo maola 4-6. Zotsatira hypotensive kumatenga maola 24.

Yemweyo katundu pharmacological lanu analogs "Enalapril" wa woukitsa.

Pharmacokinetics

Monga kudafotokozedwa pamwamba, mayamwidwe wa chinthu yogwira mankhwala kumachitika mokwanira msanga. Odzipereka okha 60% ya enalapril maleate, buku zayamba lonse chimamanga zonsezo plasma. Akatswiri Atchule ogula 'chakuti mayamwidwe pawiri si amadalira kudya chakudya.

Mlingo mkulu malowedwe a enalapril kudzera-GHB zopinga chifukwa kapangidwe maselo a pophika yogwira. Ndiponso wakutheker kugonjetsa chotchinga placental ndipo amapezeka m'mawere minofu ndi mkaka wam'mawere mu akazi lactating.

Excretion mankhwala ikuchitika makamaka ndi impso (60%). Choncho unaltered linanena bungwe la za 20% ndipo 40% - monga metabolite a. Zotsalira mankhwala yogwira kunja kupyolera matumbo, mmene chiŵerengero cha enalapril / enalaprilat ali zizindikiro 6-8% / 25-27%.

Zizindikiro ndi contraindications

The zikuonetsa ntchito ya medicament "Enalapril" ndi kuwonjezeka kulimbikira magazi chifukwa cha matenda monga matendawa ndi CHF. Komanso, mankhwala kawirikawiri amagwiritsidwa ntchito mankhwala prophylactic odwala ndi matenda inatsekeratu ischemia, anasiya kukanika yamitsempha yamagazi (kuphatikizapo asymptomatic). Kuti ndi mankhwala "enalapril" zikuonetsa ntchito, koma kudzimvera medicate Mulimonsemo ali osavomerezeka. Only katswiri mungapange zolondola chithandizo chakudya ndi kudziwa mlingo.

Pa mayeso, dokotala kwanu angathe kukhazikitsa kukhalapo kapena kusapezeka kwa contraindications zotheka. Zikuphatikizapo matenda ndi matenda a ntchito kwa ziwalo:

1. Kuchuluka kudziwa pophika yogwira mankhwala (ofanana "Enalapril" nthawi yomweyo komanso akufuna kuletsa, ngati iwo ali nthawi zambiri zofanana ndi chiphunzitso ichi mankhwala).
2. Mimba, mkaka wa m'mawere ndi ana osaposa zaka 18.
3. Previous mlandu angioedema pa kukonzekera chithandizo ku gulu la Ace-zoletsa.
4. Cerebrovascular insufficiency, ndi matenda ena cerebrovascular.
5. Cerebrovascular hematopoiesis.
6. matenda aimpso, kuphatikizapo aimpso mtsempha wamagazi stenosis (unilateral kapena amgwirizano), kulephera aimpso, pamaso pa limba kuziika.
7. chiwindi matenda.
8. Matenda pa mundawo m'mimba pamodzi ndi kutsekula ndi kusanza.
9. Matendawa ndi matenda ena autoimmune okhudza zimakhala connective.
10. Kulakwila njira kagayidwe kachakudya mu thupi, kuphatikizapo hyperkalemia.
11. Shuga.

Chikuonetseratu "Enalapril" zinthu zonse tafotokozazi ayenera sanaithetse, kapena mankhwala ikuchitika kuyang'aniridwa zonse akatswiri.

Mankhwala "enalapril": mndandanda wa zotsatira zoyipazi

Ngakhale ubwino waukulu wa mankhwala, pamene phwando odwala kuona zosiyanasiyana zotsatira zoyipa zomwe zimakhudza pafupifupi onse machitidwe limba. Information pa zochitika chowawa ali tebulo pansipa.

Makamaka zinthuzo chikwiyire ndi kukopa mwachindunji pa thupi yaikulu yogwira mankhwala mankhwala "Enalapril". Analogs (malangizo ntchito iwo lili mudziwe zambiri pa nkhaniyi) akhoza kuyambitsa matenda ofanana. Wodwalayo ndipo adokotala ake n'kofunika kuona zizindikiro za zotsatira zoyipa, ngati kunyalanyaza iwo zingachititse kuti chisokonezo kwambiri kugwira ntchito kwa thupi.

Kodi kutenga miyala "enalapril" njira ndi mlingo

Ziziyenda magazi akatswiri amalangiza ntchito nthawi yaitali mankhwala (kuphatikizapo analogues zace, mwachitsanzo, "hexane Enalapril" mankhwala). Pa siteji yoyamba ya mankhwala a matenda oopsa Ndi bwino kutenga mankhwala pa mlingo wa 5 mg pa tsiku. Kuwonjezeka mwadongosolo kuthamanga pa masabata awiri a mankhwala mlingo ndi chinawonjezeka ndi 5 mg. Dziwani kuti poyamba maola 2-3 pambuyo chiyambi cha mankhwala, wodwala ayenera kukhala moyang'aniridwa ndi achipatala. Izi zimathandizanso kudziwa mavuto oyambirira pa chitukuko. Mlingo pazipita sayenera upambana mg ndi 40 tsiku, koma ngakhale ntchito ndalama za mankhwala zimatheka ngati kuli koyenera kutero komanso zogwira mtima tolerability wa medicament lapansi.

Patapita masabata 2-3 pambuyo chiyambi cha monotherapy "Enalapril" mankhwala, odwala anasamutsa kuchirikiza mankhwala phwando mode. Nthawi imeneyi, mlingo tsiku 10-40 mg wa mankhwala. Mapiritsi ayenera kumwa nthawi 1-2 tsiku. Analimbikitsa pa chithandizo zonse kuyeza magazi.

Kuvomereza pamwamba ntchito odwala amene musati akudwala matenda concomitant monga hyponatremia ndi renovascular oopsa. Kodi Mlingo ayenera kutenga mankhwala? Monga ulamuliro, izo zimatengera makhalidwe munthu wodwalayo ndi mmene matenda. Mlingo woyambilira Mulimonsemo kuchita masamu yekha ndi dokotala nawo.

Nthawi phwando medicament ndi kumatengera zifukwa zingapo, monga alili ndi zotsatira za mayeso zasayansi. Akatswiri kuona kuti achire mwadzidzidzi mankhwala kungakhale ndi zotsatirapo zoipa. Choncho, ngakhale kwambiri kutsitsa magazi odwala ndi kulandira mankhwala "enalapril" ayenera pang'onopang'ono kuchepetsa mlingo.

Zizindikiro ndi mankhwala mankhwala ambiri osokoneza bongo

Kotero, ife anayang'ana pa makhalidwe zofunika mankhwala "enalapril" (mapiritsi), kumene kuthandiza ndi zotsatira za phwando awo pa mapeto. Ndi nthawi yopita pa tsogolo ndi kukambirana za nkhani imeneyi, ndi ambiri osokoneza za mankhwala. Nthawi zambiri odwala amavomereza Mlingo waukulu wa mankhwala pofuna kuchotsa zizindikiro zosasangalatsa. Zikatero, ngati izo zichitika kumwa mankhwala "Enalapril" munthu, zotsatira zake zikhoza kukhala zoopsa kwambiri. Ndi kuchepetsa magazi kugwa kumachitika odwala kuti nthawi zambiri kumayambitsa m'mnyewa wamtima infarction aakulu kapena matenda oziziritsa kufalitsidwa.

Childs, zizindikiro choyamba cha mankhwala osokoneza bongo ndi imfa ya chikumbumtima, mkhalidwe stupor kapena maonekedwe a khunyu. Komanso, pangakhale zizindikiro zina ndi chotupa cha otaya oziziritsa magazi ndi kuvutika mtima: wotumbululuka khungu, mutu kwambiri, ululu kumbuyo breastbone lapansi.

Chithandizo cha wodwala ndi ambiri osokoneza a "Enalapril" mankhwala symptomatic. Mu poyizoni wofatsa kukuonetsedwa kulandira saline ndi chapamimba lavage. Nthawi zambiri aakulu kungafune mtsempha jekeseni wa saline ndi madzi a m'magazi mmalo, komanso hemodialysis.

Mwanjira mankhwala

Miyala "Enalapril" wokhoza kuchita atypically, pamene phwando pamodzi ndi mankhwala ena. Nonsteroidal odana ndi yotupa mankhwala ( "Ibuprofin" ndipo m. P.) Ndipo mankhwala estrogensoderzhashie kwakukulukulu kuchepetsa kanthu ake hypotensive. Blockers, mankhwala nitratsoderzhaschie, dzanzi ndi Mowa kuonjezera mphamvu ya mankhwala "enalapril". mankhwala Diuretic atengedwa pamodzi ndi mankhwala kuti kuchepetsa vuto la kuthamanga, angachititse chitukuko hyperkalemia. Ndi kusamala kwambiri ayenera kumwedwa mankhwala ku gulu la immunosuppressants, chifukwa iwo pa phwando limodzi ndi mankhwala okhala enalapril kwambiri kumapangitsanso haematotoxicity ake.

mankhwala Reviews

Chibwenzi za mankhwala angamvele onse ndemanga zabwino ndi zoipa. The yoyamba ntchito "Enalapril" mapiritsi - Price (20-25 rubles pa paketi), amene sakhoza amati ndi mkulu. Komanso, wawachititsa pokonza ndi nchito zake. Udindo wa zovuta zazikulu ndi mbali zosiyanasiyana ambiri ndi chiopsezo cha matenda oyamba pamaso pa matenda concomitant.

odwala kwambiri 'Enalapril' mapiritsi anathandiza tichotse kuchuluka ka magazi. Pakuti ogula omwe ali ndi pangano wachititsa chisokonezo kugwira ntchito kwa ziwalo zosiyanasiyana, izo anali kupereka osati pa mankhwala, komanso analogues ake, monga nthawi zambiri, iwo ali yemweyo yogwira mankhwala kapena ngati enalapril indapamide. Ndicho chifukwa Akatswiri ali osavomerezeka kutenga mankhwala angapo magazi kuchepetsa.

Analogs "Enalapril": kusiyana, ubwino ndi kuipa

Pa pali mankhwala ambiri ofanana ndi mankhwala "enalapril" dziko msika mankhwala. Nthawi zambiri, iwo ndi mtengo wapamwamba, zomwe si nthawi zonse mutsimikizira pakalibe zosiyanasiyana chokhwima kapena efficacy apamwamba mankhwala. Taonani mndandanda wa mankhwala amene wapangidwa mankhwala yogwira, zikufanana ndi zomwe zili mu "Enalapril" miyala. Childs, Laboratories mankhwala m'mayiko Western ntchito ndi mbali yaikulu amplodipin enalapril, amene isiyana maleate enalapril Mwa dongosolo ndi maselo. Zina ali ndi makhalidwe omwewo ndi katundu.

Mu msika Russian mankhwala pali analogs zotsatirazi "Enalapril":

1. Mapiritsi ndi makapisozi kwa jekeseni "Enap" ndi Chisiloveniya kampani KRKA. mtengo akuyamba pa 280 ndi amapita kwa 4000 rubles kwa ma CD a mapiritsi, ndi 500 rubles kwa mbale 10 ndi njira. Monga mmene taonera, motsutsana ndi "Enalapril" mankhwala, mtengo si mkulu, zomwe zimapangitsa mankhwala a mtundu uwu kuwerengedwa ambiri ogula. Pa nthawi yomweyo, akatswiri onani apamwamba a analogi lapansi.
2. Miyala "Enalapril hexane" ku German wopanga SANDOZ. M'banja mankhwala kwa nchito zake si otsika ku medicament anapatsidwa. Mtengo wa analogue Choncho pang'ono kuposa mtengo wa "Enalapril" ndipo watsala 78-100 rubles pa paketi.
3. Miyala "Berlipril" opangidwa ndi kampani German mankhwala, "Berlin-Chemie". Waukulu yogwira pophika mankhwala ndi amlodipine, enalapril. Chifukwa chakuti chiphaso cha mankhwala ndi zovuta ndi mtengo, mapiritsi mtengo ndi za 140-180 rubles pa paketi.
4. Miyala "Renitek" kuchokera MERCK, mtengo umene ndi mwezi wa zosiyanasiyana ndipo ndi 80-150 rubles pa paketi.

Komanso mu pharmacies mungapeze ngati ofanana mu kapangidwe ndi kanthu kwa analogues mankhwala "Enalapril" monga "Kalpiren", "Miopril", "Envas", "Vazopren" ndi "Miopril". Komabe, akatswiri amanena kuti mankhwala si nthawi zonse anatchula ntchito mmalo Sichinatsitsidwe anayandikira mtima, pakuti chirichonse zifukwa, mankhwala zoweta. mfundo ndi yakuti mu kapangidwe kake iwo pafupifupi kubwereza wathu "Enalapril", kutanthauza kuti angathe kuyambitsa zosiyanasiyana zosokonezeka. Komanso, madokotala akulangizidwa kulabadira zikuchokera amapangidwa kunja mankhwala. Amplodipin enalapril, amene isiyana maleate enalapril ndi ang'ono, zikhoza kuchita zikuwononga pa thupi. Mulimonsemo, asanayambe ntchito ngati mankhwala yaikulu iliyonse ya analogs zatchulidwazi, m'pofunika kukaonana ndi dokotala.