Maantibayotiki fluoroquinolones - yogwira omenyana thanzi lanu

Mu 1962, pamene mankhwala oyamba amphamvu a kalasi, palibe mmodzi ananeneratu izo bwino zimenezi. Iwo anatulukira ngati njira matenda thirakiti mkodzo, koma pambuyo pake anakhala mankhwala otchuka. Zochita matenda, gulu mlingo anamukwiyira mwachangu okhawo mu 80 ntchentche wa XX atumwi. Lero, mankhwala fluoroquinolones kungoti irreplaceable mankhwalawa matenda kupuma. Pa gawo la Russia ndi wotchuka padziko lonse gulu la mankhwala awa kalekale m'mibadwo yanu. Koma, mwatsoka, mugawo ili salola wothandizila kudziwa mipweya awo ndi sipekitiramu ntchito. Choncho, nthawi zambiri za fluoroquinolones (mankhwala), nenani, Kupeleka magulu 2 - akale ndi atsopano.

gulu la mankhwala

Kwa Mankhwala gulu zaka "Ofloxacin" mankhwala "enoxacin" "Ciprofloxacin" ndi ena. Latsopano mankhwala - mankhwala "sparfloxacin", "Klinafloksatsin", "Moxifloxacin". Komabe, ena mwa mankhwala anayamba ndi sichikupezeka, monga masikolala zotsatira zina zoyipa pozigwiritsa ntchito apezeka.

Kugwiritsa ntchito mankhwala

Gulu la mankhwala kale ntchito matenda a thirakiti mkodzo, matenda m'mimba ndi matenda, opatsirana pogonana. Zochizira matenda kupuma mankhwala fluoroquinolone ntchito, mwatsoka, ochepa, ngakhale amatha mwakhama ntchito pa mitundu ina ya tizilombo toyambitsa matenda.

mankhwala

Maantibayotiki Fluoroquinolones bwino chosakanikirana ndi kapepala kakuti m'mimba, ndi kudzapeza maganizo madzi zimakhala pambuyo maola 3 pambuyo ntchito yawo. Ngati pa nthawi yomweyo kudya chakudya, mayamwidwe wa pang'ono yogwira pang'onopang'ono, koma kanthu adzakhala monga yogwira. Limagwirira cha zochita za mankhwala ndi chopinga wa DNA gyrase ndi topoisomerase IV tizilomboto, kotero palibe mtanda kukana kwa atumiki antimicrobial. Awa ambiri amagwiritsa ntchito mankhwala kwa matenda achikazi (wamkazi matenda zoberekera), mu inflammations makamaka cha ziwalo m'chiuno, zomwe uka chifukwa cha zinthu wolimba wa-zamoyo yaying'ono kuti kudutsa mu kapepala chapamwamba maliseche. Tengani quinolones analimbikitsa pa chopanda kanthu m'mimba, ngakhale chovomerezeka ndi ntchito mukatha kudya.

zotsatira zoyipazi

Mankhwala fluoroquinolones bwino analekerera pa ingestion ndi jakisoni mtsempha. zosiyanasiyana chokhwima n'zochepa, koma ngati iwo atero, iwo amangoona bwanji ntchito za kapepala m'mimba ndi mantha dongosolo ntchito. Mukhoza kuona nseru, m'mimba, mutu, chizungulire, omangana, manjenje. Ambiri, izi gulu la mankhwala amakhala ndi magawo apamwamba pharmacokinetic.

masitepe Basic sitepe fluoroquinolones

1. Malowedwe mwa Kakhungu mu selo.
2. Chopinga wa enzyme DNA gyrase.
3. DNA biosynthesis.
4. Chiwonongeko aligorivimu selo magawano.
5. Kusintha kapangidwe selo.
6. selo imfa.

Gulu la mankhwala ankagwiritsa ntchito mankhwala, ndipo ngati ntchito amatha kupereka chithandizo champhamvu thanzi la munthu.