Mankhwala "Amiodarone": analogues, malangizo, ndemanga

Mtima, monga inu mukudziwa, thupi lathu lalikulu, koma nthawi zambiri amalephera. Pofuna kubwezeretsa uziyenda mwake ntchito zosiyanasiyana mankhwala. Mmodzi wa iwo ndi "Amiodarone". Analogs ndi zambiri zodula, monga amapangidwa kunja ndipo si nthawi zonse zothandiza.

The zikuchokera mankhwala ndi mawonekedwe a

The medicament "Amiodarone" imene ndemanga zosiyanasiyana limapangidwa mu limodzi la mg ndi 200 wa yogwira pophika - amiodarone hydrochloride. kukonzekera wapangidwa zambiri monga njira kumene 3 ml ya 5% wa yogwira pophika.

Wothandiza chigawo linapangidwa limodzi ndi: mbatata wowuma, crystalline microcellulose, lactose, maltodextrin, primelloza, polyvinylpyrrolidone, magnesium stearate.

Miyalayo yokutidwa ndi glaze wa mtundu woyera ndi pang'ono, wochenjera kirimu mthunzi. Iwo ndi maonekedwe a Valium ndi mbali ndi Valium. Choncho, ngati n'koyenera, n'zosavuta kugawidwa mu magawo awiri ofanana.

Mankhwala amagulitsidwa makatoni komwe kapena awiri matuza ndi miyala khumi. mankhwala ndi kubala mu galasi, polymeric ndi pulasitiki mabotolo, amene mapiritsi 30 kapena 100.

Limagwirira pharmacological kanthu mankhwala

katundu Antiarrhythmic ndi antianginal yodziwika ndi "Amiodarone" analogues zina mukhoza m'malo mwake. Ake kanthu odana arrhythmic zachokera panopa kuchepetsa ayoni potaziyamu pamene chinaperekedwa kwa maselo nembanemba - cardiomyocytes. Izo zimayambitsa kuchepetsa mu nkusani mfundo imene imagwiritsidwa bradycardia.

Ntchito mankhwala "Amiodarone" (mapiritsi) angadwale kutalika kwa refractory mtima conduction limagwirira. Kumabwezera mmbuyo ndi madutsidwe wa njira sekondale odwala matenda aakulu a syndrome Wolff-Parkinson-White. Poyankha, zotsatira antianginal mankhwala wamangidwa pa kuchepetsa mowa m'mnyewa wamtima mpweya ndi kuchepetsa imakhudzira minofu wolumikizira. Wapangidwa ndi ayodini, umene uli ntchito ya kachulukidwe amasintha zili chithokomiro timadzi, chifukwa mu mlingo wa zimakhudza awo pa myocardium ndi yafupika.

"Amiodarone" ali ndi zotsatira chokhala ndi zotsatira kutchulidwa pa tanthauzo lake limapezeka pokhapokha sabata imodzi ntchito zonse za mankhwala, ndi pazipita kukufika pambuyo masabata awiri atatu.

Mkati odzipereka 40% kumwa mlingo, Cmax plasma limapezeka pambuyo maola 3-7. Zotsatira amatha angakhale kwa masabata angapo. njira kagayidwe kachakudya chichitike makamaka chiwindi, komwe mchitidwe yogwira aumbike dezetilamiodaron, ndilo metabolite lalikulu. Bwererani ndi ya ndulu tochoka ndi mkodzo, T1 / 2 - pambuyo mlingo umodzi wa mankhwala 3,2-20,7 H, ndi mankhwala yaitali - pambuyo 53 ± 24 maola.

Medicine "Amiodarone": zikuonetsa ntchito

Mankhwala mankhwala kuti kupewa ndi kuchiza wa arrhythmias, amene akhoza wodwala zingawononge moyo wa anthu, komanso arrhythmias yamitsempha yamagazi, flutter yamitsempha yamagazi mu mphamvu wosakhazikika komanso ntchito mankhwala "Amiodarone."

Zikuonetsa kulola kugwiritsa ntchito mankhwala ndi:

• matenda flutter;
• supraventricular arrhythmias;
• syndrome Wolff-Parkinson-White;
• zosayembekezereka wa tachycardia;
• fibrillyatsionnogo akhoza ventricles;
• arrhythmia akuwuka chifukwa mtima ndi inatsekeratu insufficiency;
• mitundu aakulu ya matenda a mitima;
• m'mnyewa wamtima infarction.

"Amiodarone": malangizo ntchito

Mapiritsi ukunenedwa kwa makonzedwe m'kamwa pambuyo Mphindi 15 pambuyo chakudya.

Pa yamitsempha yamagazi matenda fibrillation mlingo analimbikitsa ndi dokotala, ndi 800-1200 mg wa pa tsiku. Kuyenera ogaŵikana madyerero 3-4. Mankhwalawa Pankhaniyi kumatenga za 5-10 masiku kuonetsetsa chikhalidwe khola la wodwala akhoza anawonjezera, ndi mlingo akhoza ayanjane 600-800 mg wa pa tsiku. Izi mankhwala tima, amene kenako n'kuyamba kupereka njira, ndi mlingo apansi zili mankhwala.

kukonza achire nyengo ndi masiku 7-14, mu nthawi ino ya mankhwala kutenga 200-400 mg. Chotero buku mankhwala anatumizidwa ziziyenda alili mu nthawi poslereabilitatsionny.

Kawirikawiri mankhwala "Amiodarone" zotchulidwa pamene wodwala ku chipatala, ndi luso lake angathe kulamulira dokotala. Izi zimathandiza kuchepetsa mavuto ndi payekha kusintha mlingo wa mankhwala.

Pamene medicament matenda angina ntchito kawiri pa tsiku pa 200 mg. Patatha milungu iwiri, mlingo anachepetsedwa kamodzi patsiku. The pazipita umodzi mlingo mlingo sayenera upambana 400 mg ndi tsiku - 1200 mg.

Poika mankhwala kwa ana ayenera adzanyamula kukumbukira kuti mankhwala bwanji mwanayo zambiri mofulumira kuposa munthu wamkulu. Choncho, mlingo ndi kuchita masamu potengera kulemera kwa mwanayo. Choncho, kilogalamu imodzi ya kulemera lidzagwa 10 mg wa medicament. mankhwalawa ayenera kuchita zimenezi pa nthawi achire wa masiku khumi mpaka alili bwino. Hereinafter, mfundo imeneyi kuchepetsa chiwerengero cha mg wa 5 pa kilogalamu thupi la mwanayo. Njira yokonza mlingo akutengedwa ndi zochokera kilogalamu imodzi 2.4 mg wa mankhwala "Amiodarone."

Zikuonetsa mankhwala zotchulidwa kugwiritsa ntchito njira yochokera yogwira pophika amiodarone hydrochloride mu arrhythmias pachimake mtima. Pankhaniyi, mankhwala chikuyendetsedwera m'nsinga, pang'onopang'ono jekeseni thupi ndi dropper a. Kuti tichite zimenezi, 250 ml ya 5% shuga njira kwa 1 kapena 2 pang'ono ndi pang'ono jekeseni mankhwala mlingo wa 5 mg pa kilogalamu kulemera thupi. Panthawi imeneyi, woleza mtima ndi kuunikira njira ECG ndi kuwerenga magazi kayesedwe.

zotsatira zoyipazi

mankhwala mankhwala ochuluka "Amidaron" m'dziko lathu. Analogs si nthawi zonse akhoza m'malo mwake. Koma ngakhale Phindu la mankhwala pa thupi la munthu, akhala kuzindikiridwa ndi mavuto.

zizindikiro zoipa makamaka chifukwa mankhwala ambiri osokoneza bongo. Izi kuphwanya dongosolo mtima, monga bradycardia, nkusani mfundo ntchito kulephera, kuletsa mtima, imfa ya mgwirizano kuyenda. Komanso pa mbali ya dongosolo kupuma chinaoneka akakufunsani interstitial m'mapapo mwanga fibrosis, interstitial chibayo, Hamm syndrome - Olemera, kupweteka m'chifuwa, fibrosis m'mapapo mwanga, tachypnea, bronchopulmonary spasms. kulephera kwa chiwindi unkachitika pamene kulandira "Amidaron" kukonzekera. Miyala iwiriyo nthawi zina amayambitsa matenda a chikasu ndiyo, matenda a chiwindi, ndi matenda enaake zina.

Kulephera kutsatira mlingo zingachititse vutoli kwambiri mahomoni chithokomiro, distireoza ndi hypothyroidism, ndi ya pogwiritsa owonjezera. Ambiri osokoneza kungachititse kuti kusokonezeka kwa zida za zithunzi, kuchititsa kudzikundikira lipids mu diso kwa mwana wa. Komanso, pali mtundu kutchulidwa ndi chikopa, photosensitivity, urticaria kapena erythema. totupa Minor sadawone nkhope, alopecia, dermatitis. Zotsatira zake zoyipa anakhudzanso ntchito zoberekera za amuna. Mu milandu pali orchitis, kusabala, ndi epididymitis. yosowa kwambiri thrombocytopenia, kulephera aimpso, kapena angioedema vasculitis.

Contraindications ntchito

"Amiodarone" (maganizo sanali abwino) akusankhidwa mosamalitsa payekha. Pali anthu kuti mankhwala sizinathandize kapena iwo alibe anaona mwamtheradi palibe kusintha mu udindo thanzi, ena anayamba zitsamwitsa pambuyo inu ntchito, anamva mtima palpitations. M'mawu awo, Propafenone ndi wokhoza kusokoneza dongosolo endocrine mahomoni kuonjezera. Choncho, asanadye mankhwala mankhwala ayenera osati powerenga malangizo, komanso kulabadira zizindikiro, mavuto ndi contraindications.

Choncho, mankhwala sayenera kugwiritsidwa ntchito ngati pali atrioventricular chipika kalasi 2-3, mu mantha cardiogenic, hyperthyroidism. Kukonzekera "Amiodarone" sanagwiritse ntchito tilinazo ake okwezeka wothandizira wa yogwira ndi iodo. Ban ndi kuswa wa conduction mtima ndi nkhani ya bradycardia ndi syncope. Musagwiritse ntchito mankhwala pa mimba ndi mkaka wa m'mawere. Mkaka wa m'mawere, m'nthawi ya mankhwala ayenera kusiya kuyamwitsa mwana mkaka.

ayamikira yeniyeni

Kodi mosamala loyang'aniridwa ndi dokotala achire mankhwala "Amiodarone". Malangizo ntchito akuonetsa kuti kugwiritsira ntchito mapiritsi pambuyo phunziro X-ray a chiwindi, m'mapapo ndi electrocardiogram lapansi. polojekiti ayenera idzachitika m'tsogolo, ngati wodwalayo akupitiriza makhwalawa.

Zovuta zochitika chowawa zambiri zimadalira mlingo, amene amagwiritsa wodwalayo. Kodi kugwiritsa ntchito mankhwala monga infrequently ngati n'kotheka ndi zedi kochepa. Zimayambitsa osasamba kugunda Kulipira "Amiodarone" mankhwala.

Malangizo ntchito - ndemanga kuti, ngakhale mavuto, mankhwala chakupulumutsa moyo kuposa wina - limanena kuti kanthu pharmacological mankhwala anakhalabe kwa milungu ina iwiri pambuyo Kulipira ake.

Mapiritsi muli ayodini, zomwe zimalimbikitsa mlingo kudzikundikira wa radioiodine mu chithokomiro England. Choncho, pa chiyambi cha mankhwala achire, nthawi ndipo pamapeto muyenera zonse kuziyeza kuti kuchuluka kwa timadzi chithokomiro.

Pa achire alowererepo n'kofunika kupewa yaitali dzuwa padzuwa, si koyenera kumtengera dzuwa lotseguka. mankhwala ayenera kuperekedwa mosamala kuti anthu okalamba ndi ochititsa dzanzi ambiri kapena m'kati mwa mankhwala oxygen. Mosamala tiyenera kugwiritsa ntchito madalaivala a magalimoto ndi anthu amene ntchito amagwirizana ndi ndende makamaka.

Nthawi cha mankhwala osokoneza bongo akhoza kuona akuchuluka mavuto, komanso hypotension, arrhythmia. Angagwe bradycardia kapena kulephera kwa AV conduction. An overabundance kungayambitse kukanika chiwindi.

Pankhaniyi, Mpofunika yomweyo chapamimba lavage, akaundula adamulowetsa makala, Mankhwalawa saline analimbikitsa njira. Ngati bradycardia jekeseni wa atropine, ntchito agonists ya maselo beta-adrenergic, opangidwa AKUYENDA.

Kugwirizana ndi mankhwala ena

CHENJEZO ayenera kugwiritsidwa ntchito mankhwala imodzi ndi mankhwala ena, makamaka ngati ali ku gulu lomwelo la antiarrhythmic. Sikuti kuphatikiza ndi phwando "mankhwalawa", "pentamidine" ndi "vincamine." Pali chiopsezo yamitsempha yamagazi tachycardia polymorphic osakaniza "sultopride". Iwo ali osavomerezeka kuphatikiza wambiri CCB ndi beta-blockers ndi "Amphotericin B" ndi mankhwala amene amayambitsa zotsatira mankhwala ofewetsa tuvi tolimba, diuretic. Mosamala ntchito mankhwala osakaniza corticosteroids, antidepressants, "Astemizole", "terfenadine." Akhoza kwambiri kumapangitsanso zotsatira za mankhwala monga "Warfarin", "Phenytoin" "Tacrolimus" kapena "Digoxin". Pamene ntchito molumikizana ndi "cimetidine" kubweza ndondomeko kagayidwe mu thupi.

Moyo ndi kusunga miyezo

The medicament "Amiodarone", amene kanthu imatsogoleredwa pa Kupha tachycardia, fibrillation yamitsempha yamagazi, tachyarrhythmia ndi matenda kuchepetsa flutter, amatanthauza gulu gulu kukonzekera "B". Alumali moyo wa mankhwala ndi zosakwana zaka zitatu. Mapiritsi ziyenera kusungidwa pa ozizira, mdima ndi patali ana.

ntchito "Amiodarone" mankhwala ayenera mosamalitsa ankalamulira. Chinsinsi ku ntchito wamulembera dokotala. Pankhaniyi ndikuvala ayenera kwathunthu mulibemo.

Analogs medicament

Ngati inu mwadzidzidzi sichinkagwirizana mankhwala "Amiodarone" analogs angapezeke mu mankhwala aliwonse. Ena mwa iwo ndi mankhwala monga: "Amiodarone Belupo" ndi "Amiodarone Aldaron", "Angoron" ndi "Atlans" ndipo m'malo mankhwala akanakhoza "Kordaron" kapena "Kordinil". Similar kuti "Amiodarone" mu zotsatira zake pa thupi la munthu "Medakoron" ndi "Palpitin". Nthawi zina, mankhwala m'malo mwa "Sedakoronom" ndi "Sandoz".

Izi mankhwala kapena muli yemweyo yogwira mankhwala kapena ofanana tingati awo antiarrhythmic wa mankhwala "Amiodarone". Analogues nthawi zambiri amapangidwa kunja ndipo kangapo mtengo kwambiri.

umboni

Odwala ambiri amati olimba a chikhalidwe chawo pambuyo kumwa mankhwalawo, "Amiodarone". Malangizo ntchito - zambiri analogs mankhwala amasankhidwa potengera makhalidwe munthu wa chamoyo - akulonjeza matenda mlingo mtima, kuthamanga. Pamene likukulira phwando pa mlingo yaing'ono, zambiri palibe vuto, ndi zochita mankhwala bwino.

Pambuyo ntchito yaitali mankhwala odwala ena anaonekera kufupika kwa mpweya, palpitations mtima, mantha ndi maganizo, mmene alili ndi kuchuluka chithokomiro timadzi, matenda thirakiti m'mimba, ndi zina, kunyansidwa ndi kusanza.

anthu ochuluka kwambiri ntchito pa matenda a angina, ndipo dziwani kuti si zoopsa kuposa kunja. Ena mantha kutenga mankhwala, chifukwa mwa iwo, amatha kupangitsa nambala za khansa. Akukhulupirira kuti mankhwala ayenera kumwedwa yekha pansi pa chikhalidwe amene agonjetsa moyo wa munthu, zinthu zina zonse, ayenera kuyang'ana kwa fanizoli. Komanso, piritsi mukhoza kungasokoneze pa ntchito wamwamuna ubereki, amenenso kuonedwa kuti pa phwando awo.

Koma anthu ambiri mankhwala "Amiodarone" iyo inali limathetseratu vuto lina lililonse, chifukwa chimene matendawa anaphwa, koma munthu anapulumuka. Osati chakuti analogues adzakhala monga ogwira. Choncho, mankhwala a matenda a mtima, musati sasamala mankhwala kutali, makamaka ngati dotolo akuonetsa izo.