Miyala "fenigidin": malangizo ntchito kwenikweni

anatanthauza mankhwala "fenigidin" ndi chiyani? Malangizo ntchito chipangizo zachipatala, contraindications ake, mavuto ndi analogs zafotokozedwa mwatsatanetsatane m'nkhani ino. Komanso, mudzaphunzila pamene apatsidwa mankhwala (zizindikiro), zimene mlingo ayenera kumwedwa, zimene akunena zokhudza izo, odwala ndi madokotala.

The zikuchokera ndi maonekedwe za kumasulidwa mankhwala

Mankhwala "fenigidin" mungazipeze pharmacies mu mawonekedwe mapiritsi. Iwo lokutidwa ndi ali yogwira pophika monga nifedipine. Mu kugulitsa nthumwi zachipatala atawalankhula bokosi katoni, kumene mukhoza kukhala kaya pellets 40 kapena 50.

Ifenso anafufuza medicament akhoza akugulitsa monga njira yothetsera makonzedwe mtsempha kapena intracoronary. Izi mankhwala muli yemweyo yogwira pophika ngati phale.

Pharmacological makhalidwe a mankhwala

ndi mankhwala "fenigidin" n'chiyani? Malangizo ntchito mankhwala limanena kuti ndi kusankha kashiamu njira blocker kalasi 2, ndi dihydropyridine ofanana nawo.

Limagwirira cha zochita za mankhwala ndi kuti kubweza kashiamu kuchuluka maselo a mtima yosalala minofu cardiomyocytes. Mankhwala akhoza kutengera hypotensive ndi zotsatira antianginal. Komanso lakamba zambiri za zotumphukira ndi inatsekeratu mitsempha, Sachita kamvekedwe ka zipangizo, amachepetsa magazi, zokhudza zonse mtima kukana, m'mnyewa wamtima contractility, kusowa kwa minofu mtima mpweya ndi amachepetsa afterload pa mtima. Komanso, mankhwala kwambiri bwino inatsekeratu magazi.

Miyala "fenigidin" odana ndi arrhythmic pang'ono kapena ayi ntchito. Komanso, iwo alibe nkhawa m'mnyewa wamtima conduction.

Pharmacokinetics mankhwala

Kodi odzipereka mankhwala "fenigidin"? Malangizo pa ntchito limanena kuti pambuyo pa kukhazikitsidwa kwa miyala mu chuma chawo yogwira mofulumira odzipereka kwa mundawo m'mimba. mankhwala ndi zimapukusidwa mu chiwindi. Izi zimachitika pamene "woyamba chindipitirire", chifukwa mu mapangidwe metabolites kulalikira.

medicament mapuloteni kumanga ndi pafupifupi 92-98%. Hafu ya moyo kumatenga za 2 h.

Masamba mankhwala mankhwala monga metabolites mu mawonekedwe unmodified (mu kufufuza ndalama) makamaka impso. Komanso, mankhwala ndi linanena bungwe mwa intestine (20%).

Zikuonetsa ntchito mankhwala

Ngati zolakwika iliyonse madokotala mankhwala odwala awo mankhwala monga "fenigidin"? Kugwiritsa ntchito mankhwala tikuonera zotsatirazi zinthu pathological:

• akulepheretseni zikwapu, kuphatikizapo angina vasospastic;
• kwa mpumulo wa angina;
• mu mavuto hypertensive;
• wolumikizira oopsa;
• matenda Raynaud a.

Contraindications ntchito mankhwala

Nthawi zina, mwina palibe sayenera kuperekedwa kwa wodwala mankhwala "fenigidin"? Malangizo ntchito miyala pansi pa kuganizira limanena kuti iwo contraindicated mu zolakwika zotsatirazi:

• mu mantha cardiogenic;
• wolumikizira hypotension (systolic magazi pamene ali ndi phindu zosakwana 90 mamilimita Hg ..);
• mu aakulu kung'ambika stenosis;
• pa kugwa;
• zoopsa aakulu mtima;
• ngati wodwalayo ali ndi tilinazo chodziwa kuti zinthu yogwira monga nifedipine.

Njira ntchito ndi mlingo wa mankhwala

Mankhwala "fenigidin" zoipazi Kwalamulidwa kokha odwala payekha. Pakuti makonzedwe m'kamwa mlingo woyambilira wa 10 mg kanayi pa tsiku.

Ngati n'koyenera, voliyumu ya mankhwala pang'onopang'ono kuchuluka. Pankhaniyi, mlingo adzakhala 20 mg wa kanayi pa tsiku.

Mu zina zochitika matenda (mwachitsanzo, zosinthika angina, kwambiri kapena matenda oopsa) kwa nthawi yochepa amaloledwa kuonjezera mankhwala mlingo 30 mg wa kanayi pa tsiku.

Kudzagwira mavuto hypertensive, komanso angina, mankhwala angagwiritsidwe ntchito si pakamwa ndi sublingually. Pankhaniyi chikuyendetsedwera mu kuchuluka kwa 10-20 mg (kawirikawiri 30 mg).

Mpumulo wa mavuto hypertensive ndi angina yogwira medicament zina kutumikiridwa m'nsinga (5 mg pa 4-8 maola).

Intracoronary bolus wa njira mankhwala kutumikiridwa 100-200 mg. Zinthu zimenezi nthawi zonse umachitikira kuti kuchotsa pachimake inatsekeratu spasms mtsempha wamagazi. stenoses mtima mlingo woyambilira akhale za 50-100 micrograms.

The pazipita tsiku mlingo kuonedwa ndi ife medicament pa ingestion 120 mg. Pakuti makonzedwe mtsempha, buku ake sayenera upambana 30 mg.

Zotsatira zoyipa za mankhwala

Mtsempha njira ndi miyala "fenigidin" zikhoza nambala mwachilungamo lalikulu mavuto. Kodi mtundu wa kuganizira pompano:

• dongosolo mtima: asystole, ankatenthetsa wa khungu, tachycardia, yamitsempha yamagazi, kumverera kutentha, akuukira angina, tachycardia, edema zotumphukira, hypotension, bradycardia.
• Zotumphukira ndi chapakati mantha dongosolo: ululu minofu, litsipa, kuwala chisokonezo zithunzi, paresthesia, kugona chisokonezo ndi kugwedeza.
• Chimbudzi: m'mimba, kunyansidwa, akuchuluka chiwindi, hyperplasia wa chingamu. Ngati inu ntchito mankhwala kwa nthawi yaitali, ndi mlingo waukulu, pangakhale dyspepsia, intrahepatic cholestasis ndi kukwezeka chiwindi transaminases.
• hemopoiesis dongosolo: kawirikawiri anati thrombocytopenia ndi leukopenia.
• Endocrine System: gynecomastia kawirikawiri anati.
• Mkodzo dongosolo: kuonjezera tsiku mkodzo linanena bungwe. Ngati inu kutenga mankhwala kwa nthawi yaitali ndi mlingo waukulu, pangakhale kuphwanya impso.
• Ziwengo: ziwengo.
• zochita Local: ngati jekeseni wa mankhwala m'nsinga, n'zotheka moto malo jekeseni.

Mmodzi Tisaiwale kuti kwa miniti imodzi pambuyo makonzedwe intracoronary, wodwalayo angaoneke zoipa zotsatira inotropic wa nifedipine ndi mlingo mtima ndi kuthamanga kwa magazi. Zizindikiro zimenezi kutha pang'onopang'ono pambuyo pa mphindi 8-15.

mogwirizana mankhwala ndi mankhwala ena

Kodi ife, pamodzi ndi mankhwala ena kumwa mankhwala "fenigidin Health"? Malangizo unazunguliridwa mu ma CD, ndi kuchenjeza kuti thanzi la munthu akhoza kwambiri iwonongeke ngati tiganizire kugwiritsa ntchito mankhwala moyenera. Pa nkhani imeneyi, pamaso phwando Mpofunika inu kukaonana ndi dokotala.

Pamene kamodzi ntchito okodzetsa, wothandizila antihypertensive ndi ena ofanana phenothiazine akhoza kumatheka zotsatira antihypertensive wa nifedipine.

Ndi ntchito munthawi yomweyo mankhwala anticholinergic mododoma chidwi ndi kukumbukira odwala chisanadze pantchito ndi zaka zopuma pantchito.

Ngati pa nthawi yomweyo kutenga mankhwala ndi beta-blockers, ndiye munthu angathe aakulu wolumikizira hypotension, ndi zina - ndi matenda a mtima.

Ndi ntchito munthawi yomweyo ndi ku feteleza kumawonjezera zotsatira antianginal wa nifedipine.

Disposable phwando kashiamu amachepetsa Mwachangu wa amafotokozera yogwira. Izi zimagwiritsa ntchito mogwirizana ndi odana nafe chifukwa kuchuluka ndende ya ayoni kashiamu mu otchedwa madzimadzi extracellular.

Mumadziwika milandu akulu ufowoko ndi kutopa ambiri tikadwala mankhwala ndi mchere magnesium.

Ngati inu ntchito "fenigidin" pamodzi ndi digoxin, zikhoza kusokoneza kuchotsa yotsirizira ku thupi, amene ndiye wobwezera chifukwa cha kuchuluka kwa ndende zake magazi.

A kamodzi mlingo wa mankhwala ndi diltiazem timapitiriza zotsatira antihypertensive.

Ndi ntchito munthawi yomweyo theophylline zikuoneka kuti kusintha mu ndende ya yotsirizira mu madzi a m'magazi.

Rifampicin mankhwala angathe kumukopa chiwindi enzyme ntchito ndi imathandizira kagayidwe wa nifedipine, zomwe mapeto kuchepa kwambiri nchito zake.

Ngati ntchito mankhwala pa nthawi yomweyo ndi phenytoin, Phenobarbital ndi carbamazepine, mwayi ndi kuchepetsa ndende ya mankhwala yogwira mu madzi a m'magazi.

Pali malipoti ambiri a kuwonjezeka woipa nifedipine plasma ndi kuwonjezeka mu AUC ake pa ntchito limodzi itraconazole ndi fluconazole.

Ngati inu kutenga mankhwala ndi fluoxetine, zikuoneka kulimbikitsa mavuto a nifedipine pa thupi la munthu.

Nthawi zina, ntchito concomitant mankhwala ndi quinidine kungachepetse ndende ya yotsirizira mu magazi ndi kuchotsa mankhwala - kwambiri kuonjezera iwo, chimene, ndithudi, zimathandiza kuti prolongation wa QT imeneyi pa electrocardiogram lapansi.

Zinthu zimenezi mwachangu monga ranitidine ndi cimetidine zina kuonjezera ndende ya nifedipine mu magazi, kuchuluka zotsatira zake antihypertensive.

Mankhwala okhala ndi mowa achuluke zotsatira za nifedipine, kuchititsa chizungulire ndi zochita zina chokhwima.

Medicine "fenigidin" pa mimba ndi mkaka wa m'mawere

Mosamalitsa kulamulidwa ndi chitetezo chokwanira maphunziro a amafotokozera yogwira monga nifedipine pa mimba sadafikeko. Choncho, ntchito mankhwala pa gestation ali osavomerezeka.

Chifukwa chakuti nifedipine adzamasulidwa pamodzi ndi mkaka mayi, muyenera kupewa ntchito pa kuyamwitsa mwana kapena kuchita kusiya mkaka wa m'mawere.

Mu maphunziro experimental anaulula embryotoxic, foetotoxic ndi teratogenic zotsatira za nifedipine pa thupi la mkaziyo.

Analogs medicament

Mankhwala akhoza m'malo "fenigidin"? Analogues chida akupezeka pharmacies onse. Ena mwa iwo ndi mankhwala zotsatirazi: "Adalat", Sponif "," Vero Nifedipine, "" Sanfidipin "," Zanifed "," Osmo-Adalat "," Kaltsigard achigonjetse "," Nifecard "," Kordafen "," Nifelat " "Kordafleks", "Nifedipine", "cordipin", "Nifedikor", "Corinfar", "Nifedikap", "Nikardiya", "Nifedeks", "Nifadyev", "Nifegeksal", "Nifebene" ndi ena.

Perekani ndalama awa ayenera dokotala.

Medicine "fenigidin": ndemanga madokotala ndi odwala

Akatswiri kuona mphamvu ya mankhwala "fenigidin". Mwamsanga relieves angina, komanso amawathandiza mavuto hypertensive, matenda Raynaud, ndipo oopsa. Komabe, pa mbali ya odwala, pali zambiri ndemanga zoipa zokhudza kukonzekera izi. Malinga ndi iwo, amayambitsa zotsatira ambiri mbali. Kwambiri kawirikawiri akuwonetseredwa ndi zopweteka minofu ndi chizungulire. Komabe, madokotala kuti maganizo ndi zotheka pamene ntchito pachithunzichi mankhwala. Pa nkhani imeneyi, iwo ayenera kugwiritsidwa ntchito kuyang'aniridwa ndi katswiri, makamaka ngati wodwalayo ali pachimake m'mnyewa wamtima infarction, kuyan'anila choopsa cha kufalitsidwa oziziritsa, shuga, matenda a chiwindi ndi impso, komanso matenda oopsa oopsa komanso hypovolemia.