"Ursofalk": analogues, malangizo ntchito ndi kumasula mawonekedwe

Medicament "Ursofalk" malangizo Buku limamutchula kuti mankhwala ndi sipekitiramu yotakata ntchito, omwe ali pakati ena, hepatoprotective, cholelitolitic, immunomodulatory katundu. Komanso, mankhwala kwambiri amachepetsa magazi milingo mafuta.

nkhani yogwira

The yogwira pophika medicament zimene asidi ursodeoxycholic. Mwa zina Ndalama ya ndulu anthu, koma chifukwa cha matenda ena ukugwirira ntchito chiwindi kaphatikizidwe ndi moyenera, zili thunthu mu ya ndulu zikhoza kuchepetsedwa.

asidi Ursodeoxycholic monga pophika waukulu alipo osati mu kukonzekera "Ursofalk". Analogs ya kapangidwe ndi pharmacological katundu - mankhwala monga "Ursosan", "Ursol", "Urdoksa". Kukambirana kwambiri za m'munsimu.

Achire zotsatira "Ursofalk" njira

• zotsatira Choleretic ndi kuchepa kuchuluka kwa ya ndulu zidulo hydrophobic ndi kuonjezera anamasulidwa mu lumen wa matumbo. Komanso, mankhwala chifukwa kukhala mu kulankhulana ndi ileum ndi amachepetsa maselo hydrophobic mayamwidwe zidulo poizoni.
• Immunomodulating kanthu chifukwa cha chakuti asidi ursodeoxycholic angathe kuchepetsa mawu a hepatocytes HLA mamolekyulu a kalasi loyamba, ndipo cholangiocytes - HLA mamolekyulu a kalasi wachiwiri. Komanso mankhwala amachepetsa kaphatikizidwe cytokines ovomereza-yotupa.
• Zotsatira cytoprotective ndi luso la mankhwala yogwira kudutsa mu zamadzimadzi wosanjikiza selo nembanemba, chifukwa mu selo nembanemba limakhazikitsa katundu wake wotetezera zabwino.
• zotsatira Hypercholesterolemic zachokera kuchepetsa ndi ileum mayamwidwe ndi kuchepa kwa mafuta m'thupi kaphatikizidwe mu chiwindi, komanso excretion zake ya ndulu ya.

Kuwonjezera zotsatira pamwamba, mankhwala "Ursofalk" (malangizo ntchito zikuonekera) ndipamene mibulu madzi ndi mafuta molekyulu kuti kumachepetsa lithogenicity ya ndulu. Chifukwa kutembenuka kwa mankhwala mafuta yafupika mapangidwe miyala ndi kuvunda awo.

Pharmacokinetics

Zotsatirazi makonzedwe m'kamwa ya mankhwala mu intestine zochepa odzipereka asidi ursodeoxycholic, mayamwidwe ndi chimakhala chogwidwa ndi zoyendera yogwira mu ileum mu gawo osatha, ndi zoyendera chabe - mu jejunum ndi ileum mu gawo chapamwamba. Pafupifupi 60-80 peresenti ya mlingo limalowera mu m'magazi.

Thunthu yogwira ndi metabolised mu chiwindi mwina limaphwasuka kusandulika mu intestine, amene kumabweretsa mapangidwe a poizoni seveni keto asidi lithocholic, amene nawonso, ndi odzipereka mu m'magazi ndi mmene ting'onoting'ono detoxifies chiwindi. Theka moyo wa mankhwala - atatu - masiku asanu. Iwo makamaka excreted mu ndowe monga metabolites.

Zikuonetsa ntchito

Kukonzekera "Ursofalk" malangizo Buku kusonyezedwa ntchito matenda a ndulu, chiwindi, limodzi ndi kuwonjezeka mu mafuta magazi, cholestasis, chiwindi ena ntchito kuchepetsa. Mwa matenda amenewa akhoza kutchulidwa biliary matenda enaake (chachikulu), biliary Reflux gastritis, matenda cholangitis (chachikulu), biliary Reflux esophagitis, chiwindi a etiology osiyana, enaake fibrosis.

Mankhwala Kwalamulidwa pamaso pa gallstones, koma ngati rentgennegativnye awiri, kukula kwawo musalumphe millimeters fifitini, ndipo wodwalayo si kusokoneza ntchito kwa ndulu ya. medicament nazonso ntchito mu nkhani ya kawopsedwe chiwindi (mwachitsanzo, kumwa mowa poyizoni), kudwala ake limodzi ndi cholestasis (ana), biliary dyskinesia, atresia wa ducts intrahepatic ya ndulu. ace odwala pa zakudya parenteral, kuti kuthetsa stagnation wa ya ndulu, komanso anthu amene opaleshoni kwa kumuika chiwindi.

Monga prophylactic wothandizila kutumikiridwa mankhwala "Ursofalk" (mankhwala analogs komanso angagwiritsidwe ntchito milandu) imodzi ndi phwando mankhwala zimene zikhoza kusokoneza ntchito kwa chiwindi (kulera m'thupi, mankhwala ndi zotsatira cholestatic).

mawonekedwe Ndinamasulidwa zikuchokera

njira ziwiri kumasula mankhwala ali "Ursofalk": kuyimitsidwa (palibe analogues, opangidwa ku Switzerland) ndi makapisozi (analogs amatuluka mu Germany). Baibulo loyamba la mankhwala ntchito makamaka kwa ana kapena anthu movutikira kumeza. Gelatin makapisozi ndi opaque, molimba, pachikuto ndi thupi utoto woyera, mkati - granules woyera kapena ufa. Zikupezeka mapaketi zidutswa 10, 25, 50 kapena 100. Kuyimitsidwa ali ndi mtundu woyera, yodziwika ndi kugwirizana kwenikweni lili mpweya thovu, ali ndi mandimu fungo. Akupezeka mu mabotolo 250 Botolo, wathunthu akachita kuyeza supuni.

250 mg asidi ursodeoxycholic ali ndi kukonzekera kapisozi, yofanana mankhwala yogwira pano mu Botolo zisanu (wina ngwanjula) slurry "Ursofalk". The manyuchi limapangidwa zigawo wothandiza: glycerol, anhydrous citric asidi, xylitol, propylene glycol, sodium mankhwala enaake, microcrystalline mapadi, asidi benzoic asidi, ndimu kukoma, sodium citrate, madzi oyera, ndi sodium cyclamate. zosakaniza Secondary mu makapisozi anapereka colloidal pakachitsulo dioxide, titaniyamu woipa, sodium lauryl sulphate ndi wowuma chimanga, magnesium stearate, gelatin, madzi oyera.

Kodi kutenga "Ursofalk"

The medicament zinachitikira limodzi phwando kopita akufuna kulandira madzulo. Kapisozi ndi kuwameza, popanda kutafuna, nasamba pansi ndi madzi okwanira lamanja. Monga tanenera kale, "Ursofalk" mankhwala kwa ana ndi bwino ntchito mu mawonekedwe a kuyimitsidwa (madzi). mlingo ayenera kuchita masamu dokotala, potengera chikhalidwe cha matenda ndi makhalidwe a thupi la wodwalayo. Makanda (ndi kulemera kwa makilogalamu asanu) ayenera kuperekedwa pa nthawi yogona kotala chingwe supuni slurry.

Childs kwa chiwindi tsiku mlingo aakulu 10-15 mg wa pa thupi kilogalamu thupi, njira ya mankhwala kumatenga kwa miyezi sikisi zaka ziwiri, ali osavomerezeka Pankhaniyi chiphwanya mu phwando medicament. Kwa anthu ndi biliary Reflux oesophagitis kapena biliary Reflux gastritis tsiku mlingo "Ursofalk" mankhwala - 250 mg mankhwala - khumi - masiku khumi ndi anai. Pamene matenda cholangitis ndi biliary matenda enaake pa tsiku, nthawi zambiri mankhwala kulandira 10-15 mg wa pa thupi kilogalamu thupi, koma ngati n'koyenera, mlingo ziwonjezeke kwa 20 mg wa pa 1 makilogalamu. Therapy zambiri kumatenga kwa miyezi sikisi zaka ziwiri. Odwala enaake fibrosis kumwa mankhwala tsiku ndi tsiku pa mlingo wa 20-30 mg wa pa kilogalamu ya kulemera kwa thupi pa miyezi isanu ndi umodzi zaka ziwiri. Pankhani ya kawopsedwe chiwindi kukuonetsedwa kunyamula mankhwala pa mlingo tsiku la 10-15 mg wa pa kilogalamu ya kulemera kwa thupi kwa sikisi - khumi miyezi.

"Ursofalk" mankhwala. analogs

The poyerekeza khalidwe la mankhwala ndi mankhwala ofanana mu kapangidwe ndi katundu pharmacological.

• Mankhwala "Ursosan". mankhwala amapangidwa mu Czech Republic ndi Germany, ndi zizipezeka mu mawonekedwe a makapisozi. Limagwirira kanthu mankhwala ofanana. Komabe, madokotala, hepatologists, nthenda madokotala pa funso limene mankhwala ndi bwino, "Ursosan" kapena "Ursofalk" anagwirizana kuyankha kuti ndi bwino kusankha kwachiwiri. maganizo oti zinalengedwa ndi akatswiri pa maziko a kuzipenya zawo matenda ndi mayankho ochokera odwala. Medicine "Ursofalk" ndi anasamutsidwa mosavuta kuposa ankaona analogi, nayonso normalizes boma la chiwindi zinchito. Koma musaiwale za khalidwe la chamoyo, pali anthu amene amatanthauza "Ursosan" amathandiza bwino. Komanso, mankhwala ndi ofunika pang'ono mtengo: paketi ndi makapisozi 50 ndalama 650-830 rubles, pamene chifukwa makapisozi 50 mankhwala "Ursofalk" kulipira 850-1200 rubles.
• "Urdoksa" njira. The mankhwala angaperekedwe amapangidwa domestically. Komabe, kutulutsa bungweli mankhwala kugula zosakaniza zofunika kunja, ndipo mu Russia pali kupanga ndondomeko mankhwala. Komanso likupezeka makapisozi, mtengo zidutswa 50 zimasiyanasiyana pakati 440-960 rubles. mankhwala onse ali pharmacologically ofanana, mu opangidwa zotsatira kwambiri kusiyana ndi mwaonapo.
• "Ursol" mankhwala. Mankhwala, monga mmene zinalili m'mbuyomu, analengedwa mu Russia. Komabe, anthu ambiri amanena kuti onse ndalama izi n'kwabwino dissolves miyala chikhodzodzo ndulu. Koma pali ena amene ali ndi mphamvu ya mankhwala anali wapamwamba pamene mukumwa mankhwala "Ursofalk". makapisozi a analembedwa zofanana, kotero kupereka mmalo imodzi kapena njira zina zovuta. Ngati mukumaika chidwi pa mtengo, ndi bwino kugula mankhwala "Ursol" ndi wotsika mtengo - 460-905 rubles kwa makapisozi 50.

zotsatira zoyipazi

medicament "Ursofalk" Wokongola bwino analekerera ndi odwala. Analogs mankhwala yodziwika ndi tolerability wabwino. Nthawi zina, pa chithandizo pali calcification wa gallstones kukhala chimbudzi mushy, kupweteka epigastric lapansi. Komanso, inu mukhoza kukhala ndi ziwengo mu mawonekedwe a pruritus, urticaria. Malipoti cha mankhwala osokoneza bongo zalembedwa kwa tsiku.

contraindications

Mkulu munthu kudziwa zigawo mankhwala ndi maziko chakuti ntchito. Mankhwala contraindicated anthu ndi cholangitis, kapena occlusion wa enaake ya ndulu ritsa, pachimake cholecystitis. Musati mankhwala mankhwala kwa odwala matenda kuphwanya galimoto ntchito ya ndulu, ya ndulu colic.

Mimba ndi mkaka wa m'mawere

Malinga ndi maphunziro, asidi ursodeoxycholic si kuonetsa mutagenic, teratogenic, ntchito embryotoxic, koma mphamvu yake kudutsa gematoplatsentarny chotchinga bwanji njira ya mimba osati afufuza mpaka kumapeto. Choncho, makhwalawa "Ursofalk" pa Kubereka pakakhala ndi zotchulidwa dokotala. Experience kugwiritsa ntchito mankhwala mu nyengo ya mkaka wa m'mawere palibe.

Mwanjira ndi mankhwala ena

Munthawi yomweyo chithandizo ndi mankhwala ochotsa asidi kukonzekera chikukhudza zotayidwa hydroxide ndi mankhwala "Colestipol" ndi "Cholestyramine" kumayambitsa zokhudza zonse mayamwidwe wa chinthu yogwira kuchepetsa. Mankhwala akhoza kusintha ndende mu madzi a m'magazi mankhwala "Tacrolimus". Ngati pali kufunika kwa ntchito anzake a mankhwala ayenera kumwedwa pa intervals wa maola osachepera awiri.