"Valsartan": malangizo ntchito. Medicine "Valsartan" - analogues ndi ndemanga

Mankhwala amatchedwa "Valsartan" malangizo Buku limafotokoza monga njira zimagwira m'gulu magulu pharmacological zotumphukira vasodilators mtundu. Kugwiritsa ntchito mankhwala ali ndi kutchulidwa hypertensive zotsatira pa mtima. Komanso, mankhwala ali ndi kusankha ankatsutsa amasintha AT ₁ maselo amene ali ndi udindo kukhazikitsa ndondomeko angiotensin II. Komanso, khalidwe zotsatira diuretic akhoza kukhala pa thupi la munthu ndi chida kuphatikiza, monga "Valsartan". Analogs kukonzekera ichi - kapisozi "Diovan" "Exforge" "Tantordio" ndi "Valsakor" - ndi katundu zofanana.

Features ya kanthu pharmacological

Koma maonekedwe a kanthu pharmacological wa wothandizila antihypertensive, ndi, yavlyas antagonist yeniyeni otchedwa angiotensin II cholandilira, mogwira kutsekereza AT ₁ zolandilira ndi kumawonjezera plasma ndende ya angiotensin II. Pa mankhwala yemweyo "Valsartan" (malangizo ntchito anafotokoza kapangidwe kake) alibe ziletsa angiotensin-akatembenuka enzyme. Komanso, iwo alibe gawo lirilonse agonist ndi kulemekeza AT ₁ -receptors. Mwazina, choyambirira "Valsartan" siikutchinga njira ion ndi maselo mahomoni zina zofunika lamulo yachibadwa a dongosolo mtima. Komanso, mankhwala alibe mphamvu pa mlingo tireoglobulinpa, asidi uric, okwana mafuta m'thupi ndi madzi a m'magazi shuga.

Pharmacokinetics

Ngati ife kulankhula za pharmacokinetics wa wothandizila odana hypertensive, monga yothetsera "Valsartan", ndiye, monga ulamuliro, izo mofulumira kwambiri odzipereka pa kapepala m'mimba pambuyo makonzedwe m'kamwa, ngakhale mlingo wa mayamwidwe zimadalira kusiyana payekha.

Kwenikweni izi antihypertensive zambiri akuyamba kulankhula patapita zana - Mphindi zana ndi makumi awiri pambuyo dosing limodzi la mankhwala, ndipo pazipita achire zotsatira zimatheka pafupifupi anayi - maola sikisi. Mtheradi bioavailability izi mankhwala ali basi pa 22%. Poyankha, kumanga kwa mapulotini magazi (makamaka albumin) ndi 94-98%. The plasma chilolezo cha mankhwala "Valsartan" imene kapangidwe ali ndi chikoka mwachindunji pa izo, ndi za 2 L / h. Iwo anasonyeza wothandizila antihypertensive makamaka ndowe (70%) ndi, pamlingo kwambiri wamng'ono ndi mkodzo. Mlengi likutsindikanso kuti mu nkhani cha kutsekeka kwa ducts ya ndulu kapena biliary matenda enaake, izi mankhwala AUC ukuwonjezeka mu pafupifupi theka. Kuwombola ntchito mankhwala kusintha kulikonse pa katundu pharmacokinetic ndi magawo anati.

Kufotokozera za mankhwala

Yopangidwa antihypertensive mankhwala "Valsartan" (malangizo ntchito imene chofunika ali m'gulu lililonse paketi) mu mawonekedwe a mapiritsi, filimu TACHIMATA, ndi mu mawonekedwe a ufa woyera. mankhwala pafupifupi insoluble m'madzi wamba mosavuta sungunuka methanol ndi Mowa. Kulemera maselo a chiphunzitso ichi ndi 430-435. Koma zikuchokera izi sing'anga-vasodilating, monga pali mfundo opaleshoni lili ndi angiotensin II cholandilira mtundu ndi diuretic thiazide.

MUNDA ntchito mankhwala

Tengani mankhwala a "Valsartan" malangizo ntchito ali makamaka analimbikitsa monga mbali ya otchedwa kuphatikiza mankhwala kwa anthu amene amadwala aakulu kulephera mtima kapena matenda oopsa.

Ndiponso, izi ndi zithunzi antihypertensive wothandizila ntchito kumapangitsanso kupulumuka kwa anthu ndi pachimake m'mnyewa wamtima infarction (kuphatikizapo zovuta yamitsempha yamagazi systolic kukanika kapena lamanzere kulephera yamitsempha yamagazi). Odwala matenda a mtima amene mankhwala chikhalidwe, okodzetsa Komanso nthawi zambiri kutumikiridwa mankhwala "Valsartan". Analogues chida Angagwiritsidwenso ntchito milandu onse pamwamba.

mlingo

Tengani mankhwala antihypertensive, madokotala zambiri amalangiza nthawi imodzi kapena awiri pa tsiku mamiligalamu makumi asanu ndi atatu kapena makumi anayi, motero. Popeza kufunika kwenikweni achire, mlingo tsiku akhoza zochuluka. Komabe, zimenezi ziyenera kuchitidwa pang'onopang'ono yekha zotchulidwa dokotala. Mlingo pazipita mankhwala chomwecho ndi mamiligalamu mazana atatu ndi makumi awiri.

Mndandanda wa contraindications kugwiritsa ntchito

Gwiritsani ntchito chida akatswiri-vasodilator mwamphamvu amalangiza kuti ngati pali munthu hypersensitivity munthu aliyense zigawo zake. Pamene anaika thupi lawo siligwirizana analogously sayenera pakumwa mapiritsi "Valsartan". Mankhwala choyambirira ayenera kumwedwa ndi odwala amene alibe atapeza zaka khumi ndi zisanu ndi zitatu. Yotsirizira ndi chifukwa chakuti chitetezo cha ntchito mankhwala antihypertensive mu Zikatero si bwino.

Ntchito pa mimba

Kwalamulidwa mankhwala "Valsartan" akazi amene akuchitira mwana, mwamtheradi contraindicated. Izi bungwe maphunziro zachipatala kusonyeza chiopsezo mwachilungamo mkulu wa mavuto wothandizila antihypertensive pa mwana wosabadwayo. Komabe, ngati aakulu matenda moyo pachiswe zimene n'zosatheka ntchito zina, mankhwala kudzanso kapena iwo sakhala ogwira, kugwiritsa ntchito mankhwala-vasodilator. Payokha ayenera ananena za inadmissibility wa ntchito chida pamene kudyetsa khanda ndi mkaka wa m'mawere.

zochita zotheka mbali

Kusankhidwa kwa oterowo mankhwala antihypertensive, monga "Valsartan" angachititse maonekedwe a mutu m'malo kwambiri, chizungulire, chifuwa ndi kufooka. Komanso, pali zambiri nseru, m'mimba, hyperkalemia, syncope, ndi tulo. ululu m'mimba, vertigo, neutropenia, thrombocytopenia, arthralgia, kupweteka kwa msana, myalgia, kutopa ndi kutupa kumachitika chifukwa cha makonzedwe ofanana mankhwala "Valsartan". Reviews odwala kale ntchito, amasonyeza chiopsezo cha pharyngitis, rhinitis, sinusitis, zosiyanasiyana matenda tizilombo ndi matenda okhudza chapamwamba m'madipatimenti kupuma. Komanso, anthu ambiri aona hyperbilirubinemia, utachepa hematocrit, hypercreatininemia, kuwonjezeka kwa magazi urea zili asafe ndi kuchepa hemoglobin. Komanso, ayenera kukumbukira nthawi zonse kuti phwando munthawi yomweyo, njira vasodilator "Valsartan" ndi mankhwala ochokera ku gulu la kukodzakodza potaziyamu-yosalekerera zingachititse chitukuko hyperkalemia. Pankhani ya mankhwala ambiri osokoneza bongo kumachitika zinthu monga bradycardia, hypotension kapena tachycardia.

kusamalitsa Basic

Pomaliza, ziyenera kuti m'pofunika ndi kusamala kwambiri ndi kokha moyang'aniridwa ndi okhwima zachipatala anaika phwando nthumwi antihypertensive odwala ndi akusowa sodium, mwaoneka kuphwanya impso ndi, amgwirizano stenosis wa otchedwa mtsempha wamagazi aimpso kapena kuchepetsa zikusintha kufalitsidwa magazi buku. Ichi ndi chifukwa makamaka kwa odwala amene ali pangozi ndi wolumikizira hypotension. Komanso, muyenera kupereka ulemu wapadera kwa anthu odwala matenda enaake biliary kapena matenda aakulu chiwindi. Odwala ndi aimpso mtsempha wamagazi stenosis amafuna polojekiti zonse za woipa wa urea asafe ndi seramu creatinine. Komanso, mwapadera yokha amafuna odwala ndi kutsekeka kwa mundawo biliary, kulandira potaziyamu-yosalekerera okodzetsa, wapadera kalisodergaszczye zowonjezera potaziyamu kapena mankhwala osokoneza bongo. Pomaliza, kusamala kwambiri ayenera kugwiritsidwa ntchito antihypertensive mankhwala "Valsartan" anthu amene ntchito yawo ndi yokhudza akuyendetsa galimoto iliyonse, ndipo amene ntchito mwachindunji interfaced ndi mkulu wa ndende tcheru.