Alpha-fetoprotein zinthu zachilendo ndipo pathological

Alpha-fetoprotein ndi zinthu chiyambi mapuloteni kamene kamapangikira ndi yolk sac wa mwana wosabadwayo atabadwa - kapepala kakuti m'mimba ndi maselo a chiwindi. Mwachibadwa, izo ali thupi 15 ng / ml.

Alpha-fetoprotein anatsimikiza pa mimba matenda zopindika wa mwana wosabadwayo. Iwo umupeza ntchito tanthauzo la chizindikiro ndi Oncology. Alpha-fetoprotein ndi oncomarker khansa testicular ndi chiwindi. Mu 70% ya anthu ndi zotupa testicular ndi kukwezeka, makamaka m'kati metastasis.

Poyamba, ndi puloteni mankhwala apanga ambiri m'mimba, ndi corpus luteum. Mu sabata lachisanu mwana wosabadwayo amayamba kutulutsa yake. Alpha-fetoprotein kumateteza mwana wosabadwayo kuyambira dongosolo la mayi m'thupi, umene ndi wothandizila yachilendo.

ndende yake adakulabe mu Molingana ndi mwazi Ndisanaumbidwe ndi magazi akuchikazi. Mtengo mulingo woyenera kwambiri chizindikiro ichi kwa matenda - pa masabata 12-16. Pa masabata 32-34 mimba umalandira mlingo pazipita alpha-fetoprotein. wathanzi ponseponse anthu zimatheka mu chaka choyamba cha moyo.

njira Research kwambiri bwanji tanthauzo la chizindikiro. Ambiri amavomereza zoti kuvutika kwa alpha-fetoprotein anali multiplicity wa apakatikati (amayi). The apakatikati ndi pakati chiwerengero mu mfundo analamula ndende mapuloteni mu mimba bwinobwino pakangotha mawu. Choncho, munthu chingayerekezedwe ndi mimba alpha-fetoprotein pamisinkhu yosiyanasiyana, ndiponso kufufuza anapanga Laboratories osiyana. Kuchuluka kwa index ili ku 0,5 kuti 2.5 amayi n'zabwinobwino.

Kuwonjezeka AFP ungasonyeze la:

• Zotupa wa bronchi ndi.
• Chiwindi metastases.
• Khansa ya m'mimba, kapamba, m'mapapo, chiwindi, m'matumbo, m'mawere.
• Embryonic testicular ndi zotupa yamchiberekero.

Mongoyembekezera ndi marginally kuchuluka alpha-fetoprotein mu pathologies zotsatirazi:

• Chiwindi matenda enaake,
• Aakulu chiwindi kulephera,
• Uchidakwa pamaso pa choipa chiwindi,
• Aakulu kapena pachimake tizilombo matenda a chiwindi.

chiwerengerochi chinawonjezeka pa mimba limapezeka milandu zotsatirazi:

• Angapo mimba.
• Aimpso matenda mwana wosabadwayo.
• Umbilical chophukacho mu mwana wosabadwayo.
• Yoopsa chiwindi necrosis.
• Malformations la chubu ubongo (rahishizis, anencephaly).
• Mphanga ya khoma kutsogolo kwa pamimba wa mwana wosabadwayo.
• malformations ena.

Komabe, yafupika alpha-fetoprotein mimba zingasonyeze zotsatirazi:

• mimba onyenga.
• Kakulidwe yomweyo.
• Yoopsa imfa.
• Molar mimba.
• Mowiriza mimba.
• Trisomy wa khromozomu 18 kapena 21.

Yafupika ndende ya alpha-fetoprotein zingasonyeze ndi mtima pachithunzichi a nthawi ya mimba, ndiye, pakati chinachitika.

Mu matenda achikazi pa siteji pamakhala yaikulu yogwira chizindikiro chowonetsa matenda yoopsa chromosomal ndi pathologies mimba. Zolakwika pa chitukuko yachibadwa yoopsa kusintha ndende yachibadwa zinthu mapuloteni mu magazi a mayi. Kumene, pazikhala osati tanthauzo la chizindikiro ichi, monga nkhani. Kwenikweni ayenera kuchititsa maphunziro ultrasound, kotheka kuonetsetsa tanthauzo yake akuti, mimba angapo ndi zina zotero. Komanso, pamafunika kuzindikira ndi mahomoni placental (chorionic gonadotropin ndi estriol ufulu), kulola adziwe molondola dongosolo fetoplacental. kuphatikiza awo ndi alpha-fetoprotein akufotokozera mayeso patatu amene amalola kudziwa chiopsezo zosiyanasiyana malformations mu mwana wosabadwayo.