Antibiotic "Remedia": malangizo a ntchito, ndemanga, zofanana

Njira zamakono zochizira matenda opatsirana sizingatheke popanda kugwiritsa ntchito mankhwala osokoneza bongo. Kukanika kwatsopano kwa tizilombo toyambitsa matenda kumatsimikizira kufufuza kwa mankhwala atsopano kapena kugwiritsa ntchito mitundu yambiri ya mankhwala, omwe amatsimikiziridwa bwino. Osagwirizana ndi kugwiritsa ntchito mankhwala oletsa antibacterial pogwiritsa ntchito mankhwala osokoneza bongo ndi kayendedwe kosayendetsedwa kwa ma antibayotiki ambiri, mmalo mwa kuyang'ana koyambirira kwa zomera zogwiritsira ntchito mankhwalawa. Mankhwala a mankhwala, omwe ali ndi mankhwala ofunika kwambiri a pharmacokinetic ndi pharmacodynamic m'magulu ambiri a fluoroquinolones, akugwiritsidwa ntchito kwambiri pochiza matenda opatsirana a zosiyana siyana.

Makhalidwe azachipatala ndi azachipatala

Njira yothetsera Remedia, kapena Levofloxacin (dzina losavomerezeka padziko lonse), ndi kukonzekera kwa antibacterial kuchokera kumtundu umodzi wa fluoroquinolones, womwe umapangidwira njira zowonongeka komanso zapamimba.

Malinga ndi chikhalidwe chake, Remedia (malangizo ogwiritsira ntchito amapereka ndondomeko iyi) ndi monofluoroquinolone, chiwombankhanga cha toloxacin, ndipo, poyerekezera ndi mankhwala ena, ali ndi phindu lalikulu la mankhwala:

• Kukhazikitsidwa kwa mankhwala ovomerezeka ndi 100%, ndi kuchuluka kwa ubale ndi mapuloteni a plasma kufika 40%;
• Zomwe zili pamtundu wa mankhwala mu seramu ya magazi zikuwonetsedwa maola 1-2 mutangotha kudya ndipo zikufanana ndi zomwe mutangotenga;
• "Remedia" imadziwika ndi kuchulukitsidwa kwa mphamvu yogawidwa m'thupi, chifukwa cholowera mkati mwa makoswe;
• Ali ndi hafu yayitali ya thupi, yomwe imayambitsa mlingo umodzi wa mankhwala tsiku lililonse.

Popeza kuti mankhwala ofunika kwambiri a fluoroquinolones amachititsa kuti chiwerengero cha mankhwala a m'magazi chiwonjezeke mofulumira, izi zimapangitsa kuti zinthu zikhale bwino kwambiri pofuna kuthetseratu tizilombo toyambitsa matenda.

Mwa njira yake pa kukula ndi kubalana kwa mabakiteriya, "Remedia" imakhala ndi bactericidal effect, sikuti imakhudza mitundu yokha ya mabakiteriya, koma ndi vegetative komanso yopanda mphamvu.

Mankhwala a metabolism amapezeka mu hepatocytes ndi okosijeni kapena deacetylation. Pafupifupi 5 peresenti ya mankhwalawa imatulutsidwa ndi impso monga mawonekedwe a metabolites, ndipo zina zonse zimatulutsidwa ndi kusungunuka kwa glomerular ndi kutseka kwa tubula. Tiyenera kukumbukira kuti pambuyo poyendetsa mkamwa gawo lalikulu la mankhwala (pafupifupi 70%) amachotsedwa m'thupi mkati mwa maola 24 ndi mkodzo, ndipo pafupifupi 80% ya mlingo amachotsedwa pambuyo pa maola 48. Chiwerengero cha mankhwala omwe amachotsedwa kudzera m'mimba ndi otsika ndipo ndi 4% okha.

Pogwiritsira ntchito mankhwala pa mlingo wa 1000 mg tsiku (kutenga mapiritsi a 500 mg), sipangakhale mwayi wambiri wopanga zotsatira.

Njira yogwirira ntchito

Njira yogwiritsira ntchito mankhwalawa imachokera ku chiletso cha mankhwala enaake omwe amachititsa kuti DNA-gyrase, yomwe imayambitsa matenda a majini, kusinthana ndi DNA. Chifukwa cha kutetezedwa kwa puloteni imeneyi, kubwezeretsa DNA, kugawa maselo, ndi kufa kwa maselo.

Remedia: malangizo a ntchito ndi zizindikiro

Pakadali pano, zizindikiro zazikulu zogwiritsira ntchito mankhwalawa ndizopatsirana pogwiritsira ntchito mabakiteriya opangira tizilombo toyambitsa matenda omwe amachititsa kuti tizilombo ta tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda.

Njira yothetsera remedi yatsimikiziridwa pa chithandizo cha kupuma kwa mabakiteriya a m'mwamba ndi apansi, monga aconitis, sinusitis, matenda opweteka a minofu ya mapapo. Izi ziyenera kuti, makamaka, kulowera bwino kwa mankhwalawa mu epithelium ya bronchi ndi mapapu, kumene ngakhale atangoyamba ntchito yoyendetsa bwino mankhwalawa amagwira ntchito.

Komanso, mankhwalawa amagwiritsidwa ntchito moyenera pofuna kuchiza matenda opangira mkodzo (pyelonephritis, cystitis, urethritis, etc.), matenda opatsirana, prostatitis, matenda a khungu, matenda a m'mimba komanso mimba.

Pofuna kuchiza matenda opatsirana pogwiritsa ntchito kupuma, Remedia imaperekedwa (malinga ndi kuopsa kwa matenda) 1-2 pa tsiku kwa 500 mg piritsi kapena mawonekedwe a mankhwala.

Pofuna kuchiza matenda opangira mkodzo, mlingo wa 250 mg wa mankhwala ndi wokwanira kamodzi patsiku, ndipo powopsa kwambiri, mlingo wa tsiku ndi tsiku ukhoza kukhala 500 mg (Remedia 500). Malangizo ogwiritsira ntchito akuti kumwa mankhwala awiri a 250 mg kungatheke m'malo mwa mlingo umodzi wa 500 mg, malingana ndi kuopsa kwa matendawa.

Pofuna kuchiza matenda opatsirana a khungu ndi mitsempha, Remedia imaperekedwa mlingo wa 250 mg kawiri pa tsiku.

Contraindications

Kusamvana kosagwirizana ndi kumwa mankhwala ndi hypersensitivity komanso kukhalapo kwa zotsatira za anamnesis kwa mankhwala a gulu la fluoroquinolones.

Palibe deta yamtengo wapatali yokhudza kudya kwa mankhwala pa nthawi yomwe ali ndi mimba, monga momwe maphunziro odziwitsira kuti aphunzire zotsatira za teratogenic kapena embryotoxic sizinayambe.

Choncho, kuikidwa kwa Remedia kwa amayi apakati ayenera kupewa, pokhapokha ngati chiopsezo chotere chingakhale chochepa kusiyana ndi ubwino wa Remedia.

Pankhani yogwiritsira ntchito mankhwalawa kwa odwala odwala porphyria, pangakhale kuwonjezereka kwa matendawa.

Powonongeka kwambiri, njira yothandizira imayenera kugwiritsidwa ntchito kwa odwala omwe ali ndi zilonda zam'mbuyo zamkati (misampha, matenda a mtima, kuwonongeka kwa ubongo), chifukwa chotheka kwambiri.

Kwa odwala omwe amagwira ntchito zovuta kumalo ogwira ntchito kapena kuyendetsa magalimoto, palibe chisonyezero chokha, koma kuthekera kwa zotsatira za mitsempha yachisokonezo monga kugona, chisokonezo, ndi zina zotero ayenera kuziganizira. Choncho, tiyenera kupewa ntchito imeneyi.

Zotsatira Zotsatira

Chimodzi mwa zotsatira zoyipa kwambiri zomwe zimayambira motsatira maziko a fluoroquinolones ndi chitukuko cha mitsempha yotchedwa cartilaginous chifukwa cha kuwonongeka kwa chondrocytes za epiphyses ndi minofu yokha. Poona izi, mankhwalawa akutsutsana ndi anthu ochepera zaka 18 ndipo ali ndi pakati. Tiyenera kukumbukira kuti odwala omwe ali ndi zaka zoposa 18 amatha kugwiritsa ntchito mankhwala osokoneza bongo nthawi yaitali, panalibenso zochitika za arthralgia kapena zofooka za ziwalo. Zotsatira zina zimaphatikizapo zotsatirazi.

Mbali ya m'mimba - tsankho, kusanza, kuchepa kwa chilakolako, kuoneka kwachisoni m'madera ozungulira chigawochi, mwinamwake kuchitika kwa m'mimba m'magazi ndi chitukuko cha gastroenteritis; Kuwonjezeka pamtundu wa aminotransferase m'magazi a m'magazi.

Kuchokera m'katikatikati mwa mitsempha ya mitsempha - chitukuko cha zizindikiro za matenda opatsirana, kupweteka mutu, chizungulire, kutaya chidziwitso, vuto la kugona ndi kusintha kwa kawirikawiri m'maganizo, maonekedwe a paresthesias, malingaliro olakwika ndi zonyenga.

Kuchokera ku chitetezo cha mthupi - chitukuko cha zomwe zimachitika pamtundu wa phulusa, kuyabwa, ndi chikhalidwe cha kuwonjezereka kwa photodermatitis kumatha.

Kuchokera ku urinary system - chitukuko cha crystalluria.

Gawo la kupuma, maonekedwe a bronchospasm ndiwotheka, ndipo mbali ya kayendetsedwe ka kayendedwe ka magazi, kuchepa kwakukulu kwa kupanikizika kwa thupi, chitukuko cha hypoglycemia, zomwe zimachokera kumagulu a hemostasis (monga thrombocytopenia, etc.).

Kuyanjana ndi mankhwala ena

Kukonzekera kwa gulu la fluoroquinolones sikunayankhidwe limodzi ndi antacids, chifukwa kumachepetsanso kuchepetsa kapangidwe kake ka mankhwala ndi ma antibiotic. Sitikulimbikitsidwa panthaŵi imodzimodziyo "Remedia" ndi kukonzekera zitsulo, komanso ndi mankhwala omwe amakhudza ntchito yogwira ntchito ya pakatikati ya mitsempha. Kuonjezera apo, pali deta pa zotsatira za probenecid ndi cimetidine pokhapokha mankhwalawa kuchokera ku thupi (izi zikhoza kuchepetsa kuthetsa ma antibiotic).

Palibe chiwonetsero chimodzi chokha cha kugwirizanitsa mankhwala ndi levofloxacin. Chifukwa cha kuchepa kwa mankhwala osokoneza bongo mu minofu yodabwitsa komanso kusagwirizana ndi mavitamini a gulu la cytochrome P450, Remedia sichisintha ntchito ya wotsirizirayi, komabe, mofanana ndi ena onse a fluoroquinolones, mankhwalawa sayenera kuphatikizidwa ndi theophylline kukonzekera ndi mankhwala osadziwika bwino a antibiotic, Poona kuwonjezeka kotheka mukumapeto kwa magaziwa.

Kugwiritsira ntchito mankhwala pakamwa

Mpaka pano, palibe chidziwitso chothekera kuti mankhwalawa alowe mu mkaka wa amayi. Ngati pakufunika thandizo la mankhwala ophera maantibayotiki panthawi ya kuyamwitsa, mankhwalawa ayenera kutayika kwa kanthaŵi (nthawi yayitali imadalira kukula kwa matenda opatsirana ndi kuchuluka kwa mankhwala opatsirana pogonana). Ngati ndi kotheka, pofuna kuteteza lactation, kupopera nthawi ndi nthawi kapena lactation imasiya kwathunthu ndi kuthandizidwa ndi zipangizo zachipatala.

Nthawi zambiri, kuyamwitsa ndi mankhwala ophera ma antibiotic ndi kotheka poyesa kuopsa kwa mwana ndi mayi.

Kutulutsa mawonekedwe ndi mlingo

"Remedia" ikupezeka mwa mitundu iwiri: maofesi otsogolera komanso otsogolera. Kwa mauthenga a pamlomo, pali mawonekedwe okhala ndi 250 kapena 500 mg yokonzekera (motsatira pansi pa mayina a malonda "Remedia 250" ndi "Remedia 500"). Kwa marenteral administration , yankho la kulowetsedwa likupezeka.

Mapiritsi a Remedia amatengedwa 1-2 pa tsiku asanadye chakudya kapena panthawi yopuma pakati pa kayendetsedwe kawo, popanda kutafuna, ndi madzi okwanira. Ngati pakufunika kugawa mlingo wa mankhwalawo theka, piritsi ikhoza kuphwanyika pa chidutswachi mu magawo awiri.

Kwa marenteral administration, njira yothandizira jekeseni imapezeka ndi mankhwala 500 mg / 100 ml (Remedia 500). Pankhani ya jekeseni yamkati, mankhwalawa amathandizidwa mofulumira kuposa ora limodzi.

Pambuyo pa kulowetsedwa kwa mankhwala, kusintha kwina kwa mawonekedwe apiritsi kumalimbikitsidwa. Kutalika kwa nthawi yake molunjika kumadalira kukula kwake kwa njira yopatsirana komanso mphamvu ya tizilombo toyambitsa matenda tizilombo toyambitsa matenda. Mankhwala (mosasamala mtundu wa kayendedwe) akulimbikitsidwa kuti apitirize kwa masiku 3-4 pambuyo pa normalization ya kutentha kwa thupi. Kudziletsa ndi kutha kwa mankhwala osakayika sikuvomerezeka, chifukwa cha chiopsezo chachikulu cha zotsatira zolakwika ndi chitukuko cha kukana kwa microflora kwa mankhwala.

Malangizo apadera

Musanayambe kulandira mankhwala pogwiritsira ntchito Remedia, malangizo othandizira amagwiritsa ntchito chitsanzo kuti mphamvu ya tizilombo toyambitsa matenda tiyambe kukonzekera. Komabe, mwa njira zambiri, chithandizo chingayambe popanda chitsanzo, kenaka kutsatiridwa kwa mankhwala ogwira ntchito kwambiri.

Pogwiritsa ntchito mankhwala a remedia, payenera kuperekedwa mwapadera ku kafukufuku wokonzera kuyendayenda kwa magazi, chifukwa kuchuluka kwa mankhwalawa kumatulutsidwa kudzera impso. Ngati kusokonezeka kwa ntchitoyi, mlingo wa mankhwalawo uyenera kusinthidwa molingana ndi chitsimikiziro cha creatinine yosagonjetsa.

Mitundu ya mankhwalawa imaloledwa kusakaniza njira zothandizira jekeseni zomwe zimakhala ndi mchere (sodium bicarbonate), komanso heparin. Chifukwa cha dilution, kulowetsedwa kumakhala "Remedia" ikugwirizana ndi isotonic sodium kloride yankho , isotonic shuga njira ndi Ringer yankho.

Pakulandila Chithandizo, kumwa mowa kumayenera kupeŵa, chifukwa kumathandiza kuonjezera poizoni wa levofloxacin m'katikatikati mwa mitsempha ya mitsempha ndi mawonetseredwe oonekera kwambiri.

Ngati zatsimikiziridwa kugwiritsa ntchito Remedia zokha, malangizo ogwiritsira ntchito, ofanana, ayenera kufufuzidwa mosamala, popeza ndizokwanira kwadzidzidzi ndi kudalira nzeru zokwanira za kukonzekera kupeŵa zolakwa zazikulu.

Kusungirako ndi kupezeka kuchokera ku pharmacies

Mankhwala samasowa malo osungirako apadera. Kutetezeka kwake kumapangidwe pa kutentha kwa madzi osachepera 25 digiri Celsius. Kuchokera ku "Remedia" yamagetsi (antibiotic) imatulutsidwa pa mankhwala.

Mukamagula mankhwala, muyenera kumvetsera kukhulupirika ndi chitetezo cha phukusi, tsiku lopanga komanso tsiku lomaliza. Malangizo ogwiritsira ntchito ayenera kukhala m'bokosili ndi mankhwala ochiza. Mapiritsi ayenera kukhala pamapangidwe apamwamba kwambiri. Mukhoza kuyang'ana zovuta zomwe zimachokera kwa iwo (ziribe kanthu momwe zingakhalire zodabwitsa). Izi zili choncho chifukwa chakuti zabodza ndi ziwonetsero zimapezeka nthawi zambiri mumsika wa mankhwala, umene sungathe kupereka mankhwala oyenera omwe amachititsa odwala mankhwalawa, komanso powavulaza kwambiri. Choncho, mukamagula mankhwala, musakhale aulesi kufunsa wamankhwala za kupezeka kwa chilembo chapamwamba chotsimikiziranso chiyambi cha mankhwala a mankhwala (mapiritsi). Malangizo ogwiritsidwa ntchito (malinga ndi mankhwala a mankhwala ogulitsidwa) ayenera kukhala ndi chidziwitso chochokera pachiyambi.

Kuchulukitsa

Pankhani ya overdose, palibe mankhwala enieni. Chizindikiro cha matendawa pamene chiwerengerochi chapitirira ndi makamaka chifukwa cha zomwe zimapangitsa kuti ntchitoyi ikhale yovuta kwambiri. Pankhaniyi, chisokonezo, kugona, chizungulire, komanso zizindikiro za chisokonezo cha mitsempha mwa maganizo, psychoses, matenda a khunyu, ndi zina zotero.

Kuchiza kumafuna kuchotsa mwamsanga mankhwalawa kuchokera ku thupi. Popeza kuti mankhwalawa ndi otsika kwambiri komanso amagawira mankhwala onse m'thupi, njira za hemodialysis zowonongeka sizingatheke. Ndikofunika kuletsa kulandila mankhwala m'thupi ndikuchita chithandizo chamankhwala.

Chifukwa cha kuchotsedwa kwakukulu kwa "Remedia" pogwiritsa ntchito mankhwala odzola pamtambo glomeruli, njira yowonongeka ndi kugwiritsa ntchito mankhwala osungiramo madzi mumchere komanso mankhwala osokoneza bongo.

Ndemanga za mankhwala

Kawirikawiri, pali ndemanga zabwino za mankhwalawa chifukwa chapamwamba kwambiri zothandizira matenda opatsirana osiyana siyana. Monga momwe malangizo ogwiritsira ntchito amagwiritsira ntchito remedia, ndemanga za mankhwala sizisiyidwa ndi odwala okha, komanso kupezeka kwa madokotala omwe amazindikira kuti ali ndi mphamvu zothandizira, kuchipatala ndi matenda a nosocomial.

ndemanga zoipa ndi kukhumudwa mankhwala kumanzere odwala waukulu. Ichi ndi chifukwa chitukuko cha zotsatira zawo mbali kapena kugwiritsa ntchito "Yothetsera". Malangizo Komabe, amapereka zambiri mabuku kwambiri za malonda. ndemanga zoipa chifukwa kugwiritsa ntchito mankhwala pa nthawi imene ndi operewera chifukwa sanali kugwilizana wa sipekitiramu wa kanthu antibacterial kwa matenda ndi tizilombo tating'onoting'ono. Tikumbukenso kuti maganizo yovuta zambiri kusiya odwala kudzimvera medicate ndi kutenga yekha kukhala kapena pa umboni wa abwenzi kapena "Yothetsera" abwenzi (malangizo pa nthawi yomweyo kawirikawiri ananyalanyaza, amene si kwambiri analimbikitsa). Zoipa ndemanga odziwa chisamaliro chaumoyo ali pafupifupi mwaonapo. Ichi ndi chifukwa ntchito olondola ndipo ndiyanzeru wa mankhwala (zokhudza "mankhwala 500" Buku lili ndi mfundo zokwanira ntchito moyenera mankhwala).

Mankhwala analogues "Yothetsera"

Kukonzekera "Yothetsera" malangizo analogs anafotokoza motere: kuyambira mankhwala ndi fluoroquinolone mankhwala levofloxacin, analogues mkulu amasankha tinganene kuti pafupifupi mankhwala onse zikuchokera ofanana. Tikumbukenso loyamba la onse "Levofloxacin", "Sol", "tsekwe", "Levoksimed" Anthu amenewa, ndi ena ambiri. Pakuti "Yothetsera" (mapiritsi) wogwiritsa ntchito amapereka analogs mankhwala monga "Leflok", "Floksium" ndi ena.

Pomaliza

The yogwira chigawo "Yothetsera" mankhwala - ndi levofloxacin mankhwala. Iye ndi wabwino antibacterial wothandizila ndi yotakata-sipekitiramu bactericidal kwenikweni. Chifukwa cha zochitika otsika mavuto ndi kupanda kukana kuti maantibayotiki mitundu yosiyanasiyana bakiteriya, wakhala bwinobwino ntchito yachipatala mchitidwe "Yothetsera". Malangizo ntchito amamuuza mabuku kwambiri ponena za ntchito ya mankhwala.