Benzylpenicillin ndi sodium mchere: malangizo ntchito. malamulo ntchito

M'nkhani ino tikambirana kukonzekera monga "Benzylpenicillin ndi sodium mchere". Malangizo ntchito, zizindikiro, mlingo ndi ayamikira ntchito lidzadzala nkhaniyi. Komanso, timaona katundu pharmacological mankhwala, chingachitike mbali ndiponso zimene ankachita mankhwala ndi mankhwala ena.

kukufikira

The mankhwala ndi wothandizila antimicrobial ndi maantibayotiki a gulu Penicillin. Benzylpenicillin ndi sodium mchere wokha, malangizo ntchito zomwe anapereka m'munsimu amapangidwa ndi bowa zosiyanasiyana.

Mankhwala gulu ntchito yoyang'anira mu mnofu, mmene zimakhala zosiyanasiyana ndipo ziwalo zimene magazi akukamba pang'ono penicillin. Mankhwala anayamba mmene ubongo ndi msana ndi meninges, subarachnoid kutumikiridwa.

Benzylpenicillin ndi sodium mchere, malangizo ntchito: pharmacologically kanthu

The mankhwala ndi polimbana mabakiteriya galamu HIV, monga:

• staphylococci;
• streptococci;
• pneumococci;
• diphtheria ;
• coli tizilombo ta matenda;
• aerobic (kupulumuka, pakalibe mpweya) sporulating ndodo.

Komanso, mankhwala ndi yogwira motsutsana galamu zoipa cocci (meningococcus, gonococcus), spirochetes, actinomycetes ndi tizilombo tina. Penicillin ndi sodium mchere ndi operewera tizilombo, rickettsiae, bowa, mogwirizana.

Mankhwala kugonjetsedwa tizilombo ta staphylococci, amene angathe kubala enzyme penicillinase, asamathe benzylpenicillin. The medicament akusonyeza ntchito otsika mu mankhwala a Pseudomonas aeruginosa, mabakiteriya matumbo ndi tizilombo tina, okhoza kuonetsetsa mosiyanasiyana penicillinase.

Pharmacokinetics

Mu mankhwala mu mnofu mofulumira akulowa m'magazi, kumene laperekedwa kwa madzi m'thupi ndipo zimakhala. Pankhani madzimadzi cerebrospinal, izo likulowerera kuti pang'ono ndi penicillin. Ndende apamwamba mu magazi pambuyo yoyang'anira intramuscularly anati pambuyo mphindi 30-50. Ngati mankhwala anali kutumikiridwa subcutaneously, mlingo wa mayamwidwe yafupika ndi chiwerengero pazipita zinthu m'magazi udzachitika ola.

maola atatu pambuyo jekeseni (subcutaneous kapena mu mnofu) wa benzylpenicillin kuda zokha m'magazi. Choncho, kukhalabe mkulu wa ndende mankhwala mu thupi kwa nthawi yaitali, m'pofunika jekeseni kudzera mawola anayi.

Pamene kutumikiridwa m'nsinga, ndende yake ya mankhwala mofulumira kugwa. Ndipo pamene akumwabe pakamwa benzylpenicillin anawononga penicillinase (enzyme) ndi madzi muzituluka.

Excreted mankhwala excreted mu mkodzo.

umboni

Iwo ayenera ankaphunzira pamaso poika mankhwala monga Penicillin ndi sodium mchere, malangizo ntchito, mlingo komanso nkhani ntchito. Tiyeni tiyambe ndi masika. Choncho, mankhwala Kwalamulidwa:

• matenda a m'mapapo ndi kapepala kupuma;
• aakulu matenda septic;
• bakiteriya endocarditis;
• sepsis;
• matenda ndi mabala kachilombo wa zimakhala zofewa khungu ndipo zimagwira ntchito zosiyanasiyana mucous;
• amayaka;
• kutupa chingwe msana ndi ubongo, mazgovyh zikopa;
• purulent pleurisy;
• peritonitis;
• cystitis;
• Pius ndi septicemia;
• osteomyelitis;
• diphtheria;
• chofiira malungo;
• chinzonono;
• erysipelas;
• Matenda mu akhanda;
• tizilombo ta matenda;
• chindoko;
• actinomycosis;
• inflammations osiyanasiyana matenda;
• matenda yotupa kukhosi, makutu ndi mphuno.

Kagwilitsidwe Nchito ndi mlingo

Malinga ndi mitundu ya mankhwala matenda ntchito benzylpenicillin ndi sodium mchere wa mankhwala akhoza kutumikiridwa. Malangizo ntchito, njira ya utsogoleli ndi mlingo zotheka tidzakambirana ndi ife mu gawo limeneli.

The njira ya mankhwala ukhoza, malingana ndi matenda, kwa masabata 4 miyezi 2 kapena kuposa. mankhwala angathe kuperekedwa m'njira zotsatirazi:

• Intramuscularly mu nusu chapamwamba kunja kwa gluteal lapansi. lokonzekera wasukuluka patsogolo makonzedwe mu madzi otchezedwa, novocaine kapena sodium kolorayidi njira.
• Mtsempha - .. Only pansi matenda aakulu, monga malungo, bakiteriya endocarditis, septicemia, etc. The mankhwala chikuyendetsedwera ola lililonse 4 kapena mosalekeza kukapanda kuleka - 30 madontho pa mphindi kwa maola 6-12.
• Lusoli kuperekedwa endolyumbalno benzylpenicillin mchere ndi sodium. Malangizo ntchito (potsatira njira) amapereka njira ya kutupa kwa ubongo ndi msana, kuphatikizapo meninges lapansi. Mankhwala jekeseni pang'onopang'ono - mphindi 1-2.
• Pali milandu kumene benzylpenicillin ntchito jekeseni ya yotupa foci. Mwachitsanzo, pamene actinomycosis, khungu leishmaniasis, pyoderma aakulu ndi matenda ena opatsirana khungu.
• Ndi inhalations - zochizira ndi kupewa matenda a m'mapapo ndi Airways. Chifukwa chaichi, wothira njira benzylpenicillin sodium kolorayidi kapena madzi otchezedwa. Inhalations zosaposa nthawi 2 pa tsiku. Chokhalitsa thandizo - kuchokera mphindi 10 mpaka 30.
• Amagwiritsidwanso jekeseni wa pleural kapena peritoneal M'mimbamo mu purulent peritonitis kapena pleurisy.
• Mu mawonekedwe a umatsuka, mafuta, Mavalidwe lonyowa, lotions ndi ufa - chifukwa amayaka, mabala a minofu zofewa, ndi osteomyelitis Al.
• Komanso njira mankhwala ntchito zochizira matenda chapamwamba kupuma ndi pochiza matenda a maso.

Penicillin angagwiritsidwe ntchito mankhwala pamodzi ndi mankhwala ena ndi kukonzekera sulfanilamide. M'menemo njira adzakhala kulimbikitsa zotsatira achire mankhwala ntchito.

zotsatira zoyipazi

Kukhoza kungasokoneze wa benzylpenicillin ndi sodium. Malangizo ntchito linanena kuti iwo akusonyeza makonzedwe mtsempha wa mankhwala zambiri.

Kwenikweni, mavuto kugwirizana ndi thupi lawo siligwirizana ndi mankhwala. Mwa zizindikiro chowawa anati:

• candidiasis;
• ming'oma;
• malungo;
• mutu;
• kuzizira;
• olowa ululu;
• Angioedema;
• eosinophilia;
• zosiyanasiyana dermatitis;
• malungo;
• lymphadenopathy;
• anaphylactic mantha - mu nthawi zina kwambiri.

contraindications

Si odwala onse angafikemo mankhwala ndi medicament mchere benzylpenicillin ndi sodium. Malangizo ntchito ndi malamulo a makonzedwe kupereka angapo contraindications. Pakati pawo:

• matenda awo sagwirizana monga urticaria, chigwagwa, bronchial mphumu, etc.
• hypersensitivity kuti ena ofanana penicillin;
• mayankho zachilendo mankhwala;
• matenda tizilomboto kukana kuti unit mlingo wa benzylpenicillin.

The oyamba a endolyumbarnym mankhwala oyenerera zomangidwa khunyu.

Mimba ndi mkaka wa m'mawere

Kuikidwa pa mimba ngati phindu kuchiza amai ndi wamkulu kuposa chiopsezo lingathe mwana wake wosabadwa. Apo ayi, mankhwala si kutumikiridwa. chiopsezo chiŵerengero ndi dzuwa anatsimikiza ndi dokotala nawo.

Ngati ndi kotheka, utsogoleli wa mankhwala pa mkaka wa m'mawere ayenera kusiya kuyamwitsa mwana mkaka.

katundu

Mankhwala mankhwala benzylpenicillin mchere ndi sodium ali mawonekedwe a woyera chabwino crystalline ufa ndi kulawa zowawa zomwe mosavuta sungunuka mu madzi.

mankhwala mosavuta anawonongedwa ndi zidulo, alkalis, oxidizing wothandizira, enzyme penicillinase, komanso magetsi. Konzani mankhwala mankhwala ayenera kukhala yomweyo isanafike utsogoleli.

kusamala

mankhwala chikuyendetsedwera yekha kuchipatala ndi mankhwala dokotala ndi kuiyang'anira. Ndi ndime ya mankhwala tiyenera kukumbukira kuti osakwanira mlingo benzylpenicillin kapena kuchotsa oyambirira chithandizo kungachititse kuti mapangidwe mitundu kugonjetsedwa tizilombo. Mu chochitika cha kukana mankhwala mankhwala ikupitirira maantibayotiki ena.

Chizolowezi thupi lawo siligwirizana kutumikiridwa pamodzi ndi mankhwala antihistaminic ndi benzylpenicillin ndi sodium. Malangizo ntchito (zochita za mankhwala zotchulidwa mwatsatanetsatane ake makamaka) imatiuza kuti pamene wodwala awo sagwirizana mawonetseredwe mankhwala yomweyo anasiya.

Mu magulu ena odwala (okalamba, makanda, chokumana ndi matenda) Mwina ndi kukana kuti benzylpenicillin, zomwe zimabweretsa chitukuko cha superinfection.

Ndi ntchito kwa nthawi yaitali, mankhwala akhoza kuletsedwa kapena mwina anawononga microflora matumbo, zikubweretsa yafupika kupanga mavitamini a gulu B. Choncho prophylactically odwala zambiri zotchulidwa mavitamini B1, B12, ndi ena.

Ngati, pambuyo chiyambi cha mankhwala kwa masiku 3 sanali anaona mphamvu iliyonse, m'pofunika kupita chithandizo ophatikizana kapena perekani latsopano mankhwala.

Kusamala

CHENJEZO wapatsa anthu ndi matenda a mtima ndi mkhutu impso ntchito benzylpenicillin mchere ndi sodium. Malangizo ntchito limalimbikitsanso mwapadera kuperekedwa kwa odwala amene asunga hypersensitivity kuti cephalosporins.

Chifukwa cha kuthekera mafangasi superinfection tikulimbikitsidwa kuti mankhwala wothandizila odana ndi mafangasi.

Mogwirizana ndi mankhwala ena

Poika mankhwala amenewo, amene bacteriostatic, kanthu bactericidal penicillin yafupika.

Kukonzekera "Probenecid" ali katundu kuchepetsa katulutsidwe tubular a maantibayotiki zimachititsa kuwonjezeka mlingo mwazi wa otsiriza ndipo monga Motero, kuwonjezera nthawi polichotsa thupi.