Hypothalamic-pituitary dongosolo

dongosolo Hypothalamo-pituitary ndi structural mgwirizano morphofunctional pituitary (ndondomeko ya mafuta m'munsi mwa ubongo) ndi ubongo imene imalamulira kutentha (khadi mu diencephalon) kuti zimakhudzidwa lamulo ntchito autonomic mu thupi chachikulu.

Yopangidwa mu dipatimenti diencephalon mahomoni ndi mwachindunji ochepetsera kapena zolimbikitsa amasintha katulutsidwe mahomoni mafuta m'munsi ubongo. Mu nkhani ya dongosolo hypothalamo-pituitary ndipo ali ndi ntchito maganizo. Iwo anafuna kuti lamulo la timadzi katulutsidwe ndi kaphatikizidwe (by kuwonjezeka ulimi wa mahomoni mu zopangitsa endocrine yafupika katulutsidwe mahomoni mu diencephalon dipatimenti). Hypothalamic-pituitary dongosolo kuyezetsa zotsatilazi, amatithandiza kusungabe mosalekeza mu thupi.

Gipofizotropnye mahomoni diencephalon khadi ogaŵikana liberiny (ikuthandizira) ndi statin (braking) za ziwalo kupanga timadzi lotentha. The wapakatikati gawo m'badwo imagwiridwa neuropeptides ubongo (a mtundu wa zedi).

Mu kwambiri mahomoni hypophysis ubongo imene imalamulira kutentha zolimbikitsa zotsatira, monga kuyenera prolactin wa - katulutsidwe ndi pansi zimandilimbikitsa ochepetsera chikoka ubongo imene imalamulira kutentha.

Ngati zowonongeka (wotsikitsitsa transection) mu m'munsi ubongo tsinde mafuta kokhazikika katulutsidwe wa oxytocin ndi vasopressin axons mu ukulu apakatikati. Choncho, woterewu shuga insipidus. Kuchotsa ubongo imene imalamulira kutentha kapena mkulu transection wa miyendo kumapangitsa oxytocin pamene kupanga imfa, vasopressin, ndi onse koma timadzi prolactin mu pituitary England.

Choncho, ntchito za dongosolo hypothalamic-pituitary.

Maphunziro Akakhalidwe Kazolengedwa adzatenge kuzindikira ubale kudzera ziwiya zipata mu adenohypophysis lapansi. Mtima khoma permeability osiyana mapulotini lalikulu. Magulu anasankha selo mtima anapanga mu ubongo imene imalamulira kutentha kwa. Mwa iwo 32 awiriawiri. Nawo mbali mu lamulo la ntchito zofunika kwambiri m'thupi. Mderali anaikira madera akuluakulu a magulu wachifundo ndi parasympathetic a dongosolo autonomic mantha mu. Choncho, kuthamanga kwa magazi lamulo ikuchitika, kutentha, kugona kupanga kutentha, kusafuna kudya, ndi zina mtima permeability.

Hypothalamic-pituitary dongosolo kumafuna osati kukhala mosalekeza chilengedwe mkati mwa munthu. Komanso ndi mwezi, ndi tsiku, nyengo, ndi zina rhythmic kusinthasintha m'thupi.

HPA olamulira (hypothalamic-pituitary-adrenal olamulira) akhoza kukhala ndi chidwi ochepetsera n'chiyani kugwira ntchito ziwalo zoberekera wamkazi mbali zosiyanasiyana. Yopangidwa mchikakamizo cha CRH (KTRG - corticotropin-kumasuka timadzi) proopiomelanocortin mapeputisayidi khama zotsatira ochepetsera pa ulimi wa hypothalamic gonadotropin-kumasuka timadzi. Glucocorticoids ziletsa yopanga LH (luteinizing timadzi) pituitary ndi progesterone ndi esitirojeni ambiri m'mimba ya m'munsi tilinazo zimakhala zosiyana estradiol.

Motero, mbali yaikulu ya HPA olamulira anatsimikiza pamene kupanga maganizo amenorrhea (kupanda kusamba pa miyezi yoposa 6), "hypothalamic". Pamodzi ndi ichi, pali mwachindunji stimulatory motani kulimbikitsa esitirojeni jini (yapitayi ndondomeko ya nucleotides), umene uli udindo kaphatikizidwe KTRG ndi nyumba noradrenergic mu CNS. Ikufotokoza pamaso pa hypercortisolism wofatsa (kuchuluka magwiridwe adrenal kotekisi), nkhawa, matenda a maganizo, mmene alili, matenda kudya ndi zizindikiro zina.