Kuchiza kwa Melanoma Mu Israeli - Oncology Kunja Kwina

Kuchiza kwapakati (magawo III ndi IV), khansa ya khansa imatengera uthenga wabwino. Ngakhale kuti chiwerengero cha khansa ya khansa ya khansa imawonjezeredwa ndi 3 mpaka 5 peresenti pa chaka, mankhwala omwe amatha kudwala matenda a khansa sakusintha kwambiri odwala ambiri. Zilonda zam'chipatala ndi chiyembekezo chabwino kwambiri chothetsa chiwindi cha khansa ya mthupi: mankhwala atsopano, njira zatsopano zothetsera matendawa. Chinthu chodalirika kwambiri ndi chithandizo chotsatira cha khansa ya m'magazi kunja:

• Allovectin-7 - mankhwalawa amatengedwera mwachindunji mu chotupa cha wodwala ndi siteji ya III kapena IV ya melanoma, yomwe imagwiritsa ntchito chitetezo cha thupi kuti chiteteze chotupacho. Mayeso oyambirira a Allovectin amasonyeza kuti zotupa mu 4% mpaka 9% mwa odwala amatsatira mankhwala.
• Genasense ndi inhibitor yapadera ya bcl-2, mapuloteni opangidwa ndi maselo a khansa. Mwa kuchepetsa kuchuluka kwa Bcl-2 m'maselo a khansa, Genasense imathandizira kuti chithandizo cha khansa yatha. Kafukufuku wasonyeza kuti Genasense kuphatikizapo mankhwala a chemotherapy amachititsa kuti munthu akhale ndi moyo wambiri poyerekeza ndi chemotherapy.
• MVax ndi katemera wa khansa yomwe imapangidwa kuchokera ku maselo a khansa. Kafukufuku wambiri wasonyeza kuti MVax angapangitse kukhululukidwa kwathunthu kwa odwala 13 peresenti, yomwe imakhala kawiri kawiri ya interleukin-2 yokha. MVax imathandizanso kwa odwala omwe ali ndi gawo la khansa ya khansa pambuyo pa opaleshoni: yawonjezeka kawiri kwa zaka zisanu poyerekeza ndi mankhwala opaleshoni okha.
• Ipilimumab ndi anti-antibody yomwe imayambitsa chitetezo cha mthupi kuti chiteteze khansa ya khansa mwa kupewa ma molecule a CTLA-4. Milandu itatu yapitayi yowonongeka kwachiwiri inasonyeza kuti mankhwala othandiza kudwala khansa ku Israel ndi Ipilimumab ndi kuchuluka kwa kupulumuka kwa 47% mpaka 51% kwa anthu omwe ali ndi masitepe a III kapena IV a melanoma, omwe amakhala oposa awiri.
• OncoveXGM-CSF ndi katemera omwe amagwira ntchito pogawidwa mu chotupa ndi kupha imfa ya maselo a khansa, kulimbikitsa chitetezo cha mthupi ndi kuwononga ziwalo zam'mimba. Zotsatira za odwala 50 omwe sagwiritsidwa ntchito mosamalitsa gawo la IIIc / IV limapangitsa kuti 28 peresenti ya odwala ayambe kuvomereza, kuphatikizapo 12% adalandira chikhululukiro chonse.

Anthu omwe amagwira ntchito m'mayesero a kachipatala amatha kupeza njira zothandizira, zomwe nthawi zambiri sizipezeka m'mayiko ena. Chithandizo cha khansa ya khansa ku Israeli ikhoza kukhala yabwino kusiyana ndi chithandizo cha mankhwala ndi chiyembekezo chokha cha odwala omwe ali ndi matenda opitirira. Mwachidule, kutenga nawo mbali m'mayesero odwala pa odwala ndi njira yokhayo yodalirika, mankhwala atsopano a khansa ya khansa kudziko lina.