Mafotokozedwe "Onbrez Brizhaler": malangizo ntchito, zikuchokera, analogues, mlingo

Zochizira aakulu obstructive khalidwe matenda m'mapapo mwanga anayamba kupanga ndi kuyesedwa pa harmlessness wa mankhwala nzeru "Onbrez Brizhaler 'zithunzi ali anapereka m'munsimu.

makhalidwe General

Mankhwalawa amapangidwa kampani Swiss AG "Novartis". Pali Mlingo awiri (pa 0,300 mg wa ndi 0,150 mg) medicament "Onbrez Brizhaler". Kufotokozera lokonzekera amadziwika ngati ufa woyera kwa inhalation, lomwe mmatumba mu makapisozi.

Iwo sympathomimetic inhalation wothandizila kuti kuchiza matenda obstructive a dongosolo kupuma. Adzaupereka kwa beta2-agonists kusankha.

Mu makapisozi molimba gelatin lachitatu apamwamba mlingo waukuluwu ali mandala popanda mtundu kapu ndi thunthu. Pamwamba pa wakuda utoto umagwiritsidwa kampani Logo, limene lili pansipa mikwapulo wakuda pansi pa kapisozi muli akuti «IDL 150", limene liposa mikwapulo wakuda.

Mu makapisozi molimba gelatin lachitatu kakang'ono mlingo ali mandala popanda mtundu kapu ndi thunthu. Pa chapamwamba theka TACHIMATA buluu utoto kampani Logo, limene lili pansipa gulu buluu, ndi mmunsi mwa kapisozi muli buluu chizindikiro «IDL 300" imene ili pamwamba pa mzere buluu.

kapangidwe

kapisozi mmodzi lili indacaterol maleate mu kuchuluka kwa 0,194 mg wa pa mlingo ndi pa 0,389 mg pa kwambiri mlingo. Mbali wothandiza ntchito mu mawonekedwe a mkaka shuga excipient, zikhoza kusintha Unyinji wa nkhani.

Zovuta ali kapisozi chipolopolo "Onbrez Brizhaler" zikuchokera, ndi malangizo zikuphatikizapo mndandanda wa onse zosakaniza. ❖ kuyanika aumbike pa mlingo wa shellac, gelatin, chitsulo okusayidi ndi ferric wakuda, madzi oyera, propylene glycol.

apamwamba mlingo kapisozi chipolopolo lili zosakaniza yosiyaniranapo. ❖ kuyanika aumbike ndi shellac, gelatin, chitsulo okusayidi ndi ferric wakuda koyera amadzimadzi sing'anga, propylene glycol, anzeru buluu pigment, titaniyamu woipa.

limagwirira wa Action

Mankhwala "Onbrez brizhaler" wogwiritsa Phunziro pankhaniyi anafotokoza mmene wa yogwira pophika indacaterol chimene mankhwala ligand ukuwonjezeka ayankhe adrenozavisimyh beta2-maselo. Amenewa pharmacological ndi chifukwa kutsegula kwa enzyme adenylcyclase m'kati mwa maselo, imene Iyamba adenosine kusintha mu maselo mawonekedwe ozungulira 3, 5'-adenosine monophosphate.

Kuwonjezeka mbali yomaliza ndi chifooke minofu bronchial yosalala. Indacaterol akusonyeza ntchito yapamwamba mwachibale kwa beta2-maselo. selectivity ake ndi ofanana ndi zochita za formoterol.

Makapisozi "Onbrez Brizhaler" pamene Mpweya chionetsero bronchodilatory zotsatira m'dera m'dongosolo kupuma.

udindo wake ndi cholukanalukana ndi wotsikirapo makoma m'mapapo distension ndi zolimbitsa kwambiri kapena boma obstructive matenda mu kaimidwe malo amodzi ndi zazikulu.

Kamodzi pa tsiku makonzedwe kumabweretsa zonse kwambiri ntchito kusintha kwa ziwalo kupuma. Thunthu yogwira wayamba mwamsanga ndi mphindi 10 kuti amadera ntchito. Ichi ndi mogwira mtima kuposa mmene salbutamol mu mlingo wa 0,200 mg kapena salmeterol / fluticasone mu mlingo wa 0.050 / 0.500 mg. Ntchito pazipita indacaterol n'zotheka pambuyo maola 3-4 kokha akuluakulu ndi inhalation. Morning kapena madzulo ntchito mankhwala sasintha bronchodilator zotsatira zake.

kuti amachitira

Medicine "Onbrez Brizhaler" malangizo Buku limatichenjeza kuti ntchito mankhwala yokonza kusintha obstructive bronchodilation thirakiti kupuma odwala ndi m'mapapo mwanga obstructive chikhalidwe aakulu a matenda. Chifukwa cha matenda otere womangika mpweya otaya amachepetsa chiwerengero cha Mpweya mpweya, kukhala kupuma movutikira. Siteji yoyamba ya matenda kuzindikiridwa ndi chifuwa, sputum, dyspnea, ndi hoarseness pa katundu mphamvu.

Kagwiritsidwe

Pa mankhwala "Onbrez Brizhaler" Mlingo ndi yoyendetsa akuluakulu utoto malangizo. Childs, madokotala amalangiza tsiku ndalama imodzi zili inhalation wa munthu kapisozi mlingo wa 0,150 mg. Ndondomeko zinachitikadi pogwiritsa ntchito inhaler kapena brizhalera, ndi monga adjunct kuti mankhwala. Mlingo akhoza ziwonjezeke kokha mwa maikidwe dokotala.

Mu aakulu inhalation obstructive m'mapapo imagwiridwa kapisozi mmodzi tsiku ndi mlingo wa 0,300 mg. Ndondomeko zinachitikadi pogwiritsa ntchito brizhalera. Zolemba malire tsiku kuchuluka kwa medicament ndi ukugwira 0,300 mg.

Mankhwala "Onbrez Brizhaler" malangizo Buku silingawafike kuunikanso zofunika mlingo odwala okalamba. Inhalation si kwaana, akutumikira pokhapokha zaka 18.

Ngati nthendayo pamodzi ndi kulephera kwa chiwindi ndi impso ntchito mu mawonekedwe wofatsa kapena zolimbitsa, mlingo kusintha si ikuchitika. Ndi kuyan'anila amphamvu a boma tatchulawa makhalidwe mankhwala mankhwala.

Mankhwala osokoneza bongo "Onbrez Brizhaler" mmene ntchito zochepa zokha kwa inhalation brizhalerom olimba chomwecho. Kapisozi mankhwala si oyenera Pomeza. Ayenera kugwiritsidwa ntchito pa nthawi inayake nthawi tsiku ndi tsiku. Ngati panali yopuma chithandizo, utsogoleli wotsatira ikuchitika zotsatirazi maola ya tsiku.

Aliyense chiphunzitso paketi "Onbrez Brizhaler" anapatsa chipangizo kwa inhalation ya phukusi ndondomeko ndi kupanga makapisozi nkhani ufa. Mankhwalawa amaperekedwa cholankhulira, nsalu yotchinga, chivindikiro, m'munsi ndi batani lancing chipangizo.

Isanafike mpheto ya inhaler chivundikiro atachotsedwa. Kutsegula chipangizo amasunga mbali m'munsi, kenako anapanduka motsogozedwa cholankhulira ndi.

Kuyambira phukusi kutenga kapisozi mmodzi ndi manja youma. Ndiye anaikapo mu inhaler, atakhala m'dera kutchula. Musamakhulupirire mankhwala mu kamwa ya. Kutseka chipangizo ndi pitani ndi kuzimva.

Chotsatira adzakhala kubaya ndi kapisozi. Kuti zimenezi zitheke, pamalo vertically amathera mpukutu pamodzi kamodzi pridavlivaniya mabatani ziwiri kuboola. Mwachibadwa, lomveka phokoso schelchkoobrazny zimene zikusonyeza puncture kapisozi ❖ kuyanika. Ndiye akanikizire batani awiri pa chipangizo inhaler.

chipangizo imatengedwa kukonzekera mpheto ndipo angagwiritsidwe ntchito. Pa chiyambi cha ntchito tisanasankhe kamwa mkamwa mwanu, wodwalayo amapuma kwambiri. Ndiye amaika chubu m'kamwa, kuchitsatira mwamphamvu clenched pakamwa. Brizhaler imodzi chapamwamba nthambi ndi kuchititsa mofulumira, yunifolomu ndiponso inhalation ya mpweya. Musakhudze hardware batani kuti kuboola.

Pogwira mpheto khalidwe anamva rattling, amene analandira mwa onsewo chikumba ndipo kenako kupopera nkhani. Wodwalayo zokoma kukoma pakamwa. Pakalibe kufunika chizindikiro zomvetsera amafuna yosindikiza inhaler kuyesa munthu kapisozi. N'zotheka sachedwa chifukwa pa malo oyamba. Ngati analephera, kapisozi atachotsedwa mothandizidwa ndi n'kudzandigunda kuwala pa m'munsi unit. Sayenera kachiwiri atolankhani mabatani pambali. Pamene angapo kupyoza ya kapisozi iwo unagwa.

Pa inhalation zikhoza khalidwe phokoso, mu chikhalidwe ichi wodwala akugwirizira mpweya wake kwa nthawi zofunika kukoka kamwa wa M'mimbamo m'kamwa. ndiye yekha wotuluka tikamapuma mpweya. Izi ndi kuteteza kutengeka zosasangalatsa. Ndi zoletsedwa nauzira chipangizo chubu.

Kuti muone kupezeka kwa ufa mkati kapisozi m'modzi ayenera kuchotsa chivindikiro ndikuyang'ana inhaler lapansi. Pamene anawona kuti nkhani kapisozi zambiri, kenako kutseka chipangizo ndi kubwereza ndondomeko yonse pamwamba kukonzekera kwa mpheto. kapisozi kwathunthu chitakonzedwa, akusowa mmodzi kapena awiri jekeseni wa mankhwala.

Inhalation kungakhale chifuwa lakuthwa. Chifukwa chikhalidwe ichi ndi kupeza mlingo wodzala medicament. Nthawi zina kugunda pang'ono ufa kuchokera kapisozi mu M'mimbamo m'kamwa. kuyan'anila onse sayenera nkhawa.

Pambuyo inhalation wodwala aziphimba chipangizo kutsegula, izi kukana kamwa kanthu kapisozi chipolopolo kuchotsedwa n'kuutaya. Chitoliro ndiye ayanjane kutseka pakamwa ndi chivindikiro. Musanditaye ndi kapisozi kanthu mkati chida cha, nadzatsuka ndi sapota izo.

Ndi ma CD atsopano sayenera kutsatira inhaler akale. Kusunga chipangizo CD ndi kokha matuza oyenera youma malo.

Pa mankhwala "Onbrez Brizhaler" Buku akuonetsa kusunga malipoti a mwai ntchito kalendala kwa mudapholiwa, omwe umagwiritsidwa pamwamba mumtima wa gululo. Pamene anthu zonse adzakumbukira kuti m'pofunika akugwira inhalation lotsatira.

Kwa mlungu chipangizo kuyeretsa kuwafafaniza padziko kufa akunja wamkati woyera, nsalu youma. Musagwiritse ntchito madzi otsukira. Ziwalo zonse inhaler ayenera kukhala wouma.

Features mankhwala

Mankhwala "Onbrez Brizhaler" malangizo Buku lilibe ayamikira ntchito odwala ndi mphumu. Zimenezi zalongosoledwa ndi kupanda mudziwe kuti adzakhala ndi efficacy ndi chitetezo cha utsogoleli wa anthu amenewa.

Kukhazikitsa akhozanso kukopeka ndi inhalation ya kuchuluka tilinazo. Ngati muli ndi ndondomeko matupi awo sagwirizana kugwirizana ndi kupuma kovuta kapena kumeza kutupa lilime, milomo ndi nkhope mutu, mpweya mu mawonekedwe a urticaria, mankhwala ayenera kuchotsedwa ndi ntchito ina.

Inhalation mankhwala imfayo bronchospasm paradoxical mtundu, onyamula chiopsezo pa moyo wa wodwalayo. Zizindikiro wina mwamsanga chifukwa Kulipira mankhwala ndi kugwiritsa ntchito mankhwala kuthetsa nkhondo.

Mankhwala "Onbrez Brizhaler" wodekha katundu wa matenda, nchifukwa chake si ntchito monga miyeso mwachangu mu magawo oyambirira bronchospasm pachimake. Ngati alili anakula ndi kutsekeka kwa mapapo chifukwa cha inhalation wa mankhwala, ndiye mwanayo boma wodwalayo thanzi ndi njira mankhwala. Idamva pazipita tsiku mlingo imangokhala zosavomerezeka.

Ngati anayamba kuukira aakulu (obstructive ndi mphumu), wodwalayo amafuna hospitalization kofunika kuwatsitsimula. mankhwala tima ayenera kuyamba posachedwapa. Kwa mankhwala njira Epinephrine, corticosteroids, aminophylline.

Mankhwala Mpweya ndi dosing analimbikitsa zambiri subala kanthu chidwi pa dongosolo mtima, zotsatira zake ngati zinthu kuchititsa ayankhe adrenozavisimyh beta2-maselo. Kwambiri mpheto mosamala ayenera kuchitidwa kwa anthu ndi matenda a myocardium ndi magazi zotengera, kuphatikizapo mtundu wa insufficiency inatsekeratu, mtima mungoli penapake, ndi kuthamanga kwa magazi, convulsive khunyu chikhalidwe ndi thyrotoxicosis. Tiyenera kusamala, ndipo pamene sanali ofanana poyankha chikoka cha zinthu zimene zimachititsa yankho beta2-adrenoceptor zinthu.

Mankhwala angathe kuchepetsa kwambiri mlingo wa ayoni potaziyamu mu magazi, potero kupangitsa chitukuko cha njira zoipa mu mtima ndi ziwiya. kuchepetsa izi K ⁺ mu plasma imatengedwa kukhala kanthawi kochepa chabe, sikutanthauza kubwezeretsa. M'njira choopsa cha kutsekeka bronchial ndi hypokalemia akufotokozera kusowa oxygen. hypoxia Chithandizo mwina zikuphatikizapo mtima arrhythmia.

Inhalation utsogoleli wa mankhwala apamwamba mlingo ndi zina kumawonjezera madzi a shuga magazi. Pa nkhani imeneyi, Mpofunika polojekiti mosamala anthu mu madzi ambiri matenda a shuga. Mungadzitetezere ku hyperglycemia sayenera kugwiritsira ntchito mankhwala kawirikawiri ndipo mu mlingo waukulu.

About medicament "Onbrez Brizhaler" Katswiri maganizo chimasonyeza ngakhale mankhwala osauka ndi agonists malo beta2-adrenoceptor ndi kukhudzana yaitali.

Amatanthauza deta chabe kuchitira obstructive kupuma thirakiti dongosolo kusintha mawonekedwe aakulu. Pamene asamadye medicament, monga mtundu bronchial mphumu, pali ngozi yatsoka mosiyanasiyana lovuta limene wodwala ali m'chipatala ndipo anagwira inubatsiyu.

Palibe uthenga womwe matenda, zimene zimaonetsa zimene indacaterol m'kati adanyamula mwana pamaso pa aakulu obstructive m'mapapo mwanga. Kodi polojekitiyi ikhudzire lili pa thupi la munthu sakudziwika. Akazi angathe kuchizidwa ndi mankhwala pamene muyenera kupeza phindu akuyembekezeka thupi la mayi, amene alumphe chiopsezo zotheka kuti mwana osabadwa. Monga ena agonists beta2-adrenergic, mankhwala pansi minofu yosalala mu chiberekero, kumene kumakhudza mphamvu ya ntchito.

Palinso palibe zokhudza kugunda indacaterol kapena metabolites ake mu mkaka anthu. Pali umboni wa kukhudzana ndi mankhwala yogwira, komanso Mpweya wothandizila beta2-adrenergic mu zopangitsa za mammary, imbaenda kufunika kwa chiyembekezo chakuti ya mankhwala "Onbrez Brizhaler" yoyamwitsa.

Mchikakamizo cha mankhwala si kusintha chonde amuna ndi akazi, umboni ndi maphunziro a ziwalo zoberekera.

Mankhwala atha kubweretsa kusintha pa kasamalidwe zoyendera kapena ntchito njira zovuta, monga izo zimayambitsa akulimbana ndi chizungulire komanso chisamaliro mkhutu.

Omwe saloledwa

The medicament "Onbrez Brizhaler" malangizo sizikhudza pamene analangiza cha kuzindikira kwambiri kwa pophika yogwira, lactose kapena zigawo zina zowonjezera.

Inhalation contraindicated kwa ana osaposa zaka 18. Samachititsa odwala matenda akusowa Lapp-lactase, galactosemia, tsankho cholowa kwa lactose ndi galactose mamolekyulu.

Amatanthauza "Onbrez Brizhaler": ndemanga madokotala

Iye chimodzi cha mankhwala zatsopano ntchito zofunika matenda obstructive m'mapapo mwanga mu phapo. Pali umboni wa efficacy ndi chitetezo cha indacaterol. chida ichi m'gulu pulogalamu Golide chikukhudza ayamikira padziko lonse mankhwala a aakulu obstructive m'mapapo mwanga mawonekedwe matenda.

mayesero chipatala anali kuchitidwa nawo indacaterol 10 000 odwala matenda izi. Umapezeka kuti mankhwala yogwira ali chapamwamba kwambiri wa yogwira pa pacifiers ndi bronchodilators zina zamakono chithandizo zikuluzikulu Khobzey.

Pa mankhwala "Onbrez Brizhaler 'ndemanga madokotala amaganiza kuti iwo ultradlitelnom kanthu ndi kudya limodzi tsiku ndi tsiku. mankhwala amapereka mofulumira bronchodilator efficacy pambuyo mphindi zisanu kumapeto kwa mpheto.

Komanso kwa ndalama "Onbrez Brizhaler" mayankho amasonyeza kuchepetsa mlingo wa kuwonongeka kwa ukupeza odwala ndi kutsekeka kwa mapapo. Pa exacerbation kuukira boma amakula mwamsanga, mtima aikidwa mu chipatala, pakhoza kubwera zotsatira woopsa. M'chipatala kumapweteketsa.

Ndi masiku mankhwala Khobzey wothandizila ake yogwira m'mapapo chifukwa inhalation ya inhalation, yomwe ikuchitika chipangizo ya m'manja. Mankhwala amachititsa zosangalatsa a minofu yosalala mu machubu bronchial, lomwe limathandiza kupititsa patsogolo mofulumira. Izi Mwachangu mkulu amachepetsa zizindikiro za matendawo. Kotero inu mukhoza kuchotsa breathlessness patapita masiku 30 kuchokera pa chiyambi cha mpheto. Choncho oyenera kapisozi "Onbrez Brizhaler" maganizo abwino. Ntchito ya mankhwala amalola wodwalayo mwakhama ndi kukhala abwinobwino ndi kukwaniritsa moyo.

maganizo odwala

A njira "Onbrez Brizhaler" umboni wa anthu akuvutika zisaonongeke obstructive m'mapapo mu mawonekedwe aakulu, kutsimikizira mphamvu ya inhalation. Patapita masiku 5 mankhwala, odwala ambiri anaona kuchepetsa kupuma movutikira, ndipo pambuyo njira ya chithandizo cha anthu anayamba kulimbana, pafupifupi mpweya.

Makapisozi akhoza kulimva "Onbrez Brizhaler" ndemanga negative. N'zokhudza maonekedwe a anthu ena odwala zotsatira kukomoka kwambiri mtima. Zikuphatikizapo chinawonjezeka kugunda kwa mtima ndi kuthamanga kwa magazi. Zikatero pamafunika kuchotsa mankhwala ndi wothandizila izi.

analogs

Mutu wa medicament "Onbrez Brizhaler" mlingo bronchodilator mankhwala njira zofunika. Iye ali ndi ntchito bwino poyerekeza ndi mankhwala pamaziko a salmeterol, formoterol ndi tiotropium.

Medicament "Flomax" imatengedwa kuti ndi analogue a mankhwala Swiss. Amakhala tiotropium bromide amene ntchito ngati mbali antiasthmatic. Izo zinabala mu mawonekedwe a makapisozi, zili ufa inhalation pa mlingo wa 0,018 mg. paketi lili ndi ndalama 30 za iwo, kuti amene Ufumuyo ndi inhaler.

Wina njira imeneyi imatengedwa mankhwala "Salmeterol" monga metered aerosol kwa inhalation. mlingo umodzi uli 0,025 mg kapena 0,050 mg wa salmeterol. Zimatanthauza bronchodilator ndi kusankha beta2-Adrenomimeticalkie kanthu.

Kusankha agonist kanthu pa β2-adrenoretseptery mankhwala ndi "formoterol" mu mawonekedwe a ufa inhalation, lomwe mmatumba mu makapisozi. Mankhwala ankachitira bronchial chopingasa matenda obstructive m'mapapo, bronchospasm mu mphumu, ziwengo kuti mpweya wozizira kapena thupi.