Analogue a Plavix.

Mmodzi wa antiplatelet mankhwala amaphatikizidwa ndi mankhwala, "Plavix". Lero komanso nthawi zambiri ntchito mankhwala, monga analogue a Plavix zilt. The zikuchokera mankhwala ikuphatikizapo clopidogrel acid acetylsalicylic. The kanthu chachikulu kukonzekera mankhwala imatsogoleredwa kwa chopinga wa ADP-cholandilira amachititsa loitanirana maselo magazi (mu maselo othandiza magazi kuundana makamaka). A amadziwika lokonzekera ndi kulisiya kumangako wa ADP-zolandilira, imbaenda zotsatira khola pa loitanirana. Chifukwa cha ntchito lilime abwezeretsedwa yekha pa imfa ya okalamba ndi kaphatikizidwe othandiza magazi kuundana latsopano. Amenewa ndi kapangidwe ndi limagwirira cha zochita za analogue a Plavix - zilta.

Clopidogrel (Plavix analogue) ntchito mlingo 75 mamiligalamu. Pa tsiku loyamba la kumwa mankhwala anasonyeza attenuation kwambiri za ntchito kupatsidwa zinthu za m'mwazi loitanirana. Pa ntchito wotsatira wa zotsatira mankhwala ukuwonjezeka. Ola kukonzekera Zolimbikitsa mankhwala ndi avareji ya masiku atatu mpaka seveni. Pambuyo discontinuation mmene mankhwala izo zimawonedwa (mokwanira kusinthidwa mpaka kwambiri za kupatsidwa zinthu za m'mwazi zikuchokera) chifukwa nthawi ina ya masiku awiri.

salicylic amachititsa chopinga wa kupatsidwa zinthu za m'mwazi loitanirana chifukwa sizingasinthe chopinga wa cyclooxygenase (Cox-1). Motero, yafupika thromboxane kaphatikizidwe ndi attenuated vasoconstriction. Monga zinachitikira clopidogrel anachititsa zotsatira anakhalabe pa moyo wa maselo a mwazi (othandiza magazi kuundana).

Chifukwa ntchito ndi analogue a Plavix ndi mankhwala yokha? The ntchito ambiri kuphatikiza antiplatelet mankhwala yilungamitsidwa pa chiopsezo mtima thrombosis wa kulikonse pamaso pa zotupa atherosclerotic.

Pali wina wotchuka kwambiri analogue a Plavix - listab. Komabe, iye, monga ena ambiri (klopilet, lopirel, plargil, detromb, plogrel, Trocken, kardutol) ndipo ankagwiritsa ntchito mchitidwe ano zachipatala.

Plavix kapena zilt?

madokotala ambiri akutsamira kwa ntchito Plavix, kuyambira nchito zake wakhala ayesedwa ndi mayesero osapanganika. Umboni m'munsi mankhwala ali kumbuyo mu 2007 ndipo pa zaka zisanu zapitazi, ntchito yogwira yekha analimbitsa udindo wa "zabwino mankhwala". Koma zilta, dzuwa ake, monga taonera ndi madokotala okha, penapake poyerekeza anati, kotero poyerekeza ndi mnzake zake kulemekeza khalidwe la mankhwala sangatero. Kwenikweni, asayansi amakhulupirira kuti dzuwa otsika iwowa ndi chifukwa kupanda ungwiro wa ndondomeko njira zamakono zotsimikizira mankhwala. Biophysics chomwecho tione zikusiyana mu dongosolo maselo pakati Plavix ndi analogue ake.

Monga mtengo, izo kwambiri wotaya Plavix ziltu. Choncho mtengo wa choyamba katatu phindu lachiwiri. Nthawi zambiri, mtengo wa mankhwala kumabweretsa kufunika kogwiritsa ntchito Anzawo inefficient. Pa malonjezo a madokotala a zipatala zamakono, ngati simungathe kugula Plavix mtengo sayenera kugula mtengo analogue zace - zilt. Kwathunthu kusiya kuvomera mankhwala ali osavomerezeka.

Monga mankhwala monga "Ko Plavix," ndiye amadziwika ndi mlingo kuchuluka kwa gawo la zigawo (100 ndi 75 mg salicylic ndi clopidogrel, motero).

Mwatsoka, kuti tsiku kupanga luso "Plavix" medicament, komanso zigawo zake constituent ndi okwera mtengo kwambiri, imbaenda kukwera mtengo kwa mankhwala. Phindu kuthandiza odwala olemera kubwera analogues wabwino kwambiri mankhwala okhala ndi dzina lodziwika.