Fibrates - ndichiyani? The zikuchokera, ntchito, contraindications

Amadziwika kuti matenda a mtima ali pakati pa pathologies ambiri mu dziko. Pafupifupi munthu aliyense okalamba amadwala matenda oopsa ndipo angina. Anthu ambiri mbiri ya matenda aakulu ponyamula, monga infarction m'mnyewa wamtima ndi ngozi cerebrovascular. Iye panopa ndi mfundo chatsimikiziridwirapo mwasayansi kuti matenda a mtima mwachindunji zokhudzana dyslipidemia. udindo Izi zikutanthauza kusintha zili mafuta ndi mafuta zidulo m'magazi. Kuteteza matenda a zamadzimadzi bwino, odwala ntchito statins ndi fibrates. Gulu la mankhwala zofunika odwala onse amene anali kuonjezera mafuta m'thupi m'magazi, mosasamala kanthu za jenda ndi zaka.

Fibrates - ndichiyani ndi zimene ntchito

Amadziwika kuti mankhwalawa atherosclerosis sizingatheke popanda statins. Iwo Kwalamulidwa kwa odwala onse amene ali ndi chizolowezi kunenepa, matenda a mitima, thrombosis. Kuwonjezera statins, pali gulu lina la kukonzekera - fibrates. limagwirira zochita kusiyana pang'ono. Choncho, mankhwala zotchulidwa ayi onse. Iwo fibric opangidwa kuchokera acid. Limagwirira waukulu kanthu - malangizo a zamadzimadzi kagayidwe mu thupi. Fibrates - ndichiyani ndi nanga chiyani? Pogwiritsa ntchito yokonzekera zimenezi zinasonyeza kuchepetsa kwambiri triglycerides magazi. Limagwirira chachikulu cha zochita za fibrates chakuti iwo yambitsa enzyme - lipoprotein lipase, potero kufulumiza kagayidwe wa mafuta. Ie bwanji njira amuzolengedwa zikuchitika mu thupi. Kuwonjezera pa kuwukonza dyslipidemia, fibrates ndi zotsatira zina. Pakati pawo - polimbana ankafuna kusintha zinthu mopitirira free, odana ndi yotupa ndi zotsatira zimandilimbikitsa. iwo nawonso anticoagulants.

zikuonetsa fibrates

Chifukwa chakuti mankhwala awa ndi zotsatira zambiri zabwino, ali osiyanasiyana chachikulu ofunsira. The chosonyeza chachikulu cholinga chawo kagayidwe kachakudya matenda. chikhalidwe ichi si nthenda palokha, koma amaona yaikulu zinanso chinthu cha chitukuko cha pathologies mtima. I kwa matenda kagayidwe kachakudya:

1. M'mimba kunenepa (m'chiuno kukula kuwonjezeka ndi masentimita 90 ndi apamwamba).
2. Mkulu mafuta mu magazi.
3. Kuchepetsa kuchuluka kwa lipoproteins mkulu osalimba.
4. triglycerides anakwezedwa ndi LDL.

Nthawi zambiri, vuto kagayidwe kachakudya ali pamodzi ndi mtundu 2 matenda a shuga amene amapezeka mu okalamba. mfundozi odana ndi chitukuko cha atherosclerosis, mwachitsanzo kudzikundikira lipids mpanda mtima. Fibrates - icho chiri ndi cholinga zimene kutumikiridwa? Kuwonjezera pa matenda kagayidwe kachakudya, zikuonetsa ntchito ndi: mitundu cholowa cha dyslipidemia, ndi hypertriglyceridemia. Iwo anasonyeza odwala ndi mbiri ya shuga ndi gout.

Kodi zinthu fibrates ali contraindicated

Ngakhale kuti fibrates ndi chiwerengero cha ubwino poyerekeza ndi mankhwala ena kuti mafuta m'thupi (statins) kuchepetsa, iwo akhoza ntchito odwala onse. Kumbukirani kuti mankhwala bwanji kagayidwe, kotero ntchito iwo koletsedwa ena limati. Fibrates ndi contraindications kugwiritsa ntchito zotsatirazi:

1. Mimba ndi kuyamwitsa.
2. chiwindi matenda. contraindication zimenezi chifukwa chakuti gulu la mankhwala bwanji kagayidwe zidulo mafuta. Mu chiwindi matenda enaake ndi mowa gepatoze ntchito thupi kwambiri kusweka. Pachifukwa ichi, fibrates zingachititse odwala ngati zovuta kwambiri, mpaka kulephera chiwindi.
3. Calculous cholecystitis. Chimodzi mwa zotsatira za fibrates ndi kulimbikitsa lithogenicity, ndiko kuti, mapangidwe gallstones.
4. Matenda aimpso kulephera. Fibrates kuwonjezera mlingo wa creatinine m'magazi. Choncho, zingawonjezere aakulu kulephera aimpso.
5. CHENJEZO ayenera mankhwala fibrates odwala okalamba. ntchito yawo ndi osafunika kwa anthu odwala uchidakwa aakulu.

Zotsatira zoyipa za fibrates

Fibrates - ndichiyani ndi zimene ali nazo mavuto? Tikumbukenso kuti, mosiyana ndi mankhwala ena, gulu la mankhwala sikawirikawiri kwambiri amachititsa sayanjana. Iwo akhoza Choncho ntchito odwala ndi mbiri ya ming'oma, chigwagwa, ndi zina zotero. D. Komabe, fibrates ndi chiwerengero cha zotsatira zina zoyipa. Ambiri ndi kunyansidwa ndi kusanza, flatulence, distension m'mimba. Iwo zingakhudze wamanjenje dongosolo. Nthawi zina, chifukwa mutu, kusowa tulo ndi maganizo. Zotsatira zake zoyipa amaonedwa ndi kusintha mu kusanthula amuzolengedwa magazi: kuchuluka creatinine, alt, Ast. Popeza matenda aakulu aimpso ndi chiwindi si woopsawo thanzi ndi wodwalayo.

Kodi mankhwala ndi fibrates gulu?

Pakali pano, pali pafupifupi 10 mitundu ya gulu la mankhwala. Kuti fibrate mankhwala monga: "Clofibrate", "bezafibrate", "Gemfibrozil" ndi "Fenofibrate". Aliyense wa kukonzekera izi chimasiyana mogwirizana ndi chiwerengero mavuto ndi mlingo. Miyala "Clofibrate" akhala kudziwika kwa zaka zambiri ndipo tsopano kawirikawiri ntchito. Ngakhale dzuwa mkulu, kawirikawiri kuyambitsa zotsatira zoyipa monga matenda a thirakiti m'mimba, kupweteka minofu (myositis), adzalandira mkulu lithogenic. Ndi zochepa poizoni mankhwala "bezafibrate". Iye sanali monga mogwira mtima mwamsanga excreted thupi. Miyala "Gemfibrozil" osavomerezeka ntchito chifukwa zotsatira zambiri mbali (koma pasanathe mu ntchito medicament "Clofibrate"). Komanso, chifukwa kufunika ntchito nthawi yaitali mlingo waukulu. amakono kwambiri woimira gulu ili mankhwala "Fenofibrate". Iwo ali Mwachangu mkulu ndi pafupifupi zotsatira palibe mbali. Komanso, Kwalamulidwa kwa odwala ndi gout, chifukwa kumachepetsa mlingo wa asidi uric.

Fibrates: malangizo ntchito mankhwala

kangati ndi zimene Mlingo ntchito mankhwala awa kumatengera mtundu kukonzekera Amasankhidwa dokotala nawo. nthawi zambiri amafunikira kudya kwa mwezi umodzi (kapena zambiri) 2-3 mapiritsi ndi tsiku. The chosonyeza chachikulu - ndi kagayidwe kachakudya matenda. Odwala zimenezi nthawi zotchulidwa fibrates. Kukonzekera ayenera pamodzi ndi kudya zakudya zopatsa nthanzi ndi kutsatira pansi pa ulamuliro wa zamadzimadzi. Miyala "Gemfibrozil" amagwiritsidwa ntchito ngati liwu 1-2 tsiku mphindi 30 musanadye kwa miyezi ingapo. analogues awo ndi mankhwala "Gevilon" ndi "Normolit". Kukonzekera "bezafibrate" zilipo mapiritsi a 200 mg ndipo anatengedwa nthawi 2 pa tsiku kwa mwezi umodzi. Kuphatikizanso ndi analogue - medicament "achigonjetse" okhala 400 mg wa mankhwala yogwira. Mankhwala "Fenofibrate" ali 2 kumasulidwa mitundu: mapiritsi ndi nanoparticles. Iwo kupereka mayamwidwe aluso ndi bioavailability ntchito 1 nthawi patsiku (200 mg) monga miyezi ingapo. analogs ake - mankhwala "Traykor" ndi "Lipantil".

Fibrates: ankachita mankhwala

Musanayambe ntchito mankhwala gulu ili, muyenera kukaonana ndi dokotala wanu ndipo mukumbuke zimene mankhwala ena ntchito. Fibrates sangathe pamodzi ndi wothandizila nephrotoxic ndi hepatotoxic. Makamaka, "Cyclosporin" mankhwala. Ntchito fibrates si zabwino odwala kutenga anticoagulant "Warfarin". Komanso, gulu la mankhwala sayenera pamodzi ndi atumiki dipolipidemicheskimi (statins). Popeza kumachititsa kukhala myositis.

Reviews madokotala ndi odwala pa fibrate

odwala ambiri ntchito fibrates kani, monga taonera kuchepa LDL mafuta m'thupi, triglycerides ndi mafuta. Madokotala amalangiza mankhwala kwa odwala onse ndi matenda kagayidwe kachakudya chifukwa cha dzuwa awo okwezeka ndi yotakata-sipekitiramu. The drawback yekha ndi contraindication kugwiritsa ntchito fibrates omwe amapezeka odwala achikulire.