Mankhwala "Celebrex": ndemanga, analogs, malangizo ntchito, mtengo

Kugonjetsedwa kwa msana, kupweteka kwambiri zimfundo ndi connective ntchito kusintha minofu pa maziko a kutupa - mwatsoka, matenda awa anali ambiri mu nthawi yathu. Pa izi zilili zimakhudza moyo, kusowa kwa ntchito bwinobwino thupi, majini. Kuwonjezera ululu umene anthu amavutika mu chikhalidwe ichi, matenda likhoza kuwononga lonse chamoyo, bongo umagwirira magazi ndi zokhudza kugwira ntchito za masiku onse ziwalo.

Choncho n'kofunika kuti aziona thanzi ndi nthawi kuchiza matenda. Mmodzi wa mankhwala zothandiza kwambiri m'dziko la gulu la mankhwala si steroidal otchedwa medicament "Celebrex". Reviews madokotala kutsimikizira nchito zake poyerekeza ndi amodzi mankhwala odana ndi yotupa.

Zotsatira waukulu wa mankhwala

Ubwino wa mankhwala angatchedwe mphamvu yake ziletsa yotupa ndondomeko ntchito pamisinkhu yosiyanasiyana matenda. Kamodzi magazi, mankhwala akhoza ziletsa TSOG2 ndondomeko yomwe imatsogolera ku mpumulo kutupa. "Celebrex" The mankhwala ali wamphamvu analgesic katundu antipyretic ntchito. Choncho, osati kumatha kutupa foci, komanso mwangwiro amachotsa ngakhale kupweteka kwambiri, kumachepetsa kutentha kwa thupi.

Ubwino wa mankhwala monga zotsatira zake kochepa pa maselo othandiza magazi kuundana, ndicho, mankhwala sayambitsa mavuto ndi clotting magazi. Mukalandira sanali steroidal wothandizila kuti palibe mkwiyo wa m'mimba ndipo matumbo, yafupika chiopsezo zilonda ndi odwala gastritis.

Choncho "Celebrex" mankhwala ntchito zambiri ambiri kuposa mankhwala ena NSAID, "naproxen", "Aspirin", "ibuprofen".

mbali

"Celebrex" makapisozi angathe kuchepetsa zovuta molumikizana mafupa, stiffness kuthetsa kulimbana ndi kutupa kwambiri. Chotero kukhudzana n'zotheka kuchiza odwala matenda ndi nyamakazi, nyamakazi. Mmene mankhwala umalandira zotsatira pazipita anali maola 24-48 pambuyo mlingo woyamba. Dysmenorrhea mankhwala bwino kumatha ululu, ngakhale kwambiri pachimake. Komanso, ndi bwino ntchito thandizo la ululu pambuyo opaleshoni (maxillo-nkhope ndi maopaleshoni amafupa).

Odwala ankylosing spondylitis mankhwala "Celebrex" amapewa njira pathological ndi bwino kuti thupi bwinobwino. Pamene kuona mphamvu m'mabanja adenomatous polyposis ntchito mankhwala zinachititsa kuti kuchepetsa kwambiri kukula kwa tizilombo ting'onoting'ono mu m'matumbo ndi duodenum: kuchepetsa chiwerengero chawo ndi kukula. Madokotala amati Mlingo chokwanira cha mankhwala ndi kutsatira regimens chithandizo akhoza kukwaniritsa zotsatira zabwino za kugwiritsa ntchito "Celebrex" mankhwala. Umboni kusonyeza zotsatira kochepa mbali pamene akumwabe mankhwala.

The mawonekedwe ndi zikuchokera mankhwala

Kwambiri kusankha woletsa ndi gelatin kapisozi pafupifupi woyera kapena woyera, si chimaonekera ndipo amalembedwa ndi n'kupanga buluu olembedwa kuti: "7767" mbali imodzi ndi "100" ndi "200" pa ena. Kapisozi zili: granulated woyera ochekenera.

The zikuchokera mankhwala monga: celecoxib (zikuluzikulu yogwira pophika), lactose, povidone K30, ndi sodium lauryl sulphate ndi mankhwala enaake a stearate, sodium croscarmellose. chipolopolo wopangidwa titaniyamu dioxide, ndi edible gelatin. Ngati makonzedwe yoyenera mankhwala jekeseni intramuscularly amaikidwa "Celebrex". mtundu wa mankhwala amachoka mu mawonekedwe a njira jekeseni wa 2.2 ml ya ampoules - zofunika mankhwala celecoxib.

Pharmacokinetics

Mankhwala bwino odzipereka mu magazi boma kusala kudya ndi kufika ntchito pazipita pambuyo pa 2-3 maola. Koma ntchito njira pamodzi ndi mafuta chakudya mwina sachedwa kudzikundikira ake kwa maola 1-2. Choncho m'pofunika dokotala nthawi ya kumwa mankhwala.

Kamodzi m'magazi, zinthu samagwiritsa kumumanga ndi maselo ofiira, koma limagwirira si bwanji kukwaniritsa ndende Napempha kwa mankhwala mu thupi. Mankhwala zimapukusidwa mu chiwindi ndi makutidwe ndi okosijeni ndipo glucuronidation yokhudza CYP2C9 enzyme. Linanena bungwe zikutanthauza ndi mkodzo ndi ndowe mu mawonekedwe a metabolites losavuta, ndi 3 yekha% ya mankhwala yogwira amakhalabe sichinasinthe.

Mankhwala "Celebrex", analogues amene ofanana mu zikuchokera, anapeza njira, kuchititsa kuwonongeka kwenikweni thanzi, chifukwa umatha kukhala odzipereka ngati kuli kotheka ndi pafupifupi kwathunthu inathetsedwa ndi thupi. Ndi kulemera otsika thupi anati ndende apamwamba mankhwala magazi, ndipo zodabwitsazi zimawonedwa kuposa akazi. Sizikudziwika chake, komanso anthu akuda anaona mphamvu yomweyo. Choncho, magulu awa odwala Kwalamulidwa mlingo m'munsi mankhwala pa chiyambi cha mankhwala.

zikuonetsa

Monga sanali steroidal odana ndi yotupa wothandizila kwa mankhwala symptomatic mankhwala zotchulidwa "Celebrex". Zikuonetsa ntchito:

• nyamakazi;
• nyamakazi;
• spondylitis;
• algomenorrhea;
• ululu waukulu (pambuyo ntchito nthawi, kupweteka kwa msana, matenda a minofu ndi mafupa);
• ntchito mankhwala a polyposis adenamotoznogo.

Tikumbukenso kuti chithandizo chokwanira zitha perekani dokotala pamaziko a kafukufuku.

Njira ka mankhwala

Kutenga mankhwala ayenera kukhala mkati, kaya chakudya. mapiritsi Chewable sayenera, muyenera kumwa madzi opanda. Tikumbukenso kuti mavuto mtima angayambe ndi makonzedwe aakulu a mankhwala. Choncho, madokotala mankhwala "Celebrex" kanthawi Inde mankhwala. Akatswiri alendo zimatsimikizira kuti mlingo pazipita mankhwala yaitali sayenera upambana 400 mg pa tsiku!

• Mankhwala a nyamakazi - chokwanira mlingo ndi 200 mg pa tsiku. Chance a mlingo umodzi kapena kugawanika pawiri (fupipafupi).
• Nyamakazi - ankayembekezera mlingo wa 100 kapena 200 mg nthawi 2 pa tsiku. Pamene mitundu ovuta kwambiri - mpaka 400 mg kawiri pa tsiku.
• Ankylosing spondylitis - 200 mg pa tsiku, 1 kapena 2 Mlingo wogawanika. Nzeru ya adokotala mlingo akhoza ziwonjezeke kwa mokwanira m'chitetezo
• Dysmenorrhea ndi ululu amphamvu - ayamba mankhwala ndi 400 mg pa tsiku ndipo anawonjezera wina mg wa 200 pa tsiku loyamba la mankhwala ngati ndi kotheka. Mu masiku awa, utenge 200 mg kawiri pa tsiku.

Nthawi chithandizo anatsimikiza ndi dokotala nawo.

Contraindications ntchito mankhwala

Kuwonjezera zotheka thupi lawo siligwirizana ndi m'nyanjazi mankhwala, pali zoletsa umene akuletsedwa ntchito mankhwala "Celebrex":

1. Bronchial mphumu, urticaria, matupi awo sagwirizana ndi NSAIDs ena.
2. The postoperative nthawi pambuyo kulambalala aortkoronarnogo.
3. Chironda chachikulu (exacerbation).
4. GI magazi.
5. Yotupa matumbo matenda.
6. Mtima kulephera.
7. Aakulu kwa chiwindi insufficiency.
8. Aimpso insufficiency.
9. Mimba ndi mkaka wa m'mawere.
10. Osavomerezeka ntchito pa 18.
11. Hypersensitivity kwa m'nyanjazi cha mankhwala ndi sulfonamides.

CHENJEZO ayenera kugwiritsa ntchito mankhwala ndi posungira madzimadzi thupi, matenda a dongosolo mtima, shuga.

zotsatira zoyipazi

Ngakhale potency mkulu wa mankhwala, yaitali kapena pachithunzichi phwando mode ndi mlingo akhoza kukhala zotsatira zoyipa za mankhwala "Celebrex". Umboni kusonyeza ambiri (kawirikawiri) zizindikiro monga:

• thupi lawo siligwirizana kuphatikizapo totupa, urticaria, pruritus.
• Flatulence, dyspepsia, edema, kusowa tulo.
• Chifuwa, rhinitis, fuluwenza, ngati zingachitike ndipo matenda thirakiti kupuma.
• Mkodzo thirakiti matenda.

Kuli pali kuchuluka nkhawa, kuchepa magazi, tinnitus, amatuluka, arrhythmia, wolumikizira oopsa. Odwala ena analembedwa ulceration pa mundawo m'mimba, angionevropatichesky edema, mapangidwe zidindo zadothi pa khungu, exacerbation wa kapamba kapena chitukuko, chisokonezo. Zizindikiro zonsezi zikhoza kudzachitika pokhapo pamene njira ya mankhwala mwachidule (kwa masabata 12, osati choposa 800 mg wa pa mlingo). Koma pa nkhani ya mankhwala yaitali (zaka 3) ali anati:

• Common: kukhumudwa mpando, matenda oopsa, matenda a makutu, angina, m'mnyewa wamtima infarction, nseru, dysphagia, prostatitis, kuchuluka creatinine.
• More osowa: arrhythmia, angina, ischemic sitiroko, atherosclerosis, kugona chisokonezo magazi ukazi, zilonda m'kamwa, dysmenorrhea, kuwonjezeka hemoglobin, kuchepa hematocrit.

Mogwirizana kwa mankhwala ndi mankhwala ena

The medicament mwachangu biotransformed yokhudza P450 2C9 (cytochrome). Choncho n'zotheka mogwirizana mwachindunji mankhwala ndi atumiki:

1. Concomitant kugwiritsa ntchito mankhwala "Warfarin" kumaonjezera ngozi ya magazi ake amapha.
2. Kukonzekera "Ketanazol" ndi "Fluconazole" kuonjezera ambiri yogwira chinthu celecoxib kuwirikiza kawiri.
3. Kulandira blockers kapena Ace zoletsa NSAIDs angiotenzita akhoza kuchepetsa mmene antigipertinzivny
4. Kuphatikiza mankhwala okhala lifiyamu, zikhoza kwambiri pa mlingo magazi.
5. Ndi zoletsedwa ndi imodzi ntchito mankhwala "Celebrex" analogs munali celecoxib, NSAIDs ena!

analogues mankhwala

Dziwani kuti "Celebrex" mtengo mankhwala si kwambiri, mtengo wake ndi pafupifupi kwa rubles 400 450. 10 makapisozi (100 mg mlingo). Komabe, mankhwala amenewa ndi okwera mtengo kwambiri kwa mankhwala wodwala yaitali. Pankhaniyi, chilolezo cha dokotala, kusankha nthumwi munali celecoxib. Mankhwala "Celebrex" analogues wa zotsatirazi:

• mankhwala "Ranselak";
• mankhwala "Revmoksib";
• miyala "Flogoksib";
• kapisozi "Artoksib".

analogs amenewa ali yemweyo yogwira mankhwala ndi kukhala zayamba zofanana achire zotsatira mu zochizira matenda. Onani kuti mlingo wokwana wa analogue ndi waperekedwanso yekha ndi dokotala nawo. Pankhaniyi dokotala amaziona zothandizira osiyana zikuchokera mu analogs, iwo ali zina zosiyanasiyana poyerekeza mankhwala "Celebrex". Malangizo amakambirana madokotala amati n'zotheka ndi matupi awo sagwirizana anachita ndi wodwalayo kwa excipients mankhwala osiyana gulu limodzi.