Medicine 'MabThera. Malangizo ntchito

Gulu la mankhwala anticancer monga mankhwala "MabThera". Kufotokozera medicament zikusonyeza mphamvu yake mwachindunji kumumanga kuti transmembrane Antigen analipo 95% ya lymphomas sanali Hodgkin, mtundu B-selo. Yogwira chigawo chimodzi - rituximab.

Medicine "MabThera". Malangizo: umboni

Mankhwala analamula kuti lymphoma B-selo sanali Hodgkin akuti:

- himioustoychivoy kapena kobwereza, CD20 HIV ndi otsika kalasi kapena follicular;

- follicular wachitatu kapena wachinayi gawo limodzi ndi mankhwala amphamvu odwala kale poyera chithandizo;

- pambuyo yankho follicular mankhwala kupatsidwa ulemu monga thandizo njira;

- CD20 HIV B-yaikulu osakaniza ndi kuwaza mankhwala amphamvu chiwembu.

Amatanthauza "MabThera" Buku akulimbikitsidwa aakulu lymphocytic khansa :

- osakaniza ndi mankhwala amphamvu odwala amene alibe zagonjetsedwa kwa chithandizo muyezo;

- kobwereza kapena himioustoychivom limodzi ndi mankhwala amphamvu.

Medicament wasonyeza akulu ndi thupi lithe a nyamakazi osakaniza medicament ndi "MTX" sangakwanitse ntchito mayankho hypersensitive kapena regimens achire.

contraindications

Amatanthauza "MabThera" malangizo osavomerezeka ngati muli hypersensitive.

Muyenera kusamala kupereka mankhwala odwala arrhythmia, angina, congestive kulephera mtima, mkulu kapena otsika magazi, thrombocytopenia, neutropenia, COPD (chifukwa Mwina zosayembekezereka wa bronchospasm).

zotsatira zoyipazi

Kugwiritsa ntchito mankhwala "MabThera" Angathe kuyambitsa nseru, kupweteka m'mimba, kusanza. Mawonetseredwe zoipa mulinso orthostatic hypotension, arrhythmia, tachycardia, bradycardia, kuwonongeka kwa ntchito aimpso, edema zotumphukira, kupweteka pa chifuwa ndi lumbosacral msana m'deralo. Mankhwala "MabThera" zingachititse zotumphukira neuropathy, neuritis, kugona kapena kugona, mukubwadamuka kapena maganizo, nkhawa, kufooka, chizungulire, kupweteka mutu. zochitika chokhwima kuti umenewu ndi matupi awo sagwirizana anachita. The kukwiya ntchito mankhwala "MabThera" malangizo ndi rhinitis, pharyngeal edema kapena lilime, kufupika kwa mpweya, bronchospasm, khungu kuyabwa, kulemera otsika thupi, matenda a kukoma, kenaka utentha mamba, kuzizira, kutentha thupi, kupweteka kwa malo khosi ndi pa malo a chotupa kutanthauzira, chitukuko cha herpetic matenda.

mlingo

mankhwala ndi kutumikiridwa ndi wosakwiya mtsempha kulowetsedwa. Pamene monotherapy ntchito kamodzi pa sabata pa 375 mg pa masabata anayi. Mlingo woyambilira wa utsogoleli woyamba wa 50mg / h. Kuwonjezeka kwa pazipita (400 mg / h) ayenera pang'onopang'ono mlingo.

Kusamala

Makumi atatu ndi mphindi makumi asanu isanafike makonzedwe analimbikitsa premedication (yokonza) ndi analgesics ndi mankhwala a antihistamine.

Pa mankhwala, ndipo m'miyezi khumi pambuyo akamaliza akazi a msinkhu wobereka ayenera kugwiritsa ntchito njira zolera odalirika.

mankhwala Antihypertensive ayenera anasiya maola osachepera khumi pamaso utsogoleli wa mankhwala "MabThera".

Osati anakhazikitsa efficacy ndi chitetezo cha mankhwala ana.

Pa yokonza "MabThera" anati kwa akatswiri ambiri positive. Komanso, mu njira ya zofufuza, chinapezeka kuti kapoloyu atangochimwa mankhwala monga monotherapy ndi, komanso kugwiritsa ntchito wotsatira monga thandizo zikutanthauza zaka ziwiri Sachita Mwina akuchuluka wa lymphoma follicular.