Medicine 'Methotrexate. malangizo

Medicine "Methotrexate" malangizo ntchito kwa odana metabolites gulu, pyrimidine analogs. Mau ofanana: "Zeksat", "Treksan", "Triksilem" ndi ena.

Amatanthauza "Methotrexate" (mapiritsi) amaloledwa kukhala kugwira ntchito monga nthumwi imodzi kapena mbali ya mankhwala amphamvu zovuta.

Mwa zizindikiro ndi monga khansa myeloblastic ndi lymphoblastic, myelogenous khansa aakulu otaya mu siteji ina, lymphosarcoma. Monga mbali ya mankhwala Integrated himiolecheniya "Methotrexate" mtsogoleri akuonetsa yamchiberekero khansa, m'mapapo, m'mawere.

Pa mlingo waukulu (pamene kulandira filinata kashiamu) mankhwala analamula kuti osteogenic sarcoma, chotupa Ewing a, choriocarcinoma uterine sarcoma minofu zofewa.

Chiphunzitso (jekeseni) ntchito matenda a zotupa psoriatic.

Amatanthauza "MTX" mu dongosolo mankhwala (wosuta lili mfundo zimenezi) pafupi kupatsidwa folic acid pa izi zimakhala zosemphana. Monga antagonist antimetabolite ndi kupereka zotsatira antifolievym, mankhwala kubweza selo magawano, chitukuko mwachangu proliferating zimakhala, mafupa komanso. The medicament "MTX" kumathandiza kuti liwiro kukula kwa neoplasms zilonda.

Mankhwalawa Kwalamulidwa mkati.

Mankhwalawa zovuta za mankhwala "Methotrexate" Buku akuonetsa wamkulu magalamu 0,03 kawiri pa mlungu. Ana mlingo patsiku - magalamu 0,02 pa centimeter lalikulu la m'dera thupi pamwamba.

Nthawi chithandizo - mpaka masabata awiri.

Tima Inde kumafuna woika ndi mlingo wamkulu 0,02-0,025 magalamu tsiku. Nthawi chithandizo - masiku asanu.

Mu mpikisanowo kumwa mankhwala "Methotrexate" Buku akuonetsa kuti kutenga yopuma mlungu umodzi kapena iwiri.

Mankhwala contraindicated limati immunodeficient, chiwindi matenda, thrombocytopenia, leukopenia, magazi m'thupi (kuphatikizapo aplastic ndi apoplastic) hypersensitivity.

Osati deta zokwanira kuchititsa maphunziro achire mankhwala "Methotrexate" mimba ndi lactating. Mogwirizana ndi mankhwala mu nthawi antenatal ndi pa mkaka wa m'mawere si anapatsidwa.

Kumeneko mankhwala "Methotrexate" mavuto. Mankhwala zingachititse gagging, nseru, m'mimba, kutupa mu mucosa m'kamwa (stomatitis). ntchito yaitali mankhwala "MTX" yodziwika chotupa ndi magazi mu mucosa m'kamwa khalidwe anam'peza, yafupika kupatsidwa zinthu za m'mwazi udindo, tsitsi imfa, utachepa hemoglobin zili m'magazi. Nthawi zina matenda sekondale zingaoneke, zikuoneka kuti chifukwa chiwindi poizoni (amangoona pamene ntchito mlingo waukulu), zotupa aimpso.

Pofuna kupewa chitukuko cha zotsatira oipa njira achire izo ikuchitika kuyang'aniridwa okhwima dokotala.

Pankhaniyi cha mankhwala osokoneza bongo si lokhazikika mawonetseredwe yeniyeni. Kupeza Vuto chikhalidwe ikuchitika ndi nkhani za mankhwala "Methotrexate" plasma.

Kusamala

chida si ntchito pleural effusion, ascites, zilonda, anam'peza matenda a m'matumbo, matenda a impso kapena gout.

Musawachite mankhwala varicella (kuphatikizapo posachedwapa anasamutsa kapena pambuyo kukhudzana ndi kachilombo), nsungu zoster ndi matenda ena pachimake chiyambi opatsirana.

Pachiyambi ndipo m'kupita kwa mankhwala n'kofunika kulamulira zotumphukira magazi chithunzi, chiwindi ndi ntchito impso.

Mu ntchito mankhwala psoriasis kapena nyamakazi, zonse magazi pa kamodzi pamwezi.

Pa kafukufuku chinapezeka zotsatira mutagenic ndi carcinogenic mankhwala "Methotrexate".