"Pyrazinamide wokhala" Mapale ndi bactericidal kapena zotsatira bacteriostatic wa odana malingana ndende. ntchito mankhwala anakhalabe yekha m'mikhalidwe acidic (pa pH wa 5.6 ndi pansi). pa nthaka mankhwala zotheka chitukuko cha kukana, omwe amachepetsa imabwera ntchito mankhwala ndi atumiki antitubercular. Kukonzekera "pyrazinamide wokhala" (malangizo Buku akutitsimikizira nkhani imeneyi) ndi zothandiza kwambiri ngati chifuwa chachikulu zowononga monga anapeza kwa nthawi yoyamba, njira caseous-chibayo mtundu tuberkulomah, caseous lymphadenitis. Mankhwala Sachita ndalama zoyendera urate acid uric, hyperglycemia zingachititse. Mankhwala kwa mundawo m'mimba pafupifupi mwathunthu ndi mofulumira odzipereka. Madzi a m'magazi mapuloteni kumumanga medicament 10-20%. Pambuyo ola limodzi kapena awiri pali ndende pazipita ndalama. Mankhwala bwino anagawira pa madzi m'thupi ndipo zimakhala, adzakwapulidwa waikamo mwa ziwalo, kuphatikizapo mapapo, chiwindi, impso ndi mbali ya zotupa encapsulated tuberculous. Njira apatsira BBB. Kagayidwe amapezeka m'chiwindi.
umboni
Medicament "pyrazinamide wokhala" (mayankho a akatswiri kutsimikizira izo) ndi chisankho choyamba pa matenda a chifuwachi.
dosing kamwedwe
Anapeza kuti monotherapy si ogwira zokwanira. Mogwirizana ndi izi Buku mankhwala "pyrazinamide wokhala" malangizo akuonetsa ntchito limodzi ndi mankhwala ena ndi TB yogwira. Kwa achikulire, mlingo wake ndi 30-35 mg / kg pa tsiku lililonse. Kwa odwala yolemera makilogalamu zosakwana makumi asanu, mlingo wake ndi miyala atatu (1.5 g). Pamene misa ndi zoposa makilogalamu 50 ayenera kumwa mapiritsi 4. (2 g). Ana pazipita mlingo - 2 gm. Mankhwala akutengedwa ndi chakudya. Ndi bwino kumwa mankhwala pa kadzutsa.
"Pyrazinamide wokhala" njira. Malangizo ntchito. Kusamala
Mankhwala ambiri osokoneza zoletsedwa ndi malamulo dokotala amayambitsa. Mukalandira wambirimbiri mankhwala anaona mavuto a chapakati mantha dongosolo - chizungulire, mutu ndi ena. zolemba matenda mu chiwindi, mwina dyspepsia. Ngati poyizoni wasonyeza mankhwala symptomatic. Mpaka pa TB mankhwala odwala zaka 60 ikuchitika polojekiti mwezi zizindikiro za bilirubin, Ast, asidi uric ndi alt. Matenda a chiwindi pamafunika kuchotsa mankhwala. Mu odwala matenda a shuga zambiri angayambe hypoglycemia. Pamene pamodzi ndi mankhwala kumwa mankhwala "Rifampicin" zingaoneke hepatotoxicity. Pamene Integrated ndi ntchito yokonza "Probenecid" mwina ndichepe excretion ndi chifukwa, kuchuluka kawopsedwe. Pangakhale mtanda tilinazo ndi mankhwala "INH", "Ethionamide" asidi nicotinic ndi njira zina kukhala ofanana dongosolo mankhwala. "Pyrazinamide wokhala" mankhwala (malangizo ntchito mfundo imeneyi) yosayenera zaka zisanu. The zikuchokera amasungidwa ma CD womata, mu malo otetezedwa ku kuwala.