"VFS": malangizo ntchito. Analogs, ndemanga ndi contraindications "VFS"

"VFS" Mapale ali woyamba kalasi gulu la wothandizira antiarrhythmic. mankhwala A angathe kutchinga njira ndi sodium mu nembanemba wa cardiomyocytes. Iwo amakwiya liwiro intraventricular ndi atrioventricular conduction shortens zinchito ndi ogwira nyengo refractory mu atria pa, mtolo chipika nthambi, AV-mfundo ndi Purkinje ulusi. Zikutanthauza mwamtheradi zopanda phindu pa nthawi ya QT-imeneyi, pafupipafupi contractions. Popeza mawonetseredwe koyamba ntchito osakwanira mtima, mankhwala "VFS" (malangizo Buku lili mfundo zimenezi) alibe mphamvu pa contractility m'mnyewa wamtima. Zilibe bwanji madutsidwe wa atrioventricular mfundo anterograde malangizo. Mtumiki alibe chowawa hypotensive kwenikweni. Zochita si amalembedwa chikoka inotropic. Pamene kulandira mankhwala si imathetsa mu automaticity nkusani mfundo. Iwo ali antispasmodic, mankhwala ochititsa m'deralo, ndi zolimbitsa anticholinergic kanthu opanda matenda digiri tanthauzo. Iwo ali koronarorasshiryayuschee pang'ono, katundu sedative. Zotsatira za m'kamwa chizindikiro makumi anai kapena maminiti makumi asanu. Akafika ntchito pazipita pambuyo Mphindi 80. Kutalika kanthu achire - by maola 8.

Pharmacokinetics milandu onse

The bioavailability pafupifupi 40%. The mankhwala ndi zimapukusidwa mu chiwindi ndipo amatha umalowa mu BBB. Excretion mankhwala kumachitika mu mkodzo. Pamene kuyan'anila za ntchito aimpso nthawi excretion ndi chinawonjezeka ndi 2-3.

Kodi limatanthauza "VFS" zikuonetsa ntchito?

mankhwala akusonyeza kuti yamitsempha yamagazi ndi extrasystoles supraventricular, paroxysmal tachycardia ndi mtundu (palibe zotupa mu mtima zachilengedwe ndi organic ndi matenda WPW), matenda flutter ndi paroxysms matenda.

dosing kamwedwe

Kukonzekera "VFS" malangizo Buku akuonetsa mlingo - 25 mg 1 nthawi pa maola 8. Popeza lofotokoza achire zotsatira medicament anatengedwa mawola 6 aliwonse. Nthawi zina analola kuti adzauka mlingo kawiri limodzi (50 mg). Nthawi imeneyi mu nkhani iyi ndi maola 6-8.

Tsiku lololedwa zosaposa 300 mg. Kutalika kwa mankhwala ndi kufunika kudzudzulidwa dera kulandira akonzedwa katswiri. kumwa mankhwala pambuyo chakudya. Udzam'pereratu kapena kumuononga chida sikuloledwa.

Medicament "VFS": mavuto

Phunziro kwa dokotala mankhwala mankhwala analekerera ndi odwala a mibadwo yonse ndi zabwino mokwanira. Komabe, pali kuthekera kwa mavuto pa maziko a mankhwala "VFS". Zotsatira zake zoyipa Choncho ndi osiyana a mwamphamvu. Nthumwi kungakhale chisokonezo ntchito ya zotumphukira ndi pakati machitidwe mantha. Makamaka, pali chizungulire, diplopia, ataxia. Mwa zotsatira zoipa zotsatira za mankhwala pa akatswiri a mtima dongosolo onani kuyan'anila mwina intraventricular ndi atrioventricular conduction, chitukuko cha kutsekeka tachycardia (ndi mankhwala yaitali). mawonetseredwe Kulanga monga zotsatira arrhythmogenic, kutalikitsa QP n'kulolera yowonjezera kusintha QRS-zovuta zina mwa chitsanzo ECG. Pamaziko a mankhwala "VFS" (malangizo Buku akuchenjeza za izo) Zikuoneka redness a khungu, kupweteka mutu kapena kumverera za kulemera. Odwala ena kuona sayanjana (zidzolo kapena khungu likuyabwa). Lili zokhudza mavuto mankhwala "VFS" malangizo Buku. akatswiri Reviews za njira portability, ambiri, positive. Komabe, anapatsidwa kuopsa kwa zina mwa zotsatira zoipa za mankhwala ikuchitika kuyang'aniridwa pafupi ndi dokotala.
Mu chochitika cha matenda oyamba ndi kuwonongeka ayenera yomweyo kukaona katswiri. Pankhaniyi, adokotala akhoza kusankha m'malo amatanthauza "VFS" mankhwala ofanana.

Pamene sanagaŵiridwe mankhwala?

Contraindications monga cardiogenic mantha, atrioventricular njerwa mu gawo lachitatu ndi wachiwiri (pakalibe mungoli yokumba mtima galimoto). Iwo saloledwa kumwa yothetsera matenda oopsa mu nthawi zovuta (systolic kuthamanga zosakwana 90 mamilimita / Hg.), Hypertrophy mu myocardium wa ventricle kumanzere kulitchula. mankhwala yoletsedwa ku positi-infarction cardiosclerosis. mankhwala ali osavomerezeka kwa anatseka misewu ya ufulu mwendo chipika mtolo nthambi (pamene pamodzi ndi matenda ku nthambi ya kumanzere), aakulu mtima kulephera ntchito lochepa kwambiri. Contraindicated mankhwala zaka 18 (chifukwa chakuti si wokhazikitsidwa chitetezo ndi efficacy wa wothandizila), fructose tsankho. Iwo saloledwa kutenga mankhwala kwa anthu ndi matenda a mkhutu resorption galactose / shuga, mimba, isomaltase kuchepekedwa / sucrose. Osavomerezeka mankhwala kwa hypersensitivity kwa zigawo zikuluzikulu. Ngati mukufuna kucheza ndi mankhwala unamwino kwa wodwalayo, mukufuna kusiya mkaka wa m'mawere.

Pamene muyenera kusintha mlingo?

Nthawi zina pali kusintha zipangizo "VFS" kulandira dera. Malangizo, ndemanga akatswiri zili ndi mfundo zimene kuchepetsa mankhwala kapena kuonjezera imeneyi pakati pa mlingo akhoza wodwala ndi chipika atrioventricular mu mlingo woyamba, matenda intraventricular conduction, bradycardia. Chenjezo kutsatira njingayo-kutsekedwa khungu, matenda magazi (zotumphukira) lolemera chikhalidwe hypertrophy prostate zimakhala. Kudzudzulidwa madera zofunika pa maziko a kagayidwe electrolyte amasintha madutsidwe mu Purkinje ulusi, anatseka misewu ya m'modzi wa miyendo mu chipika mtolo nthambi. Tiyenera kusamala pamene kulandira mankhwala ena antiritmicheskih imodzi ndi mankhwala "VFS". Reviews a akatswiri ambiri sankafuna kusintha kwambiri pa nkhani ya kusintha mlingo ndi zopanda phindu.

Kuti mudziwe zambiri,

Asanayambe chithandizocho kumatha matenda a madzi ndi bwino electrolyte mu ndondomeko ya kulandira mankhwala pofuna zonse ndi mosamala amailamulira. mtima kukondoweza pakhomo achuluke odwala amene anali kudwala mtima (pachimake), matenda a mtima, kapena ndi pacemaker yokumba. Mu chochitika cha chizungulire, masomphenya awiri, mutu analimbikitsa kuchepetsa mlingo. Pamene nkusani tachycardia pamaziko a yaitali phwando mankhwala beta-blockers amapatsidwa akamavutika. Kukonzekera izi analimbikitsa pa mlingo wochepa. Pamaziko a mankhwala ayenera kusamala pamene ntchito zinthu zingakhale woopsawo kuti zikuyenela chidwi ndi ndende mofulumira kapena anachita.

ambiri osokoneza

Chifukwa chakuti mankhwala ali ndi kupingasa otsika ntchito achire, kuledzera aakulu angayambe mosavuta zokwanira. chiopsezo makamaka mkulu wa poyizoni pa chiphaso cha mankhwala ena antiarrhythmic. Mu ambiri osokoneza amalembedwa elongation PR- ndi QT-intervals, amplitudes kuonjezera T-yoweyula kuwonjezeka QRS-zovuta. Against maziko a kuledzera ukapezeka asystole, bradycardia, utachepa contractility mu myocardium lapansi. The wodwala anatinso sinotrialnaya anatseka misewu, kuchepetsa kuthamanga chitaperekedwa matenda m'mimba dongosolo. Kuledzela limodzi ndi paroxysmal polymorphic tachycardia yamitsempha yamagazi, kusawona bwino, chizungulire, kupweteka mutu. Mu chochitika cha ambiri osokoneza mankhwala symptomatic kukuonetsedwa. Chithandizo cha tachycardia yamitsempha yamagazi ikuchitika ntchito antiarrhythmic mankhwala gulu I A ndipo ine C Kukula QRS-zovuta, hypotension ndi bradycardia inathetsedwa carbonate ndi sodium wa hydrogen.

Mogwirizana ndi medicaments ena

Pamene anatengedwa pamodzi ndi inducers wa microsomal kwa chiwindi michere efficacy mankhwala "VFS" amachepetsa. Izi kumaonjezera ngozi ya zotsatira poizoni. Pamene kulandira mankhwala antiarrhythmic magulu ena kuchuluka imabwera osauka chikoka arrhythmogenic. Chida komanso timapitiriza ntchito za si depolarizing relaxants minofu.

Muli ndi mankhwala ogwira ndi njira zofanana wa zomwe muzachita?

Amatanthauza "Allaritmin" muli yemweyo yogwira mankhwala monga mankhwala "VFS" - lappaconitine hydrobromide. The medicament amatanthauza kalasi Ine mankhwala antiarrhythmic. "Allaritmin" Mankhwalawa ndi alembedwe chathabwa ndipo monga njira jekeseni mu mnofu kapena mtsempha. Pamene anatengedwa pakamwa, zotsatira medicament amapezeka pafupifupi ola. Patapita maola 4-5, kufika Mwachangu pazipita. Nthawi zotsatira - maola 8 kapena kuposa. Mawu oyamba opanda mankhwala kumachitika mofulumira - mkati mphindi 15-20. Mosiyana medicament "VFS" amatanthauza "Allaritmin" tikulimbikitsidwa kumwa 3 zina tsiku 25 mg. Makhwalawa akhale asanadye. Mapiritsi zofunika kugona tulo. Mu nkhani ya kupanda efficacy akhoza chinawonjezeka mlingo ndi pafupipafupi phwando. Dongosolo mtsempha ikuchitika pang'onopang'ono, pa mphindi 5. Mlingo anapereka malinga ndi kulemera kwa wodwalayo. Analimbikitsa ndi 0.3-0.4 mg / kg. Nthawi zina (makamaka) mankhwala kutumikiridwa mobwerezabwereza pa maola 6. Mu minofu kutumikiridwa 0.4 mg / kg pa mosinthanasinthana maola 6. Iwo ananena kuti makonzedwe mtsempha ali osavomerezeka kuchita kunyumba. Mankhwala "Allaritmin" ali malamulo chomwecho pa ntchito ngati mankhwala "VFS". Chithandizo ikuchitika kuchipatala moyang'aniridwa nthawi zonse sing'anga ndi ECG polojekiti. Zimenezi n'zofunika kwambiri makamaka pa matenda a odwala ndi digiri yoyamba atrioventricular chipika, kulephera mtima, decompensated aakulu Inde mtundu.

Pomaliza

Amatanthauza "VFS", ntchito zimene ziyenera mosamalitsa ankalamulira, ngati antiarrhythmics zina, limabweretsa gulu la mankhwala amphamvu. Popeza zotsatira achire sayenera kuonjezera chake pamene mukumwa zotchulidwa mlingo wa katswiri. Ichi ndi chifukwa chakuti pali chiopsezo kuledzera ndi mavuto wotsatira. Musanayambe perekani mankhwala, dokotala ayenera kuika mtima kudziwa zotsatira zotheka mbali ndi contraindications. Nawonso mtima limanena za kukhalapo tsankho, kuphatikizapo mu mbiri, mawailesi aliyense, komanso mankhwala zimatengera owonjezera. Tisanayambe mankhwala ayenera kufufuza Zamkati.