Anticoagulants - mankhwala bwanji magazi clotting

M'mikhalidwe yachibadwa magazi ndi madzi amene amapereka kayendedwe ka dongosolo magazi. Matenda opatsirana ndi parasitic, komanso intoxications kusintha physico-mankhwala ake katundu, amene zikuwononga amakhudza njira kagayidwe kachakudya ndi kugwira ntchito kwa ziwalo. Choncho tanthauzo kwachilengedwenso ali mlingo clotting. Iwo akhoza inapita patsogolo ndi kuchedwa. Mu mankhwala, ntchito zambiri wothandizila pharmacological mothandizidwa ndi zomwe mungathe kusintha liwiro clotting magazi. Anticoagulants - mankhwala kusokoneza ndondomeko ya coagulation magazi, monga njira imathandizira amenewa zodzitetezera otchedwa coagulants.

Limagwirira ya coagulation ndi thrombus mapangidwe - kuipidwa amuzolengedwa ndondomeko oteteza thupi ku kutaika kwa magazi pochita mtima wosagawanika kuphwanya. Zimenezi ikuchitika likuvutika prothrombin, amene apanga mu chiwindi, ndi maselo othandiza magazi kuundana, amene amatsatira kolajeni ulusi m'mbali mwa chotengera kuonongeka. Mu ndondomeko hydrolysis allocated mankhwala kupatsidwa zinthu za m'mwazi kulemera (adenozintrifosfatnaya acid adenozindifosfatnaya), thromboplastin ndi vasoconstrictors - norepinephrine, Epinephrine, serotonin. Iwo achepetse chotengera lumen. Thromboplastin mchikakamizo kashiamu ndi plasma mapuloteni chikugwirizana ndi prothrombin ndi thrombin mitundu, amene ndi mapuloteni (fibrinogen) ndilo anatembenuzidwa kuti Ulimbo insoluble, kusindikiza ndi mtima lumen.

Magazi clotting kubweza matenda kugwirizana ndi milingo yafupika kashiamu mu magazi, kuchepa kupatsidwa zinthu za m'mwazi kuwerenga, prothrombin kaphatikizidwe matenda fibrinogen, thrombokinase ntchito osakwanira ndi vitamini K. The coagulants ntchito mankhwala, thrombin, fibrinogen, calcium enaake, menadione, asidi aminocaproic, masamba kukonzekera (masamba nettle, madzi tsabola).

Anticoagulants - mankhwala ziletsa ntchito zamoyo dongosolo, amene amathandiza magazi coagulation ndiponso kupewa mapangidwe kuundana mu mitsempha ya magazi. Iwo ziletsa onse kapena ena mwa magawo clotting magazi. Amadziwika kuti magazi madzi boma anakhalabe ndi michere yeniyeni ndi antitrobminom. Pofuna kupewa mapangidwe magazi kuundana, anticoagulants ntchito mwachindunji. Iwo bwanji magazi clotting zinthu anachedwa ndondomeko mu thupi kapena chubu. Sodium citrate (ndi sodium citrate) ndi EDTA (asidi ethylenediaminetetraacetate) kumumanga kashiamu ionized magazi ndi kusintha mu kashiamu citrate kapena complexed ndi EDTA. Mogwirizana ndi kuchotsa ayoni kashiamu kwa dongosolo magazi clotting aumbike thrombin ndi Ulimbo. Heparin inactivates zinthu thrombogenic ndi kumabwezera mmbuyo kutembenuka kwa prothrombin kuti thrombin. Anticoagulants - mwachindunji mankhwala Kwalamulidwa kwa mwaziwo ndi hematology zasayansi maphunziro kwa kupewa clotting magazi ndi zochizira matenda amene anatsagana ndi mofulumira clotting magazi. Mankhwalawa amagwiritsidwa ntchito pa kupewa ndi kuchiza matendawo thromboembolic.

Anticoagulants wa mozungulira kanthu - bishydroxycoumarin, coumarin, sinkumar - ndigwire kaphatikizidwe michere kuti zimakhudzidwa clotting magazi. Iwo ziletsa thrombin lomenyera chiwindi. Zimenezi akufotokozera mu chamoyo pasanathe maola 12-72 ndi zikusonyezedwa masiku awiri kapena khumi. Izi ndi mankhwala yaitali wotenga. Anticoagulants - mankhwala mozungulira analamula kuti kupewa ndi kuchiza thrombosis, embolism, thrombophlebitis.