"Azithromycin" ana: malangizo Buku, ndemanga

Mu nkhani ya matenda kobvuta kuti sangathe kusamalira Penicillin mankhwala pogwiritsa, madokotala mankhwala "azithromycin". Ana (malangizo ntchito amatanthauza kuti) mankhwala kumakhudza amphamvu kwambiri, nthawi zina, angasokoneze zisanathe kupangidwa chamoyo, kotero kutenga kofunika Mlingo osachepera.

mawonekedwe Ndinamasulidwa zikuchokera

Chiphunzitso imakhala mankhwala yogwira ndi excipients wothandiza azithromycin imene perekani mapiritsi miyambo mawonekedwe. Komanso kuyamika zinthu izi odzipereka bwino mankhwala.

Chifukwa yotakata sipekitiramu mankhwala ntchito zosiyanasiyana amasulidwe mankhwala ntchito mankhwala amakono:

• gelatine makapisozi zovuta ndi buluu chivindikiro thupi ndi buluu, mkati amene ali woyera woongoka chikasu ufa (kapena misa ting'onoting'ono basi). Pamene inu tilimbikire yopuma. makapisozi The zili kuwonjezera pa pophika yogwira, microcrystalline mapadi, ndi sodium lauryl sulphate ndi mankhwala enaake a stearate.
• "Azithromycin" (125) malangizo ntchito ana limafotokoza mapiritsi filimu TACHIMATA mu buluu, mawonekedwe zozungulira, biconcave. Pa dzanja limodzi ali chosema "PLIVA", ina - "125". Ngati inu kuswa, mukhoza kuona kuti kumayambiriro kwa mankhwala woyera. Amakhala wa adjuvants zotsatirazi: anhydrous kashiamu wa phosphate wa hydrogen, hypromellose, wowuma chimanga, microcrystalline mapadi, wowuma pregelatinized, sodium lauryl sulphate ndi magnesium stearate.
• Mankhwala "Azithromycin" ana malangizo ntchito akuonetsa mawonekedwe a kuyimitsidwa, kotero pharmacies mungagule ufa wapadera kukonzekera ndi chitumbuwa kapena nthochi fungo.

Mtengo wa ukuwonjezeka mankhwala malinga ndi zomwe zili za pa chuma yogwira.

makhalidwe pharmacological

"Azithromycin" amatanthauza mankhwala yotakata-sipekitiramu. Pamene woipa mkulu cholinga cha kutupa amapezeka imfa ya tizilombo.

tcheru kwambiri mankhwala galamu HIV cocci: Streptococcus pneumoniae, Streptococcus magulu CF ndi G, Staphylococcus aureus, St. Pyogenes, St. Viridans, St. agalactiae; Galamu alibe mabakiteriya: Moraxella catarrhalis, H. Ducrei, Haemophilus influenzae, Legionella pneumophila, Bordetella pertussis, Neisseria gonorrhoeae, B. Parapertussis, Gardnerella vaginalis ndi Campylobacter jejuni; anaerobic zamoyo: mauka trachomatis, Bacteroides bivius, Ureaplasma urealyticum, Peptostreptococcus spp, Clostridium perfringens, Borrelia burgdoferi, Treponema pallidum, ndi Mycoplasma pneumoniae. Galamu HIV mabakiteriya kugonjetsedwa ndi mankhwalawa, mankhwala opha tizilombo toyambitsa ndi wotembenuka kuti thupi kulalikira.

Pharmacokinetics

"Azithromycin" ana (malangizo ntchito amatanthauza kuti) mofulumira odzipereka kwa mundawo m'mimba chifukwa zoipa acidic sing'anga ndi lipophilicity. Mofulumira anagawira thupi lonse. Mosavuta likulowerera osati mu kapepala kupuma, minofu zofewa ndi khungu, komanso kuti ziwalo thirakiti urogenital. Chifukwa, ndi kumangako otsika azithromycin ndi seramu mapuloteni, luso malowedwe a ku maselo eukaryotic ndi ndende mu sing'anga ndi pH otsika, lysosomes zachilengedwe kuchuluka nthawi theka moyo ndi ndende mu zimakhala.

Zonsezi Mzimuyo buku apamwamba yogawa (malita 31,1 pa kg) ndi mkulu plasma chilolezo. Kwa chiwonongeko cha tizilombo toyambitsa matenda okhudza maselo ambiri chapadera kwambiri ndi luso "Azithromycin" kudziunjikira mwachindunji mu lysosomes lapansi.

Chifukwa phagocytes mankhwala amapatsidwa malo a matenda, kumene anamasulidwa mu ndondomeko ya phagocytosis. Patapita maola 12-72 kutenga cholinga cha kutupa zimatheka ndi mkulu wa ndende mankhwala, amene ali apamwamba kwambiri kuposa osachepera ochepetsera ukaidi matenda a tizilombo toyambitsa matenda.

Monga tanenera kale, theka moyo ndondomeko yaitali, Mwachitsanzo, amafuna maola 60 76 kuchotsa nsalu. Bactericidal ndende ya mankhwala amasungidwa malo a kutupa kwa masiku 5-7 pambuyo mlingo otsiriza, n'zotheka kuti ntchito maantibayotiki limodzi mu tsiku, njira ya mankhwala si kuposa sabata.

Kusonyeza "Azithromycin" ambiri mu ya ndulu, ndi chabe nusu - pamene kukodza.

Zikuonetsa yopemphera

"Azithromycin" malangizo ntchito ya ana amalimbikitsidwa kuti asankhe matenda opatsirana ndi yotupa, amene amayamba ndi mabakiteriya atengeke azithromycin. matenda monga: chibayo, chifuwa, sinusitis, pharyngitis, minofu zofewa ndi matenda ena a pakhungu, zilonda zapakhosi, media otitis, matenda Lyme ndi urethritis. Pakuti amaganiziridwa madokotala chibayo amakonda yomweyo mankhwala opha tizilombo, ngakhale popanda zotsatira za X-ray bwino. Chithandizo cha matenda ayenera kuyamba mu nthawi yabwino, mwinamwake angakutsutseni zotsatira Kalanga kwambiri. Mankhwala ngati mlandu amusankha kutenga nkhani zizindikiro zonse, tizilomboto ankaimbidwa ndi chithunzi matenda onse. Kudziwa lake kuchititsa matenda, m'badwo wa mwana n'komwe. Ngati chibayo ndi achifwamba mu mwana zaka miyezi 1 mpaka 6, ndiye. osalephera, nthumwi - a Staphylococcus aureus, chaka chimodzi mpaka zaka zisanu - Streptococcus pneumoniae. Ndi mitundu onse mabakiteriya bwino amalimbana "Azithromycin".

dosing

Mankhwalawa kamwedwe kudzadalira matenda, koma mlingo okwana ayenera anakhalabe. Dokotala angakupatseni mankhwala "Azithromycin" ana. Malangizo ntchito amalola mapiritsi kutenga akulu okha popeza muli mg wa 250 500 a mankhwala yogwira, ndipo ndalamazo kuchita masamu pa misa m'malo lalikulu. chakuti mapiritsi ayenera kuwameza lonse, ali osavomerezeka kutiwononga kapena pogaya chifukwa choncho sangathe kusunga analimbikitsa mlingo wa ntchito limodzi nthawi (10 mg / kg). Ndi chifukwa chake achinyamata monga nthumwi antibacterial kutumikiridwa "Azithromycin" (125). Malangizo ntchito ana piritsi limaletsa kumwa mpaka zaka 12, iwo akhoza m'malo ndi madzi kapena kuyimitsidwa.

Zochizira matenda pachimake yotupa airway, otitis, chibayo yoikidwiratu umodzi mlingo mankhwala (10 mg / kg). Mankhwala "Azithromycin" (125) malangizo ntchito ana mapiritsi akuonetsa kuti yekha akafika zaka 14. Chithandizo Ana anachita yekha ntchito slurry.

Kuyenera otchulidwa kuti magalamu 5 manyuchi "Sumamed" (piritsi) ndi chiphunzitso ena analogs analinso ndi 125 mg wa mankhwala yogwira. Choncho, muyezo mlingo ana okulirapo ndi 1-2 supuni, malingana ndi kulemera. Pa izi masiku anayi a mankhwala akupitiriza, koma pa mlingo yomweyo yafupika 5 mg / kg. Mu nkhani ya aakulu matenda mlingo akhoza kawiri, koma zimenezo, ntchito maantibayotiki ndi chovomerezeka yekha kuyang'aniridwa ndi katswiri. Kukonzekera "Azithromycin" (125) malangizo ntchito ana akhoza kugwiritsidwa ntchito ngati kulandira kamodzi kapena kawiri pa mlingo wa 30 mg / kulemera makilogalamu thupi.

contraindications

Mankhwala "Azithromycin" chifukwa Buku ana malangizo limaletsa akulemera makilogalamu osachepera asanu. Komanso, iwo contraindicated odwala ndi hypersensitivity kwa zigawo zikuluzikulu zili zikuchokera kwa aliyense maantibayotiki ena macrolide. Izi mankhwala ali Mulimonsemo sayenera kugwiritsidwa ntchito mu chiwindi kwambiri ndi kulephera impso.

Ambiri osokoneza ndi mankhwalawo

Chifukwa Moms amene amagwiritsa mankhwala "Azithromycin" ana, malangizo ntchito (wodwala umboni za ntchito mankhwala kuperekedwa mu nkhaniyi) imapereka mndandanda wa zotsatira zoyipa. Pa mbali ya dongosolo ndipo magazi lymphatic mapangidwe angathe trombotsipenii.

Odwala kuwonetseredwa ndewu, ofuntha, mantha ndi nkhawa. Kuchokera mantha dongosolo chizungulire, khunyu, mutu, somnolence, ndipo ngakhale kukomoka. Nthawi zina, mankhwala amachititsa sleeplessness, kutopa, paresthesias, komanso anasokonezeka maganizo fungo ndi kukoma.

Infrequently macrolides (gulu la mankhwala, maziko a dongosolo mankhwala omwe protrude macrocyclic 14- kapena 16-ziwalo lactone mphete ndi Ufumuyo zatsalira zimam'patsa), ndi zimene ziri "azithromycin" kutsogolera kumva imfa. Kawirikawiri, koma pali mavuto a khalidwe dyspeptic ndi kuwonetseredwa matupi awo sagwirizana zochita.

"Azithromycin" malangizo ntchito zimathandiza ana kugwiritsa ntchito, koma ana mankhwala akhoza kumwedwa kokha mu mawonekedwe a kuyimitsidwa a. Kwa ana okulirapo agwirizane ndi mawonekedwe kapisozi wa antibayotikiyo. Patsogolo ntchito mankhwala, muyenera kuti mupeze chilolezo dokotala ndi kuwerenga phukusi Ikani malangizo mosamala.

About ambiri osokoneza zingasonyeze m'mimba sukhalitsa kumva imfa, kunyansidwa ndi kusanza. Mu nkhani ya wozingidwa ndi Mlingo analimbikitsa ayenera yomweyo rinsed m'mimba, kupitirira mankhwala symptomatic.

Kusamala

Ntchito "Azithromycin" pa mimba ndi osafunika kwambiri, koma zovomerezeka ngati kosatheka kuti ntchito kuthandiza mkazi (mankhwala zotsatira pa chitukuko yoopsa pa 100% sichinayambe anaphunzira). Nthawi mkaka wa m'mawere pamene ntchito pa nthawi ya mankhwala pakamwa yoyamwitsa.

Ana osaposera zaka 12 ndi bwino kusankha analogi "Azithromycin".

Kumwa mowa sikumangotikhudza zochita za mankhwala, Koma ntchito yake anawonjezera kuti matenda alionse. Choncho, kuchuluka kwa mowa ankadya tikulimbikitsidwa kuchepetsa kwa pazipita, ndi bwino kupereka mankhwala kwathunthu.

Mwanjira mankhwala

Pa polandira "Azithromycin" ndi Mankhwalawa ayenera kumwedwa kuti muli calcium, magnesium ndi zotayidwa, izo kubweza mayamwidwe wa mankhwala Chotero kofunika kusunga 2 maola imeneyi pakati Mlingo wa mankhwala.

Chachikulu kusiyana pakati mankhwala opha tizilombo ena macrolide - palibe kulankhulana ndi dongosolo cytochrome. Choncho, pamene anatengedwa ndi "theophylline", "carbamazepine", "Digoxin", "terfenadine" ndi "triazolam" palibe mogwirizana.

Ngati mankhwala ntchito ndi "warfarin", m'pofunika kuyan'ana prothrombin nthawi.

Lincosamides kuchepetsa mphamvu ya mankhwala ndipo ndi chloramphenicol ndipo amafunika tetracycline kuchuluka.

Zokwaniritsa ndi mawu

maantibayotiki The ziyenera kusungidwa pa ana sangawapeze pa kutentha kwa madigiri 25. Pa alumali moyo wa umboni umene ulipo mankhwala "Azithromycin" (ana), malangizo Buku. kuyimitsidwa anakonza zikhoza kusungidwa kwa palibe masiku oposa 5, ufa palokha - zaka 2, ndi miyala ndi makapisozi - zaka 3.

Analogs ndi maganizo odwala

Amene anagwiritsa ntchito "Azithromycin" ana (malangizo ntchito makapisozi ali osavomerezeka kutenga ana), anasiya ndemanga makamaka positive. Pambuyo mlingo woyamba wa kusintha kwa mankhwala akutali yokulirapo patsogolo zina.

Ndi analogues wa mankhwala monga "Azitsin", "Zomax," "Sumamed", "Azitral", "Azaks", "Zitroks" ndi ena.