Mankhwala "sofosbuvir": malangizo ntchito, limagwirira cha zimenezi, analogs

Chibwenzi, dziko pafupifupi mazana atatu miliyoni anthu ali ndi kachilombo chiwindi C. Komabe, komabe anayamba katemera ndi matenda oopsa.

Features matendawa

Lowopsya HIV infects maselo zofunika kwa thupi ndi moyo wa anthu - chiwindi. Pambuyo chiwindi kuti C amalenga buku kosaoneka maselo akhudzidwa kufalitsa matenda.

Today anaulula njira zingapo tizilombo chiwindi:

• ndi magazi;
• zizindikiro, kutema mphini ndi njira zina amagwiritsidwa ntchito ngati masingano sanali wosabala;
• ntchito singano umodzi ndinkalephera anthu;
• pogonana;
• kuchokera kwa mayi kupita kwa mwana pa mimba.

Features mankhwala

madokotala ambiri kuyerekeza chiwindi C ndi HIV. Achire nthenda yoopsa imeneyi si panopa zotheka. Komabe, pali mankhwala omwe cholinga chake ndi kuchepetsa kufala kwa HIV.

Mankhwala otere zambiri ntchito mankhwala awiri: "interferon Alpha" ndi "Ribavirin". Woyamba ndi kuchepetsa kufala kwa HIV maselo wathanzi, ndi wachiwiri umalimbana popewa kubalana ake. Komabe, mankhwala amenewa kamwedwe ndi nambala yaikulu mavuto ndi otsika lapamwamba.

Choncho, akatswiri kupitiriza kukhala mankhwala atsopano kuti kuthetsa chiwindi C. wina wa kupambana atsopano a mankhwala ndi nzeru mankhwala "sofosbuvir". Malangizo ntchito ali ndi mfundo zonse zofunikira za izo.

Kufotokozera lokonzekera

Mankhwala akupezeka piritsi mawonekedwe zozungulira mawonekedwe, amene pamwamba TACHIMATA yekha sungunuka madzi muzituluka. Mfundozi lili Ufumuyo mankhwala "sofosbuvir" malangizo. The zikuchokera limapangidwa wapadera mankhwala mankhwala ndi dzina lomweli monga mankhwala ndi excipients.

Chofunika mlingo wa mankhwala ndi 400 mg ndipo pa piritsi chomwecho. phukusi lili 28 mankhwala, ndiwo zokwanira kukhala moyo chithandizo kwa mwezi umodzi.

Mmene thupi

Iwo anafotokoza mmene thupi zilipo mankhwala "sofosbuvir" malangizo Buku. Limagwirira kanthu, mawu osavuta, ndi kuti chinthu zofunika ndi medicament woletsa wa enzyme ano chiwindi C. Iwo ali zotsatira zovuta pa akhudzidwa chamoyo ndi HIV. mayesero chipatala wasonyeza kuti ngakhale kwambiri wofooka matenda chamoyo atamwa mankhwala wakhala azilandira azimuth positive. Ichi ndi choona pa matendawa genotypes 1-4.

Komabe, pamene matenda ndi chiwindi C ndi HIV, madokotala ambiri osaganizira bwino ntchito mankhwala. mfundo ndi yakuti mu nkhani iyi, nchito zake sichinayambe zatsimikiziridwa. Nkofunika kuzindikira kuti ngakhale malangizo mwatsatanetsatane kuti lili mankhwala kuti "sofosbuvir" malangizo ntchito, Mlengi amatichenjezanso wozengereza kudzikonda. mankhwala tima ndi mawonekedwe aakulu a chiwindi C awerenge yekha ndi dotolo odziwa. The njira ya mankhwala amachitidwa kuyang'aniridwa ndi akatswiri.

Kagwiritsidwe mankhwala

madokotala ambiri amakhulupirira kuti mankhwala "sofosbuvir" ayenera kumwedwa yekha limodzi ndi mankhwala ena. Pakuti ichi kale ntchito njira zotsatirazi, zomwe zimadalira genotype matendawa:

• Pamene genotypes 3-6 mtundu wa mankhwala "sofosbuvir" zotchulidwa ndi mankhwala, "Ribavirin" ndi "interferon Alpha". mankhwala mu nkhani iyi ayenera upambana miyezi 3.
• Pankhani ya chiwindi 1 komanso ndikosatheka ntchito medicament monga "Interferon Alpha" (pamaso pa tsankho payekha kapena contraindication). Pankhaniyi, ndithudi wakhala anawonjezera kawiri.
• Pamene ntchito osakaniza kukonzekera 2 genotypes chiwembu "sofosbuvir" mankhwala "ribavirin" kwa miyezi 3.
• Pa nkhani ya munthu wodwala kuyembekezera kwa kumuika chiwindi akulimbikitsidwa kugwiritsa ntchito mankhwala onse, "Ribavirin" ndi "sofosbuvir". Malangizo ntchito akuonetsa kutambasuka kwa chithandizo mpaka kupatsidwa zina.

Ngati pamene pali zotsatira zomwe zimapezeka ndi kutenga mmodzi mwa mankhwala osakaniza mankhwala ayenera anasiya mankhwala. Data pa efficacy wa mankhwala odwala amene alibe zaka ambiri, mu dziko ayi.

Mankhwala "sofosbuvir" kutenga 1 nthawi patsiku pa mlingo zotchulidwa dokotala. Pali malamulo amene ayenera kutsata iyi:

• Musagwiritse kutafuna kapena kugawa miyala, pamene iwo kulawa zowawa kwambiri. mankhwala chikuyendetsedwera pachakudya.
• Mu nkhani ya emesis maola awiri pambuyo medicament ayenera kumwa mlingo owonjezera.
• Kusiya mankhwala, ngati akuchedwa ndi maola 18, kutenga anaphonya piritsi. Ngati nthawi zambiri zadutsa - kutenga mlingo lotsatira pa nthawi uchitike.

Kusamala

Mitundu yonse ya nkhani zina kuti ndi kofunika kudziwa pamene mukumwa mankhwala, lili Ufumuyo mankhwala "sofosbuvir" malangizo. Zikuonetsa ntchito mankhwala mu mankhwala zovuta kwakukulukulu kudziwa mavuto.

Mu mankhwala, muyenera kudziwa zotsatirazi:

• yafupika ndende ndi liwiro anachita, kotero muyenera kusiya galimoto ndi zina;
• mimba si zofunika, kotero muyenera kuonetsetsa kuti njira yodalirika kulera.

zotsatira zoyipazi

Today Sikuti zonse zobwera mbali kukonzekera "sofosbuvir". Malangizo ntchito lili deta malingana mitundu ya mankhwala ndi mankhwala ena.

Pankhani ya kaphatikizidwe mankhwala ndi mankhwala, "Ribavirin" anati:

• zoposa 10% milandu - kuchepa msinkhu hemoglobin ndi kuchuluka kwa bilirubin mu magazi, nseru, kufooka, kugona zipolowe, mutu, manjenje;
• 1% milandu - kutupa kwa zilonda za mphuno komanso pakhosi, kuchepetsa mlingo wa chitsulo magazi, maganizo, chifuwa, kutsegula molongosola, mavuto ndi kugwira ntchito pa mundawo m'mimba, tsitsi imfa, kuyabwa, cramping, malungo.

Ndi utsogoleli zina za mankhwala chiwembu cha "Interferon Alpha" pali chiopsezo kuti padzakhala:

• magazi m'thupi, kusowa tulo, chizungulire, utachepa chiwerengero cha neutrophils, maselo othandiza magazi kuundana ndi lymphocytes ndi kuchuluka bilirubin mu magazi, zotupa, kuyabwa, malungo, kutsekula m'mimba, kusanza, malungo;
• kuwonda, maganizo ndi mantha matenda, migraine, kudzimbidwa, kufupika kwa mpweya, kupweteka ndi zotsatira zina.

More mwatsatanetsatane zonse zobwera mbali anatchulidwa Ufumuyo mankhwala "sofosbuvir" malangizo Buku.

analogs

Pali zingapo analogues wa mankhwala "sofosbuvir". Iwo akhoza kugawidwa m'magulu 2. Analogs wa chinthu yogwira ali: "Viropak", "Grateziano", "Hepsinat", "Hopetavir". A mndandanda wa mankhwala amenewa "sofosbuvir" zotsatira achire ndi okulira kwambiri. Kungotchulapo ena a iwo: "Algeron", "Ledipasvir", "Neovir", "TSikloferon" ndi ena ambiri.

Komabe, inu kusankha angapo ubwino "sofosbuvir" kutsogolo kwa anzake:

• Disinfection wa genotypes osiyana za matenda C;
• mkulu Mwachangu;
• yochepa Inde mankhwala poyerekeza ndi mankhwala ena ambiri;
• bwino analekerera;
• Zilibe bwanji khalidwe la moyo wodwalayo.

mtengo wa

mankhwala amakono sakudziwa mankhwala ambiri ogwira mtima bwinobwino kuthetsa chiwindi C, kuti wadutsa mu gawo aakulu. German mankhwala "sofosbuvir" oyenera odwala wamkulu. Malangizo ntchito limakupatsani kuyerekeza ndi mankhwala ena ofanana.

Chifukwa chakuti mankhwala amasonyeza dzuwa ndi mkulu, ubwino bwino poyerekeza ndi analogues, mtengo wake zedi mkulu. Inde wina ndalama wodwala madola zikwi zingapo. N'chifukwa chake mankhwala "sofosbuvir" mu pharmacies kuli kovuta.

Lero, langwiro kwambiri ndi otetezeka mankhwala ntchito zochizira chiwindi C, ndi njira. Mfundozi amatsimikizira Ufumuyo medicament "sofosbuvir" malangizo. Analogs, malinga ndi madokotala, musalole kuti iyende ngati kwambiri.

Ndendende chifukwa cha mankhwala chimatengedwa ngati nambala yaikulu madokotala lonse. Iwo amakhulupirira kuti lero mankhwala aluso kuti akhoza kwambiri tisaletse moyo odwala mwakayakaya, kulibe.