Naiz (piritsi) - malangizo Buku.

mawonekedwe mlingo

lokonzekera amapangidwa m'njira 3 mankhwala - kuyimitsidwa, mapiritsi dispersible ndi ochiritsira. Kuyimitsidwa ndi fungo lokondweretsa ndi kafungo chikasu mtundu ndi khalidwe ndithu kukoma kwa mankhwala. kuyimitsidwa akhoza redispersed ndi kugwedeza vial.

Mapiritsi amapangidwa pafupifupi woyera, ndi pang'ono chikasu kum'chitira. Mapiritsi a mawonekedwe zozungulira, biconcave, pamalo ake onse yosalala.

Nise zikuchokera:

kuyimitsidwa

yogwira mankhwala

• Nimesulide - 50 mg (5 ml ya kuyimitsidwa)

Excipients:

• sorbitol
• shuga
• xanthan chingamu
• propyl
• methylparaben
• citric acid
• chinanazi kununkhira
• Yellow utoto WS
• glycerol
• polysorbate
• madzi oyera

mapiritsi dispersible

yogwira mankhwala

• Nimesulide - 50 mg (Table 1).

excipients

• aspartame
• kashiamu wa phosphate
• microcrystalline mapadi
• carboxymethyl wowuma
• wowuma chimanga
• talc
• mankhwala enaake a stearate
• Colloidal pakachitsulo woipa
• chinanazi kununkhira

mapiritsi

yogwira mankhwala

• Nimesulide - 100 mg (Table 1).

Excipients:

• mankhwala enaake a stearate
• Kashiamu wa hydrogen mankwala
• microcrystalline mapadi
• Anhydrous colloidal pakachitsulo
• wowuma chimanga
• Sodium wowuma glycolate
• woyeretsedwa talc

The kanthu pharmacological mankhwala

kanthu pharmacological anafotokoza makamaka Nise - mapiritsi, malangizo lili deta kwa mitundu yonse mlingo. The mankhwala ndi NSAID, munali mu dongosolo sulfonilidnuyu ake grouping. Nimesulide zavuta chikukhudza zoletsa a Cox-2, kotero kuti mavuto odana ndi yotupa ndi analgesic, kuwonjezera, mankhwala amphamvu zotsatira analgesic, koma mlingo wochepa.

Limagwirira cha zochita za mankhwala kugwirizana ndi yimitsira wa kaphatikizidwe prostaglandins mu kutupa ndi yimitsira la mapangidwe ankafuna kusintha zinthu mopitirira mpweya ndi chopinga wa myeloperoxidase kumasulidwa.

Pharmacokinetics

Nise mwangwiro odzipereka kwa mundawo m'mimba, kufika pazipita ake m'magazi kale pambuyo maola 2. The mankhwala ndi 99% mapuloteni womangidwa.

Kukonzekera nize - mapiritsi kalozera wochokera magwero boma metabiliziruetsya mu chiwindi ndi excreted mu mkodzo, ndi 98% ya mlingo analandira ndi linanena bungwe masana.

umboni

• matenda enaake ophwanya kuti kukhala panja kapisozi olowa
• nyamakazi
• Kutupa ndi ululu pambuyo opaleshoni
• Ululu chifukwa cha dysmenorrhea
• Malungo ndi ululu pachimake kutupa mu Airways chapamwamba

Zotsatira zoyipa Nise

Mapiritsi, malangizo amene tsopano ali, zingabweretse mbali-zotsatira mu machitidwe osiyanasiyana ndi ziwalo:

Zotsatira zoyipa za mankhwala, amene ikukhudzana bwanji ndi kapepala kakuti m'mimba

• nseru
• kutentha
• kupweteka kwa m'mimba
• dikira chimbudzi

Zotsatira zoyipa za mankhwala, amene akufotokoza za chapakati mantha dongosolo:

• mutu
• kusinza
• chizungulire

Zotsatira zoyipa za mankhwala, amene ikukhudzana bwanji ndi thupi lawo siligwirizana:

• erythema
• totupa
• urticaria

zotsatira zina zoyipa za mankhwalawa:

• Posungira mu madzimadzi thupi
• oliguria
• kutupa

contraindications Nise

Kodi mndandanda wa contraindications umene tikulimbikitsidwa kupewa kutenga mankhwala, ndipo ngati kuli koyenera kutero yekha atakambilana ndi dokotala.

• Magazi kuchokera m'mimba thirakiti
• kulephera impso
• kwa chiwindi kulephera
• Mimba ndi mkaka wa m'mawere
• Zilonda matenda m'mimba

mogwirizana mankhwala nize

Mapiritsi, malangizo pa ntchito imene suchokera mu deta wathunthu ndi mabuku pa ankachita onse mankhwala chiphunzitso anali motere: osavomerezeka ndi wothandizila zotsatirazi - phenytoin, digoxin, okodzetsa aliyense, mankhwala lifiyamu, anticoagulants, mankhwala antihypertensive, NSAIDs, methotrexate, cyclosporin .