Pachimake myeloid khansa

Pachimake khansa - matenda a dongosolo hematopoietic, zochokera - kuchuluka malire maselo chotupa, amene ali gawo lapansi ake morphological. Pachimake myeloid khansa pa Fab gulu lagawidwa options zisanu ndi ziwiri. Maziko a gulu - mlingo zosiyanasiyana maselo kuimira gawo lapansi khansa. Myeloblasts chotupa choyerekeza lachokera ku maselo tsinde, amene angathe kubala madera ambiri a myeloid maselo, megakaryocytes, erythrocytes, macrophages.

The kaŵirikaŵiri anati mitundu M0-M3. Chifukwa cha woyamba awiri - maselo popanda zosiyanasiyana. differentsirovanokletochny - m2 mwina. M3 promyelocytic chimake amakhala ndi maselo nthenda kuti mbewu chiphona. M4 ndi M5 - myeloblastic khansa ndi monoblastny. M6 - erythromyelosis, ndi kuchuluka kuchuluka kwa maselo erythroid. M7 - megacaryoblastic khansa. Pa njira zonse, amene anapatsidwa pachimake myeloblastic khansa, madokotala ananena zawo ndi ambiri yabwino pamene M0-m2.

etiopathogenesis khansa

Kodi pachimake myelogenous khansa. The matenda - bwino luso la maselo masinthidwe chifukwa zochita za zinthu zina (poizoni mavairasi, mankhwala zinthu) ndi kutengera za kwa Kusakhazikika majini a matupi athu ndi. Izi zimachititsa maselo chotupa angathe magawano malire. Iwo amapanga choyerekeza amene nawonso, ndi masinthidwe mobwerezabwereza zinagwira subclones.

maselo chotupa ali mosalekeza opangidwa ku m'mafupa, ndi kukakamiza sichikupindulitsani yachibadwa nyongolosi hematopoiesis. Pang'onopang'ono, iwo kupita magazi zotumphukira ndi metastasize ziwalo, kupanga foci zina hematopoiesis nthenda. Akutukuka myeloid khansa ndi khalidwe matenda chithunzi iye.

Clinic pachimake myelogenous khansa

Chifukwa cha kusokonezeka kwa hematopoiesis yachibadwa odwala ndi magazi m'thupi, chiwerengero cha neutrophils okhwima ndi maselo othandiza magazi kuundana amachepetsa yokhudza ufiti. Nkhawa chizungulire. kufooka. Pali zizindikiro magazi: kukha magazi pakhungu ndi mucous zimagwira ntchito zosiyanasiyana, kuchuluka magazi pa msambo, nosebleeds. Kupweteka mafupa, kutupa lymph mfundo za magulu osiyana. Kuchuluka ndulu ndi chiwindi. Chifukwa matenda Ntchito leukocytes, kuchepetsa chitetezo chokwanira pachimake myeloblastic khansa utuluke inalowa matenda. nthawi zambiri amasonyezera angina kwambiri.

Mu ndondomeko ina akhoza Ufumuyo zizindikiro kulephera impso ndiponso minyewa.

Mu madziwo pachimake myeloblastic khansa chimafikira sitepe kufalitsidwa mawonetseredwe, chikhululukiro, kumwa. Pankhani ya chithandizo osamveka izo zikutsiriza siteji osachiritsika. Siteji ya matenda yodziwika ndi zizindikiro zina matenda ndi magazi chithunzi ndi mafupa.

matenda a khansa

Pachimake myeloid khansa opangidwa ndi maphunziro cytochemical maselo woimira ake gawo lapansi ndi immunophenotyping - kudziwa myeloid zolembera. njira Morphological kwa kudziwika maselo kuphulika kudziwa mtundu wa khansa umapatsidwa mtengo zimasonyeza, ngakhale kupitiriza kusangalala.

Nthawi zina ankagwiritsa ntchito genotypic zochokera polymerase unyolo anachita. Izo ntchito kudziwa mawonetseredwe yotsalira ya matenda odwala ku chikhululukiro.

Pachimake myelogenous khansa madokotala ananena zawo zochepa yabwino kuposa kuti madokotala ananena zawo za pachimake lymphatic khansa. Mpaka 75% a odwala ndi chithandizo chokwanira akwaniritsa chikhululukiro. Pali umboni wa machiritso wa 20% akwaniritsa chikhululukiro ndi anapitiriza chithandizo mwakayakaya. Zolimbikitsa akamagwira mafupa kupatsidwa zina.