The timadzi 17 HA-progesterone. 17 HA-progesterone: mlingo wa magazi

Cholinga chachikulu cha zimene zimachitika m'thupi mwa akazi pa kuzungulira kusamba - ovulation. Pa ndondomekoyi, ndi pansi pa ulamuliro wa ubongo imene imalamulira kutentha kwa. Pankhaniyi, zinthu malamulo mankhwala amene tochoka mu zapambuyo pituitary England: FSH ndi LH.

mapangidwe ovulation

Mu gawo chisanadze ovulatory wa mkombero kusamba yamchiberekero follicle amaloŵamo masinthidwe angapo. kusintha zikuchitika mchikakamizo cha FSH. Pambuyo follicle kufika kukula ena, komanso ntchito zinchito mu LH ovulatory pachimake aumbike. Izi kukhazikitsa "kusasitsa" linagwira (woyamba meiotic magawano). Pambuyo imeneyi discontinuity amapezeka mu mapangidwe follicle, ndi kunja imene dzira. The imeneyi pakati pa nsonga ndi ovulation gawo la dongosolo la maola 36-48. Pa postovulatory gawo kusamutsidwa limapezeka ambiri dzira kuti chiberekero cha mazira chubu. Pankhani ya umuna kwa wachitatu chachinayi tsiku Ndisanaumbidwe ndi likulowerera mu uterine patsekeke. Pali implantation ake. Ngati umuna sichinachitikepo, ndiye dzira masana kumwalira mazira chubu.

Zinthu nawo n'zodalirika wa ntchito ya ubereki wamkazi

Mu zopangitsa za endocrine anapanga mankhwala biologically yogwira. Iwo akutchedwa mahomoni. Ndi chifukwa iwo kudzera dongosolo hypothalamic-pituitary-yamchiberekero ndi kuonetsetsa pali ntchito wolimba wa Ziwalo zoberekera. Aliyense pawiri amagwiranso ntchito zina. Mmodzi mwa mankhwala nawo ndondomeko mu ziwalo zoberekera, ndi 17 HA-progesterone. Follicular gawo loyenda kuwonjezeka kwambiri ndende zake. pawiri Izi apanga zedi yaing'ono n'kuwasanganiza lapansi. Kuwonjezeka zili thunthu ndi gawo pachimake cha pH. Kenako, pakati pa kuzungulira, ndende yafupika kwa nyengo yaifupi. Progesterone mu gawo follicular kubweza endometrial kuchuluka analimbikitsa ndi esitirojeni. Pawiri chifukwa ali pansi kusintha. Chifukwa chachikulu cha kusamba ndi kutha mwadzidzidzi kupanga ndi corpus luteum progesterone mkombero zitakwanira. Kupitiriza yokumba wa luteal gawo endometrial stroma anapanga decidual anachita. Ndi yofanana ndi kusintha kuchitika pa chiyambi cha mimba. Progesterone amapereka lamulo la zopangitsa mu khomo pachibelekeropo, amachepetsa contractility patsekeke. Pawiri komanso kumabwezera mmbuyo kusamba.

The timadzi 17 HA-progesterone. mafotokozedwe

Ndi kalambulabwalo mankhwala. Zace adrenal tochepa anapanga mchikakamizo cha michere monga 11-B 21 hydroxylase kapena hydroxylase. 17 HA-progesterone mu akazi lithe androstenedione. Nkhanizi ndi kalambulabwalo wa testosterone ndi estradiol. Iwo aumbike mwa thumba losunga mazira ndi zopangitsa adrenal. Magazi progesterone 17-HA alipo ufulu ndi omangidwa ndi mapuloteni chonyamulira monga transcortin ndi albumin. Popeza umuna mankhwala ndende amachepetsa. Pankhani ya implantation wa dzira ambiri m'mimba, ndi corpus luteum akupitiriza kuzichita izo.

ndende

17 HA-progesterone kuchuluka m'mawa. Osachepera nkhani zake anaulula usiku. Masana, mlingo wake zimasiyanasiyana. Ndipo pawiri ndende zimasiyanasiyana pa kuzungulira kusamba. A kuwonjezeka kwambiri mlingo anaona Chadzulo LH pachimake. Pamakhala gawo ndende pazipita (m'ma mkombero). Woyembekezera, zili mankhwala ali kwambiri kuchuluka. 17 HA-progesterone, mlingo umene anatsimikiza mogwirizana ndi msinkhu wa ana ali pang'ono. magawanidwe Large zimapezeka kokha mu nthawi chonde ndi yomweyo pambuyo pa kubadwa. Pankhaniyi, makanda msanga zili zimakhalanso zikuluzikulu. Mlungu woyamba wa mathithi mlingo kugwirizana. Iwo anati kuwonjezeka mwapang'onopang'ono pa unamwali. Nthawi imeneyi, progesterone 17-HA achinyamata pang'onopang'ono umalandira ndende yomweyo monga akuluakulu.

N'chifukwa chiyani muyenera atayezetsa?

17 HA-progesterone ndi mankhwala wapakatikati. Komabe, kafukufuku wake ndi wofunika ku matenda a pathologies zosiyanasiyana. Ndi umboni wa phunziro la monga osabereka, hirsutism, matenda mkombero. Pamene adrenal hyperplasia monga chithandizo kwa odwala kutumikiridwa steroid m'malo mankhwala. Kuwunika kuwunika mogwira waperekedwanso. 17 HA-progesterone anaphunzira makanda. ndende phunziro ake amaganiziridwa akusowa 21 hydroxylase. Chakuchepa kwa enzyme uyu anati mu kobadwa nako adrenal mtundu hyperplasia.

Kukonzekera kukayezetsa zasayansi

Ngati dokotala alibe nthawi ina iliyonse, magazi amapereka pa wacitatu tsiku lachisanu mkombero. Ankachitira phunzirolo pa chopanda kanthu m'mimba m'mawa. Iwo saloledwa ntchito khofi kapena tiyi. Anandilola kumwa madzi opanda. Popeza chakudya womaliza asanafe chopereka magazi ayenera kukhala maola osachepera asanu ndi atatu. Akatswiri amaona zosayenera timadzi kuphunzira ntchito yachiwiri pa tsiku 20-23. Ngati nthawi ya vuto la masiku 42, ndi chitsanzo magazi ikuchitika pa 35 tsiku TH. Pa tsiku 23. ya gawo loyamba mpaka pano. Mlingo wa progesterone yafupika, koma silimanena kulephera kwa gawo luteal kapena anovulation. Iwo safuna tinganene kuti phunziro ndende pa mimba ndi kugwiritsa ntchito mankhwala aliwonse. Pankhaniyi, mkulu 17 HA-progesterone - ponseponse. Chotero zili kuchipatala kuti akalandire chithandizo si chofunika.

kutanthauzira zotsatira

Monga tanena ndi kambiri wa timadzi progesterone, 17 HA kudzadalira msinkhu. Kufunika ndi kugonana mutu. ndende anatsimikiza mu ng / ml. Mulingo woyenera zili ana mpaka mwezi - 0-16,63; miyezi 1-2-. - 1,8-9,7; 3 months. - 0,07-1,7. Kwa odwala pansi chaka chimodzi - 0-1,65; kwa zaka 3 - 0-0,99; 3 10 - 0,07-1,69. mlingo chovomerezeka kwa amuna - 0.5-2.1. Kwa amayi mu gawo follicular - 0,41-2,72; ovulatory - 0,33-2,8; luteal - 0,33-2,8. Mu trimester kuti akalandire chithandizo progesterone 17-HA Payenera kukhala mu ndende ya 1,17-5,62; Chachiwiri - 1,17-6,7; wachitatu - 1,24-11. Mu postmenopausal mulingo woyenera zili 0,13-0,51.

adrenal hyperplasia

Ndi kobadwa nako autoimmune kudwala. Kawirikawiri akufotokozera chifukwa cha kuperewera kwa michere nawo kaphatikizidwe wa mankhwala. Kupanda mankhwala mwina madigiri osiyanasiyana mwamphamvu. Mu Chiyambi chake mu hyperplasia kobadwa nako akufotokozera virilization (mapangidwe makhalidwe chachimuna ndi akazi). Zikavuta, ndi akusowa enzyme amakwiya kuswa mu kaphatikizidwe mankhwala, imfa mchere, amene akhoza kukhala moyo pachiswe. Tsankho akusowa cha enzyme anapezeka akulu, ingathenso kukhala kobadwa nako mu chirengedwe. Pankhaniyi, poyamba kuyan'anila zimachitika mu uthunthu zobisika, ndipo si nthawi zonse wapezeka ana. Chakhungu kaphatikizidwe michere akhoza kukhala ndi khalidwe pang'onopang'ono. Mchikakamizo cha zinthu chowawa pathological kumawonjezera ndi Mwina kusintha zinchito ndi morphological mu zopangitsa kwa adrenal, mawonetseredwe chimodzimodzi syndrome kobadwa nako. Chifukwa cha kuvulala chitukuko kugonana achinyamata. Mu zambiri progesterone, 17 HA tikunena ntchito yake pa kaphatikizidwe androgens. mankhwala awa kufalitsidwa wakhanda ndipo imautsa atsikana mawu a makhalidwe kugonana mtundu wamwamuna. Choncho, kuphunzira ndende yake n'kofunika kudziwa mphamvu ya mankhwala analandira.

The akusowa owopsa kwa enzyme 21 hydroxylase

Kupanda pawiri zinaonetsedwa pa chionetserocho yafupika aldosterone mapangidwe. Izi timadzi adrenal amapereka lamulo la madzi ndi mchere malire kuchedwa mu thupi la mchere. Makanda, pali "mavuto zomvetsa." Pakuti chikhalidwe chotere yodziwika ndi kudzikundikira madzimadzi lalikulu zedi. Pa nthawi yomweyo thupi mwachangu mupewe mchere kutero. Motero, zili potaziyamu amayamba kukula ndi sodium wochuluka - pansi. Tsankho enzyme insufficiency Yodziwika achotsa chithunzi matenda. Kukayikitsa akusowa kuonekera mu maziko a kuyan'anila za kutha msinkhu ndi kukula mu msinkhu, ali wamkulu - ndi osabereka ndi makutu pa msambo, atsikana - ndi hirsutism.

Pomaliza

Ntchito mahomoni kugonana ndi chimodzi mwa zinthu kudziŵa osati kugwira ntchito ziwalo zoberekera mu akazi. Zimene mankhwala, bata awo ndi ntchito bwinobwino, mbali mu njira zosiyanasiyana, komanso pamaso pa ndende mulingo woyenera ndi mbali yaikulu pa chitukuko chonse cha thupi ndi thanzi ambiri. The akatswiri akuchenjeza kuti kupatuka aliyense mfundo alipo mankhwala si nthawi zonse chizindikiro cha kudwala. Pa nkhani imeneyi, pa nkhani iliyonse kuti sikutanthauza chithandizo. Komabe, madokotala amalangiza nthawi zonse amapereka magazi kuwunika choyezera, pochitika mayeso. Ena matenda nawo maonekedwe zobisika ndi matenda mwadzidzidzi kumabweretsa mavuto aakulu. Chofunika kwambiri ndi boma la akazi m'thupi. Sakudziwika matenda ubwana ndi zaka m'kati, kuchititsa disruptions mu ntchito kwa kachitidwe uchembere wabwino ndi ena mu thupi. Nthawi zina, munthu akakhala wosabereka - limodzi mwa mavuto onena lero - chifukwa cha matenda mochedwa. Kwa odwala kulandira m'malo mankhwala komanso zanthawi zonse cheke akuluakulu ndi mayesero magazi. Zotsatira kulola osati kuti aone achire efficacy mankhwala, komanso kusintha ntchito zawo chiwembu.