Ubongo wanu akalamba bwanji msanga? Asayansi apeza majini kiyi

ubongo wanu akhoza kuyamba zaka zambiri mofulumira pamene inu mupita zaka 65. Kapena mwina kuyamba. Likukhalira, izo zimatengera Baibulo zomwe kwa mbewu makamaka anapeza mu matupi athu wanu. Ndi asayansi apeza pa kafukufuku wa posachedwapa. Ofufuzawa anapeza jini imene imalamulira liwiro limene ubongo wanu ukalamba, ndipo nthawi yomweyo iwo amati m'Baibulo linalake la jini uyu akhoza kupereka chitetezo ambiri matenda obwera ndi ukalamba ubongo monga maganizo senile.

Gene amene Angakutetezeni kwa maganizo?

jini uyu, wotchedwa TMEM106B, akuyamba kuchita akakhala nthawi munthu ayamba zaka 65. Posakhalitsa, anthu amene ali ndi kukhalapo mu Baibulo zoipa jini ya, ubongo adzayang'ana zaka 10-12 wamkulu kuposa ubongo wa anthu amene ali ndi kukhalapo mu chabwino, Baibulo mwaluso jini lapansi. anapeza Izi zingathandize madokotala kudziwa zomwe abambo ali pa chiopsezo cha yatsoka mikhalidwe matenda a ubongo chifukwa chakuti ali ndi Baibulo zoipa jini lapansi. Kungakuthandizeninso polenga mankhwala kuchipatala, mmene umene timalembera anthu jini kupereka anthu ndi zambiri wathanzi okalamba ubongo.

Munthu wofunika kwambiri pa chibadwa onse

M'zaka zaposachedwapa, asayansi atulukira ambiri majini kugwirizana ndi matenda a Alzheimer ndi Parkinson ndi matenda ena a muubongo. Komabe, majini izi ndi kufotokoza mbali yaing'ono chabe ya matenda amenewa. Monga timadziwira, waukulu chiopsezo chinthu matenda neurodegenerative ndi okalamba. Zinthu zinasintha mu ubongo pamene ukukula, ndipo zimenezi zimapangitsa chakuti mukhala atengeke matenda a ubongo. The malangizo majini wakupatsa TMEM106B jini angakhale kuti "chinachake." Ndipo magulu awa zikhonza kuchilango mavuto obwera chifukwa cha ukalamba kapena kukulitsa iwo. Ngati inu mukuyang'ana pa gulu la anthu okalamba, ena mwa iwo adzayang'ana wamkulu kuposa ena, ndi ena -molozhe. Chimodzimodzi kusiyana chomwecho mu ukalamba zingaoneke mu kotekisi mazunzo, dera ubongo udindo njira zovuta lingaliro.

Kafukufuku watsopano pa maziko a m'mbuyomu

maphunziro Previous asonyeza jini ndi maonekedwe ochititsa chidwi kwambiri a maganizo lotchedwa frontotemporal alibe. Koma phunziro la limasonyeza kuti mbewu imeneyi nthawi zambiri ambiri kugwirizana ndi ubongo ukalamba kudziŵa mmene anthu achikulire kukhalabe ntchito zawo chidziwitso. Kudziwa zimene mukhoza kulamulira ubongo kukalamba, ofufuza awiri kusanthula mfundo majini zoposa 1200 anthu zitsanzo ubongo a anthu amene si ndi matenda aliwonse neurodegenerative pamene iwo adakali ndi moyo. Iwo adaona majini mazana ochepa kuti mwina kuwonjezera efficacy kale kapena utachepa pa kukalamba kwa anthu. Asayansi anapanga tchati deta awa, chimene iwo ankachitcha "masiyanidwe kukalamba". Zithunzi Izi zikusonyeza kusiyana lino (kapena kuchuluka) zaka ubongo ndi zaka lake lenileni.

ndi peculiarity wa mbewu imeneyi?

jini mmodzi, TMEM106B chomwecho, anaima ndi enawo, kusonyeza wokha ngati masiyanidwe kukalamba injini. Iwo likukhalira kuti mbewu izi, asaaonerera kutupa ndi imfa ya manyuroni mu ubongo. Koma jini uyu ali m'mitundu iwiri kapena kani, alleles ziwiri: woyamba amagwirizana ndi chiopsezo inapita kukalamba ubongo ANKACHULUKA, pokhala winayo ali ndi zoteteza ndi kuteteza mofulumira kukalamba. Munthu aliyense ali awiri Mabaibulo a mbewu izi mu matupi athu, ndipo pafupifupi makumi atatu peresenti ya anthu Mabaibulo awiriwa - zoipa. peresenti makumi asanu alionse, allele wina ndi zoteteza, ndipo zina zotsatira zoipa ubongo, chabwino, ndi peresenti yotsalayo makumi awiri ndi alleles awiri zozitetezera.

A zosiyanasiyana osakaniza ndi zimene zikutanthauza

Monga momwe mukhoza adzaweruzidwa pa nthawi imeneyi, zotsatira zoipa za alleles awiri ndi chokhala. Izi zikutanthauza kuti ubongo wa munthu, amene ali alleles awiri zoipa, zikuwoneka zaka zisanu wamkulu kuposa ubongo wa anthu amene ali mmodzi yekha zoipa allele. Ndipo ubongo awo, nawonso, zikuwoneka zaka zisanu wamkulu kuposa ubongo wa anthu amene alibe alleles negative. Ndiyeno mmodzi wa malingaliro zazikulu za jini ndi limodzi mwa zomwe TMEM106B asaaonerera ayankhe pulogalamu ubongo wa munthu pa stressors m'badwo. Monga mbali ya Kafukufuku yemweyo ofufuza anayang'ana pa ubongo wa anthu amene pa moyo wake anadwala matenda a Alzheimer kapena Huntington ndipo anapeza ndendende mmene womwewo wa jini pa kukalamba ubongo. M'pofunikanso kukumbukira kuti jini amakhala ogwira akafika zaka 65, pamaso pa anthu onse pa mlingo chomwecho.