Dongosolo Antinociceptive anthu kuchepetsa ululu

Antinociceptive dongosolo la thupi la munthu bwino delimited dongosolo mitsempha yomwe ili m'madera onse ndi madera onse a chapakati mantha dongosolo. kuphatikiza awo ndi mtundu wa utsogoleri wolowezana wa yogwira manja neurochemical, ndi luso suspend magwiridwe nyumba chopweteka mwa dongosolo nociceptive.

Action dongosolo antinociceptive

Pamene dongosolo umagwiritsidwa antipain zambiri opiotergicheskaya malamulo dera. Ndi mogwirizana kwa maselo opioid ndi ligands-opioids. Owayimira antinociceptive dongosolo akhoza kuletsa kusapeza mumamva kutengeka misinkhu yosiyanasiyana. Chifukwa cha ntchito ya limagwirira cha ululu komanso nkhawa sanakhale kumverera osakhala mu moyo wa munthu. Ngakhale pamene ululu akubwera, zinthu zochitika dongosolo antinociceptive aphatikizidwa ntchito kuti mungathe kumva mu mphindi ululu mthunzi, Imani. Izi ndi ntchito yaikulu ya limagwirira izi zoteteza thupi la munthu aliyense.

Tanthauzo la othetsa ululu chomwa mankhwalawa lero

Chidwi chomwa mankhwalawa Mankhwala, ndi njira, komanso anabereka dongosolo antinociceptive. The Maphunziro Akakhalidwe Kazolengedwa wa thupi bwino zafotokozedwa cholinga cha mankhwala mankhwala: iwo ntchito monga wamphamvu mankhwala ochititsa mankhwala omwe angathandize kuthetsa ululu antinociceptive dongosolo kapena kuchita mmalo ake.

Pakali pano, mankhwala - njira yokhayo wogwira mtima symptomatic mankhwala a odwala matenda a kansa. N'zotheka ndithu kulungamitsa ntchito mankhwala, kutenga nkhani mmene analgesic. Komabe, onse amene akudziwika sangathe waukulu wa mankhwala angapeze chokwanira, munthu wolimba maganizo mu cholengedwa yozungulira akukumana wapadzadziko chisauko ndi mwina zinatha ntchito yake isanakwane.

Kusiyana pakati nociceptive ndi machitidwe antinociceptive

dongosolo Antinociceptive ndi determinant ululu, limene linapatsa ululu kwathunthu maganizo. Polingalira mawu amenewa, kusiyana lingaliro ili ndi akuti "dongosolo imalandira" akhoza kumatanthauza mosavuta. Popeza analandira lofunika "chipangizo", T. E. Choncho liwulo chowunikira likhoza kutchedwa mpukutu osiyana dongosolo sensa, ndi nociceptive ndi dongosolo antinociceptive cumulatively kuimira osati determinant, ndi kudzikonda somatic dongosolo m'malo zovuta.

Kuti timvetse bwino zimenezi, m'pofunika kupereka chitsanzo. Khalani amadziwa nthawi zina kusowa ululu kumverera anthu, ndi titadziwa. Nthawiyi, waukulu nociceptive momwe ntchito bwinobwino, mwachitsanzo. E. Kupewa limagwirira ukugwira ntchito ululu.

Monga pali ululu ndi mantha Chowawa?

Ndi 70 TH zaka za m'ma otsiriza, ofufuza potsiriza anapanga maganizo mbali iyi ya dongosolo chapakati mantha monga ubongo dongosolo antinociceptive. Pa nthawi imeneyo, asayansi anali kupeza kutisokoneza angathe kupweteka malemeredwe, nyumba overvoltage kupewa nociceptive dipatimenti. Kuwonjezeka kuyabwa nociceptive yogwira dongosolo braking amakwiya ndondomeko zinthu antipain.

Madandaulo ululu angayambe kokha pamene zotsatira kwambiri pa thupi dongosolo antinociceptive sangathe kuletsedwa chifukwa cha chikoka cha zinthu extraneous. Yafupika ananyema ntchito ndi zinadzala ndi overexcitation dongosolo nociceptive ndi kuchititsa zosayembekezereka zosayembekezereka ululu wa chilengedwe psychogenic mu sankaganiza ziwalo sanali matenda.

Analgesic dongosolo la dongosolo thupi

Poganizira mfundo antinociception (antinociceptive dongosolo), muyenera khutu ku zigawo zake payekha. Pakati pawo, poyamba pa zonse izo Dziwani zinthu za dorsal midbrain ndi medulla (imvi kanthu, phata la mapangidwe reticular ndi raphe phata, gelatinous chigawo chimodzi cha chingwe msana).

Chifukwa cha iwo, pali zofunika Letsani ululu. Munthu yense pamodzi ndi kumva ululu pamene adakweza nociceptive malemeredwe kamwazi amenable kuti chopinga. Ntchito izi ndi za ulamuliro atsikira ululu. Zinthu zazikulu zosonyeza kuti braking ntchito mchitidwe opioids ndi ena mahomoni, monga serotonin. Kukhoza kuwatcha modulators chifukwa amasokoneza choyambirira malo amalire manyuroni, ngakhale kudutsa mu malangizo awo zotsatira zosangalatsa.

Timene ndi maselo mu ululu dongosolo antitsitseptivnoy

Waukulu ndi predetermining manyuroni machitidwe analgesic ndi anthu amene ankakhala mu nkhani imvi ya midbrain lapansi. yofunika kwambiri apa ndi axons, amene mkuuka cha ubongo imene imalamulira kutentha ndi njira zina za kumanzere oziziritsa Chigawo. Iwo mbali zosiyana kwa chingwe msana. Amkhalapakati a manyuroni zimenezi akuti pentapeptides, monga enkephalins subspecies. owayimira amenewa mu mawonekedwe a amino zidulo ayenera kupeza methionine, ndi leucine.

Enkephalins amatha mu nthawi yochepa, kuyambitsa zonse maselo a opiate. Pamene opiatergicheskih synapses, zolandilira izi zili makamaka pa Kakhungu, amene akuchita ntchito za postsynaptic "khushoni". Nawo synapses kukhala zopweteka, pamene Kakhungu ayenera allocated owayimira amatsogolera wovuta malemeredwe ku ubongo makamaka kwa wina.

Amkati dongosolo antinociceptive ali ndi khalidwe zolandilira opioid, kuti ayamba metabotropic. Iwo amaganizira bioregulator kuchititsa chopinga wa adenylate cyclase mwa kuzindikira okhudza maselo ambiri. Zotsatira za pamwamba onse ndi chisokonezo mu dongosolo kaphatikizidwe antipain. Kuwonjezera pathological kuchepetsa kashiamu mu thupi monga la nkhoswe chachikulu cha zowawa, T. E. Thupi limayamba kutulutsa iwo paokha. The owayimira ambiri chisoni ndi:

• mankhwala P;
• cholecystokinin;
• somatostatin;
• asidi glutamic.

Ubongo imene imalamulira kutentha ndi lamanzere Chigawo ubongo - activators kanthu

Ndi kapangidwe ka dongosolo monga antipain analgesic nyumba hypothalamic ndi somatosensory kotekisi wa kumanzere oziziritsa Chigawo. Kukula mphamvu zawo ochepetsera pa nociceptive zimagwirira munthu zimatheka kupyolera:

• chopinga wa zotsatira pambuyo pake pa manyuroni wa chingwe msana;
• kotulukira braking amasintha manyuroni wa thalamus ya;
• zotsatira adamulowetsa dongosolo tatchulawa kulamulira pamwamba-pansi mabuleki a.

Disengagement ululu mu thupi

kachitidwe Nociceptive ndi antinociceptive cha thupi ndi mogwirizana pafupi. Yotsirizira umabala amkati zigawo opioid, zomwe kwenikweni ndi mankhwala mkati.

Zikuphatikizapo endorphins, dynorphin, ndi zina zotero. D. The peculiarity wa mipweya ndi phompho peputayidi mindandanda, monga tinthu ting'onoting'ono mapuloteni omwe amapangidwa ndi amino zidulo.

Udindo wa mapeputisayidi sanali opioid ndi opioid

Mu nambala zaphindu kwa manyuroni monga antinociceptive dongosolo zolandilira yeniyeni ili ndi zinthu zina. Mwachitsanzo, anakumana ndi maselo opioid umatchulidwatchulidwa pa wotsatira braking ntchito manyuroni payekha. Pankhaniyi, nociceptive ululu dongosolo amakhala akulephera ndi ululu pafupifupi Kodi samva. Chinthu manyuroni yaing'ono dongosolo analgesic ndi kutsekeka kwa kufala ndi kufalitsa ululu wotsatira malemeredwe unyolo mathero.

The ndondomeko zolimbana mwa zikamera wa ululu sikumangotanthauza opioid mapeputisayidi. Non-opioid mapeputisayidi (mwachitsanzo, neurotensin) kusokoneza chomaliza bolevospriyatie anthu. Akuwuka osiyanasiyana magwero ululu akhoza ziletsa noradrenaline, dopamine, serotonin ndi makatekolamaini ena.

Kodi limagwirira wa yimitsira ululu?

Antinociceptive ntchito ya dongosolo thupi kungakhale njira zingapo:

1. Limagwirira kanthu mwamsanga. Pali zimene nzothandiza chowawa, kuchititsa synaptic malemeredwe mu dongosolo wafika ulamuliro ochepetsera. Mwa nyanga kumbuyo kwa chingwe msana pa nthawi imeneyi Tingaone Kuchepetsa afferent nociceptive kukondoweza. Mu gawo lalikulu la analgesia limagwirira izi. Pamene yimitsira ululu imodzi ntchito awiri chowawa kuwalimbikitsa.
2. Limagwirira kanthu kochepa. Yambani ubongo imene imalamulira kutentha, yokhudza ulamuliro ananyema dongosolo atsikira mtundu wa dorsal midbrain ndi medulla. Kuti yambitsa limagwirira kuti Kuchepetsa malemeredwe ululu pa mlingo wa stressors msana ndi zina ubongo zofunika.
3. Limagwirira kanthu yaitali. Madera aakulu zili ubongo imene imalamulira kutentha kwa, adamulowetsa pa kupweteka m'thupi. Updraft chowawa malemeredwe imafalikira ku ziwalo zonse za ulamuliro kunsi. Mwa dongosolo nociceptive zikugwirizana ndi coloration maganizo a ululu. Chotero kuyesa nthawi zambiri si cholinga.
4. Zimandilimbikitsa limagwirira. Chifukwa ntchito yake zonse dongosolo antinociceptive amapereka malo mbali yozungulira ndi mazunzo a kotekisi ubongo. Iwo zili Lobe mazunzo, kumbuyo maso. Ntchito nociceptive dongosolo anaonetsetsa zonse braking kwenikweni. Mwa njira, ndondomeko imeneyi Tingaone, ndi anasiya ululu.

ululu ndi chiyani?

Antsinotsitseptivnaya dongosolo la thupi, kulamulira Kapangidwe ka kotekisi oziziritsa, amathandiza pokonzekera zotsatira chisanadze kuvulazidwa, Ndiyeno mutenge nzothandiza ululu ndi kuchepa kwa zosasangalatsa, zomverera wovuta.

Kuyambira onse pamwamba, mungapeze mfundo yosavuta kuti mphamvu ndi chikhalidwe cha ululu anakonzeratu mbali ya ntchito kwa machitidwe awiri: nociceptive ndi antinociceptive. Choyamba - zowawa, chachiwiri - antipain. Limatchula za mogwirizana awo Mzimuyo chikhalidwe cha ululu anakumana ndi munthu. ululu angakhale osiyana, motere:

• Hyperalgesia - boma pamene kuchuluka kudziwa ululu, chifukwa cha yomwe ikhoza kukhala mkulu mukubwadamuka dongosolo nociceptive kapena antinociceptive otsika dongosolo malemeredwe.
• Hypoalgesia - boma pa maola kudziwa ululu chifukwa cha azisiyana: ululu antinociceptive dongosolo kuchuluka ndi kuchepetsedwa nociceptive dongosolo malemeredwe.

Onse zinthu kungatithandize zabwino pa thupi, ndipo iwo kwakukulukulu kudalira pa pakhomo la ululu. phindu ili mukuimira munthu wa sanali malo amodzi makina chigawo, zimasiyana ndi mbali ya ululu ndi machitidwe analgesic. Ndipo antinociceptive ndi kupanga dongosolo limodzi nociceptive ululu zovuta, kukhala yekha zanyengo.

Kodi likuoneka kuvulaza munthu?

M'malo zovuta imalandira bolevospriyatiya dongosolo koyenera kuti munthu kukhalabe thupi ndi ziwalo mtima wosagawanika. Komanso, kachitidwe liziyenda matenda (ululu ndi antipain) zimakhudza moyo wa munthu zoipa. Mu pachimake yochepa kapena aakulu zomverera ululu, zotsatirazi akupezeka:

1. kugona chisokonezo.
2. Kupanda chilakolako chogonana.
3. Irritability, inattention.
4. The kuchepa ntchito galimoto.
5. Depression maganizo psycho-maganizo boma.

Madandaulo ululu - imfa

ululu amachepetsa kupuma, nthawi zina kusiya kwathunthu, pamene ofooka maziko ululu zingakhudze mathamangitsidwe ake. Mu ululu kumawonjezera mlingo mtima, kuthamanga magazi, zomwe zingasokoneze kukula kwa zotumphukira mtima kuphipha.

Choyamba, khungu amakhala wotumbululuka, koma ululu dilated yochepa Mitsempha chifukwa ankatenthetsa izo. Yafupika katulutsidwe malovu, madzi muzituluka ndi kupanga kapamba, matumbo peristalsis oyima, zomwe nthawi zambiri kumayambitsa anuria. Chitukuko cha mantha zopweteka kwambiri ululu ana amakumana ndi mavuto oopsa.