"Epoetin alfa": Buku malangizo, ndemanga ndi analogues

Uncharacteristic mlingo wa ndende ya hemoglobin - chimodzi mwa zizindikiro za kuchepa kwa magazi m'thupi. Ndipotu, si matenda, koma chizindikiro kuti ndi chizindikiro cha matenda ambiri. Patsogolo matenda amenewa zingasonyeze kuti chotupa chachikulu cha dongosolo magazi.

The stimulator wa erythropoiesis, amadziwika pansi pa dzina mayiko sanali kampani monga "Epoetin alfa" malangizo ntchito monga mkulu ntchito pamalo reagent katundu pharmacological akupita kwa mankhwala ndi kupewa anemias wa etiologies osiyana. Bwino osankhidwa mlingo ndi amathandiza osati ziziyenda magazi chigawo dongosolo, komanso ali ndi ubwino minofu mtima.

mawonekedwe kumasuka ndi mipweya

Mankhwala mankhwala akupezeka mu pharmacies mu mawonekedwe a:

• wosabala disposable syringe ndi mlingo preset (kapangidwe amapereka masingano chitetezo zina);
• yothetsera mu mbale.

Ntchito ya pophika wothandiza wapatsidwa;

• madzi injectable;
• mankhwala enaake dihydrate ndi sodium wochuluka hydrogenphosphate;
• polysorbate 80.

Ntchito zamoyo ndi thunthu mu botolo kungakhale osiyana. Nthawi zambiri, chikwi kapena zikwi ziwiri mayunitsi mayiko pa 0.5 ml ya madzi. Komabe, pali komanso kugulitsa njira zina reagent, kuphatikizapo "epoetin alfa" ma PC 10,000. / 1 ml.

Limagwirira kanthu pharmacological

Tizilombo ndi immunological katundu wa mankhwala apanga zofanana ndi erythropoietin achilengedwe. Choncho, mankhwala bwino kwambiri limaleka zizindikiro za kuchepa magazi, ndipo amatilangiza magazi monga glycoprotein lililonse. Ine ndiyenera kunena kuti "epoetin alfa" kwenikweni umalimbana kuwonjezeka hematocrit ndi milingo hemoglobin normalization. Wake "mtima ntchito," komanso chizolowezi cha zigawo za kusintha magazi kuti zimakhala ndi zochepa kutchulidwa.

theka nthawi:

• jekeseni mtsempha - maola anayi
• pamene jekeseni subcutaneously ndi - pafupifupi tsiku.

Ndende pazipita ndi reactant mu madzi kuti tiyembekezere pambuyo maola 12-18.

mokoma pharmacokinetic

Kafukufuku akusonyeza kuti mankhwala anafotokoza induces mapangidwe chitetezo mu mode "matalala" ndi kufunika kwake pharmacological mu njira ya mafupa fibrosis ali pafupi ziro. Mapuloteni kachigawo medicament "Epoetin alfa" tso za 165 kwa amino zidulo (58% ya kulemera okwana maselo), ndipo izi zimaonekera digiri ndi khalidwe la zigawo zimakhudza magawano / zosiyanasiyana maselo kholo.

Mobwerezabwereza makonzedwe mtsempha (pakalibe pathologies aimpso) sichichititsa kudzikundikira thunthu yogwira; ana osaposera zaka 12 ndi mwina prolongation mwa nthawi T1 / 2 maola 6.

zikuonetsa kuti

"Epoetin alfa" akulimbikitsidwa kugwiritsa ntchito ngati:

• magazi m'thupi matenda monga matenda ntchito hematopoietic, zomwe zimathera khansa (chichitike kuti sanali myeloid zotupa);
• wodwala akumva kufunika hemodialysis zonse kapena peritoneal dialysis ;
• ndi funso kukwaniritsa opaleshoni zovuta ntchito kuikidwa allogeneic magazi;
• wodwalayo ali ndi kachilombo ka HIV ndi kulandira mankhwala pamaziko a zidovudine;
• Kugoletsa amafuna kupewa.

The mulingo woyenera dosing kamwedwe

Kukonzekera "Epoetin alfa", tikutsata ndondomeko za kusankha munthu wa mlingo tsiku. Komabe, ayamikira ambiri a Mlengi okha kuti malamulo amenewa ndi miyezo:

• kumayambiriro kudzudzulidwa gawo makumi asanu mayunitsi kanthu (IU) pa thupi kilogalamu thupi, koma palibe zoposa zitatu jekeseni / infusions pa sabata;
• pakalibe kuonekera kosangalatsa: 75 mayunitsi / kg pa imeneyi chomwecho, koma palibe mwezi kale kuposa wina ukatha mwambo wa chithandizo;
• vuto kwapadera: 100-200 U / kg, mosamalitsa chotsatira anati jekeseni ndandanda (sitepe kuwonjezeka - 25 mayunitsi / mwezi);
• yokonza mankhwala: mlingo kutumikiridwa pa mlingo umene unali mu hematocrit osiyanasiyana 30-35 Vol. %.

Monga mmene kuchita, kuti "mfundo" Nthawi zambiri anatengedwa mlingo umodzi wa 30-100 IU / kg, amene zambiri galimoto mapeto a dialysis. Kutalika mulingo woyenera kwambiri ine / g kulowetsedwa - wina kwa mphindi ziwiri; limagwirira yobereka subcutaneous mwa mankhwala yogwira kutsatira malamulo omwewo.

Gulu la zotheka mavuto

Pa anachita zitsanzo atypical chamoyo ndi kukhalapo kwa zigawo mankhwala "Epoetin alfa" malangizo Buku inanena izi:

• zotheka kuti muzione zizindikiro zenizeni mavairasi fuluwenza - chizungulire kwambiri, maganizo, kufooka, malungo, aakulu olowa ululu / minofu;
• analola imbalances mtima ndi magazi mitsempha - kuwonjezeka lakuthwa magazi, zilonda matenda oopsa;
• wina sangaunyalanyaze chiopsezo thrombocytosis (matenda, ngakhale ali gwero ali osowa kwambiri, koma ana amakumana ndi mavuto aakulu);
• reagent mu dongosolo mkodzo ndi chokhoza kusonkhezera ndi kusintha kuchuluka kwa potaziyamu ndi mankwala mu thupi (osati anatulutsa milingo creatinine kuwonjezera madzi a m'magazi).

Pa khungu komanso nthawi zina noticeable kuyabwa amayamba ndi kumayambiriro "Epoetin alfa" kukonzekera. Malangizo, makamaka akulankhula za totupa, chikanga, angioedema. Ndipo kodi chidwi: pamene subcutaneous jekeseni kuchuluka mwamphamvu ndi apamwamba: pafupifupi milandu chikwi, mlandu nkhani za 4 (ndi pa / mu infusions - 1.6 okha).

Pa kusintha cha m'thupi chimene chingasokoneze anati zoona, palibe mfundo zodalirika (chidwi kupatula ndaitchula mphamvu ya mankhwala kupangira mapangidwe chitetezo).

Malinga ndi contraindications Mlengi

Mfundozi zachokera operekedwa mu kalozera wa boma, "Epoetin alfa" (analogs monga "Binokrit" ndi "Eralfon" chikutanthauza kukhala pafupi ndi wapachiyambi) sayenera kugwiritsidwa ntchito ngati:

• anandipeza ndi matenda oopsa kusalankhula;
• wodwalayo amakhala hypersensitivity kuti zosakaniza;
• kusanthula kuyambirira anasonyeza yovuta mizere pathologies magazi;
• wodwalayo anadwala matenda a mtima (tikulankhula za m'mbuyomu posachedwapa);
• pali chifukwa chokhulupirira kuti kusokoneza otaya yachibadwa magazi mu ubongo.

M'mawu ena, chiyambi cha mankhwala ayenera yoyamba Kupenda dokotala.

Kusamala

"Epoetin Alpha" (tradename amapanga zofanana chiphunzitso angakhale osiyana - mwachitsanzo, mmalo adzapelekedwa analogs "Aeprin", "Repoetin-SP", "Epokomb", "Eprex", etc ...) Ayenera kugwiritsidwa ntchito ndi kuchuluka kusamala ndi anthu odwala matenda kobwereza / aakulu a minofu zotumphukira. ulamuliro Izi zimachitika makamaka ngati mbiri ngati zimene thupi zakudya mankhwala ena kale olembedwa nkhani ya zochita convulsive.

Sikukukolana ndi maso ndi gout. Kumvera pa kulankhula choyamba tiyenera kuika pa nkhani zokhudza magazi ndi zosayembekezereka wa litsipa (antihypertensives - imodzi mwa zotsatirazi mankhwala Inde Kusintha). Komabe, ofunika kuti asa- ndi boma oona za masitolo zachitsulo (pamaso jakisoni zonse). Pamene tikugwira ntchito mokwanira si anasonyeza mwa mawu a magazi, njira anafotokoza pharmacological mankhwala ndi ndinayima.

Tiyenera kukumbukira kuti impso kulephera, khansa ndi HIV ali pa mndandanda wa matenda mu njira imene, ndi maziko a hematocrit ndende, pali kuchepa khalidwe madzi a ferritin mu madzi a m'magazi. Pochepetsa imbalances achisangalalo ku M'MALO mankhwala yokhudza Fe munali reactants.

Zitsanzo kwa hemoglobin kuti m'pofunika kuti atenge 1 nthawi iliyonse masiku 7. Komanso pa kukhazikitsidwa kwa miyezi iwiri chofunika polojekiti zonse za kupatsidwa zinthu za m'mwazi kuwerengedwa. Ndipo kwa masiku 5-10 isanafike opaleshoni, wodwala kutumikiridwa mankhwala khadi zinthu ndi katundu antithrombotic.

Mlengi sakulamulira kuti zigawo zikuluzikulu za mankhwala zingakhudze mitundu ina ya zotupa, kotero ananena wodwalayo sayenera anasiya ngakhale mapeto a yogwira gawo chithandizo.

Kodi kuchita ngati mankhwala osokoneza bongo?

"Epoetin Alpha" (ofanana-mankhwala, poyamba, zinthu ngati zomwezi) ndi mankhwala osokoneza bongo amachita malinga ndi ma aligorivimu kuwonjezekeredwa mu mankhwala opangidwa zophatikizananso erythropoietin i.e. amakwiya polycythemia hematocrit msinkhu ndi oscillations. Chifukwa chosowa ZINGATHANDIZE tingachipeze powerenga, zinthu zina chapadera deactivation wa zosakaniza si ikuchitika - basi zimafika mankhwala wina kusankhidwa.

Dala magazi m'mitsempha applicable milandu la mwadzidzidzi, pamene pamwamba-malire chizindikiro cha hemoglobin amasonyeza owononga moyo.

Mwanjira ndi Mankhwala

Kuchititsa Mipikisano gawo zovuta mankhwala n'chofunika kwambiri kumvetsa mfundo za "pharmacological khalidwe" "Epoetin alfa" reagent (kumasulidwa mawonekedwe, monga tafotokozazi, angakhale osiyana, koma limagwirira wa linachepa amuzolengedwa sasintha).

Choncho, makamaka, ikufanana ndi kumayambiriro mankhwala magazi kuli ndi ubwino pa kuwongolera mphamvu. Koma tikumbukire kuti dilution wa njira ya wina ndi inadmissible. The mankhwala ndi "wogwirizana" cyclosporin zinadzala ndi kucheperachepera ndende ya yotsirizira (momwe akadakwanitsira volumetric chiŵerengero cha Mlingo wa anatsimikiza empirically).

Comments

Analysis malingaliro chikusonyeza kuti chiwerengero chachikulu cha mafunso pankhani njira kupezeka kwa kuthetsa vuto lomwelo. Mwachitsanzo, ochepa odwala ndi odziwa kusiyana zimene zikuchitika pakati mankhwala amenewa pharmacological, monga "epoetin alfa" ndi "epoetin beta."

Kodi kusiyana - mosavuta, ngati ife kulabadira zimene madokotala. chakuti chitsanzo structural wa erythropoietin zachilengedwe ukufanizidwa ndi maunyolo awiri, ndi a mtima dongosolo magazi ndi onse. Opanga mankhwala omwewo, chifukwa cha kusiyana sayansi, kapena lithe alpha-mpukutu kapena beta.

Koma ndemanga pa yokonza palokha, ambiri mwa anthu amene anali kuyesa nokha, zimasonyeza kuti amatanthauza ndi mogwira mtima ndithu, ndi zina zapadera ndipo nthawi zonse chofunika kwa magulu ena a anthu odwala.