Mankhwala "Akineton": malangizo ntchito, maonekedwe, ndemanga

Thunthu yogwira "Akinetona" ndi biperiden hydrochloride. Piritsi accommodates 2 mg wa mankhwala yogwira. Komanso, pamaso pa zigawo zina (chimanga wowuma, wowuma mbatata, lactose monohydrate, magnesium stearate, microcrystalline mapadi, copovidone, calcium wa hydrogen mankwala dihydrate, talc, madzi woyera) amatenga mankhwala "Akineton".

Malangizo ntchito, chithunzi zikusonyeza kuti piritsi mawonekedwe a mankhwala ali pafupifupi mtundu woyera, Valium mawonekedwe. Pa mbali imodzi ya piritsi pali chiopsezo cha beveled mawonekedwe mtanda.

1 ml ya yothetsera lili biperiden lactate mu kuchuluka kwa 5 mamiligalamu. zigawo zina ndi: jekeseni madzi ndi sodium wochuluka lactate.

zotsatira pharmacological

Main pophika biperiden - holinoblokator kanthu chapakati.

Impact kumafuna ogwetsa luso ntchito cholinergic okhudza mitsempha mu striatum, amene ndi structural unit wa dongosolo extrapyramidal.

Mankhwala amachititsa zotsatira ganglioblokiruyuschimi, mwamphamvu mamita-anticholinergic zotsatira antispasmodic ndi zolimbitsa pa periphery (antispasmodic).

Ntchito ya mankhwala amathandiza kuthetsa nthambi kugwedeza, yomwe ikutuluka ntchito mankhwala cholinergic (mwachitsanzo, pilocarpine) ndi catalepsy ndi minofu chinthu chimodzimodzi odwala kulandira neuroleptics. Amatha kupangira mukubwadamuka.

Pharmacokinetics

"Akineton" womangidwa kwa mapulotini plasma pa 91-94%. Madzi a m'magazi chilolezo adzakhala 11,6 ± 0,8 ml ya / mphindi / kg thupi. A mlingo umodzi wa chiphunzitso m'kamwa ali ndi bioavailability pafupifupi 33 ± 5%.

Wapambana mu mkaka wa m'mawere.

Biperiden kwathunthu zimapukusidwa mu thupi la munthu. Mu mkodzo, mankhwala si anatsimikiza mawonekedwe unaltered. The metabolites lalikulu ndi bicycloheptane ndi piperidine, zimene linanena bungwe kuchokera ndowe ndi mkodzo.

Elliminatsiya ikuchitika magawo awiri, ndi moyo theka (T 1/2) kwa mphindi zosachepera 90 pa gawo loyamba ndi maola 24 - gawo lachiwiri. Odwala achikulire, hafu ya moyo angadwale zayamba.

zikuonetsa

"Akineton" ntchito matenda extrapyramidal anachititsa ndi utsogoleli wa mankhwala ena (neuroleptics, antipsychotics).

Komanso, mankhwala akusonyeza kuti matenda a matenda syndrome Parkinson, parkinsonism (wothandizila kutumikiridwa mu mankhwala osakaniza ndi maziko a)

contraindications

Cholinga cha mankhwala sitingachisonyeze pamene muli hypersensitive kwa pophika yogwira mankhwala "Akineton".

Malangizo ntchito imatiuza kuti mankhwala ayenera kuzipewa ku matenda a matenda wodwalayo monga Prostate kukulitsa, njingayo-kutsekedwa khungu, kusintha obstructive mu intestine ndi (pylorus stenosis, manjenje ileus Genesis).

Arrhythmia, khunyu, kuyamwitsa, okalamba, mimba zinthu zimene "Akineton" kutumikiridwa mosamala kwambiri.

zotsatira zoyipazi

CNS mavuto ali kuwonetseredwa asthenia, kutopa, ulesi, kufooka, dzanzi, chizungulire, kumverera kwa nkhawa, nkhawa, kuwonongeka kukumbukira, chisokonezo, kuyerekezera zinthu m'maganizo, catalepsy, kudalira mankhwala mankhwala "Akineton".

Malangizo ntchito akulankhula za mbali-zotsatira ndi mbali ya masomphenya - mydriasis, chosokoneza wa malawi.

Cardio-mtima dongosolo amakhala ndi kufulumizitsa kwa kugunda kwa mtima (tachycardia); nthawizina - deceleration (bradycardia); Pamene ntchito jekeseni mawonekedwe lokonzekera - amachepetsa magazi (hypotension).

Pa mbali ya dongosolo m'mimba - youma pakamwa, zizindikiro dyspeptic, kudzimbidwa.

Pa mbali ya kagayidwe - ndichepe thukuta.

Pa mbali ya dongosolo mkodzo - odwala ndi kukulitsa (hypertrophy) ku prostate - movutikira zotheka kukodza.

thupi lawo siligwirizana: okhadzula pakhungu, kuyabwa.

Njira Ntchito

Pakuti mu mnofu, mtsempha, ndi m'kamwa piritsi mawonekedwe kuyenera kukonzekera "Akineton".

Malangizo ntchito akusonyeza kuti mankhwala "Akinetonom" ambiri akuyamba ku Mlingo yaing'ono, mlingo kwambiri ukuwonjezeka stepwise malingana kufunika kwenikweni achire ndi mavuto.

Akuluakulu pa ntchito mawonekedwe ndi m'kamwa kukonzekera kuyamba mankhwala pa mlingo wa 1 mg 1-2 phwando masana kapena 2 mg wa ogaŵikana Mlingo awiri patsiku. Komanso, mlingo akhoza ziwonjezeke kwa 8 mg awiri kapena anayi Mlingo osiyanasiyana. Komabe, mlingo sayenera kuonjezera oposa 2 mg wa pa tsiku. Musalumphe mlingo pazipita akutanthauza 6 mu Th-16 mg pa masiku asanu. Single mlingo mawonekedwe injectable mankhwala sayenera upambana 2.5-5 mg. mankhwalawa uyenera kubwerezedwa pambuyo theka la ola, koma chiwerengero cha maboma patsiku sayenera upambana nthawi 4. Mlingo pazipita medicament mu injectable mawonekedwe ndi 20 mg pa masiku asanu. Pamene mlingo mulingo woyenera kukufika, ndiye kusintha ku phwando "achigonjetse Akinetona."

Koma musaiwale za njira munthu aliyense wodwala poika biperidenom mankhwala.

Extrapyramidal kudwala akuwuka chifukwa ingestion mankhwala ena (antipsychotics kapena neuroleptics) imayenereza ntchito mankhwala anapatsidwa mu mlingo umodzi wa 2 mg wa kuwauza kapena parenterally. Dongosolo Bwerezani wa Mlingo anati angakhale aliyense theka la ora. Komabe, monga tanena kale, chiwerengero cha maboma sayenera upambana nthawi 4. Mlingo m'kamwa ayenera kugawidwa Mlingo umodzi atatu.

matenda Parkinson kumaphatikizapo kugwiritsira mankhwala pakamwa pa 6-8 mg wa mu 2-4 anagawa Mlingo kwa tsiku, mlingo akhoza pang'onopang'ono kuchuluka kwa 6-16 mg.

Ana osaposera cholinga chaka zikusonyeza kuthekera mankhwala mu injectable mawonekedwe pang'onopang'ono, mlingo umodzi wa 1 mg kapena 0.2 ml. Pamene zaka chaka chimodzi mpaka zaka zisanu ndi chimodzi kutumikiridwa 2 mg kapena 0.4 ml. Kuyambira zaka 6 mpaka 10 - 3 mg kapena 0,6 ml. mankhwalawa uyenera kubwerezedwa pambuyo theka la ola ndi ovulala pangozi. Pamaso pa mavuto pa utsogoleli wa mankhwala ayenera anasiya jekeseni.
Pa mawonekedwe m'kamwa wa mankhwala kuyambira zaka zaka 3 mpaka 15 yopititsa mlingo wa 1-2 mg wa maola 1-3 pa tsiku.

Miyalayo Simungathe kumwera pa chopanda kanthu m'mimba, ndipo muyenera kumwa zolimbitsa kuchuluka kwa madzi. Pa zosayembekezereka ya zotsatira osafunika mbali kuyambira dongosolo m'mimba ayenera kutenga mankhwala mwamsanga pambuyo chakudya, kuchepetsa kuopsa kwa amadza chowawa amatanthauza "Akineton".

Malangizo ntchito limasonyeza kuti nkhani ya chikonga poizoni akuluakulu muyezo mankhwala zovuta amadziwikanso kutumikiridwa mankhwala, ndi mlingo wake ndi 5-Th-TB-10 mg likamanena m'jekeseni, koma pokha pokha zimene zingawononge moyo wodwalayo.

Pamene chiphe organic phosphorous zosakaniza biperiden dosing ikuchitika payekha malinga ndi kukula kwa zotupa. Kuyambira mlingo wa 5 mg mu nkhani ya utsogoleli mtsempha, utsogoleli mobwerezabwereza kupitiriza mpaka zizindikiro zikawoneka poizoni.

ambiri osokoneza

Ambiri osokoneza kuwawonetsera kutchulidwa zotsatira anticholinergic chifukwa cha mankhwala "Akineton".

Malangizo ntchito, madokotala weniweni kulabadira chakuti chithandizo cha chikhalidwe ichi posimptomnaya (yokonza wa mtima ndi machitidwe kupuma mankhwala mpweya, hyperthermia kudzudzulidwa, ndi mkodzo catheter akonzedwa, ngati n'koyenera). Liyenela kukhazikitsa ndi cholinesterase woletsa (physostigmine kwenikweni) .

mogwirizana

"Akineton" pamene ntchito mamita-holinoblokatorami, mankhwala ndi antihistamine ndi kanthu antiepileptic timapitiriza mawu a mtsogolo. Komabe, munthawi yomweyo kugwiritsa ntchito metoclopramide amachepetsa zotsatira zake achire. Pali okhazikika zosagwirizana mankhwala ndi Mowa. Pangano quinidine ukuwonjezeka mu nthawi kusamala angathe kukhala zizindikiro dyskinesia. M-cholinergic zotsatira kumatheka Pamene ntchito levodopa.

Yosungirako ndi zogulitsa

Kugula mankhwala amafuna mankhwala kupereka pharmacist. Kusunga "Akinetona" ayenera kutsatira kutentha, T. E. yozungulira kutentha sayenera upambana madigiri 25 (Celsius lonse). Tiyenera kufikira kwa ana ku chipatala "Akineton".

Buku amapereka alumali moyo wa mankhwala - zaka zisanu.

Kusamala

Kusankha biperiden pa mimba ndi yoyamwitsa (mkaka wa m'mawere) amafuna adziwe chilichonse.

Biperiden mukhoza kupeza kuti mwanayo kudzera mu mkaka wa m'mawere kuchititsa kulephera zosakhalitsa yoyamwitsa kwa discontinuation wa mankhwala "Akineton".

Mankhwala kufotokoza ananena kuti tipanga pa poika biperiden pa mimba ndi mkaka wa m'mawere kuganizira chiopsezo lingathe khandalo, mwana wosabadwayo.

Okalamba chimakhala chinthu chiopsezo cha mankhwala ndi mankhwala. Choncho adzaika "Akineton" gulu la anthu amawagwiritsa.

Kickaha kusapezeka kwa umboni uliwonse wa ntchito chitetezo ana, ndiye chifukwa chake siligwira ntchito kwa ana mankhwala "Akineton".

Kufotokozera za kukonzekera (malangizo Buku) n'chakuti chakuti kusamala chofunika ntchito mankhwala odwala ndi khunyu kapena fibrillation.

Ndi ntchito yaitali angathe mankhwala chidakwa.

Chiopsezo syndrome achire kumaphatikizapo kutha pang'onopang'ono mankhwala "Akinetonom".

kumwa munali mowa ayenera kupewedwa nthawi chithandizocho.

Chithandizo ndi mankhwala kumafuna kudziletsa kwa galimoto magalimoto ndi masewera zinthu zimene amafuna ndende mkulu ndi zochita mofulumira psychomotor, chifukwa chiri ndi zoopsa chifukwa chiopsezo chizungulire.

"Akineton". Malangizo ntchito. analogs

Mau ofanana kukonzekera ndi zinthu zotsatirazi: "Biperiden" "Mendileks" "hydrochloride biperiden".

"Akineton". Reviews

Mankhwala othandiza kwambiri pa matenda a Parkinsonism inagwedezeka mu nthambi ndi kutsazikana patapita nthawi yochepa imeneyi. Wanena bwino analekerera mankhwala "Akineton".

Feedback pa maonekedwe akulankhula zokhuza kuthekera chiwonetsero cha zotsatira zina mbali pamene akumwabe mankhwala.

Price "Akinetona". kumene kugula

Mtengo wa njira akhale mozungulira 800 rubles.

Price m'kamwa chiphunzitso "Akinetona" - 560-580 rubles.