"Oseltamivir": malangizo ntchito, analogs, ikulongosola za mankhwala

N'chifukwa mankhwala mankhwala "Oseltamivir"? Malangizo ntchito, analogs, zizindikiro ndi contraindications mankhwala adzakhala anafotokoza patsogolo pang'ono. Ifenso kukuuzani mawonekedwe zimene mungathe kugula anati medicament, zomwe zimatha iwo ali, kaya mavuto ndi zina zotero. D.

The mawonekedwe, kapangidwe, ikulongosola za mankhwala

Mu kugulitsa mankhwala akubwera mu maonekedwe a makapisozi chikasu woyera. "Oseltamivir" - ndi prodrug. Pamene ingested, ndi hydrolyzed ndi kutembenuza kwa yogwira pophika - oseltamivir carboxylate.

Kuwonjezera makapisozi ndi medicament amachoka mu mawonekedwe a ufa kuwala kwa kuyimitsidwa m'kamwa.

Features mankhwala

mankhwala "Oseltamivir" Kodi ntchito? Malangizo pa ntchito limanena kuti zotsatira achire wa mankhwala zachokera yimitsira a ntchito za michere, zomwe zili padziko HIV virion fuluwenza.

Pa chiphaso cha medicament mu thupi chigawo waukulu likamadzakonzedwa kwa metabolite yogwira. Choncho, oseltamivir carboxylate kusankha kumabwezera mmbuyo neuraminidase. Chifukwa cha kukhudzana ngati ikutha tizilombo selo chulutsa ndondomeko.

Malinga ndi luso, kutenga mankhwala ayenera kuperekedwa pasanathe maola 35 kuchokera zizindikiro woyamba wa fuluwenza. Mwa njira iyi nthawi ya matenda kuchepetsedwa ndi 30%, ndipo Mwina mavuto ndi kuopsa kwa zizindikiro - 40%.

Pharmacokinetics mankhwala

Kaya mankhwala odzipereka "Oseltamivir"? Malangizo ntchito zikusonyeza kuti pafupifupi 90% ya oseltamivir wa phosphate odzipereka mu kapepala gastro-m'mimba. Thunthu yogwira ndi wotembenuka ku carboxylate wa oseltamivir ndipo kenako walowa kufalitsa zokhudza zonse.

About 3% ya pophika yogwira amangidwa zonsezo plasma. bioavailability ake ndi pafupifupi 76-85% ndipo kuwonongedwa theka moyo - mphindi 120.

Kuyambira oseltamivir anthu carboxylate lachokera ndi impso (pafupifupi 80%) ndi m'matumbo (20%.) Theka-moyo wa mankhwala ndi maola 6-10.

zikuonetsa

N'chifukwa mankhwala mankhwala "Oseltamivir" (munda gulu -. Wothandizila mavairasi oyambitsa)? Malinga ndi malangizo, medicament ntchito pofuna kuchiza fuluwenza A ndi B. Komanso, amagwiritsidwa ntchito kawirikawiri kupewa matenda tizilombo.

contraindications

Kodi contra "Oseltamivir" (kulongosola lokonzekera waperekedwa pamwamba)? Malinga ndi malangizo, kupanga mankhwala ndikoletsedwa pa:

• Hypersensitivity kwa pophika yogwira;
• aimpso kulephera (chitetezo ndi efficacy wa mankhwala odwalawo sichinayambe kuzindikiridwa);
• ana osakwana 1 chaka (pali njakata monga mapangidwe a BBB ana);
• mimba ndi yoyamwitsa (izo Sizikudziwika ngati mankhwala ndi excreted mu mkaka wa m'mawere wa amayi, ndipo kaya zimakhudza mwana wosabadwayo).

Iwo ayenera kukumbukira kuti mankhwala ali osavomerezeka chifukwa ana a zaka 13, monga akatswiri osati atsimikiza chitetezo ndi efficacy wa 'Oseltamivir' kuti kupewa ndi kuchiza wa fuluwenza.

Mankhwala "Oseltamivir": malangizo ntchito

Vidal (Mankhwala Handbook) muli mfundo mabuku mmene nanga mlingo muyenera kutenga mankhwala mu funso. Komabe, tisaiwale kuti mankhwala mankhwala ayenera dokotala. Ndipotu yekha katswiri wodziwa adzatha kusankha bwino mankhwala chakudya, amene mwamsanga ndi mogwira kuthetsa zizindikiro zonse zosasangalatsa matenda tizilombo.

Choncho zimene mlingo Kwalamulidwa "Oseltamivir"? Malangizo ntchito akusonyeza kuti mankhwala ayenera kugwiritsidwa ntchito mwa masiku 2 pambuyo isanayambike zizindikiro loyamba la chimfine.

Ana okulirapo kuposa zaka 13 ndi akulu ndi mankhwala kutumikiridwa mu kuchuluka kwa 75 mg kawiri pa tsiku kwa masiku 5. Ziyenera kukhala yomweyo ananena kuti akawawonjezere mlingo wa mankhwala (mwachitsanzo, mpaka 150 mg pa tsiku) sanali patsogolo zotsatira achire.

Ngati mankhwala mukufuna angayike ana zaka 1-12, mlingo kusintha malingana ndi mwana thupi.

Pofuna kupewa fuluwenza kwa akulu ndi ana oposa zaka 13 Kwalamulidwa 75 mg 1 kamodzi kwa masabata 6 pa tsiku (mwachitsanzo, panthawi ya mliri).

Odwala CL creatinine zosakwana 30 ml ya pa mphindi chofunika kudzudzulidwa mlingo (75 mg kamodzi kwa masiku 5 pa tsiku).

Zotsatira zoyipa za mankhwala pambuyo ingestion

zochita chilichonse chowawa zimachitika pambuyo ka 'Oseltamivir' kukonzekera? Malangizo pa ntchito limanena kuti zambiri akuwonetseredwa zosiyanasiyana chokhwima ndi kunyansidwa ndi kusanza. Nthawi zambiri, zotsatira wofatsa kapena amtengo lofotokozeredwa ndipo zambiri zimachitika m'masiku oyambirira a chithandizo.

Iwo ayenera kukumbukira kuti odwala ena odwala kulandira mankhwala pansi review, kukhala matenda, vertigo tulo, kusakhazikika angina, pseudomembranous matenda a m'matumbo, kuchepa magazi, chibayo, zikukhudza humerus, peritonsillar abscess ndi malungo.

yosowa kwambiri anthu kutenga mankhwala "Oseltamivir", pali ululu m'mimba, kukhumudwa kumva, nosebleeds ndi conjunctivitis. Nthawi zambiri, zosiyanasiyana zimachitikira kamodzi kokha ndi kutha paokha, ngakhale mankhwala anapitiriza. zochitika zimenezi popanda discontinuation mankhwala.

Zotsatirazi poika mankhwala mavairasi oyambitsa ana ndi achinyamata umaonekera mavuto. Zimenezi ndi zinthu monga zotupa poizoni epidermal necrolysis, kutupa lilime kapena nkhope, arrhythmia, chisokonezo, khunyu ndi akuchuluka a shuga otaya.

Mwanjira mankhwala

Information zopezera nthawi ya maphunziro pharmacokinetic ndi pharmacological amanena kuti chitukuko cha ankachita kukomoka kwambiri mankhwala ndi mankhwala ndi chodziwikiratu.

The malangizo zinaphatikizapo ndi mankhwala, zikunenedwa kuti ntchito munthawi yomweyo ya medicament ndi probenecid amatsogolera ndi kuwonjezeka AUC wa metabolite yogwira nthawi 2. Komabe, kusintha mlingo si chofunika.

Nthawi cha mankhwala osokoneza bongo

ndi zizindikiro zooneka odwala ndi "Oseltamivir" mlingo waukulu wa mankhwala chiyani? Reviews ndi malangizo kunena kuti tsiku palibe Zikatero anauka. Komabe, Mlingo umodzi wa mankhwala mavairasi oyambitsa zingachititse kusanza kapena kunyansidwa.

Pofuna kuthetsa zizindikiro zimenezi, symptomatic mankhwala.

ayamikira Specific kulandira mankhwala

Kodi mukufuna kudziwa wodwala, asanadye "Oseltamivir"? Malangizo ntchito (ana ndi akulu akhoza kuona zotsatira osiyana mbali) Izi zikusonyeza zimene mankhwala sichiri katemera pachaka. Iye sanaletse chitukuko cha mavuto amene angayambe matenda tizilombo komanso matenda bakiteriya.

Analogs medicament

"Oseltamivir" - mankhwala anafuna kuti mankhwala ndi kupewa fuluwenza. Ndi wothandizila mavairasi oyambitsa limene limafotokoza kuti zoletsa wa neuraminidase. Izi mankhwala imadziwika pansi pa chizindikiro dzina "Tamiflu". analogs kandalama izo kulibe. Wapafupi, koma pang'ono otsika ntchito, mankhwala awa ali mmalo, "Relenza", "Arbidol", "Flustol", "Kagocel" ndi ena.

Reviews ndi potaya mphamvu ya mankhwala

Malinga ndi zotsatira mayeso, zomwe zimapezeka mu United States ndi Mexico, ndi mavairasi watsopano amazindikira zoletsa neuraminidase ( "Zanamivir" ndi "Oseltamivir"), koma ndi kugonjetsedwa ndi gulu linalo - adamantanes ( "rimantadine", "Amantadine") .

Iwo ayenera kukumbukira kuti akatswiri alibe efficacy wa mankhwala pa matenda a fuluwenza wakhala anaika mwa anthu ndi mtima aakulu ndi matenda kupuma.

Malingana ndi madokotala, mankhwala kuchepetsa nthawi ya zizindikiro ndi tsiku 1, koma izi zokha ngati mankhwala linayamba maola ochepa choyamba pambuyo kukhudzana ndi wodwalayo.

Pakali pano, palibe mfundo zodalirika ngati zotsatira za madyedwe a mankhwala pa zochitika za mavuto a matenda tizilombo kapena matenda.