"Plagril": malangizo ntchito, madokotala weniweni. Mankhwala analogues "Plagril"

Matenda a dongosolo mtima ndi mankhwala amakono mwina mu malo oyamba. The amafa ku matenda amenewa ndi apamwamba. Pali mavuto pa nkhani imeneyi kuti akhoza zikuvutitsa munthu tsiku la kubadwa. Komabe, pali anthu amene chitukuko munthu mwini kumabweretsa ndithu "chopereka". Mmodzi mwa anthu amenewo matenda - atherosclerosis. Ngati vutoli amakhudza makamaka mitsempha kugawa zotanuka minofu mtundu. Mfundo yaikulu ya matenda, chifukwa chophwanya mapuloteni ndi zamadzimadzi kagayidwe kudziunjikira mu mitsempha ya madipoziti mafuta ndi m'nyanjazi ena a lipoproteins. Choncho anapanga mipukutuyi atherosclerotic. M'kupita kwa nthawi, minofu connective makoma chiwiya mipukutuyi patsogolo, chifukwa mu kuchepetsa wa lumen wa mtsempha wamagazi mpaka occlusion lapansi.

Pofuna kuthandiza odwala awa ofufuza apanga mndandanda wa mankhwala amachepetsa kapumidwe kapenanso kwathunthu kupondereza ndondomeko loitanirana (mankhwala, kulumikiza) ya maselo othandiza magazi kuundana. Zinthu ndi maluso amenewa amatchedwa antiplatelet (antithrombotics). Mmodzi mankhwala amenewa ndi "Plagril".

Kapangidwe ndi Kaonekedwe

Mankhwala akupezeka mu miyala ndi chithope filimu ❖ kuyanika pinki. miyala ndi kuzungulira, biconvex. Kumbali ina amalimbikitsa embossing "C 127". Waukulu yogwira pophika mankhwala - clopidogrel. Zodabwitsa ndizakuti, mu mankhwala a "Plagril" alendo (mayiko Nonproprietary Dzina) ali ofanana kuti dzina la chigawo chachikulu - clopidogrel. Okhutira buku pa piritsi - 75 mg. Kuwonjezera zigawo zikuluzikulu za medicament ndi excipients: microcrystalline mapadi, mannitol, croscarmellose sodium, colloidal pakachitsulo woipa, magnesium stearate. Opanga kubala mankhwala mapaketi chithuza zidutswa 10.

Limagwirira mankhwala

The mankhwala ndi yeniyeni woletsa (ziletsa - ziletsa, kupondereza ndondomeko aliyense) loitanirana (pawiri) othandiza magazi kuundana. Iwo ali kanthu koronarorasshiryayuschee. Ndondomeko deceleration kupatsidwa zinthu za m'mwazi loitanirana (40%) Tingaone pambuyo maola 2 pambuyo ingestion mankhwala pa mlingo wa 400 mg. Pofuna kukwaniritsa Mwachangu pazipita (60% chopinga wa loitanirana) Zotsatira kuchokera mapiritsi "Plagril", malangizo ntchito mogwirizana ndi kufunika kwa mankhwala kwa masiku 4-7. Mlingo okwana patsiku akhale 50 100 mg. Pankhaniyi, antiplatelet zotsatira lidzakhalapo kwa lonse mkombero moyo wa othandiza magazi kuundana (masiku 7 mpaka 10). Patangotha masiku 5 pambuyo mlingo achire mankhwala a kupatsidwa zinthu za m'mwazi loitanirana, ndipo magazi nthawi kubwerera ku ntchito koyamba.

Excreted "Plagril" impso ndi intestine (50% 46% motero). deducing Nyengo - maola 120 pambuyo utsogoleli.

The ogula waukulu "Plagrila"

Pali gulu lapadera odwala mtima amene amaoneka kugwiritsa ntchito mankhwala "Plagril". Malangizo ayenera kutenga mankhwala kwa anthu akuvutika atherosclerosis. Mankhwala ndi othandiza ngati muyeso njira zochepetsera chiopsezo cha mavuto kugwirizana ndi thrombosis anthu omwe anali infarction m'mnyewa wamtima kapena ischemic sitiroko. Ndi zoonanso kwa odwala matenda a occlusion (kuwonongeka kwa permeability) mitsempha zotumphukira.

Mu tandem ndi asidi acetylsalicylic (ndi aspirin) angagwiritsidwe ntchito "Plagrila" pofuna kupewa mavuto thrombotic anthu amene akudwala matenda pachimake inatsekeratu. Izi zikhoza monga anthu angina (wosakhazikika mawonekedwe), ndi infarction m'mnyewa wamtima popanda mapangidwe yoweyula Q. Mukhoza kugwiritsa ntchito mankhwala odwala amene anakumana stenting. Mfundo yaikulu ya opaleshoni - unsembe mu akhudzidwa chotengera stent (woonda bwino meshed zitsulo chubu), chimene chiri kenako mpweya zibaluni wapadera, potero kukula permeability chotengera ndi kuwongolera magazi mtima.

modes ntchito: Mlingo

Medicine "Plagril" odwala akhoza kumwedwa pakamwa, kaya zakudya. Odwala likufa m'mnyewa wamtima infarction, ischemic sitiroko kapena matenda anakhazikitsa za patency ya mitsempha kuwonongeka, mlingo wa 75 mg anatengedwa kamodzi pa tsiku. Nyengo ya mankhwala mankhwala pambuyo Q-yoweyula m'mnyewa wamtima infarction zikhoza kwa masiku 35. Mu sitiroko ischemic, malingana ndi kuopsa kwa chikhalidwe, mankhwala lingayambire pakukhala masiku 7 miyezi isanu ndi umodzi.

Pamene zikwapu mu mawonekedwe wosakhazikika, ndi m'mnyewa wamtima infarction popanda mapangidwe Q-yoweyula ndi amangoona muyezo kamwedwe miyala ili: choyamba, kamodzi Mumakonda mlingo wa 300 mg, kenako 75 mg pa tsiku pamodzi ndi aspirin ndi (75 325 mg wa pa tsiku). Chifukwa zakudya wa aspirin kumaonjezera ngozi ya magazi, pazipita umodzi mlingo sayenera upambana 100 mg. mankhwala - mpaka 1 chaka.

phwando "Plagril" antiplatelet mankhwala ndi anasonyezanso kuti pachimake m'mnyewa wamtima infarction. Mankhwala mankhwala Pa mlingo wa 75 mg, tsiku limodzi. Ndi bwino kuyamba chithandizo ndi koyamba Mumakonda mlingo osakaniza ndi asidi acetylsalicylic. Mwina kufanana kutenga thrombolytics (kapena ayi kutenga).

Ngati odwala ali anawoloka zaka 75 zakubadwa malire, "Plagril" (ofanana clopidogrel komanso zovomerezeka) amasankhidwa popanda koyamba Mumakonda mlingo. Pambuyo kuoneka kuphatikiza chithandizo zizindikiro ayenera anayamba mwamsanga. Inde ayenera masabata osachepera 4.

chingachitike mbali ya

Pa nthawi ya mankhwala ndi yokonza "Plagril" malangizo Buku imatiuza kuti zosiyanasiyana chingachitike mbali ku machitidwe osiyanasiyana ziwalo.

magazi clotting dongosolo zambiri angayankhe maonekedwe a magazi m'mimba. Kamodzikamodzi angathe hemorrhagic sitiroko, magazi kuchokera mphuno ndi mokulira, kuchuluka kwa magazi nthawi. Nthawi zina zimakhala hematomas, hematuria.

kusonyezedwa zosiyanasiyana kwa dongosolo hemopoietic. Zikuphatikizapo eosinophilia, neutropenia, thrombocytopenia. N'zochititsa chidwi zochepa angayambe granulocytopenia, yosavuta kapena aplastic magazi m'thupi.

Pa mbali ya dongosolo chapakati ndi zotumphukira mantha akhale mutu, chizungulire, paresthesia, vertigo (imfa ya malire limodzi ndi lingaliro la kasinthasintha wa zinthu padziko thupi, kapena mosinthanitsa - thupi la kasinthasintha), kuyerekezera zinthu m'maganizo, chisokonezo. yosowa kwambiri, koma milandu zochitika chowawa zimachitika ndi dongosolo la mtima, mwa mawu a kuthamanga utachepa magazi, vasculitis chitukuko. Bronchospasm ndi interstitial pneumonitis - imeneyi kungakhale zimene dongosolo kupuma kulandira mankhwala.

Nthawi zambiri pa mankhwala "Plagril" (ndemanga madokotala ndi odwala amatsimikizira izi) amachitira dongosolo m'mimba. Zimene thupi akuwonetseredwa mu chitukuko cha kutsegula m'mimba, dyspepsia, kupweteka m'mimba. zochita zochepa wamba zotheka monga nseru, kusanza, kudzimbidwa, pachimake gastritis ndi chapamimba ndi zilonda mmatumbo, flatulence. Kawirikawiri koma n'zotheka yatsoka matenda monga matenda a m'matumbo, kapamba, stomatitis, matenda a chiwindi, kukoma adasandulika, chitukuko chifukwa chakuti chiwindi.

Osteo-akulu dongosolo akhoza kunena yokha nyamakazi, myalgia. Ngakhale kuti zimachitika kawirikawiri. Glomerulonephritis chingachitike n'chiyani zimene dongosolo mkodzo. Dermatologists amati chifukwa nkotheka kwa "Plagrila" ndi kuyabwa, bullous zotupa erythematous zotupa ndere planus, chikanga. Mwina chitukuko cha thupi lawo siligwirizana mu mawonekedwe a angioedema, anaphylaxis, seramu matenda. Zotsatira wamba mbali akhoza taonera malungo, okwera seramu creatinine.

Ntchito "Plagrila": choti

Ngati nkhani ina ndi osafunika antiplatelet mphamvu, kapena akuyenera opaleshoni, muyenera kuletsa thandizo "Plagril". Malangizo ntchito akuonetsa kuchita masiku osachepera 7 isanafike opaleshoni. Pambuyo chiyembekezo chakuti mankhwala kusiya mwadzidzidzi anayamba magazi adzafunika nthawi zambiri. Odwala ayenera anachenjeza za ndipo analangiza kudziŵitsa dokotala chilichonse magazi zachilendo. Mu chidwi wodwala kudziŵitsa dokotala za mankhwalawa "Plagrilom" mu zonsezi ngati kukhala opaleshoni iliyonse, kapena wodwala ulipo kwa mankhwala alionse latsopano.

Mu njira ya mankhwala mankhwala ndi kofunika kupitiriza m'manja mwa magawo dongosolo la homeostasis (kupatsidwa zinthu za m'mwazi kuwerenga, mayesero a ntchito zinchito, APTT). Ntchito zinchito chiwindi ayenera nthawi zonse kuyang'aniridwa ndi ayesedwa pamene zolakwika kwambiri ntchito ankatha azitaya hemorrhagic diathesis.

Medicaments, amene yaikulu yogwira pophika ndi clopidogrel ( "Plagril" analogs), ali osavomerezeka chifukwa anthu amene avutika ndi pachimake m'mnyewa wamtima infarction, osachepera pa masabata oyambirira angapo pambuyo isanayambike. madokotala musati amalangiza "Plagrilom" mankhwala ngati wodwalayo wosakhazikika angina, ndi ischemic sitiroko mu inatsekeratu opaleshoni kulambalala.

Ndi kuchuluka kwa kusamala ayenera kutenga mankhwala kwa anthu olumala mu ntchito kwa impso.

Kutsutsa-phwando "Plagrila"?

"Plagril" (mapiritsi) malangizo limaletsa odwala hypersensitivity kapena tsankho kwa munthu Gawo ndi wothandiza wa medicament lapansi. Musawachite mankhwala pa matenda aliwonse zinanso kwa magazi (muzituluka ndi zilonda mmatumbo, hyperfibrinolysis, khansa ya m'mapapo, TB, etc.). A m'munsi amphamvu si ntchito "Plagrila" ali pachimake kwa chiwindi kulephera, hemorrhagic matenda. Kuwonjezera pa pamwamba, ndi contraindicated kumwa mankhwala azimayi oyembekezera ndi azimayi unamwino. Osati kuti mankhwala mankhwala kwa ana osaposera zaka 18.

kukonzekera analogues

Mu msika mankhwala lero, gulu la mankhwala antiplatelet wothandizila ( "Plagril" ofanana matanthauzo ake okhutira wa Gawo yogwira) zilipo mokwanira ambiri. Kuposa 3 dazeni mankhwala - antiplatelet wothandizila chimodzimodzi yogwira pophika (clopidogrel) ndi pa mlingo yemweyo (75 mg). Kupatula opanga Russian kubala antiplatelet Indian makampani opanga mankhwala, mabungwe ang'onoang'ono Hungary, Israel, Malta, France.

"Dr. Reddies Laboratories" "Plagril" palokha imatulutsa Indian kampani. Ndi chitsanzochi, ife angaphatikizepo French "Plavix" German "Clopidogrel ratiopharm," Chihangare "Clopidogrel-Richter," Israeli "Clopidogrel Teva," Chimatisi "Liporel" Chimakedoniya "Listab 75". "Zilt" akhoza olekanitsidwa wotchuka kwambiri ndipo ambiri mu ankafuna wothandizila Russian.

"Zilt" - Russian "Plagril"

Waukulu yogwira thunthu la yokonza "Zilt" ( "Plagril" chifukwa amadziwa zogwirizana) ndi clopidogrel. Mankhwala uli gulu la wothandizira antiplatelet. Mlingo koyamba (kuti "Zilt" - 400 mg) pambuyo maola 2 pambuyo makonzedwe kubweza kupatsidwa zinthu za m'mwazi loitanirana. Monga "Plagril", "Zilt" kusamalira kulandira 50-100 mg wa pa tsiku adzapereka pazipita achire zotsatira pambuyo masiku 4-7.

Medicament zimapukusidwa mu chiwindi. The zikuchokera magazi a metabolites yogwira ndi wapezeka. Pafupifupi 50% "Zilta" excreted ndi impso, otsala 46% mwa masiku 5 Atalandira adzakhala kudzipatula kudzera intestine lapansi.

Zikuonetsa ntchito ya "Zilta" ndi amodzi mwa "Plagrila": kupewa thrombus lomenyera odwala likufa m'mnyewa wamtima infarction, ischemic sitiroko kapena akudwala matenda mtsempha wamagazi patency.

ogula maganizo

Ngati mankhwala alionse, "Plagrila" ali ndi HIV ziyenera a ogula, onse ndemanga zabwino ndi zoipa. Pali odwala amene mankhwala anasankhidwa kwa mankhwalawa angina ndi anadzionetsa mankhwala othandiza kwambiri. Ndi ntchito zake kuukira zinachitika kapena konse, kapena iwo anakhala kwambiri zochepa. Pamodzi ndi makasitomala mu kufufuza mankhwala "Plagril" ayankhe madokotala.

Komabe, mukhoza kukumana ndi kuyang'anila za mavuto chifukwa cha ntchito mankhwala. Anthu ena analemba za maonekedwe a mikwingwirima, ena kuonekera magazi m'thupi. Iwo anali odwala ndi nkhani ya mutu kwambiri, malangizo ndi matenda osiyana kwambiri dongosolo m'mimba. Osowa, koma angamvele pa patsogolo mu ndondomeko ya kulandira "Plagrila" chapamimba chilonda kapena mmatumbo chilonda.

Ambiri, izo ziyenera kuti mankhwala "malangizo Plagril 'ntchito ali pabwino monga lalikulu mankhwala okwanira ndi sikugwirizana ndi mankhwala. Ali ndi mndandanda mwachilungamo kwambiri contraindications, angachititse kwambiri mavuto osiyanasiyana machitidwe ndi ziwalo. ntchito kusalankhula ungawonjeze zoipa zokwanira (ndi zina sizingasinthe) zotsatira za thanzi la wodwalayo.

Mapeto kuchokera pamwamba pa zonse ndi n'zodziŵika. "Plagril" kwa Inde mankhwala adzasankhidwa ndi dokotala nawo. Ndipo Njira ya mankhwala ndi mankhwala - kuchipatala ndipo kuyang'aniridwa ndi akatswiri. Only mu nkhani iyi timangokhala kwa ubwino wa mankhwala ndi chiopsezo kochepa mavuto.