Avidity - zikutanthauza chiyani? chitetezo Avidity IgG kuti Cytomegalovirus: mbali ndi decrypting

Tsopano kuposa ndi kale, ndikofunika kuzindikira mwamsanga ndi kupewa matenda opatsirana. Izi zimafuna apamwamba ndi njira mofulumira matenda. Pachikhalidwe chipatala amagwiritsa ntchito njira serological kwa kudziŵa kukula kwa ndondomeko ndi mfundo anasamukira matenda tizilombo toyambitsa ndi mafangasi. Koma mayeso amenewa ali tcheru mokwanira kusiyanitsa chachikulu matenda, reinfection ndi kumwa. Choncho, asayansi amakono akufuna njira ya kudziŵa avidity wa IgG-chitetezo.

Avidity: zikutanthauza chiyani?

Kusiyanitsa malingaliro a kuyandikana ndi avidity. Kuyandikana - ndi thermodynamic khalidwe quantitatively Pofotokoza mphamvu ya mogwirizana kwa oteteza ndi Antigen mofanana. Nawonso avidity Mzimuyo mgwirizano mphamvu pakati pa Antigen ndi oteteza. mfundo izi mwachindunji zokhudzana ndi mzake. Makombo zambiri Antigen zonse, mphamvu za intaneti. Kusiyanitsa otsika ndi mkulu avidity.

Kutanthauza mkulu avidity? Tiyeni tifufuze. Pamene antigens kulowa thupi kwa nthawi yoyamba, amatithandiza maselo B yotulutsa immunoglobulins. Poyamba IgM, koma ndiye iwo m'malo mwa IgG. Pambuyo kukhudzana loyamba kuyandikana, ndipo motero avidity, otsika, basi njira chitetezo ya thupi amazolowera tizilomboto latsopano. Patapita masabata asanu ndi awiri, IgG «okhwima», ndi zenizeni kwambiri, choncho, mkulu avidity. Ndipo tsopano, mu nkhani ya kukonzanso matenda, chitetezo cha m'thupi anadzakhala akusasanyika mwamsanga kuti kumuopseza.

avidity index

Mlingo avidity inversely amadalira Antigen mlingo ndi chikhalidwe ndi mlingo wa masinthidwe maselo a anthu. Ang'onoang'ono mlingo koyamba, ndi apamwamba kuyandikana, ndi mosemphanitsa.

Ndiye pathophysiology ndi immunology akukumana ndi chodabwitsa cha kuchepa kwa chitetezo chokwanira ndi zaka. Tinaganiza ndi anadziŵa ena chiŵerengero, wotchedwa avidity index. Kodi zikutanthauza avidity index? chiwerengerochi anatchula ntchito wachibale wa immunoglobulin ndi kum'manga Antigen. The index mu osiyanasiyana pakati pa 15 peresenti ndipo 50 zikusonyeza matenda chachikulu, ngati mtengo kuposa 50 peresenti, ndiye wodwalayo kale ankadwala matenda.

chikuku

The chikuku HIV ali ndi kungasokoneze kwambiri pa mwana wosabadwayo, kotero nkofunika kuona ngati mayi woyembekezera anali kudwala matenda, kapena pa mimba iye ayenera katemera. Pakuti matenda ntchito serological mayesero kwa chitetezo kuyandikana kwa antigens lapansi. Ngati immunoglobulins pafupi kwathunthu chifukwa particles ndi tizilombo, choncho mkulu avidity chitetezo. Zimenezi zikusonyeza kapena matenda yapita, ndi chitetezo chokwanira bwino pambuyo katemera.

Nthawi zina, chifukwa cha kukondoweza kwa lymphocyte oyeserera wa chikuku Kachiromboka wapezeka onyenga zabwino anachita kwa immunoglobulin M. Komanso, monga chifukwa Tingaone anthu odwala omwe anakwezedwa magazi rheumatoid china. Only pali kupezeka kwa chitetezo kuti ndi otsika avidity. Kodi zikutanthauza chiyani? Izi zikhoza kuonedwa kuti umboni kwa matenda a pulayimale ndi chikuku HIV. Mu obstetrics ndi umboni mwachindunji kwa mimba.

toxoplasmosis

Monga ulamuliro, matenda izi chobisika, ndi mawonetseredwe a zizindikiro matenda ndi kudwala anapeza (mwachitsanzo, monga kutupa mwanabele) ali otsika matenda mtengo, pamene muyenera kupeza nthawi yaitali bwanji munthu akamadwala. Khama la chitetezo IgG avidity lachindunji kwambiri ndi njira tcheru kuti matenda a toxoplasmosis pachimake chachikulu, chimene chiri chofunika makamaka pamene kufufuza amayi apakati kuthetsa kufala angathe toxoplasmosis kobadwa nako ana.

M'mbuyo monsemu, ndi chilipo serologic zofufuza kudziwa kukula kwa ndondomeko anali kudziwa immunoglobulin kalasi M ndi kuwonjezera titer wa IgG. Ngati mkati mwa sabata kuchuluka kwa immunoglobulin G kuchuluka kanayi kapena kupitirirapo, ndi umboni zotsalira za kupitilira matenda.

Ngakhale ndi mayesero serological dokotala ndi kovuta kudziwa ndendende pamene munthu kachilombo, monga immunoglobulin M ndi G kungapitirire kwa nthawi yaitali mu magazi. Choncho, njira yodalirika ndi kudziwa avidity. Kodi zikutanthauza chiyani? Kuyandikana m'munsi chotero avidity Toxoplasma kale atagonjetsa mu thupi. Komanso posachedwapa anatsegula njira ya kulekanitsa otsika kuyandikana ndi mkulu kuyandikana chitetezo chifukwa chomasuka ochuluka ndi kudziwa mtundu wa matenda.

Herpes simplex kachilombo

Anthu ambiri m'dzikoli ali ndi kachilombo ndi nsungu simplex HIV. matenda Wina akupezeka mu mawonekedwe zobisika, koma zizindikiro ambiri anati, ngakhale ali aang'ono. Komanso pali mavuto ena ndi mmene kudziwa avidity wa nsungu. Kodi zikutanthauza kuchita? HIV Izi amakhala ndi oteteza atypical, kungakhale mu thupi moyo, zopereka zotsatira zabodza HIV ndi wabodza-negative. zoipa abodza nthawi imene immunoglobulins si anapanga kapena mu seramu mu kufufuza ndalama. Zotsatira onyenga HIV zimachitika chifukwa yaitali kufalitsidwa chitetezo kaya matenda.

Komanso, ali ndi antigens mtanda zotakasika motengera mmene histocompatibility antigens wa zimakhala zachilendo thupi, ndi zina nsungu HIV. China chonyenga zochita zabwino ofunitsitsa ndi matenda sekondale ndi kamene kamawononga chitetezo m'thupi.

cytomegalovirus matenda

HIV Izi zikuoneka kuti ambiri kwa mimba mimba msanga. Kusatetezeka zimadalira mlingo wa chitetezo mayi pa nthawi yomwe mayi. Ngati matenda koyamba zinachitika trimester, mpata wa matenda ndi 50 peresenti.

Kodi zikutanthauza avidity kwa CMV? Monga zina zonse, mtima wa kuyandikana kwa IgG ndi IgM anachita zabwino molondola kutsimikizira kapena kukana pamaso pa matenda chachikulu CMV. Komanso, amalola kupewa njira yowawa ndi mtengo kwa mayi woyembekezera.

Chiwindi C kachilombo

Matenda a chiwindi zochokera kudziwa zolembera zenizeni zikusonyeza chitukuko cha ndondomeko matenda. Pankhaniyi, IgM angayambe patapita nthawi yaitali kuposa IgG, kapena imodzi ndi iwo. N'zovuta kudziwa isanayambike matenda ndi nthawi ya matenda chachikulu.

Lokhalo lodalirika serological kusanthula ndi serokoversiya ndi IgG avidity pa. Kodi zikutanthauza chiyani? Ngati avidity index ndi otsika, ichi ndi chitsimikizo mwachindunji za matenda chachikulu. Pankhani ya kudziwa avidity mkulu chitetezo kalasi IgG angathe kunena aakulu chiwindi kapena asamuka.