"Gabapentin" ndi mowa: ndemanga. "Gabapentin": malangizo ntchito, pamene umboni uperekedwa mtima ndi madokotala

Nthawi, omangana minofu Musiyeni anthu ambiri. Komabe, anthu ochepa kuganizira chifukwa limati ngati zambiri uka.

Malinga ndi luso, khunyu angakhale osiyana: zowombetsa mkota (zimandilimbikitsa, clonic, zimandilimbikitsa-clonic ndi myoclonic) ndi tsankho (yosavuta zovuta). mankhwala amagwiritsidwa ntchito pofuna kuchiza khunyu wotsiriza monga "Gabapentin". Malangizo ntchito, ndemanga ndi contraindications mankhwala Adzaperekedwa pang'ono.

Iwo ayenera yomweyo kudziŵika kuti, chifukwa khunyu tsankho yodziwika ndi kusapezeka kwa imfa ya chikumbumtima. Chotero chikhalidwe osowa. Iwo amaoneka clonic khunyu chikhalidwe yokhudza minofu manja, mapazi ndi nkhope.

Zikuchokera, maonekedwe, ma CD mankhwala kapangidwe kake

anagulitsa medicament "Gabapentin" ndi thupi lotani? Umboni amanena kuti mankhwala izi zikhoza kugulidwa pa mankhwala mu mawonekedwe a makapisozi gelatin khama woyera. amanena ndi loyera kapena chikasu ufa mankhwala.

The yogwira pophika wothandizila izi gabapentin. Komanso, kumaphatikizapo chinthu zina mwa mawonekedwe a sodium wochuluka carboxymethyl wowuma, calcium stearate ndi microcrystalline mapadi. Koma makapisozi, iwo ali gelatin ndi titaniyamu woipa.

Mu phukusi anagulitsa mankhwala "Gabapentin"? Ogula ndemanga kuti pa maalumali wa pharmacies mankhwala angapezeke mu makatoni mapaketi, amene anayikidwa kapena polymeric makapisozi zitini kapena mizere ya chipindacho.

Mfundo kanthu za mankhwala ndi

Kodi mankhwala "Gabapentin"? Malangizo (ndemanga za mankhwala zimapezeka pa mapeto a nkhani) linati mankhwala akuphatikizapo ndi ofanana kwambiri kwa mtundu Popanga madzi a gamma-aminobutyric asidi (GABA kwa lalifupi). Komabe, tisaiwale kuti mfundo ya kanthu ake ndi mwapadera kwa mankhwala ena kuti mucheze ndi GABA-maselo (mwachitsanzo, valproate, barbiturates, benzodiazepines, GABA transaminase zoletsa, GABA reuptake zoletsa, GABA agonists ndi prodrugs wa GABA).

Ankaona mankhwala alibe GABA-tsa katundu ndi sikumangotikhudza ndi adani ndipo thupi la GABA. Akatswiri Research asonyeza kuti yogwira pophika wothandizila ndi kumanga kwa α2-δ-kagawo kakang'ono wa voteji amadalira kashiamu njira, kwambiri kuchepetsa otaya ayoni calcium, amene kumathandiza kwambiri isanayambike ululu neuropathic.

NKHANI anticonvulsant mankhwala

katundu Kodi ena wogwidwa ndi mankhwala "Gabapentin"? Reviews madokotala amanena kuti ndi othandiza kwambiri ululu neuropathic. Izi mankhwala kumachepetsa glutamate amadalira okhudza mitsempha imfa, kuwonjezeka GABA kaphatikizidwe, komanso ndondomeko yimitsira a magulu mtundu kumasuka ndi monoamine.

Sitingathe kunena kuti pa woipa kukomoka zogwirizana mankhwala "Gabapentin" Kodi kuwamanga kuti zolandilira mankhwala ena (kapena timene), kuphatikizapo zolandilira GABAA ndi GABAB, ndi glutamate, benzodiazepine zolandilira, glycine, ndipo N-methyl-D- aspartate.

Mosiyana "Carbamazepine" ndi "phenytoin", anaganizira medicament si kucheza ndi ngalande ndi sodium. Kukonzekera "gabapentin" pang'ono attenuates zotsatira za glutamate cholandilira agonist monga N-methyl-D-aspartate. Komanso kwambiri kuchepetsa kutuluka kwa timene monoamine.

The kayendedwe katundu wa mankhwala

ndi chibadidwe kayendedwe magawo makapisozi "Gabapentin" n'chiyani? Umboni sadzatha kuyankha funso ili. Kupeza, mudzakhala ndi kutembenukira kwa akatswiri odziwa kapena malangizo akachita.

Malinga ndi yamasika, ndi bioavailability wa anati mankhwala si njila kwa mlingo atsopano. Pamene kuchuluka kwa mankhwala yafupika.

Pa kulandira medicament mu pazipita plasma maganizo ake anati pambuyo 3 h. The bioavailability mtheradi ya mankhwala mu makapisozi pafupifupi 60%. Chakudya, kuphatikizapo mafuta kwambiri, alibe zotsatira pa kinetics mankhwala.

Achire "Gabapentin" magazi wodwalayo ikuchitika ndi chitsanzo liniya. theka moyo nthawi zimadalira pa mlingo ndi pafupifupi 5-7 maola.

The katundu kayendedwe mankhwala samasintha ngakhale pamene amanena mobwerezabwereza. The ndende ya mankhwala magazi akhoza ananeneratu zochokera zotsatira za mlingo wake umodzi.

The medicament "Gabapentin" zayamba Kodi kuwamanga zonsezo plasma (zosakwana 3%). Iwo chimaonetsedwa mawonekedwe zikutsatiridwa ndi impsozo.

Metabolize mankhwala si poyera. Komanso, sikuti kupangira michere kwa chiwindi zobwera chifukwa cha okosijeni, amene mukugwira nawo kagayidwe mankhwala ena.

The chilolezo cha nthumwi kwa magazi amachepetsa anthu achikulire ndi anthu odwala ndi opuwala ntchito impso.

Kukonzekera "gabapentin" atachotsedwa thupi ndi hemodialysis.

Zikuonetsa kuti alandire mankhwala othandiza

Kodi matenda tiganizire ndiwo kwenikweni mankhwala? Zimene anthu amanena zokhudza maganizo izi?

"Gabapentin" amasonyeza wabwino wokha:

• neuropathic ululu odwala wamkulu (zaka 18 ndi kuposerapo);
• monotherapy kapena ngati mankhwala wowonjezera zochizira khunyu tsankho, limodzi ndi generalization sekondale akuluakulu ndi achinyamata ochokera zaka 12 zakubadwa.

Contraindications kulandira mankhwala

Kodi contraindications mankhwala ali "Gabapentin"? Ndemanga za ntchito kukanena kuti ali ndi zoyipa pa thupi, ngati mankhwala walandiridwa pa:

• hypersensitivity kuti aliyense wa thunthu;
• khunyu tsankho pansi ndi zaka 12.

kusamalidwa ndi njira analamula kuti kulephera impso.

Kodi Ine kutenga mankhwala "Gabapentin"?

Ndemanga (neuralgia mankhwala zimenezi zimathandiza zabwino kwambiri) amati mankhwala ayenera kuperekedwa pokhapokha ndi dokotala wodziwa, pambuyo matenda zolondola.

Gelatin makapisozi anatengedwa pakamwa mwa Pomeza lonse, mu mawonekedwe awo. Mankhwala ayenera kudyedwa kaya chakudya, kuchapa pansi ndi madzi wochuluka. Ngati mukufuna kuchepetsa mlingo wa mankhwala kuletsa kapena m'malo analogue pake, zimenezi ziyenera kuchitidwa pang'onopang'ono sabata.

Chithandizo cha ululu neuropathic akuluakulu

Monga boma zochita ankaona mankhwala? Zimene anthu amanena zokhudza ndemanga mankhwala? "Gabapentin" mwaluso kwambiri kumaonekera kwa ululu neuropathic. Pochiza ngati chikhalidwe koyamba tsiku mlingo akhale 900 mg. Anati kuchuluka lagawidwa mbali zitatu. Ngati chofunika, mlingo pang'ono ndi pang'ono kuchuluka kwa munthu pazipita (i.e., mpaka 3600 mg wa pa tsiku).

tsankho khunyu

Kodi Ine kutenga mankhwala "gabapentin" mu matenda? Reviews onena kuti chida awerenge osati kwa akulu, koma zaka achinyamata ku 12.

Mlingo ochiza khunyu tsankho ankaona 900-2400 mg wa pa tsiku. Chithandizo cha matenda angayambe ndi 300 mg wa mankhwala katatu patsiku. Kenako mlingo idzikhala ziwonjezeke kwa 900 mg, ndi zambiri mpaka 2400 mg wa patsiku (ogaŵikana Mlingo atatu ofanana).

Nthawi imeneyi pakati Mlingo wa mankhwala pa phwando ake patatu sayenera maola kuposa 12 (kupewa resumption a khunyu).

zotsatira zoyipazi

zosiyanasiyana zimene chowawa kumachitika odwala kulandira anticonvulsant? Zimene anthu amanena zokhudza ndemanga katundu? "Gabapentin" mankhwalawa ululu neuropathic zingachititse:

• asthenia, mwangozi choipa, kupweteka kwa kutanthauzira osiyana, kupweteka kwa nsana, matenda, matenda chimfine, mutu, kunenepa kwambiri, edema zotumphukira;
• gait bata ataxia, amnesia, hypoesthesia Kusokonezeka m'maganizo, chizungulire, maganizo mkhutu, kugona, kugwedeza;
• kudzimbidwa, flatulence, kutsekula m'mimba, kusanza, youma pakamwa, dyspepsia, nseru, kupweteka m'mimba;
• zotupa pa khungu;
• kufupika kwa mpweya, zilonda zapakhosi;
• amblyopia.

Mankhwalawa khunyu tsankho mankhwala kumathandiza kuti maonekedwe:

• kupweteka kwa msana, kutopa, malungo, kupweteka kwa mutu, tizilombo, edema zotumphukira, kunenepa kwambiri, kutopa, malaise, nkhope edema;
• kudzimbidwa, matenda mano, kutsekula m'mimba, kudzimbidwa, kuchuluka njala, youma pakamwa kapena pakhosi, nseru kapena kusanza, kupweteka m'mimba, bloating, anorexia, gingivitis;
• chizindikiro cha vasodilation kapena matenda oopsa;
• leukopenia, purpura;
• fractures, myalgia ndi arthralgia;
• amnesia, ataxia, chisokonezo, incoordination, maganizo, dysarthria, maganizo lability tulo, manjenje, nystagmus, kugona, maganizo nthenda, kugwedeza, kukokana kwa minofu, chizungulire, hyperkinesia; phindu kufooka kapena kusapezeka kwa bongo, nkhawa, paresthesia, udani;
• abrasions, ziphuphu, khungu kuyabwa, zotupa pa khungu;
• chifuwa, pharyngitis, rhinitis, chibayo;
• amblyopia, diplopia, amaona masomphenya;
• matenda thirakiti mkodzo, kusabala.

Nthawi cha mankhwala osokoneza bongo

Kodi zizindikiro cha mankhwala osokoneza bongo zingachititse anati medicament? Nanga bwanji izi kuti ndemanga? "Gabapentin" ambiri osokoneza amachititsa awiri masomphenya, chizungulire, tulo, kulankhula mkhutu, ulesi ndi kutsekula m'mimba.

Kuthetsa limati ngati mankhwala symptomatic, komanso wovulalayo kutsukidwa m'mimba ndi kumupatsa adamulowetsa makala.

Odwala insufficiency aakulu aimpso, hemodialysis kukuonetsedwa.

Mankhwala "Gabapentin" ndi mowa

Reviews akatswiri amanena kuti dzuwa mankhwala ankaona ndi mkulu. Koma ndi kukachitika kuti nthawi tanthauzo lake wodwala kwathunthu anasiya kumwa mowa.

Ngati mankhwala ali pamodzi ndi mowa, wodwalayo mwina kwambiri kuvutika zochita chilango chochokera kwa dongosolo chapakati mantha (stupor, ataxia, etc.).

Mwanjira mankhwala

Mankhwala "gabapentin" mu neuroscience, ndemanga zimene ziri zoposa zabwino, akhoza pamodzi osati ndi mankhwala.

Malinga ndi malangizo, Mankhwalawa ayenera kumwedwa kuchepetsa bioavailability wa mankhwala.

Myelotoxicity mankhwala kuwonjezera haematotoxicity makapisozi "Gabapentin".

Pamene pamodzi morphine pharmacokinetics yake sanasinthe. Komabe, pamene ngati osakaniza ayenera kuyang'aniridwa Nkosatheka anakwiya ya ubongo.

Ankaona medicament akhoza kumwedwa nthawi imodzi ndi mankhwala antiepileptic (mwachitsanzo, "pentobarbital", "Carbamazepine", "Phenytoin" ndi valproic acid) ndi kulera m'kamwa. Mu nkhani iyi, sasintha kinetics.

ayamikira yeniyeni

Ngakhale kuti achire matenda ndi pakutchulidwa a khunyu mankhwalawa "gabapentin" unalibe ndi kutha mwadzidzidzi wa ndi mankhwala antiepileptic anthu ndi khunyu tsankho angathe kuutsa zopweteka amphamvu.

Ankaona mankhwala si njira kulimbana ndi kusapezeka khunyu.

Anthu amene muyenera mankhwala zovuta ndi morphine, angafunike ndi mlingo kuchuluka kwa "gabapentin". Pankhaniyi, kuonetsetsa polojekiti zonse wodwalayo kuti chitukuko cha kusinza. Pa mankhwala ake akudzizindikiritsa mlingo ayenera mokwanila yafupika.

Zimagwira "gabapentin" ndi zina mankhwala anticonvulsant zalembedwa zotsatira zabodza abwino mu mtima wa mapuloteni mu mkodzo ntchito n'kupanga mayeso Ames N-Multistix SG. Pa nkhani imeneyi, maphunziro amenewa kulengeza ntchito njira yeniyeni mpweya ndi asidi sulfosalicylic.

akatswiri Reviews ndi ogula

ndemanga kwambiri madokotala ndi odwala za "Gabapentin" kukonzekera abwino. Malipoti amenewa akusonyeza kuti mankhwala bwino kupirira ntchitoyo. Komabe, pamene pamodzi ndi mowa zambiri kukhala aakulu zosiyanasiyana chokhwima mu wamanjenje dongosolo.

N'kosatheka kuona mfundo yakuti kusuta mwadzidzidzi mankhwala zingachititse odwala blunted kutsitsimuka, ulesi ndi maganizo oipa.

Anthu ambiri amanena kuti zakudya izi zikutanthauza kuti ndi maganizo ndi maganizo ofuna kudzipha. Komanso, mankhwala zimayambitsa chitukuko cha kapamba pachimake.

Akatswiri amalangiza mankhwala "Gabapentin" yekha kuyang'aniridwa ndi dokotala amene adzatha mofulumira kusintha kamwedwe achire akamavutika.