"Sodium dichloroacetate": zikuchokera, maganizo ndi malangizo ntchito

Ndiyamika sayansi ku yunivesite ya Alberta malo kupangidwa mu Canada, akugonjetsa khansa. Iwo akhoza kuthana ndi kutsegula matenda kwa mayitirokondiriyoni akhala kuletsedwa. Anayambitsa mankhwala "ndi sodium dichloroacetate," malinga ndi sayansi, kupirira vuto ili ndipo akulimbana ndi mitundu ya khansa.

chizindikiro makamaka ogwira mankhwala polimbana ndi khansa ya m'mapapo, mu ubongo ndi chifuwa. Back mu 30s zaka mazana makumi awiri, asayansi kuona kuti kuvutika zinchito maselo mitochondria chimayambitsa khansa. Mitochondria ndi organelles zofunika ya selo lamoyo, ndipo mpaka posachedwapa, asayansi ankaganiza kuti chiwonongeko - si chifukwa cha khansa, ndipo zotsatira zake. Chotero, popeza 2005 Michelakis adakaikira amanena, mayeso anayamba ntchito pa mamolekyulu wa dichloroacetate ndi sodium.

Laboratory maphunziro a mankhwala

Laboratory mayesero ndi mayesero nyama asonyeza kuti mankhwala "ndi sodium dichloroacetate" ndi activator wa michere kwa mayitirokondiriyoni amene achotsa chifukwa cha matenda ena mosaganizira mtundu wa khansa. Kuchepetsa wa maselo a khansa zimatheka ndi normalizing ntchito za organelles. The mankhwala ndi zimasiyana kwambiri ndi mankhwala amphamvu kuti si poizoni ndipo sachita oppressively pa maselo wathanzi wodwala.

Professor Michelakis limanena kuti ntchito zake zosiyanasiyana za chinthu zili mankhwala, limachititsa kuthana ndi njira ambiri a khansa, kupatulapo sarcomas. Mankhwala ali zimakhudzanso maphunziro khansa, amene sakhoza anakhudzidwa ndi mankhwala ena. Thunthu la mankhwala sikuli kwa aliyense wa makampani mankhwala alipo, kotero mankhwala si setifiketi. Izi zimadalira kwambiri chifukwa chodya wake.

Laboratory mayesero anasonyeza kuti mankhwala, kupereka kulamulira mmene maselo a khansa popanda okhudza wathanzi nthawi yomweyo pa ziwalo za thupi.

Pamene kuyamba kutenga mankhwala?

Nkofunika mu mankhwala a khansa amatanthauza "Sodium dichloroacetate" kutenga pamene chikhalidwe thupi akadali zogwira mtima. Sitidikira ndimeyi maphunziro angapo mankhwala amphamvu lomwe lili ndi chiwonongeko kwambiri. Komanso, maselo a khansa amakhala asanazolowere mankhwala. Iwo kalekale aona madokotala. Maphunziro oyamba a mankhwala amphamvu anachita ndi zotsatira zabwino pa njira ya matenda, yotsatira M'malo mwake, sizithandiza. Choncho, mankhwala ayenera kuyamba posachedwapa, ngakhale molumikizana ndi maphunziro zimapangidwira. Komabe, mlingo sayenera upambana 15 mg pa 1 makilogalamu thupi.

Kukonzekera "ndi sodium dichloroacetate": kapangidwe

The zikuchokera mankhwala - ndi sodium wochuluka mchere asidi dichloroacetic. Sol ndi chiphunzitso mu mawonekedwe a monohydrate, ndiko za 12% - .. Water analimbikitsa.

Asayansi panopa kugwiritsa njira kuchepetsa kawopsedwe wa mankhwala ankaona ndi nchito zake polimbana ndi khansa.

mankhwala

M'pofunika kudziwa, ngati mwaganiza kugula mankhwala "ndi sodium dichloroacetate." Kodi kutenga mankhwala kuthandiza odwala chamoyo, asayansi waonetsedwa kale. Kuchokera pa makilogalamu 1 kulemera - 25-50 mg wa tsiku lonse. Ntchito mankhwala kwa zaka ziwiri pa 50 mg zingachititse neuropathy zotumphukira Choncho mlingo mlingo anachepetsedwa kuti 25 mg, omwe ankalimbikitsa kutha zochitika zosasangalatsa.

Ngati mankhwala pa mlingo wa 25 mg pa 1 makilogalamu thupi amachititsa kudzimbidwa, nseru, dzanzi zala, kupuma mavuto (komanso zingachititse maganizo, kugwedeza, chizungulire, tulo, pafupipafupi pokodza, nkhawa), mlingo ayenera kusanduka 10 mg pa 1 makilogalamu thupi . Nthawi zina amalangiza ambiri kuti siyani kumwa mankhwalawa kwa masiku angapo. Pamenepo kofunika kuti abwerere kwa mlingo chomwecho - 25 mg pa 1 makilogalamu thupi patsiku. Katswiri milandu citric acid, zomwe zochitika ndichepe neuropathy zotumphukira atalandira "ndi sodium dichloroacetate" kukonzekera. Malangizo ntchito kufunika kuchepetsa ndi medicament ankaona ndi madzi (100-150 ml). Izi ndi zovuta kuchita, popeza mankhwala ndi mawonekedwe ufa. Muyenera kupewa khungu kukhudzana ndi mankhwala - zingayambitse mkwiyo.

Gwiritsani ntchito mankhwala mu lysis a zotupa

Mankhwala zingachititse lysis a zotupa zilonda mu pachimake lymphatic khansa, lymphoma sanali Hodgkin a, pachimake mielotsiticheskoy khansa, khansa ya m'mawere carcinoma selo, aakulu lymphatic khansa, khansa testicular, carcinoma selo, medulloblastoma.

Lysis chotupa zilonda wotchedwa aputosisi mofulumira kwambiri ya maselo a khansa (ma selo imfa), limodzi ndi kuwonongeka zakuthwa ukupeza (milandu kwapadera, angachititse imfa). Zikatero, muyenera yomweyo suspend mankhwala ndi dokotala. Patapita masiku angapo, mwina aloledwe kuyambiranso ntchito mankhwala, pamene kuchepetsa mlingo.

Information za zosagwirizana mankhwala amatanthauza "Sodium dichloroacetate" ndi mankhwala ena si chifukwa cha zachilendo ake (kupatulapo - mankhwala "Lasix").

Ntchito imodzi ndi teas kofeinizirovannymi, mlingo waukulu wa vitamini B1, mitundu citric acid, coenzyme Q, ndi alpha-lipoic asidi anawonjezera lapamwamba.

Mphamvu ya mankhwala

Efficacy medicament "ndi sodium dichloroacetate" kumatengera zifukwa zingapo. N'zochititsa chidwi kuchepetsa katundu akangofika osasamalika wodwala. Mwachitsanzo, pamene chifukwa matenda anakhudzidwa ziwalo zofunika kwambiri, kapena chiwonongeko zinachitika atamwa mankhwala amphamvu. Komanso, musati kulengeza ntchito ndalama, ngati wodwalayo sasefukira, nthawi zonse zowawa, iye amatenga mankhwala.

Amachepetsa Mwachangu za kukonzekera ndi amphamvu matenda kugonjetsedwa chiwindi. Pamene sangathe kulimbana ndi maselo akufa chotupa ndi mankhwala kuwonongeka amene amagwa mu magazi, vuto limakhala zovuta.

Pa mogwira otsika mlingo wa mankhwala ndi otsika, pamene mlingo waukulu chifukwa amakhala noticeable. Koma pali zinthu zina chiopsezo. Pa mlingo waukulu, izo zikhoza kuchitika kuti oipa mankhwala a chotupa chiwindi sangathe kulimbana. Uyu adzachititsa kuledzera, kunyansidwa ndi kusanza. Choncho, mlingo ayenera kusankhidwa molondola.

Kumene kugula?

Kodi ngati munthu ayenera kugula mankhwala "ndi sodium dichloroacetate"? Kumene kugula? Mukhozanso ankaona mankhwala Canada, kotero inu mukhoza kuyitanitsa pogwiritsa ntchito chuma intaneti tidaipanga. Palinso mwayi kugula ogulitsa mankhwala mu Russia, kugula mu Canada. Mtengo wa mankhwala si mkulu, kotero gulani angakwanitse odwala za thupi strata osiyana siyana.

Reviews kukonzekera

Ubwino wa mankhwala "dichloroacetate ndi sodium" zomwe amakambirana kutsimikizira izo, agona mu ambiri odwala khansa. mankhwala ntchito nthawi yomweyo ndi njira ya mankhwala amphamvu, ndi mankhwala ena amene sanali kuchepetsa nchito zake. Madokotala ena sakhulupirira ayambe odwala awo. Anadabwa pamene odwala anali pa peza lapansi. Ambiri mfundo za kusowa mavuto tikadwala mankhwala.

ndemanga zoipa ochepa kwambiri. Iwo onse amanenanso za kupanda mankhwala "dichloroacetate ndi sodium." Ndi chiyani icho? Amadziwika kuti odwala ena mankhwala sanali kuthandiza muchisiye matenda. Anthu ena amanena zikamera wa zisadzachitikenso matenda.

Kodi kutsimikizira kudalirika kwa mankhwala

Lodalirika "Sodium dichloroacetate" mankhwala akusonyeza zifukwa zingapo: tichipeza timibulu woyera, kulawa zowawa. Ngati mtundu ndi timibulu chikasu, ndi medicament ali otsika quality, ndipo osavomerezeka. Pamene Kutha mankhwala mu madzi, sitiyenera kutaya kukoma kwake owawa. Pamene sitimadzipereka kwa slurry ufa ndi nthawi ntchito kwa khungu la mkono kapena pamwamba lamkati la paphewa pa intervals wa 1 miniti pa mphindi 10, ndiye patapita kanthawi ndi edging ndi aumbike unobtrusive malo. Ndipo pambuyo maola 5-10 wa malo adzakhala kwambiri wofiira ndi momveka. Patatha masiku angapo pa malo khungu angayambe peel. Njira imeneyi yachinsinsi akulimbikitsidwa kugwiritsa ntchito pa nkhani kwambiri: kuwonjezera ufa asidi sulfuric ntchito galimoto batire, anachita amapezeka ndi zamoyo wa kutentha ndi fungo asidi dichloroacetic. Self mankhwala ali pafupifupi palibe fungo. The apamwamba khalidwe la mankhwala komanso fungo zochepa. Ngati inu kulawa ufa, izo adzachititsa dzanzi, kuzizira ndi zotsatira astringent.